A role for leptin in sexual maturation and puberty?

Hormone Research

Volumn 51, Issue SUPPL. 3, 1999, Pages 55-63

  Kiess, Wieland ^a   Reich, A ^b   Meyer, K ^b   Glasow, A ^b   Deutscher, J ^b   Klammt, J ^b   Yang, Y ^b   Muller G ^b   Kratzsch, J ^b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b NONE

Author keywords

Energy; Gender; Gestation; Leptin; Leptin receptors; Neonatal life; ob Gene; Pubertal stage; Puberty; Reproduction

Indexed keywords

ANDROGEN; LEPTIN; TESTOSTERONE;

ADIPOCYTE; ANDROGEN SYNTHESIS; AUTONOMIC NERVOUS SYSTEM; BIRTH; BODY FAT; BODY WEIGHT; BROWN ADIPOSE TISSUE; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; ENERGY BALANCE; FEEDING BEHAVIOR; FEMALE; GENE EXPRESSION; HUMAN; LABOR; LACTATION; MALE; METABOLIC RATE; MUSCLE MASS; NONHUMAN; PLACENTA; PRIORITY JOURNAL; PUBERTY; REPRODUCTION; SEXUAL MATURATION; SIGNAL TRANSDUCTION; SYNTHESIS; THIRD TRIMESTER PREGNANCY; WHITE ADIPOSE TISSUE;

EID: 0032718820     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000053163     Document Type: Conference Paper

References (59)

