Leptin in pregnancy

Biology of Reproduction

Volumn 63, Issue 5, 2000, Pages 1219-1228

  Henson, M C ^a   Castracane, V D ^a  

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Conceptus; Gene regulation; Hormone action; Leptin; Leptin receptor; Placenta; Pregnancy; Syncytiotrophoblast

Indexed keywords

BETA ACTIN; BINDING PROTEIN; CHORIONIC GONADOTROPIN; CORTICOTROPIN; CYCLIC AMP; ESTRADIOL; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GONADOTROPIN; GROWTH HORMONE; HORMONE; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; PROLACTIN;

GENE CONTROL; HUMAN; NONHUMAN; PERINATAL MORBIDITY; PLACENTA; PREGNANCY; PRIORITY JOURNAL; SHORT SURVEY; SYNCYTIOTROPHOBLAST;

ANIMALIA; PRIMATES;

EID: 0033755561     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod63.5.1219     Document Type: Short Survey

References (148)

1. Leptin and other secretory products of adipocytes modulate multiple physiological functions
2. Leptin and the regulation of body weight
3. The role of leptin in human obesity and disease: A review of current evidence
4. Central administration of leptin inhibits food intake and activates the sympathetic nervous system in rhesus macaques
5. Regulation of body weight in humans
6. Clinical aspects of leptin
7. The leptin receptor
8. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
9. Localization of leptin receptor in the human brain
10. Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin
11. Identifcation and expression cloning of a leptin receptor, OB-R
12. Leptin receptor isoforms expressed in human adipose tissue
13. Positional cloning of the mouse obese gene and its human homologue
14. Leptin: A molecule integrating somatic energy stores, energy expenditure and fertility
15. Effects of recombinant leptin therapy in a child with congenital leptin deficiency
16. Molecules in focus: Leptin
17. Leptin and the regulation of body weight in mammals
18. Clinical endocrinology of human leptin
19. Leptin's action on the reproductive axis: Perspectives and mechanisms
20. Leptin and reproduction
21. Early onset of reproductive function in normal female mice treated with leptin
22. Leptin accelerates the onset of puberty in normal female mice
23. Leptin is a metabolic signal to the reproductive system
24. The adipose obese gene product, leptin: Evidence of a direct inhibitory role in ovarian function
25. Adipose obese gene product, leptin, inhibits bovine ovarian theca cell steroidogenesis
26. The stimulatory effect of leptin on the neuroendocrine reproductive axis of the monkey
27. The expression of leptin and its receptor in pre-ovulatory human follicles
28. Expression of functional leptin receptors in the human ovary
29. Lepfin antagonizes the insulin-like growth factor-I augmentation of steroidogenesis in granulosa and theca cells of the human ovary
30. Physiological perspectives on leptin as a regulator of reproduction: Role in timing of puberty
31. A role for leptin in sexual maturation and puberty?
32. Leptin is inversely related to age at menarche inhuman females
33. Gender differences in serum leptin levels in humans
34. Serum leptin concentration in women: Effect of age, obesity and estrogen administration
35. Longitudinal study of leptin concentrations during puberty: Sex differences and relationships to changes in body composition
36. Estrogen increases in vivo leptin production in rats and human subjects
37. Serum leptin concentration in cord blood: Relationship to birth weight and gender
38. Leptin levels in pregnant women and newborn infants: Gender differences and reduction during the neonatal period
39. Leptin values in placental cord blood of human newborns with normal intrauterine growth after 30-42 weeks of gestation
40. Leptin concentration in newborns' cord blood: Relationship to gender and growth-regulating hormones
41. Ontogeny of leptin in human fetuses and newborns: Effect of intrauterine growth retardation on serum leptin concentrations
42. Circulating leptin in women: A longitudinal study in the menstrual cycle and during pregnancy
43. Longitudinal changes in maternal serum leptin concentrations, body composition, and resting metabolic rate in pregnancy
44. Leptin in human reproduction: Serum leptin levels in pregnant and lactating women
45. Levels of leptin in maternal serum, amniotic fluid, and arterial and venous cord blood: Relation to neonatal and placental weight
46. Longitudinal analysis of maternal serum leptin levels during pregnancy, at birth and up to six weeks after birth: Relation to body mass index, skinfolds, sex steroids and umbilical cord blood leptin levels
47. Leptin in human pregnancy: The relationship with gestational hormones
48. Leptin levels in pregnancy: Marker for fat accumulation and mobilization
