Longitudinal study of leptin concentrations during puberty: Sex differences and relationship to changes in body composition

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 3, 1999, Pages 899-905

  Ahmed, Marion Lynn ^a   Ong, Ken K L ^a   Morrell, David J ^b   Cox, Les ^c   Drayer, Nick ^a   Perry, Leslie ^d   Preece, Michael A ^c   Dunger, David B ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; ESTRADIOL; LEPTIN; PRASTERONE SULFATE; SEX HORMONE BINDING GLOBULIN; SOMATOMEDIN C; TESTOSTERONE; THYROXINE;

ADOLESCENT; ARTICLE; BODY COMPOSITION; BODY FAT; CHILD; FEMALE; HORMONAL REGULATION; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; LONGITUDINAL STUDY; MALE; NORMAL HUMAN; PHYSICAL DEVELOPMENT; PRIORITY JOURNAL; PUBERTY; SEX DIFFERENCE; SEXUAL MATURITY; WEIGHT GAIN;

EID: 0032988738     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.84.3.899     Document Type: Article

References (40)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman J. 1994 Positional cloning of the mouse obese gene and its human homologue. Nature. 372:425-432.
2. Maffei M, Fei H, Lee GH, et al. 1995 Increased expression in adipocytes of ob RNA mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci USA. 92:6957-6960.
3. Stephens TW, Basinski M, Bristow PK, et al. 1995 The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature. 377:530-534.
4. Vaisse C, Halaas JL, Horvath CM, Darnell Jr JE, Stoffel M, Friedman JM. 1996 Leptin activation of Stat3 in the hypothalamus of wild type and ob/ob mice but not db/db mice. Nat Genet. 14:95-97.
5. Montague CT, Farooqi IS, Whitehead JF, et al. 1997 Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 387:903-908.
6. Clément K, Vaisse C, Lahlou N, et al. 1998 A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 392:398-401.
7. Strobel A, Issad T, Camoin L, Ozata M, Strosberg AD. 1998 A leptin mis-sense mutation associated with hypogonadism and morbid obesity. Nat Genet. 18:213-215.
8. Qureshi A, Kopelman PG. 1997 Leptin-fat messenger or fat controller? Clin Endocrinol (Oxf). 47:169-171.
9. Chessler SD, Fujimoto WY, Shofer JB, Boyko EJ, Weigle DS. 1998 Increased plasma leptin levels are associated with fat accumulation in Japanese Americans. Diabetes. 47:239-243.
10. Ravussin E, Pratley RE, Maffei M, et al. 1997 Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat Med. 3:238-240.
11. Rohner-Jeanrenaud F, Cusin I, Sainsbury A, Zakizewska KE, Jeanrenaud B. 1996 The loop system between neuropeptide Y and leptin in normal and obese rodents. Horm Metab Res. 28:642-648.
12. Ahima RS, Dushay J, Flier SN, Prabakaran D, Flier JS. 1997 Leptin accelerates the onset of puberty in normal female mice. J Clin Invest. 99:391-395.
13. Cheung CC, Thornton JE, Kuijper JL, Weigle DS, Clifton DK, Steiner RA. 1997 Leptin is a metabolic gate for the onset of puberty in the female rat. Endocrinology. 138:855-858.
14. Chehab FF, Mounzih K, Lu R, Lim ME. 1997 Early onset of reproductive function in normal female mice treated with leptin. Science. 275:88-90.
15. Apter D. 1997 Leptin in puberty. Clin Endocrinol (Oxf). 47:75-176.
16. Mantzoros CS, Flier JS, Rogol AD. 1997 A longitudinal assessment of hormonal and physical alterations during normal puberty in boys vs. rising leptin levels may signal the onset of puberty. J Clin Endocrinol Metab. 83:1066-1070.
17. Blum WF, Englaro P, Hanitsch S, et al. 1997 Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J Clin Endocrinol Metab. 82:2904-2910.
