Internalization and intracellular fate of TCR-CD3 complexes

Critical Reviews in Immunology

Volumn 20, Issue 4, 2000, Pages 325-346

  Alcover, Andres ^a   Alarcon, Balbino ^b  

^a INSTITUT PASTEUR   (France)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Activation; Degradation; Endocytosis; Intracellular trafficking; Signal transduction

Indexed keywords

CD3 ANTIGEN; CELL SURFACE RECEPTOR; PROTEIN SERINE KINASE; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ENDOCYTOSIS; ENZYME ACTIVITY; INTERNALIZATION; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; DOWN-REGULATION; ENDOCYTOSIS; HALF-LIFE; HUMANS; LYMPHOCYTE ACTIVATION; PHOSPHORYLATION; PROTEIN KINASE C; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; SERINE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0033735397     PISSN: 10408401     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (130)

1. Endocytosis and molecular sorting
2. Linking cargo to vesicle formation: Receptor tail interactions with coat proteins
3. The T-cell receptor. Structural and functional studies
4. Structural basis of T-cell recognition
5. T-cell antigen receptor signal transduction pathways
6. A novel dileucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains
7. Ligand recognition by αβ T-cell receptors
8. Endocytosis and recycling of the T3 T-cell receptor complex
9. Intracellular accumulation of T-cell receptor complex molecules in a human T-cell line
10. Internalization and cycling of the T-cell antigen receptor. Role of protein kinase C
11. T-cell receptor/CD3 complex internalization following activation of a cytolytic T-cell clone: Evidence for a protein kinase C-independent staurosporine-sensitive step
12. The Staphylococcus aureus enterotoxin B superantigen induces specific T-cell receptor downregulation by increasing its internalization
13. Molecular characterization of the dileucine-based internalization motif of the T-cell receptor
14. Rapid endocytosis of interleukin-2 receptors when clathrin-coated pit endocytosis is inhibited
15. pH and the recycling of transferrin during receptor-mediated endocytosis
16. Binding of apotransferrin to K562 cells: Explanation of the transferrin cycle
17. T lymphocyte receptor deficiencies
18. Differential cytosolic tail dependence and intracellular fate of T-cell receptors internalized upon activation with superantigen or phorbol ester
19. Rapid turnover of the CD3ζ chain independent of the TCR-CD3 complex in normal cells
20. Receptor engagement transiently diverts the T-cell receptor heterodimer from a constitutive degradation pathway
21. Triggering the TCR complex causes the downregulation of non-engaged receptors by a signal tranduction-dependent mechanism
22. Endocytosis of interleukin-2 receptors in human T lymphocytes: Distinct intracellular localization and fate of the receptor α, β, and γ chains
23. The human T3 γ chain is phosphorylated in serine 126 in response to T lymphocyte activation
24. CD3γ contains a phosphoserine-dependent dileucine motif involved in downregulation of the T-cell receptor
25. T-cell receptor ζ allows stable expression of receptors containing the CD3γ leucine-based receptor-sorting motif
26. Regulation and function of the CD3γ DxxxLL motif: A binding site for adaptor protein-1 and adaptor protein-2 in vitro
27. The phosphorylation state of CD3γ influences T-cell responsiveness and controls T-cell receptor cycling
28. Clonotypic surface structure on human T lymphocytes: Functional and biochemical analysis of the antigen receptor complex
29. Activators of protein kinase C downregulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes
30. Serial triggering of many T-cell receptors by a few peptide-MHC complexes
31. Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester
32. Association of phosphorylation of the T3 antigen with immune activation of T lymphocytes
33. Multiple kinases and signal transduction. Phosphorylation of the T-cell antigen receptor complex
34. Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin
35. Tolerance of T-cell clones is associated with membrane antigen changes
36. Tumor promoter phorbol esters induce unresponsiveness to antigen and expression of interleukin-2 receptor on T cells
37. Degradation of CD4 following phorbol-induced internalization in human T lymphocytes. Evidence for distinct endocytic routing of CD4 and CD3
38. Leucine-based receptor sorting motifs are dependent on the spacing relative to the plasma membrane
