Leptin: A molecule integrating somatic energy stores, energy expenditure and fertility

Trends in Endocrinology and Metabolism

Volumn 9, Issue 3, 1998, Pages 117-124

  Rosenbaum, Michael ^a   Leibel, Rudolph L ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN;

ENERGY EXPENDITURE; FERTILITY; FOOD INTAKE; GENE MUTATION; HUMAN; MOLECULAR CLONING; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SURVIVAL;

EID: 0031956176     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(98)00028-9     Document Type: Article

References (109)

1. Ahima R, Prabakaran D, Mantzoros Cet al. Role of leptin in the neuroendocrine response to fasting. Nature. 382:1996;250-252.
2. Aubert R, Herzog J, Camus M, Guenet J, Lemonnier D Description of a new model of genetic obesity: the dbPas mouse. J Nutr. 115:1985;327-333.
3. Bahary N, Leibel RL, Joseph L, Friedman J Molecular mapping of the mouse db mutation. Proc Natl Acad Sci USA. 87:1990;8642-8646.
4. Bahary N, Siegel D, Walsh Det al. Microdissection of proximal mouse chromosome 6: identification of RFLPs tightly linked to the ob mutation. Mamm Genome. 4:1993;511-515.
5. Brabant G, Horn R, Mayr Bet al. Serum leptin levels following hypothalamic surgery. Horm Metab Res. 28:1996;728-731.
6. Broadwell R, Balin B, Salcman M, Kaplan R Blood-brain barrier? Yes and no. Proc Natl Acad Sci USA. 80:1983;7352-7356.
7. Campfield LA, Smith F, Guisez Y, Devos R, Burn P Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 269:1995;546-549.
8. Carlsson B, Lindell K, Gabrielsson Bet al. Obese (ob) gene defects are rare in human obesity. Obes Res. 5:1997;30-35.
9. Caro J, Kolaczynski J, Nyce MRet al. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet. 348:1996;159-161.
10. Chagnon Y, Lamothe M, Perusse Met al. Genetic linkages between markers on human 1p32-p22 and body fat and insulin levels. Obes Res. 5:1997;115-121.
11. Chapman I, Wittert G, Norman R Circulating leptin concentrations in polycystic ovary syndrome: relation to anthropometric and metabolic parameters. Clin Endocrinol. 46:1997;175-181.
12. Chehab F, Lim M, Lu R Correction of the sterility defect in homozygous obese female mice by treatment with recombinant human leptin. Nat Genet. 12:1996;318-320.
13. Cheung C, Thornton J, Kuijper Jet al. Leptin is a metabolic gate for the onset of puberty in the female rat. Endocrinology. 138:1997;855-858.
14. Chua S, White D, Wu-Peng Xet al. Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr). Diabetes. 45:1996;1141-1143.
15. Chua S, Chung WK, Wu-Peng Set al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science. 271:1996;994-996.
16. db affects body composition and leptin homeostasis in adult mice. Am J Physiol (in press).
17. Clayton P, Gill M, Hall Cet al. Serum leptin through childhood and adolescence. Clin Endocrinol. 46:1997;727-737.
18. Clement K, Garner C, Hager Cet al. Indication for linkage of the human OB gene region with extreme obesity. Diabetes. 45:1996;687-690.
19. Coleman D Effects of parabiosis of obese with diabetes and normal mice. Diabetologia. 9:1973;294-298.
20. Coleman D Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia. 14:1978;141-148.
21. Coleman D Diabetes-obesity syndromes in mice. Diabetes. 31:1982;1-6.
22. Collins S, Kuhn C, Petro Aet al. Role of leptin in fat regulation. Nature. 380:1996;677.
23. Considine R, Considine E, Williams Cet al. Evidence against either a premature stop codon of the absence of obese gene mRNA in human obesity. J Clin Invest. 95:1995;2986-2988.
24. Considine R, Considine E, Williams CJet al. Mutation screening and identification of a sequence variation in the human ob gene coding region. Biochem Biophys Res Commun. 220:1996;735-739.
25. Duggirala R, Stern M, Mitchell BDet al. Quantitative variation in obesity-related traits and insulin precursors linked to OB gene region on human chromosome 7. Am J Hum Genet. 59:1996;694-703.
26. Erickson J, Hollopeter G, Palmiter R Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science. 274:1997;1704-1707.
