Current concepts concerning the role of leptin in reproductive function

Molecular and Cellular Endocrinology

Volumn 157, Issue 1-2, 1999, Pages 11-20

  Holness, M J ^a   Munns, M J ^a   Sugden, M C ^a  

^a Dept of Diabet and Metab Medicine   (United Kingdom)

Author keywords

Lactation; Leptin; Neonatal growth; Pregnancy; Reproduction; Sexual maturation

Indexed keywords

INSULIN; LEPTIN; LEPTIN RECEPTOR;

FETUS DEVELOPMENT; FETUS GROWTH; HUMAN; LACTATION; NUTRITIONAL REQUIREMENT; PERINATAL DEVELOPMENT; PREGNANCY; PRIORITY JOURNAL; REPRODUCTION; REVIEW; SEXUAL MATURATION; UTERUS GROWTH;

EID: 0032722980     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(99)00126-4     Document Type: Article

References (90)

1. Ahima R.S., Prabakaran D., Mantzoros C., Qu D., Lowell B., Maratos-Flier E., Flier J.S. Role of leptin in the neuroendocrine response to fasting. Nature. 382:1996;250-252.
2. Aiston S., Agius L. Leptin enhances glycogen storage in hepatocytes by inhibition of phosphorylase and exerts an additive effect with insulin. Diabetes. 48:1999;15-20.
3. Auwerx J., Staels B. Leptin. Lancet. 351:1998;737-742.
4. Barash I.A., Cheung C.C., Weigle D.S., Ren H., Kabigting E.B., Kuijper J.L., Clifton D.K., Steiner R.A. Leptin is a metabolic signal to the reproductive system. Endocrinology. 137:1996;3144-3147.
5. Barr V.A., Malide D., Zarnowski M.J., Taylor S.I., Cushman S.W. Insulin stimulates both leptin secretion and production by rat white adipose tissue. Endocrinology. 138:1997;4463-4472.
6. Bi S., Gavrilova O., Gong D.W., Mason M.M., Reitman M. Identification of a placental enhancer for the human leptin gene. J. Biol. Chem. 272:1997;30583-30588.
7. Blum W.F., Englaro P., Hanitsch S., Juul A., Hertel N.T., Muller J., Skakkebaek N.E., Heiman M.L., Birkett M., Attanasio A.M., Kiess W., Rascher W. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J. Clin. Endocrinol. Metab. 82:1997;2904-2910.
8. Bray G.A., York D.A. Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol. Rev. 59:1979;719-809.
9. Bray G.A., Fisler J., York D.A. Neuroendocrine control of the development of obesity: understanding gained from studies of experimental animal models. Frontiers Neuroendocrinol. 11:1990;128-181.
10. Campfield L.A., Smith F.J., Guisez Y., Devos R., Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 269:1995;546-549.
11. Carey D.G., Jenkins A.B., Campbell L.V., Freund J., Chisholm D.J. Abdominal fat and insulin resistance in normal and overweight women: Direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM. Diabetes. 45:1996;633-638.
12. Carlsson B., Ankarberg C., Rosberg S., Norjavaara E., Albertsson-Wikland K., Carlsson L.M. Serum leptin concentrations in relation to pubertal development. Arch. Dis. Child. 77:1997;396-400.
13. Chehab F.F. The reproductive side of leptin. Nat. Med. 3:1997;952-953.
14. Chien E.K., Hara M., Rouard M., Yano H., Phillippe M., Polonsky K.S., Bell G.I. Increase in serum leptin and uterine leptin receptor messenger RNA levels during pregnancy in rats. Biochem. Biophys. Res. Commun. 237:1997;476-480.
15. Cohen B., Novick D., Rubinstein M. Modulation of insulin activities by leptin. Science. 274:1996;1185-1188.
16. 13C NMR study of the effects of leptin treatment on kinetics of hepatic intermediary metabolism. Proc. Natl. Acad. Sci. USA. 95:1998;7385-7390.
17. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., Ohannesian J.P., Marco C.C., McKee L.J., Bauer T.L., Caro J.F. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New Engl. J. Med. 334:1996;292-295.
18. Coon P.J., Rogus E.M., Drinkwater D., Muller D.C., Goldberg A.P. Role of body fat distribution in the decline in insulin sensitivity and glucose tolerance with age. J. Clin. Endocrinol. Metab. 75:1992;1125-1132.
19. Couce M.E., Burguera B., Parisi J.E., Jensen M.D., Lloyd R.V. Localization of leptin receptor in the human brain. Neuroendocrinology. 66:1997;145-150.
20. Dessolin S., Schalling M., Champigny O., Lonnqvist F., Ailhaud G., Dani C., Ricquier D. Leptin gene is expressed in rat brown adipose tissue at birth. FASEB J. 11:1997;382-387.
21. Emilsson V., Liu Y.L., Cawthorne M.A., Morton N.M., Davenport M. Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes. 46:1997;313-316.
22. Garcia-Mayor R.V., Andrade M.A., Rios M., Lage M., Dieguez C., Casanueva F.F. Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage. J. Clin. Endocrinol. Metab. 82:1997;2849-2855.
23. Gettys T.W., Harkness P.J., Watson P.M. The beta 3-adrenergic receptor inhibits insulin-stimulated leptin secretion from isolated rat adipocytes. Endocrinology. 137:1996;4054-4057.
24. Halaas J.L., Gajiwala K.S., Maffei M., Cohen S.L., Chait B.T., Rabinowitz D., Lallone R.L., Burley S.K., Friedman J.M. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 269:1995;543-546.
25. Hardie L.J., Guilhot N., Trayhurn P. Regulation of leptin production in cultured mature white adipocytes. Horm. Metab. Res. 28:1996;685-689.
26. Hardie L., Trayhurn P., Abramovich D., Fowler P. Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy. Clin. Endocrinol. 47:1997;101-106.
27. Harigaya A., Nagashima K., Nako Y., Morikawa A. Relationship between concentration of serum leptin and fetal growth. J. Clin. Endocrinol. Metab. 82:1997;3281-3284.
28. Harris R.B., Zhou J., Redmann S.M. Jr., Smagin G.N., Smith S.R., Rodgers E., Zachwieja J.J. A leptin dose-response study in obese (ob/ob) and lean (+/?) mice. Endocrinology. 139:1998;8-19.
29. Hassink S.G., de Lancey E., Sheslow D.V., Smith-Kirwin S.M., O'Connor D.M., Considine R.V., Opentanova I., Dostal K., Spear M.L., Leef K., Ash M., Spitzer A.R., Funanage V.L. Placental leptin: an important new growth factor in intrauterine and neonatal development? Pediatrics. 100:1997;E1.
30. Herrera E., Lasuncion M.A., Palacin M., Zorzano A., Bonet B. Intermediary metabolism in pregnancy. First theme of the Freinkel era. Diabetes. 40(Suppl. 2):1991;83-88.
31. Hoggard N., Hunter L., Duncan J.S., Williams L.M., Trayhurn P., Mercer J.G. Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta. Proc. Natl. Acad. Sci. USA. 94:1997;11073-11078.
32. Igel M., Kainulainen H., Brauers A., Becker W., Herberg L., Joost H.G. Long-term and rapid regulation of ob mRNA levels in adipose tissue from normal (Sprague Dawley rats) and obese (db/db mice, fa/fa rats) rodents. Diabetologia. 39:1996;758-765.
33. Ishida K., Murakami T., Mizuno A., Iida M., Kuwajima M., Shima K. Leptin suppresses basal insulin secretion from rat pancreatic islets. Regul. Pept. 70:1997;179-182.
34. Jaquet D., Leger J., Levy-Marchal C., Oury J.F., Czernichow P. Ontogeny of leptin in human fetuses and newborns: effect of intrauterine growth retardation on serum leptin concentrations. J. Clin. Endocrinol. Metab. 83:1998;1243-1246.
35. Kieffer T.J., Heller R.S., Habener J.F. Leptin receptors expressed on pancreatic beta-cells. Biochem. Biophys. Res. Commun. 224:1996;522-527.