49. Cord blood leptin reflects fetal fat mass
50. Leptin expression during the differentiation of subcutaneous adipose cells of human embryos in situ
51. Abundance of leptin mRNA in fetal adipose tissue is related to fetal body weight
52. Leptin is present in human cord blood
53. Serum leptin concentration in cord blood: Relationship to birth weight and gender
54. Serum leptin concentrations during pregnancy and their relationship to fetal growth
55. Difference of plasma leptin levels in venous and arterial cold blood: Relation to neonatal and placental weight
56. Changes of maternal serum leptin levels during pregnancy
57. A positive umbilical venous-arterial difference of leptin level and its rapid decline after birth
58. Synthesis of leptin in human placenta
59. Placental leptin: An important new growth factor in intrauterine and neonatal development?
60. Non-adipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans
61. Expression of placental leptin and leptin receptor transcripts in early pregnancy and at term
62. Placental leptin
63. Leptin and neuropeptide Y gene expression in human placenta: Ontogeny and evidence for similarties to hypothalamic regulation
64. Augmentation of leptin synthesis and secretion through activation of protein kinases A and C in cultured human trophoblastic cells
65. Effects of pregnant human, nonpregnant human, and fetal bovine sera on human chorionic gonadotropin, estradiol, and progesterone release by cultured human trophoblast cells
66. Endocrinology of pregnancy
67. Pregnancy maintenance and the regulation of placental progesterone biosynthesis in baboon pregnancy
68. Effects of reduced maternal lipoprotein-cholesterol availability on placental progesterone biosynthesis in the baboon
69. Timing of the luteal-placental shift in the baboon (Papio cynocephalus)
70. The relationship of estrogen to placental steroidogenesis in the baboon
71. Serum leptin concentrations and expression of leptin transcripts in placental trophoblast with advancing baboon pregnancy
72. Divergent signaling capacities of the long and short isoforms of the leptin receptor
73. Leptin receptor transcripts are constitutively expressed in placenta and adipose tissue with advancing baboon pregnancy
74. Increase of mouse leptin production by adipose tissue after midpregnancy: Gestation profile of serum leptin concentration
75. Ontogeny of the expression of leptin and its receptor in the murine fetus and placenta
76. Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta
77. Mouse placental cells secrete soluble leptin receptor (sOB-R): cAMP inhibits sOB-R production
78. Leptin is not necessary for gestation and parturition but regulates maternal nutrition via a leptin resistance state
79. Gestational profile of leptin messenger ribonucleic acid (mRNA) content in the placenta and adipose tissue in the rat, and regulation of the mRNA levels of the leptin receptor subtypes in the hypothalamus during pregnancy and lactation
80. Increase in serum leptin and uterine leptin receptor messenger RNA levels during pregnancy in rats
81. Concentrations of leptin in the serum of pregnant, lactating, and cycling rats and of leptin messenger ribonucleic acid in rat placental tissue
82. Serum leptin levels do not rise during pregnancy in age-matched rats
83. The placenta is not the main source of leptin production in pregnant rat: Gestational profile of leptin in plasma and adipose tissues
84. Colocalization of leptin receptor (OB-R) mRNA and placental lactogen-II in rat trophoblast cells: Gestational profile of OB-R mRNA expression in placentae
85. Hyperleptinemia of pregnancy associated with the appearance of a circulating form of the leptin receptor
86. Leptin and reproduction
87. Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting
88. Free leptin, bound leptin, and soluble leptin receptor in normal and diabetic pregnancies
89. Suppression of leptin during lactation: Contribution of the suckling stimulus versus milk production
90. Effect of acute food deprivation on lactational infertility in rats is reduced by leptin administration
91. Leptin as a metabolic regulator during fetal and neonatal life and in childhood and adolescence
92. Leptin: In search of role(s) in human physiology and pathophysiology
93. Relationship between concentrations of serum leptin and fetal growth
94. Leptin concentration in cord blood correlates with intrauterine growth
95. Cord blood leptin concentrations in relation to intrauterine growth
96. Leptin concentrations in maternal serum and cord blood: Relationship to maternal anthropometry and fetal growth
97. Cord blood leptin is associated with size at birth and predicts infancy weight gain in humans
98. Regulation of in vivo growth hormone secretion by leptin