1. Friedman J: Leptin, leptin receptors, and the control of body weight; in Blum WF, Kiess W, Rascher W (eds): Leptin - The Voice of the Adipose Tissue, J & J ed. Heidelberg, J.A. Barth, 1997, pp 3-22.
2. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-432.
3. Sinha MK: Human leptin: the hormone of adipose tissue. Eur J Endocrinol 1997;136:461-464.
4. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P: Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995;269: 546-549.
5. Considine RV, Caro JF: Leptin: genes, concepts and clinical perspective. Horm Res 1996; 46:249-256.
6. Köpp W, Blum WF, von Prittwitz S, Ziegler A, Lübbert H, Deter H-C, Remschmidt H, Hebebrand J: Do low leptin levels predict amenorrhea in underweight and eating-disordered women?; in Blum WF, Kiess W, Rascher W (eds): Leptin - The Voice of the Adipose Tissue, J & J ed. Heidelberg, J.A. Barth, 1997, pp 285-290.
7. Hamann A, Matthei S: Regulation of energy balance by leptin. Exp Clin Endocrinol Diabetes 1996;104:293-300.
8. Kiess W, Siebler T, Englaro P, Kratzsch J, Deutscher J, Meyer K, Gailaher B, Blum WF: Leptin as a metabolic regulator during fetal and neonatal life and in childhood and adolescence. J Pediatr Endocrinol Metab 1998;11:1-13.
9. Blum WF: Leptin - the voice of the adipose tissue. Horm Res 1997;48(suppl 4):2-8.
10. Kiess W, Schubring C, Prohaska F, Englaro P, Rascher W, Attanasio A, Blum WF: Leptin in amniotic fluid at term and at midgestation; in Blum WF, Kiess W, Rascher W (eds): Leptin -The Voice of the Adipose Tissue, J & J ed. Heidelberg, J.A. Barth, 1997, pp 192-200.
11. Schubring C, Kiess W, Englaro P, Rascher W, Dötsch J, Hanitsch S, Attanasio A, Blum WF: Levels of leptin in maternal serum, amniotic fluid, and arterial and venous cord blood: relation to neonatal and placental weight. J Clin Endocrinol Metab 1997;82:1480-1483.
12. Schubring C, Siebler T, Englaro P, Blum WF, Kratsch J, Triep K, Kiess W: Rapid decline of leptin serum levels in healthy neonates after birth (letter). Eur J Pediatr 1998;157:263-264.
13. Schubring C, Siebler T, Englaro P, Blum WF, Kratsch J, Triep K, Kiess W: Rapid decline of leptin serum levels in healthy neonates after birth. Clin Endocrinol 1999;51:199-204.
14. Kiess W, Blum WF, Aubert ML: Leptin, puberty and reproductive function: lessons from animal studies and observations in humans. Eur J Endocrinol 1997;138:26-29.
15. Schubring C, Blum WF, Kratzsch J, Deutscher J, Schmitt S, Kiess W: Leptin, the ob gene product, in female health and reproduction. Eur J Gynecol Obstet Reprod. In press.
16. Kiess W, Anil M, Blum WF, Englaro P, Juul A, Attanasio A, Dötsch J, Rascher W: Leptin serum levels in children and adolescents with diabetes in relation to metabolic control and body mass index. Eur J Endocrinol 1998;138: 501-509.
17. Butte NF, Hopkinson JM, Nicolson MA: Leptin in human reproduction: serum leptin levels in pregnant and lactating women. J Clin Endocrinol Metab 1997;82:585-589.
18. Schubring C, Kiess W, Englaro P, Rascher W, Dötsch J, Hanitsch S, Attanasio A, Blum WF: Longitudinal analysis of levels of leptin in maternal serum, amniotic fluid, and arterial and venous cord blood: relation to neonatal and placental weight. Horm Res 1998;50:276-283.
19. Hassink SG, Sheslow DV, de Lancey E, Opentanova I, Considine RV, Caro JF: Serum leptin in children with obesity: relationship to gender and development. Pediatrics 1996;98:201-203.
20. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF: Serum immunoreactive leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292-295.
21. Chen H, Chariat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP: Evidence that the diabetes gene encodes leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996;84:491-495.
22. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FF, Deeds J, Muir C, Sanker Y, Moriarty A, Moore KJ, Smutko JS, Mays GG, Woolf EA, Monroe CA, Tepper RI: Identification and expression cloning of a leptin receptor, OB-R. Cell 1995;83:1263-1271.
23. Tomaszuk A, Simpson C, Williams G: Neuropeptide Y, the hypothalamus and the regulation of energy homeostasis. Horm Res 1996;46: 53-58.
24. Spitzweg C, Heufelder AE: More clues from fat mice: leptin acts as an opponent of the hypothalamic neuropeptide Y system. Eur J Endocrinol 1997;136:590-591.
25. Brzechffa PR, Jakimuik AJ, Agarwal SK, Weitsman SR, Buyalos RP, Magoffin DA: Serum immunoreactive leptin concentrations in women with polycystic ovary syndrome. J Clin Endocrinol Metab 1996;81:4166-4169.
26. Blum WF, Englaro P, Hanitsch S, Juul A, Hertel NT, Kiess W, Skakkebaek NE, Birkett M, Heiman M, Attanasio A, Rasche W: Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J Clin Endocrinol Metab 1997;82:2904-2910.
27. Sinha MK, Opentanova I, Ohannesian JP, Kolaczynski JW, Heiman ML, Hale J, Marco C, Caro JF: Evidence of free and bound leptin in human circulation. J Clin Invest 1996;98: 1277-1282.
28. Auwerx J, Staels B: Leptin. Lancet 1998;351: 737-742.
29. Zachow RJ, Magotfin DA: Direct intraovarian effects of leptin: impairment of the synergistic action of IGF-I on FSH-dependent estradiol-17r3 production by rat ovarian granulosa cells. Endocrinology 1997;138:847-850.