36. Kieffer T.J., Heller R.S., Leech C.A., Holz G.G., Habener J.F. Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells. Diabetes. 46:1997;1087-1093.
37. Kratzsch J., Dehmel B., Pulzer F., Keller E., Englaro P., Blum W.F., Wabitsch M. Increased serum GHBP levels in obese pubertal children and adolescents: relationship to body composition, leptin and indicators of metabolic disturbances. Int. J. Obes. Rel. Metab. Dis. 21:1997;1130-1136.
38. Laharrague P., Larrouy D., Fontanilles A.M., Truel N., Campfield A., Tenenbaum R., Galitzky J., Corberand J.X., Penicaud L., Casteilla L. High expression of leptin by human bone marrow adipocytes in primary culture. FASEB J. 12:1998;747-752.
39. Lepercq J., Cauzac M., Lahlou N., Timsit J., Girard J., Auwerx J., Hauguel-de Mouzon S. Overexpression of placental leptin in diabetic pregnancy: a critical role for insulin. Diabetes. 47:1998;847-850.
40. Leroy P., Dessolin S., Villageois P., Moon B.C., Friedman J.M., Ailhaud G., Dani C. Expression of ob gene in adipose cells. Regulation by insulin. J. Biol. Chem. 271:1996;2365-2368.
41. Leturque A., Guerre-Millo M., Lavau M., Girard J. Effect of insulin on glucose metabolism in adipocytes from virgin and late-pregnant rats. Biochem. J. 224:1984;685-688.
42. Leturque A., Ferre P., Burnol A.F., Kande J., Maulard P., Girard J. Glucose utilization rates and insulin sensitivity in vivo in tissues of virgin and pregnant rats. Diabetes. 35:1986;172-177.
43. Liu Y.L., Emilsson V., Cawthorne M.A. Leptin inhibits glycogen synthesis in the isolated soleus muscle of obese (ob/ob) mice. FEBS Lett. 411:1997;351-355.
44. Liu L., Karkanias G.B., Morales J.C., Hawkins M., Barzilai N., Wang J., Rossetti L. Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes. J. Biol. Chem. 273:1998;31160-31167.
45. MacDougald O.A., Hwang C.S., Fan H., Lane M.D. Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc. Natl. Acad. Sci. USA. 92:1995;9034-9037.
46. Maffei M., Fei H., Lee G.H., Dani C., Leroy P., Zhang Y., Proenca R., Negrel R., Ailhaud G., Friedman J.M. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc. Natl. Acad. Sci. USA. 92:1995;6957-6960.
47. Maffei M., Halaas J., Ravussin E., Pratley R.E., Lee G.H., Zhang Y., Fei H., Kim S., Lallone R., Ranganathan S., Kern P.A., Friedman J.M. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med. 1:1995;1155-1161.
48. Mantzoros C.S., Flier J.S., Rogol A.D. A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty. J. Clin. Endocrinol. Metab. 82:1997;1066-1070.
49. Mantzoros C.S., Varvarigou A., Kaklamani V.G., Beratis N.G., Flier J.S. Effect of birth weight and maternal smoking on cord blood leptin concentrations of full-term and preterm newborns. J. Clin. Endocrinol. Metab. 82:1997;2856-2861.
50. Masuzaki H., Ogawa Y., Isse N., Satoh N., Okazaki T., Shigemoto M., Mori K., Tamura N., Hosoda K., Yoshimasa Y., Jingami H., Kawada T., Nakao K. Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue. Diabetes. 44:1995;855-858.
51. Masuzaki H., Ogawa Y., Sagawa N., Hosoda K., Matsumoto T., Mise H., Nishimura H., Yoshimasa Y., Tanaka I., Mori T., Nakao K. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat. Med. 3:1997;1029-1033.
52. McCann S.M., Kimura M., Walczewska A., Karanth S., Rettori V., Yu W.H. Hypothalamic control of FSH and LH by FSH-RF, LHRH, cytokines, leptin and nitric oxide. Neuroimmunomodulation. 5:1998;193-202.