99. Leptin alters the response of the growth hormone releasing factor-growth hormone-insulin-like growth factor-I axis to fasting
100. Regulation of growth hormone (GH)-releasing hormone and somatostatin on leptin-induced GH secretion
101. Leptin is a potent stimulator of spontaneous pulsatile growth hormone secretion and the GH response to GH-releasing hormone
102. Intact leptin receptor is selectively expressed in human fetal pituitary and pituitary adenomas and signals human fetal pituitary growth hormone secretion
103. Physiological role of human placental growth hormone
104. Current concepts concerning the role of leptin in reproductive function
105. A role for leptin and its cognate receptor in hematopoiesis
106. Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction
107. Serum leptin level: Possible association with haematopoiesis in adolescents, independent of body mass index and serum insulin
108. Leptin receptor in human term placenta: In situ hybridization and immunohistochemical localization
109. Biological action of leptin as an angiogenic factor
110. Leptin, the product of ob gene, promotes angiogenesis
111. Serum leptin levels in women throughout pregnancy and the postpartum period and in women suffering spontaneous abortion
112. Modulation of human cytotrophoblastic leptin secretion by interleukin-1α and 17 β-oestradiol and its effect on HCG secretion
113. Effects of interleukin-6 (II-6) on cytotrophoblastic cells
114. Role of gonadal steroids in the sexual dimorphisms in body composition and circulating concentrations of leptin
115. Elevated leptin concentrations in pregnancy and lactation: Possible role as a modulator of substrate utilization
116. Detection and regulation of leptin receptor mRNA in ovine mammary epithelial cells during pregnancy and lactation
117. Adipose tissue ob mRNA expression in humans: Discordance with plasma leptin and relationship with adipose TNFα expression
118. Tumor necrosis factor-α contributes to obesity related hyperleptinemia by regulating leptin release by adipocytes
119. The role of SOCS-3 in leptin signaling and leptin resistance
120. Relationship between leptin and oestrogens in healthy women
121. Serum leptin concentrations during the menstrual cycle in normal weight women: Effects of an oral triphasic estrogen-progestin medication
122. Plasma leptin during the menstrual cycle
123. Changes of circulating leptin levels during normal menstrual cycle: Relationship to estradiol and progesterone
124. Leptin levels vary significantly during the menstrual cycle, pregnancy, and in vitro fertilization treatment: Possible relation to estradiol
125. Serum leptin profiles in the normal menstrual cycles and gonadotropin treatment cycles
126. Circulating leptin levels during ovulation induction: Relation to adiposity and ovarian morphology
127. Effects of short-term hormone replacement on serum leptin levels in postmenopausal women
128. Effects of administration of 17β-oestradiol on serum leptin levels in healthy postmenopausal women
129. Serum leptin levels in postmenopausal women: Effects of transdermal hormone replacement therapy
130. Synchronicity of frequently sampled 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women
131. Influence of sex differences in subcutaneous fat mass on serum leptin concentrations
132. Regulation of leptin gene expression and secretion by steroid hormones
133. Effects of exogenous gonadal steroids on leptin homeostasis in rats
134. Human obese gene expression, adipocyte-specific expression and regional differences in adipose tissue
135. Difference in leptin mRNA between omental and subcutaneous abnormal tissue from obese humans
136. Depot-specific differences in adipose tissue gene expression in lean and obese subjects
137. Identification of a placental enhancer for the human leptin gene
138. Demonstration of a leptin binding factor in human serum
139. Soluble hormone receptors
140. Elevation of plasma leptin levels during pregnancy in normal and diabetic women
141. Augmented placental production of leptin in preeclampsia: Possible involvement of placental hypoxia
142. Maternal plasma leptin is increased in preeclampsia and positively correlates with fetal cord concentration
143. Pre-eclampsia disrupts the normal relationship between serum leptin concentrations and adiposity in pregnant women
144. Selective deficit of angiogenic factor characterizes pregnancies complicated by pre-eclampsia
145. Overexpression of placental leptin in diabetic pregnancy: A critical role for insulin
146. Leptin concentrations in cord blood in normal newborn infants and offspring of diabetic mothers
147. Relative hypoleptinaemia in women with mild gestational diabetes mellitus
148. Macrosomia revisited: Ponderal index and leptin delineate subtypes of placental overgrowth