27. Frederich R, Hamann A, Anderson Set al. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med. 1:1995;1311-1314.
28. Friedman J, Leibel RL, Siegel DA, Walsh J, Bahary N Molecular mapping of the mouse ob mutation. Genomics. 11:1991;1054-1062.
29. Frisch R, Revelle R Height and weight at menarche and a hypothesis of critical body weights and adolescent events. Science. 169:1970;397-399.
30. Frisch R, Revelle R, Cook S Components of weight at menarche and the initiation of the adolescent growth spurt in girls: estimated total body water, lean body weight, and fat. Hum Biol. 45:1973;469-483.
31. Frisch R, McArthur J Menstrual cycles: fatness as a determinant of minimum weight for height necessary for their maintenance or onset. Science. 185:1974;949-951.
32. Frisch R, Wyshak G, Vincent L Delayed menarche and amenorrhea in ballet dancers. New Engl J Med. 303:1980;17-19.
33. Golden P, Maccagnan T, Pardridge W Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels. J Clin Invest. 99:1997;14-18.
34. Gong D, Bi S, Pratley R, Weintraub B Genomic structure and promoter analysis of the human obese gene. J Biol Chem. 271:1996;3971-3974.
35. Green E, Maffei M, Braden VVet al. The human obese (ob) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7. Genome Res. 5:1995;5-12.
36. Guerremillo M The leptin receptor, a novel member of the cytokine receptor superfamily. M S-Med Sci. 12:1996;386-387.
37. Halaas J, Gajiwala K, Maffei Met al. Weight-reducing effects of the plasma protein encoded by the ob gene. Science. 269:1995;543-546.
38. Halaas J, Boozer C, Blair-West Jet al. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci USA. 94:1997;8878-8883.
39. Hale R Exercise, sports, and menstrual dysfunction. Clin Obstet Gynecol. 26:1983;728-735.
40. Hamilton B, Paglia D, Kwan A, Deitel M Increased obese mRNA expression in omental fat cells from massively obese humans. Nat Med. 9:1995;953-956.
41. Harris R Role of set-point theory in regulation of body weight. FASEB. J 4:1990;3310-3318.
42. Harris R, Hervey E, Hervey G, Tobin G Body composition of lean and obese Zucker rats in parabiosis. Int J Obes. 11:1987;275-283.
43. Hasstedt S, Hoffman M, Leppert M, Elbein S Recessive inheritance of obesity and familial non-insulin dependent diabetes mellitus, and lack of linkages to 9 candidate genes. Am J Hum Genet. 61:1997;668-677.
44. Hausberger F Parabiosis and transplantation experiments in hereditarily obese mice. Anat Rec. 130:1959;313.
45. Hervey G The effects of lesions in the hypothalamus on parabiotic rats. J Physiol. 145:1959;336.
46. Hube F, Lietz U, Igel Met al. Differences in leptin mRNA levels between omental and subcutaneous abdominal adipose tissue from obese humans. Horm Metab Res. 28:1996;690-693.
47. Hummel K, Dickie M, Coleman D Diabetes, a new mutation in the mouse. Science. 153:1966;1127-1128.
48. Ingalls A, Dickie M, Snell G Obese, a new mutation in the house mouse. J Hered. 41:1950;317-318.
49. Isse N, Ogawa Y, Tamura Net al. Structural organization and chromosomal assignment of the human obese gene. J Biol Chem. 270:1995;27728-27733.
50. Katzeff H, O'Connell M, Horton Eet al. Metabolic studies in human obesity during overnutrition and undernutrition: thermogenic and hormonal responses to norepinephrine. Metabolism. 35:1986;166-175.
51. Keesey R, Corbett S: 1984. Metabolic defense of the body weight set-point. In Stunkard AJ., Stellar E., eds. Eating and its Disorders, New York, Raven Press, pp 77-96.
52. Kennedy A, Gettys T, Watson Pet al. The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin-sensitivity, and energy expenditure. J Clin Endocrinol Metab. 82:1997;1293-1300.
53. Kennedy G The role of depot fat in the hypothalamic control of food intake in the rat. Proc R Soc London Ser. B 140:1953;578.
54. Kirkwood R, Mitaru B, Gooneratne A, Blair R, Thacker P The influence of premating feed intake on the reproductive performance of gilts. Can J Vet Res. 52:1988;134-136.