53. Mikhail A.A., Beck E.X., Shafer A., Barut B., Gbur J.S., Zupancic T.J., Schweitzer A.C., Cioffi J.A., Mizuno T.M., Bergen H., Funabashi T., Kleopoulos S.P., Zhong Y.G., Bauman W.A., Mobbs C.V. Obese gene expression: reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity. Proc. Natl. Acad. Sci. USA. 93:1996;3434-3438.
54. Montague C.T., Farooqi I.S., Whitehead J.P., Soos M.A., Rau H., Wareham N.J., Sewter C.P., Digby J.E., Mohammed S.N., Hurst J.A., Cheetham C.H., Earley A.R., Barnett A.H., Prins J.B., O'Rahilly S. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 387:1997;903-908.
55. Montague C.T., Prins J.B., Sanders L., Digby J.E., O'Rahilly S. Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution. Diabetes. 46:1997;342-347.
56. Mounzih K., Lu R., Chehab F.F. Leptin treatment rescues the sterility of genetically obese ob/ob males. Endocrinology. 138:1997;1190-1193.
57. Mounzih K., Qiu J., Ewart-Toland A., Chehab F.F. Leptin is not necessary for gestation and parturition but regulates maternal nutrition via a leptin resistance state. Endocrinology. 139:1998;5259-5262.
58. Muller G., Ertl J., Gerl M., Preibisch G. Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J. Biol. Chem. 272:1997;10585-10593.
59. Muoio D.M., Dohm G.L., Fiedorek F.T. Jr., Tapscott E.B., Coleman R.A. Leptin directly alters lipid partitioning in skeletal muscle. Diabetes. 46:1997;1360-1363.
60. Nemecz M., Preininger K., Englisch R., Fernsinn C., Schneider B., Waldhausl W., Roden M. Acute effect of leptin on hepatic glycogenolysis and gluconeogenesis in perfused rat liver. Hepatology. 29:1999;166-172.
61. Nystrom F., Ekman B., Osterlund M., Lindstrom T., Ohman K.P., Arnqvist H.J. Serum leptin concentrations in a normal population and in GH deficiency: negative correlation with testosterone in men and effects of GH treatment. Clin. Endocrinol. 47:1997;191-198.
62. Palmert M.R., Radovick S., Boepple P.A. The impact of reversible gonadal sex steroid suppression on serum leptin concentrations in children with central precocious puberty. J. Clin. Endocrinol. Metab. 83:1998;1091-1096.
63. Pelleymounter M.A., Cullen M.J., Baker M.B., Hecht R., Winters D., Boone T., Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 269:1995;540-543.
64. Rayner D.V., Dalgliesh G.D., Duncan J.S., Hardie L.J., Hoggard N., Trayhurn P. Postnatal development of the ob gene system: elevated leptin levels in suckling fa/fa rats. Am. J. Physiol. 273:1997;R446-R450.
65. Rentsch J., Chiesi M. Regulation of ob gene mRNA levels in cultured adipocytes. FEBS Lett. 379:1996;55-59.
66. Rohner-Jeanrenaud F., Jeanrenaud B. Obesity, leptin, and the brain. New Engl. J. Med. 334:1996;324-325.
67. Rosenbaum M., Leibel R.L. Leptin: a molecule integrating somatic energy stores, energy expenditure and fertility. Trends Endocrinol. Metab. 9:1998;117-124.
68. Rossetti L., Massillon D., Barzilai N., Vuguin P., Chen W., Hawkins M., Wu J., Wang J. Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J. Biol. Chem. 272:1997;27758-27763.
69. Saladin R., De Vos P., Guerre-Millo M., Leturque A., Girard J., Staels B., Auwerx J. Transient increase in obese gene expression after food intake or insulin administration. Nature. 377:1995;527-529.
70. Schubring C., Kiess W., Englaro P., Rascher W., Dotsch J., Hanitsch S., Attanasio A., Blum W.F. Levels of leptin in maternal serum, amniotic fluid, and arterial and venous cord blood: relation to neonatal and placental weight. J. Clin. Endocrinol. Metab. 82:1997;1480-1483.
