Orphanin FQ potentiates formalin-induced pain behavior and antagonizes morphine analgesia in rats

Neuroscience Letters

Volumn 235, Issue 1-2, 1997, Pages 37-40

  Zhu, Chong Bin ^a   Cao, Xiao Ding ^a   Xu, Shao Fen ^a   Wu, Gen Cheng ^a  

^a The State Key Laboratory of Medical Neurobiology   (China)

Author keywords

Formalin pain; Morphine analgesia; Orphanin FQ

Indexed keywords

FORMALDEHYDE; MORPHINE; NEUROPEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG INDUCED DISEASE; DRUG POTENTIATION; HYPERALGESIA; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; NOCICEPTION; NONHUMAN; PAIN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RNA TRANSLATION;

ANALGESIA; ANIMALS; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FORMALDEHYDE; MALE; MORPHINE; OLIGONUCLEOTIDES, ANTISENSE; OPIOID PEPTIDES; PAIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID;

EID: 0030777654     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00704-0     Document Type: Article

References (20)

1. Dubuisson D., Dennis S.G. The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain. 4:1977;161-174.
2. Famser O.B., Berge O.-G., Hole K. Changes in nociception after lesions of descending serotoninergic pathways induced with 5,6-dihydroxytryptamine. Different effects in the formalin and tail-flick tests. Neuropharmacology. 24:1985;729-734.
3. Gintzler A.R., Adapa I.D., Toll L., Medina V.M., Wang L. Nociceptin can modulate evoked enkephalin release from the myenteric plexus. Soc. Neurosci. Abstr. 22:1996;1306.
4. Gogas K.R., Cho H.J., Botchkina G.I., Levine J.D., Basbaum A.I. Inhibition of noxious stimulus-evoked pain behaviors and neuronal fos-like immunoreactivity in the spinal cord of the rat by supraspinal morphine. Pain. 65:1996;9-15.
5. Grandy, D.K., Fiorillo, C., Mercuri, N.B., Bernardi, G., Williams, J.T and Bonci, A., Orphanin FQ (OFQ) inhibits central monoaminergic neurons, 27th Meeting of the International Narcotics Research Conference, Abstr. (1996) 83.
6. Meunier J.C., Mollereau C., Toll L., Suaudeau C., Moisand C., Alvinerie P., Butour J.-L., Guillemot J.-C., Ferrara P., Monsarrat B., Mazargull H., Vassart G., Parmentier M., Costentin J. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature. 377:1995;532-535.
7. Mogil J.S., Grisel J.E., Zhangs G., Belknap J.K., Grandy D.K. Functional antagonism of μ, δ and κ-opioid antinociception by orphanin FQ. Neurosci. Lett. 214:1996;131-134.
8. Monteillet, G.G., Lamm, H., Fein, J., Keith, D., Jr., Singh, P., Stewart, P., Evans, C.J. and Anton, B., Immunolocalization of MOR and ORL-1 receptors in spinal pain processing pathways, 27th Meeting of the International Narcotics Research Conference, Abstr. (1996) 80.
9. Murphy N.P., Ly H.T., Maidment N.T. Intracerebroventricular orphanin FQ/nociceptin suppresses dopamine release in the nucleus accumbens of anaesthetized rats. Neuroscience. 75:1996;1-4.
10. Reinscheid R.K., Nothacker H.-P., Bourson A., Ardati A. Ard, Henningsen R.A., Bunzow J.R., Grandy D.K., Langen H., Monsma F.J., Civelli O. Orphanin FQ: a neuropeptide that activates an opioid like G-protein-coupled receptor. Science. 270:1995;792-794.
11. Rossi G.C., Leventhal L., Pasternak G.W. Naloxone sensitive orphanin FQ-induced analgesia in mice. Eur. J. Pharmacol. 311:1996;R7-R8.
12. Schulz S., Schreff M., Nuss D., Gramsch C., Hollt V. Nociceptin/orphanin FQ and opioid peptides show overlapping distribution but not co-localization in pain-modulatory brain regions. NeuroReport. 18:1996;3021-3025.
13. Sugimoto M., Kuraishi Y., Satoh M., Takagi H. Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain. Neuropharmacology. 25:1986;481-485.
14. Vaughan C.W., Ingram S.L., Christie M.J. Actions of the ORL1 receptor ligand nociceptin on membrane properties of rat periaqueductal gray neurons in vitro. J. Neurosci. 17:1997;996-1003.
15. Wick M.J., Minnerath S.R., Lin X., Elde R., Law P.-Y., Loh H.H. Isolation of novel cDNA encoding a putative membrane receptor with high homology to the cloned μ, δ and κ opioid receptors. Mol. Brain Res. 27:1994;37-44.
16. Yang H.L., Luo R.S., Wang L.X., Zhu D.X., Chi C.W. Primary structure and disulfide bridge location of arrowhead double-headed proteinase inhibitors. J. Biochem. 111:1992;537-545.
17. Zhu C.-B., Zhang X.-L., Xu S.-F., Cao X.-D., Wu G.-C. Intracerebroventricular injection of orphanin FQ induces hyperalgesia and attenuates acupuncture analgesia in rats. Soc. Neurosci. Abstr. 22:1996;1368.
18. Zhu C.-B., Xu S.-F., Cao X.-D., Wu G.-C., Zhang X.-L., Li M.-Y., Cui D.-F., Chi C.-W. Antagonistic action of orphanin FQ on acupuncture analgesia in rat brain. Acupunc. Electro-Ther. Res. 21:1996;199-205.
19. Zhu, C.-B., Zhang, X.-L., Xu, S.-F., Cao, X.-D., Wu, G.-C., Li, M.-Y., Cui, D.-F. and Qi, Z.-W., Antagonistic effect of orphanin FQ on opioid analgesia in rat, Acta Pharmacol. Sin., 19 (1998) in press.
20. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 16:1983;109-110.