55. Klein S, Coppack S, Mohamed-Ali V, Landt M Adipose tissue leptin production and plasma leptin kinetics in humans. Diabetes. 45:1996;984-987.
56. Kotani K, Tokunaga K, Fujioka Set al. Sexual dimorphism of age-related changes in whole-body fat distribution in the obese. Int J Obes. 18:1994;202-207.
57. Lane P, Dickie M Fertile, obese male mice. J Hered. 45:1954;56-58.
58. Laughlin G, Morales A, Yen S Serum leptin levels in women with polycystic ovary syndrome: the role of insulin resistance/hyperinsulinemia. J Clin Endocrinol Metab. 82:1997;1692-1696.
59. Legradi G, Emerson C, Ahima R, Flier J, Lechan R Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology. 138:1997;2569-2576.
60. Leibel RL A biologic radar system for the assessment of body mass. The model of a geometry sensitive endocrine system is presented. J Theor Biol. 66:1977;297-306.
61. Leibel RL Is obesity due to a heritable difference in 'set point' for adiposity? West J Med. 153:1990;429-443.
62. Leibel RL, Rosenbaum M, Hirsch J Changes in energy expenditure resulting from altered body weight in man. New Engl J Med. 332:1995;621-628.
63. Leibel RL, Chua SC, Chung WK: 1996. Animal models of genetic obesity. In Angel A, Anderson H, Bouchard C, Lau D, Leiter L, Mendelson R, eds. Progress in Obesity Research: 7th International Congress on Obesity. London, John Libbey and Co Ltd, pp 263-277.
64. Leibel RL, Chung WK, Chua SC The molecular genetics of rodent single gene obesities. J Biol Chem. 272:1997;31937-31940.
65. Maffei M, Halaas J, Ravussin Eet al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med. 1:1996;1155-1161.
66. Mantzoros C, Dunaif A, Flier J Leptin concentrations in the polycystic ovary syndrome. J Clin Endocrinol Metab. 82:1997;1687-1691.
67. Mantzoros C, Flier J, Rogol A A longitudinal assessment of hormonal and physical alterations during normal puberty in boys V. Rising leptin levels may signal the onset of puberty. J Clin Endocrinol Metab. 82:1997;1066-1070.
68. Meyer F, Moisan J, Marcoux D, Bouchard C Dietary and physical determinants of menarche. Epidemiology. 1:1990;377-381.
69. Mezey E, Palkovits M Meningeal relations of the rat hypothalamo-hypophyseal system. Extravascular fluid spaces in and around the median eminence. Brain Res. 250:1982;21-30.
70. Montague C, Farooqi I, Whitehead Jet al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 387:1997;903-908.
71. Montague C, Prins J, Sanders L, Digby J, O'Rahilly S Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution. Diabetes. 46:1997;342-347.
72. Mounzih K, Lu R, Chehab F Leptin treatment rescues the sterility of genetically obese ob/ob males. Endocrinology. 138:1997;1190-1193.
73. Nagy T, Gower B, Trowbridge Cet al. Effects of gender, ethnicity, body composition, and fat distribution on serum leptin levels in children. J Clin Endocrinol Metab. 82:1997;2148-2152.
74. Neel J Diabetes mellitus: a 'thrifty' genotype rendered detrimental by 'progress'? Am J Hum Genet. 14:1962;353-362.
75. Nishizawa Y, Bray G Evidence for a circulating ergostatic factor: studies on parabiotic rats. Am J Physiol. 239:1980;R344-R351.
76. Niskanen L, Haffner S, Karhunen Let al. Serum leptin in relation to resting energy expenditure and fuel metabolism in obese subjects. Int J Obes. 21:1997;309-313.
77. Norman R, Leibel RL, Chung WKet al. Absence of linkage of obesity and energy metabolism to homologs of rodent obesity genes in Pima Indians. Diabetes. 45:1996;1229-1232.
78. Ohtake M, Bray G, Azukizawa M Studies on hypothermia and thyroid function in the obese (ob/ob) mouse. Am J Physiol. 233:1977;R110-R115.
79. Pellymounter M, Cullen M, Baker Met al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 269:1995;540-543.
80. Phillips M, Liu Q, Hammond Het al. Leptin receptor missense mutation in fatty Zucker rats. Nat Genet. 13:1996;18-19.
81. Reed P, Ding Y, Xu Wet al. Extreme obesity may be linked to markers flanking the human ob gene. Diabetes. 45:1996;691-694.