18. Clayton PE, Gill MS, Hall CM, Tillmann V, Whatmore AJ, Price DA. 1997 Serum leptin through childhood and adolescence. Clin Endocrinol (Oxf). 46:727-733.
19. Garcia-Mayor RV, Andrade M.A, Rios M, Lage M, Dieguez C, Casaneuva FF. 1997 Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones and pubertal stage. J Clin Endocrinol Metab. 82:2849-2855.
20. Carlsson B, Ankarberg C, Rosberg S, Norjavaara E, Albertsson-Wikland K, Carlsson LMS. 1997 Serum leptin concentrations in relation to pubertal development. Arch Dis Child. 77:396-400.
21. Wabitsch M, Blum WF, Muche R, et al. 1997 Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J Clin Invest. 100:808-813.
22. Tanner JM. 1962 Growth at adolescence. Oxford: Blackwell; 325.
23. Cameron N. 1984 The measurement of human growth. Kent: Croom Helm; 182.
24. Morrell D, Dadi H, More J, et al. 1989 Monoclonal antibody to human Insulin-like growth faclor-I: characterisation, use in radio-immunoassay and effect on the biological activities of the growth factor. J Mol Endocrinol. 2:201-206.
25. Dunger DB, Perkins J, Jowett JP, et al. 1990 A longitudinal study of total and free thyroid hormones and thyroid binding globulin during normal puberty. Acta Endocrinol (Copenh). 123:305-310.
26. Wathen NC, Perry LA, Rubenstein E, Chard T. 1987 A relationship between SHBG and DHEAS in normally menstruating females. Gynecol Endocrinol 1:47-50.
27. Fattah D, Chard T. 1981 A simplified method for the measurement of sex hormone binding globulin. Clin Chem. 27:1277-1279.
28. Brook CGD. 1971 Determination of body composition of children from skinfold measurements. Arch Dis Child. 46:182-184.
29. Durnin JVGA, Rahaman MM. 1967 The assessment of the amount of fat in the human body from measurements of skinfold thickness. Br J Nutr. 21:681-689.
30. Reilly JJ, Wilson J, Durnin JVGA. 1995 Determination of body composition from skinfold thickness: a validation study. Arch Dis Child. 73:305-310.
31. Siri WE. 1956 The gross composition of the body. Adv Biol Med Phys. 4:239-280.
32. Bland JM, Altman DG. 1995 Calculating correlation coefficients with repeated observations. I. Correlation within subjects. Br Med J. 310:446.
33. Forbes GB. 1978 Body composition in adolescence. In: Falkner F, Tanner JM, eds. Human growth. London: Bailliere Tindall; vol 2:239-272.
34. Matkovic V, Ilich JZ, Skugor M, et al. 1997 Leptin is inversely related to age at menarche in human females. J Clin Endocrinol Metab. 82:3239-3245.
35. Stark O, Peckham CS, Moynihan C. 1989 Weight and age at menarche. Arch Dis Child. 64:383-387.
36. Frisch RE, Revelle R, Cook S. 1973 Components of weight at menarche and the initiation of the adolescent growth spurt in girls: estimated total water, lean body weight and fat. Hum Biol. 45:469-483.
37. Jockenhovel F, Blum WF, Vogel E, et al. 1997 Testosterone substitution normalizes elevated serum leptin levels in hypogonadal men. J Clin Endocrinol Metab. 82:2510-2513.
38. Palmert MR, Radovick S, Boepple PA. 1998 The impact of reversible gonadal sex steroid suppression on serum leptin concentrations in children with central precocious puberty. J Clin Endocrinol Metab. 83:1091-1096.
39. Yoshida T, Momotani N, Hayashi M, Monkawa T, Ito K, Saruta T. 1998 Serum leptin concentrations in patients with thyroid disorders. Clin Endocrinol (Oxf). 48:299-302.
40. Slieker LJ, Sloop KW, Surface PL, et al. 1996 Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J Biol Chem. 271:5301-5304.