39. A tyrosine-based sorting signal in the β2 integrin cytoplasmic domain mediates its recycling to the plasma membrane and is required for ligand-supported migration
40. T-cell receptor α-chain tail is required for protein kinase C-mediated downregulation, but not for signaling
41. Evidence for protein tyrosine kinase involvement in ligand-induced TCR/CD3 internalization and surface redistribution
42. Role of CD3γ and CD3δ cytoplasmic domains in cytolytic T lymphocyte functions and TCR/CD3 downmodulation
43. Two distinct pathways exist for downregulation of the TCR
44. Internalization of human T lymphocytes receptors
45. + T cells
46. Major histocompatibility complex independent clonal T-cell anergy by direct interaction of Staphylococcus aureus enterotoxin B with the T-cell antigen receptor
47. Agonist-induced T-cell receptor downregulation: Molecular requirements and dissociation from T-cell activation
48. Degradation of T-cell receptor (TCR)-CD3-ζ complexes after antigenic stimulation
49. Physical dissociation of the TCR-CD3 complex accompanies receptor ligation
50. Ubiquitin and the control of protein fate in the secretory and endocyctic pathways
51. Novel aspects of degradation of T-cell receptor subunits from the endoplasmic reticulum (ER) in T cells: Importance of oligosacharide processing, ubiquitination, and proteasome-dependent removal from ER membranes
52. Activation-induced ubiquitination of the T-cell antigen receptor
53. T-cell antigen receptor ubiquitination is a consequence of receptor-mediated tyrosine kinase activation
54. Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway
55. Altered peptide ligand-induced partial T-cell activation: Molecular mechanisms and role in T-cell biology
56. The dynamics of T-cell receptor signaling: Complex orchestration and key roles of tempo and cooperation
57. Peptide-induced T-cell receptor downregulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T-cell activation
58. Differential T-cell signaling induced by antagonist peptide-MHC complexes and the associated phenotypic responses
59. Altered hapten ligands antagonize trinitrophenyl-specific cytotoxic T cells and block internalization of hapten-specific receptors
60. A T-cell receptor (TCR) antagonist competitively inhibits serial TCR triggering by low-affinity ligands, but does not affect triggering by high affinity anti-CD3 antibodies
61. Relationships among TCR ligand potency, thresholds for effector function elicitation, and the quality of early signaling events in human T cells
62. 2+ flux correlates with thymocyte selection
63. Serial TCR engagement and downmodulation by peptide:MHC molecule ligands: Relationship to the quality if individual TCR signaling events
64. Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonism
65. T-cell receptor (TCR) antagonism without a negative signal: Evidence from T-cell hybridomas expressing two independent TCRs
66. The activation of protein kinase C is not necessary for the monoclonal antibody-induced modulation of CD3 and CD4 antigens
67. Receptor signalling and the regulation of endocytic membrane transport
68. Complex complexes: Signaling at the TCR
69. Opposing effects of protein tyrosine kinase inhibitors on the monoclonal antibody induced internalization of CD3 and CD4 antigens
70. Activation of the Lck tyrosine kinase targets cell surface T-cell antigen receptors for lysosomal degradation
71. Transient alteration of T-cell fine specificity by a strong primary stimulus corelates with T-cell receptor downregulation
72. Antigen-induced TCR-CD3 downmodulation does not require CD3δ or CD3γ cytoplasmic domains, necessary in response to anti-CD3 antibody
73. + T cells: Compulsory cytoskeletal alterations for the triggering of an intracellular calcium response
74. + thymocytes by p561ck tyrosine kinase: Basis for differential signaling by CD4 and CD8 in inmature thymocytes expressing both coreceptor molecules
75. EGF receptor signaling stimulates Src kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake
76. Syk protein tyrosine kinase regulates Fc receptor γ chain-mediated transport to lysosomes
77. The Syk family of protein tyrosine kinases in T-cell activation and development
78. Degradation of ZAP-70 following antigenic stimulation in human T lymphocytes: Role of calpain proteolitic pathway
79. Integration of T-cell receptor-dependent signaling pathways by adapter proteins
80. Adaptors and molecular scaffolds in immune cell signaling
81. Requirement for the adapter protein GRB2 in EGF receptor endocytosis