82. Rethelyi M Diffusional barrier around the hypothalamic arcuate nucleus in the rat. Brain Res. 307:1984;355-358.
83. Rosenbaum M, Nicolson M, Hirsch Jet al. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab. 81:1996;3424-3427.
84. Rosenbaum M, Leibel RL, Hirsch J Medical progress: obesity. New Engl J Med. 337:1997;396-407.
85. Rosenbaum M, Nicolson M, Hirsch Jet al. Effects of weight change on plasma leptin concentrations and energy expenditure. J Clin Endocrinol Metab. 82:1997;3647-3654.
86. Rouru J, Anttila L, Koskinen Pet al. Serum leptin concentrations in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 82:1997;1697-1700.
87. Saad M, Damani S, Gingerich RLet al. Sexual dimorphism in plasma leptin concentration. J Clin Endocrinol Metab. 82:1997;579-584.
88. Salbe A, Nicolson M, Ravussin E Total energy expenditure and physical activity correlate with plasma leptin concentrations in five-year-old children. J Clin Invest. 99:1997;592-595.
89. Shimizu H, Shimomura Y, Nakanishi Yet al. Estrogen increases in vivo leptin production in rats and human subjects. J Endocrinol. 154:1997;285-292.
90. Smith F, Campfield L, Moschera J, Bailon P, Burn P Feeding inhibition by neuropeptide Y. Nature. 382:1996;307.
91. Spicer L, Francisco C The adipose obese gene product, leptin: evidence of a direct inhibitory role in ovarian function. Endocrinology. 138:1997;3374-3379.
92. Stephens T Life without neuropeptide Y. Nature. 381:1996;377-378.
93. Stewart DE Reproductive function in eating disorders. Ann Med. 24:1992;287-291.
94. Strobel A, Issad T, Camoin M, Ozata M, Strosberg AD A leptin mutation associated with hypogonadism and morbid obesity. Nat Genet. 18:1998;213-215.
95. Takahashi M, Funahashi T, Shimomura I, Miyaoka K, Matsuzawa Y Plasma leptin levels and body fat distribution. Horm Metab Res. 28:1996;751-752.
96. Takaya K, Ogawa Y, Hosoda K, Yamori Y, Nakao K Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat. Nat Genet. 14:1996;130-131.
97. Tartaglia L, Dembski M, Wend Xet al. Identification and expression cloning of a leptin receptor. OB-r. Cell. 83:1995;1263-1271.
98. Thompson B, Janssen R, Ossowski Vet al. Evidence for linkage between a region on chromosome 1p and the acute insulin response in Pima Indians. Diabetes. 44:1995;478-481.
99. Toth M, Gottlieb S, Fisher Met al. Plasma leptin concentrations and energy expenditure in heart failure patients. Metabolism. 46:1997;450-453.
100. Truett G, Bahary N, Friedman J, Leibel RL Rat obesity gene (fa) maps to chromosome 5: evidence for homology with the mouse gene diabetes (db). Proc Natl Acad Sci USA. 88:1991;7806-7809.
101. Tuominen J, Ebeling P, Heiman M, Stephens T, Koivisto V Leptin and thermogenesis in humans. Acta Physiol Scand. 160:1997;83-87.
102. Wade GN, Lempicki R, Panicker A, Frisbee R, Blaustein J Leptin facilitates and inhibits sexual behavior in female hamsters. Am J Physiol. 272:1997;R1354-R1358.
103. Weigle D, Bukowski T, Foster Det al. Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest. 96:1995;2065-2070.
104. Wilde RD Some aspects of feeding of brood gilts and sows. J South African Vet Assoc. 50:1979;115-118.
105. Wu-Peng X, Chua SC, Okada Net al. Phenotype of the obese Koletsky (f) rat due to tyr763 stop mutation in the extracellular domain of the leptin receptor (lepr): evidence for deficient plasma-to-CSF transport of leptin in both the Zucker and Koletsky obese rat. Diabetes. 46:1997;513-518.
106. Yu W, Kimura M, Walczewska A, Karanth S, McCann S Role of leptin in hypothalamic-pituitary function. Proc Natl Acad Sci USA. 94:1997;1023-1028.
107. Zamorano P, Mahesh V, DeSevilla Let al. Expression and localization of the leptin receptor in endocrine and neuroendocrine tissues of the rat. Neuroendocrinology. 65:1997;223-228.
108. Zhang Y, Proenca R, Maffei Met al. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:1994;425-432.
109. Zhang F, Basinski M, Beals Jet al. Crystal structure of the obese protein leptin-E 100. Nature. 387:1997;206-209.