30. Teirmaa T, Luukkaa V, Rouru J, Koulu M, Huupponen R: Correlation between circulating leptin and LH during the menstrual cycle in normal-weight women. Eur J Endocrinol 1998; 139:190-194.
31. Chehab F, Lim M, Lu R: Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 1996;12:318-320.
32. Chehab F, Mounzih K, Lu R, Lim ME: Early onset of reproductive function in normal mice treated with leptin. Science 1996;275:88-90.
33. Mounzih K, Lu R, Chehab FF: Leptin treatment rescues the sterility of genetically obese ob/ob males. Endocrinology 1997;138:1190-1193.
34. Frisch RE, McArthus JW: Menstrual cycles: fatness as a determinant of minimum weight necessary for their maintenance or onset. Science 1974;185:949-951.
35. Köpp W, Blum WF, von Prittwitz S, Ziegler A, Lübbert H, Emons G, Herzog W, Herpertz S, Deter H-C, Remschmidt H, Hebebrand J: Low leptin levels predict amenorrhea in underweight and eating disordered females. Mol Psychiatry 1997;2:335-340.
36. Miller KK, Paruiekar MS, Schoenfeld E, Anderson E, Hubbard J, Klibanski A, Grinspoon SK: Decreased leptin levels in normal weight women with hypothalamic amenorrhea: the effects of body composition and nutritional intake. J Clin Endocrinol Metab 1998;83:2309-2312.
37. Flier JS: What's in a name? In search of leptin's physiologic role. J Clin Endocrinol Metab 1998;83:1407-1413.
38. Pombo M, Herrera-Justiniano E, Considine RV, Hermida RC, Galvez MJ, Martin T, Barreiro J, Casanueva FF, Dieguez C: Nocturnal rise of leptin in normal prepubertal and pubertal children and in patients with perinatal stalk-transection syndrome. J Clin Endocrinol Metab 1997;82:2751-2754.
39. Shehawat PS, Garland JS, Shivpuri C, Mick GJ, Sasidharan P, Peiz CJ, McCormick KL: Neonatal cord blood leptin: its relationship to birth weight, body mass index, maternal diabetes, and steroids. Pediatr Res 1998;43:338-343.
40. Ellis KJ, Nicolson M: Leptin levels and body fatness in children: effects of gender, ethnicity and sexual development. Pediatr Res 1997;42: 484-488.
41. Clayton PE, Gill MS, Hall CM, Tilimann V, Whatmore AJ, Price DA: Serum leptin through childhood and adolescence. Clin Endocrinol 1997;46:727-733.
42. Ambrosius WT, Compton JA, Bowsher RR, Pratt JH: Relation of race, age, and sex hormone differences to serum leptin concentrations in children and adolescents. Horm Res 1998;49:240-246.
43. Havel PJ, Kasim-Karakas S, Dubuc GR, Molier W, Phinney SD: Gender differences in plasma leptin concentrations. Nat Med 1996;2: 949-950.
44. Nagy TR, Gower BA, Shewchuk RM, Goran MI: Serum leptin and energy expenditure in children. J Clin Endocrinol Metab 1997;82: 4149-4153.
45. Wabitsch M, Blum WF, Muche R, Braun M, Hube F, Rascher W, Heinze E, Teller W, Hauner H: Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J Clin Invest 1997; 100:808-813.
46. Lahlou N, Landais P, De Boissieu D, Bougneres PF: Circulating leptin in normal children and during the dynamic phase of juvenile obesity: relation to body fatness, energy metabolism, caloric intake, and sexual dimorphism. Diabetes 1997;46:989-993.
47. Steiner RA: Lords and ladies leapin' on leptin (editorial). Endocrinology 1996;137:4533-4534.
48. Kiess W, Englaro P, Hanitsch S, Rascher W, Attanasio A, Blum WF: High leptin concentrations in serum of very obese children are further stimulated by dexamethasone. Horm Metab Res 1996;28:708-710.
49. Vogel G: Leptin: a trigger for puberty? Science 1996;274:1466-1467.
50. Mantzoros CS, Flier JS, Rogol AD: A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty. J Clin Endocrinol Metab 1997;82: 1066-1070.
51. Palmert MR, Radovick S, Boepple PA: Leptin levels in children with central precocious puberty. J Clin Endocrinol Metab 1998;83:2260-2265.
52. Heger S, Partsch CJ, Peter M, Blum WF, Kiess W, Sippell W: Serum leptin levels in patients with progressive central precocious puberty. Pediatr Res. In press.
53. Gill MS, Hall CM, Tilimann V, Clayton PE: Constitutional delay in growth and puberty (CDGP) is associated with hypoleptinemia. J Clin Endocrinol Metab. In press.
54. Montague CT, Faroqui S, Whitehead JP, O'Rahilly S: Congenital leptin deficiency is associated with severe early onset obesity in humans. Nature 1997;387:903-908.
55. Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougneres P, Lebouc Y, Froguel P, Guy-Grand B: A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998;392:398-401.
56. Strobel A, Issad T, Camoin L, Ozata M, Strosberg AD: A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 1998;18:213-215.
57. Urbanski HF, Pau KY: A biphasic developmental pattern of circulating leptin in the male rhesus macaque (Macaco mulatta). Endocrinology 1998;139:2284-2286.
58. Plant TM, Durrant AR: Circulating leptin does not appear to provide a signal for triggering the initiation of puberty in the male rhesus monkey (Macaca mulatta). Endocrinology 1997;138: 4505-4508.
59. Krassas GE, Kaltsas TT, Pontikides N, Jacobs H, Blum WF, Messinis I: Leptin levels in women with polycystic ovary syndrome before and after treatment with diazoxide. Eur J Endocrinol 1998;139:184-189.