82. c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor
83. The evolutionary conserved N-terminal region of Cbl is sufficient to enhance downregulation of the epidermal growth factor receptor
84. Enhancement of Fcγ receptor-mediated phagocytosis by transforming mutants of Cbl
85. Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323
86. The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative phosphorylation site of ZAP-70
87. Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice
88. Membrane microdomains and caveolae
89. Membrane compartmentation is required for efficient T-cell activation
90. Engagement of GPI-linked CD48 contributes to TCR signals and cytoskeletal reorganization: A role for lipid rafts in T-cell activation
91. Engagement of T-cell receptors triggers its recruitment to low-density detergent-insoluble membrane domains
92. LAT palmitoylation: Its essential role in membrane microdomain targeting and tyrosine phosphorylation during T-cell activation
93. T lymphocyte costimulation mediated by reorganization of membrane microdomains
94. Aggregation of lipid rafts accompanies signaling via the T-cell antigen receptor
95. + T lymphocytes
96. Failure to synthesize the CD3γ chain: Consequences for T-cell antigen receptor asembly, processing and expression
97. Expression and function of a variant T-cell receptor complex lacking CD3γ
98. The CD3γ chain is essential for development of both TCRαβ and TCRγδ lineages
99. Herpes virus saimiri transformation of T cells in CD3 γ immunodeficiency: Phenotypic and functional characterization
100. Crippling of the CD3-ζ ITAMs does not impair T-cell receptor signaling
101. The CD3ε subunit of the TCR contains endocytosis signals
102. Several weak signals in the cytosolic and transmembrane domains of the interleukin-2-receptor β chain allow for its efficient endocytosis
103. Endocytosis of the common cytokine receptor γc chain. Identification of sequences involved in internalization and degradation
104. Evidence for multivalent structure of T-cell antigen receptor complex
105. Peptide antigen or superantigen-induced down-regulation of TCRs involves both stimulated and unstimulated receptors
106. Multivalent structure of an alphabeta T-cell receptor
107. Structure of the T-cell receptor in a TiαVβ2, αVβ8-positive T-cell line
108. Cooperative activation of TCRs by enterotoxin superantigens
109. Three-dimensional segregation of supramolecular activation clusters in T cells
110. The immunological synapse: A molecular machine controling T-cell activation
111. Adaptors for clathrin-mediated traffic
112. Cytolitic T lymphocyte-associated antigen-4 and the TCRζ/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2
113. Microtubule depolymerization inhibits clathrin coated-pit internalization in nonadherent T-cell lines while interleukin-2 endocytosis is not affected
114. Endocytosis and mitogenic signals
115. Tyrosine and serine protein kinase activities associated with ligand-induced internalized TCR/CD3 complexes
116. Recruitment of activated p561ck on endosomes of CD2-triggered T cells. Colocalization with ZAP-70
117. Induction of specific clonal anergy in human T lymphocytes by Staphylococcus aureus enterotoxins
118. Different responses are elicited in cytotoxic T lymphocytes by different levels of T-cell receptor occupancy
119. Signal extinction and T-cell repolarization in T helper cell-antigen-presenting cell conjugates
120. A dominant-negative mutant of the Rab5 GTPase enhances T-cell signaling by interfering with TCR downmodulation in transgenic mice
121. Adhesion receptors of the immune system
122. ZAP-70 tyrosine kinase is required for LFA-1-dependent T-cell migration
123. Irreversible association of peptides with class II MHC molecules in living cells
124. TCR-mediated internalization of peptide-MHC complexes acquired by T cells
125. Cloned T cells internalize peptide from bound complexes of peptide and purified class II major histocompatibility complex antigen
126. B lymphocytes secrete antigen-presenting vesicles
127. Eradication of stablished murine tumors using novel cell-free vaccine: Dendritic cell-derived exosomes
128. Molecular characterization of dendritic cell-derived exosomes: Selective accumulation of the heat shock protein hsc73
129. TCR-mediated adhesion of T-cell hybridomas to planar bilayers containing purified MHC class II/peptides complexes and receptor shedding during detachment
130. A new model for lethal hit delivery by cytotoxic T lymphocytes