71. Scott J. New chapter for the fat controller. Nature. 379:1996;113-114.
72. Scrocchi L.A., Brown T.J., Drucker D.J. Leptin sensitivity in nonobese glucagon-like peptide I receptor -/- mice. Diabetes. 46:1997;2029-2034.
73. Senaris R., Garcia-Caballero T., Casabiell X., Gallego R., Castro R., Considine R.V., Dieguez C., Casanueva F.F. Synthesis of leptin in human placenta. Endocrinology. 138:1997;4501-4504.
74. Shekhawat P.S., Garland J.S., Shivpuri C., Mick G.J., Sasidharan P., Pelz C.J., McCormick K.L. Neonatal cord blood leptin: its relationship to birth weight, body mass index, maternal diabetes, and steroids. Pediatr. Res. 43:1998;338-343.
75. Spicer L.J., Francisco C.C. The adipose obese gene product, leptin: evidence of a direct inhibitory role in ovarian function. Endocrinology. 138:1997;3374-3379.
76. Spiegelman B.M., Flier J.S. Adipogenesis and obesity: rounding out the big picture. Cell. 87:1996;377-389.
77. Sugden M.C., Holness M.J. Fuel selection: the maternal adaptation to fetal nutrient demand. Biochem. Soc. Trans. 26:1998;79-86.
78. Tamura T., Goldenberg R.L., Johnston K.E., Cliver S.P. Serum leptin concentrations during pregnancy and their relationship to fetal growth. Obstet. Gynecol. 91:1998;389-395.
79. Tanizawa Y., Okuya S., Ishihara H., Asano T., Yada T., Oka Y. Direct stimulation of basal insulin secretion by physiological concentrations of leptin in pancreatic beta cells. Endocrinology. 138:1997;4513-4516.
80. Tartaglia L.A. The leptin receptor. J. Biol. Chem. 272:1997;6093-6096.
81. Tartaglia L.A., Dembski M., Weng X., Deng N., Culpepper J., Devos R., Richards G.J., Campfield L.A., Clark F.T., Deeds J., Muir C., Sanker S., Moriarty A., Moore K.J., Smutko J.S., Mays G.G., Woolf E.A., Monroe C.A., Tepper R.I. Identification and expression cloning of a leptin receptor, OB-R. Cell. 83:1995;1263-1271.
82. Taylor S.I., Barr V., Reitman M. Does leptin contribute to diabetes caused by obesity? Science. 274:1996;1151-1152.
83. Trayhurn P., Thomas M.E., Duncan J.S., Rayner D.V. Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (ob/ob) mice. FEBS Lett. 368:1995;488-490.
84. Tuominen J.A., Ebeling P., Laquier F.W., Heiman M.L., Stephens T., Koivisto V.A. Serum leptin concentration and fuel homeostasis in healthy man. Eur. J. Clin. Invest. 27:1997;206-211.
85. Wang Y., Kuropatwinski K.K., White D.W., Hawley T.S., Hawley R.G., Tartaglia L.A., Baumann H. Leptin receptor action in hepatic cells. J. Biol. Chem. 272:1997;16216-16223.
86. Weigle D.S., Bukowski T.R., Foster D.C., Holderman S., Kramer J.M., Lasser G., Lofton-Day C.E., Prunkard D.E., Raymond C., Kuijper J.L. Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J. Clin. Invest. 96:1995;2065-2070.
87. Wolff G.L. Obesity as a pleiotropic effect of gene action. J. Nutr. 127:1997;1897S-1901S.
88. Yu W.H., Kimura M., Walczewska A., Karanth S., McCann S.M. Role of leptin in hypothalamic-pituitary function. Proc. Natl. Acad. Sci. USA. 94:1997;1023-1028.
89. Yura S., Sagawa N., Ogawa Y., Masuzaki H., Mise H., Matsumoto T., Ebihara K., Fujii S., Nakao K. Augmentation of leptin synthesis and secretion through activation of protein kinases A and C in cultured human trophoblastic cells. J. Clin. Endocrinol. Metab. 83:1998;3609-3614.
90. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:1994;425-432.