Longitudinal analysis of maternal serum leptin levels during pregnancy, at birth and up to six weeks after birth: Relation to body mass index, skinfolds, sex steroids and umbilical cord blood leptin levels

Hormone Research

Volumn 50, Issue 5, 1998, Pages 276-283

  Schubring, C ^a   Englaro, P ^e   Siebler, T ^b   Blum, W F ^c,d   Demirakca, T ^c,d   Kratzsch, J ^b   Kiess, W ^b  

^a Agaplesion Evangelisches Krankenhaus Mittelhessen   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c LILLY DEUTSCHLAND GMBH   (Germany)

^d JUSTUS LIEBIG UNIVERSITY   (Germany)

^e UNIVERSITY OF PADOVA   (Italy)

Author keywords

Cord blood; Intrauterine growth; Leptin; Postnatal life; Pregnancy

Indexed keywords

ESTRADIOL; LEPTIN; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; ARTICLE; BIRTH WEIGHT; BODY FAT; BODY MASS; CHILDBIRTH; CORRELATION FUNCTION; DELIVERY; ENERGY EXPENDITURE; FEMALE; FETUS DEVELOPMENT; GESTATIONAL AGE; HUMAN; HUMAN EXPERIMENT; LONGITUDINAL STUDY; MATERNAL SERUM; NORMAL HUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PUERPERIUM; RADIOIMMUNOASSAY; SKINFOLD THICKNESS; UMBILICAL CORD BLOOD;

ADIPOSE TISSUE; ADULT; BODY COMPOSITION; BODY MASS INDEX; BODY WEIGHT; ESTRADIOL; FEMALE; FETAL BLOOD; GONADAL STEROID HORMONES; HUMANS; INFANT, NEWBORN; LEPTIN; MALE; PREGNANCY; PROSPECTIVE STUDIES; PROTEINS; RADIOIMMUNOASSAY; SEX HORMONE-BINDING GLOBULIN; SKINFOLD THICKNESS; TESTOSTERONE;

EID: 0032439745     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000023290     Document Type: Article

References (31)

1. Campbell S, Soothill P: Detection and management of intrauterine growth retardation: A British approach; in Chervenak FA, Isaacson GC, Campbell S (eds): Ultrasound in Obstetrics and Gynecology. Boston, Little, Brown, 1993, vol 2, pp 1432-1435.
2. Harding JE, Charlton V: Experimental nutritional supplementation for intrauterine growth retardation; in Harrison M, Golbus MS, Filly RA (eds): The Unborn Patient. Philadelphia, Saunders, 1991, pp 598-609.
3. Friedman JM: The alphabet of weight control. Nature 1997;385:119-120.
4. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-432.
5. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P: Recombinant mouse ob protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 1995;269: 546-549.
6. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F: Effects of the obese gene product on body weight in ob/ob mice. Science 1995;269:540-543.
7. Lindpainter K: Finding an obesity gene: A tale of mice and man. N Engl J Med 1995;332:679-680.
8. De Vos P, Saladin R, Auwerx J, Staels B: Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem 1995;270: 15958-15961.
9. Lönqvist F, Arner P, Nordfors L, Schalling M: Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med 1995;1:950-953.
10. Considine RV, Sinha MK, Heiman ML: Serum immunoreactive leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292-295.
11. Sinha MK, Ohannesian JP, Heiman ML, Kriauciunas A, Stephens TW, Magosin S, Marco C, Caro JF: Nocturnal rise of leptin in lean, obese, and non-insulin dependent diabetes mellitus subjects. J Clin Invest 1996;97:1344-1347.
12. Hamilton BS, Paglia D, Kwan AYM, Deitel M: Increased obese mRNA expression in omental fat cells from massively obese humans. Nat Med 1995;1:953-956.
13. Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB, O'Rahilly S: Congenital leptin deficiency is associated with severe early onset obesity in humans. Nature 1997;387:903-908.
14. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP: Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/ db mice. Cell 1996;84:491-495.
15. Stephens TW, Basinski M, Bristow PK, Bue-Valleskey JM, Burgert SG, Craft L, Hale J, Hoffmann J, Hsiung HM, Kriauciunas A, MacKellar W, Rosteck PR, Schoner B, Smith D, Tinsley FC, Zhang XY, Heiman M: The role of neuropeptide Y in antiobesity action of the obese gene product. Nature 1995;377:530-532.
16. Blum WF, Kiess W, Rascher W (eds): Leptin - The Voice of Adipose Tissue. Heidelberg, Johann Ambrosius Barth Verlag, Edition J&J, 1997.
17. Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwern J: Transient increase in obese gene expression after food intake or insulin administration. Nature 1995; 377:527-529.
18. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM: Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995;269:543-546.
19. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM: Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995;1: 1155-1161.
20. Butte NF, Hopkinson JM, Nicolson MA: Leptin in human reproduction: Serum leptin levels in pregnant and lactating women. J Clin Endocrinol Metab 1997;82:585-589.
21. Schubring C, Kiess W, Englaro P, Rascher W, Dötsch J, Hanitsch S, Attanasio A, Blum WF: Leptin concentrations in amniotic fluid, venous and arterial cord blood and maternal serum: High leptin synthesis in the fetus and inverse correlation with placental weight. J Clin Endocrinol Metab 1997;82:1480-1483.
22. Kiess W, Blum WF, Aubert M: Leptin, puberty and reproductive function: Lessons from animal studies and observations in humans. Eur J Endocrinol 1998;138:26-29.
23. Blum WF, Englaro P, Hanitsch S, Juul A, Hertel TN, Müller J, Skakkebaek NE, Birkett M, Heiman M, Attanasio A, Kiess W, Rascher W: Plasma leptin levels in healthy children and adolescents: Dependence on body mass index, body fat mass, gender, pubertal stage and testosterone. J Clin Endocrinol Metab 1997;82: 2904-2910.
24. Hassink SG, de Lancey E, Sheslow DV, Smith-Kirwin SM, O'Connor DM, Considine RV: Placental leptin: An important new growth factor in intrauterine and neonatal development? Pediatrics 1997;100:124.
25. Sagawa N, Mori T, Masuzaki H, Ogawa Y, Nakao K: Leptin production by hydatidiform mole. Lancet 1997;350;1518-1519.
26. Senaris R, Garcia-Caballero T, Casabiell X, Gallego R, Castro R, Considine RV, Dieguez C, Casanueva FF: Synthesis of leptin in human placenta. Endocrinology 1997;138:4501-4504.
27. Jockenhovel F, Blum WF, Vogel E: Testosterone substitution normalizes elevated serum leptin levels in hypogonadal men. J Clin Endocrinol Metab 1997;82:2510-2513.
28. Wabitsch M, Blum WF, Muche R, Teller M, Rascher W: Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J Clin Invest 1997; 100:808-813.
29. Palmert MR, Radovick S, Boepple PA: The impact of reversible gonadal sex steroid suppression on serum leptin concentrations in children with central precocious puberty. J Clin Endocrinol Metab 1998;83:1091-1096.
30. Schubring C: Temperature regulation in healthy and resuscitated newborns immediately after birth. J Perinat Med 1986;14:27-33.
31. Tome MA, Lage M, Camina JP, Garcia-Mayor RV, Dieguez C, Casanueva FF: Sex-based differences in serum leptin concentrations from umbilical cord blood at delivery. Eur J Endocrinol 1997;137:655-658.