Two distinct pathways exist for down-regulation of the TCR

Journal of Immunology

Volumn 161, Issue 1, 1998, Pages 260-267

  Lauritsen, Jens Peter H ^a   Christensen, Mette D ^a   Dietrich, Jes ^a   Kastrup, Jesper ^a   Ødum, Niels ^a   Geisler, Carsten ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; PROTEIN KINASE C; T LYMPHOCYTE RECEPTOR;

ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; INTERNALIZATION; LIGAND BINDING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; T LYMPHOCYTE;

AMINO ACID SEQUENCE; DOWN-REGULATION; HUMANS; JURKAT CELLS; LIGANDS; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FYN; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL; SRC-FAMILY KINASES; T-LYMPHOCYTES; TYROSINE;

EID: 0031803218     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (74)

1. Lamb, J. R., B. J. Skidmore, N. Green, J. M. Chiller, and M. Feldmann. 1983. Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin. J. Exp. Med. 157:1434.
2. Zanders, E. D., J. R. Lamb, M. Feldman, N. Green, and P. C. L. Beverley. 1983. Tolerance of T-cell clones is associated with membrane antigen changes. Nature 303:625.
3. Valitutti, S., S. Muller, M. Cella, E. Padovan, and A. Lanzavecchia. 1995. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375:148.
4. Valitutti, S., S. Muller, M. Dessing, and A. Lanzavecchia. 1996. Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy. J. Exp. Med. 183:1917.
5. + T cells. J. Exp. Med. 185:641.
6. La Face, D. M., C. Couture, K. Anderson, G. Shih, J. Alexander, A. Sette, T. Mustelin, A. Altman, and H. M. Grey. 1997. Differential T cell signaling induced by antagonist peptide-MHC complexes and the associated phenotypic responses. J. Immunol. 158:2057.
7. Reinherz, E. L., S. Meuer, K. A. Fitzgerald, R. E. Hussey, H. Levine, and S. F. Schlossman. 1982. Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex. Cell 30:735.
8. Telerman, A., R. B. Amson, F. Romasco, J. Wybran, P. Galand, and R. Mosselmans. 1987. Internalization of human T lymphocyte receptors. Eur. J. Immunol. 17:991.
9. Boyer, C., N. Auphan, F. Luton, J.-M. Malburet, M. Barad, J.-P. Bizozzero, H. Reggio, and A.-M. Schmitt-Verhulst. 1991. T cell receptor/CD3 complex internalization following activation of a cytolytic T cell clone: evidence for a protein kinase C-independent staurosporine-sensitive step. Eur. J. Immunol. 21:1623.
10. Ando, I., G. Hariri, D. Wallace, and P. Beverley. 1985. Tumor promoter phorbol esters induce unresponsiveness to antigen and expression of interleukin 2 receptor on T cells. Eur. J. Immunol. 15:196.
11. Cantrell, D. A., A. A. Davies, and M. J. Crumpton. 1985. Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes. Proc. Natl. Acad. Sci. USA 82:8158.
12. Dietrich, J., X. Hou, A.-M. K. Wegener, and C. Geisler. 1994. CD3γ contains a phosphoserine-dependent di-leucine motif involved in down-regulation of the T cell receptor. EMBO J. 13:2156.
13. McCarthy, S. A., A. M. Kruisbeek, I. K. Uppenkamp, S. O. Sharrow, and A. Singer. 1988. Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes. Nature 336:76.
14. + cells by CD4. Science 249:1558.
15. + thymocytes by p561ck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules. J. Exp. Med. 178:1701.
16. Cosgrove, D., D. Gray, A. Dierich, J. Kaufman, M. Lemeur, C. Benoist, and D. Mathis. 1991. Mice lacking MHC class II molecules. Cell 66:1051.
17. lck. Nature 357:161.
18. Stone, J. D., L. A. Conroy, K. F. Byth, R. A. Hederer, S. Howlett, Y. Takemoto, N. Holmes, and D. R. Alexander. 1997. Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-zeta, and ZAP-70. J. Immunol. 158:5773.
19. lck regulates TCR expression and T cell selection. Int. Immunol. 7:617.
20. Schonrich, G., U. Kalinke, F. Momburg, M. Malissen, A. M. Schmitt Verhulst, B. Malissen, G. J. Hammerling, and B. Arnold. 1991. Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction. Cell 65:293.
21. Rocha, B., and H. von Boehmer. 1991. Peripheral selection of the T cell repertoire. Science 251:1225.
22. Ferber, I., G. Schonrich, J. Schenkel, A. L. Mellor, G. J. Hammerling, Arnold, and B. 1994. Levels of peripheral T cell tolerance induced by different doses of tolerogen. Science 263:674.
23. Tafuri, A., J. Alferink, P. Moller, G. J. Hammerling, and B. Arnold. 1995. T cell awareness of paternal alloantigens during pregnancy. Science 270:630.
24. Valitutti, S., and A. Lanzavecchia. 1997. Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition. Immunol. Today 18:299.
25. Salio, M., S. Valitutti, and A. Lanzavecchia. 1997. Agonist-induced T cell receptor down-regulation: molecular requirements and dissociation from T cell activation. Eur. J. Immunol. 27:1769.
26. D'Oro, U., M. S. Vacchio, A. M. Weissman, and J. D. Ashwell. 1997. Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation. Immunity 7:619.
27. Weiss, A., and D. R. Littman. 1994. Signal transduction by lymphocyte antigen receptors. Cell 76:263.
28. Cantrell, D., A. A. Davies, M. Londei, M. Feldman, and M. J. Crumpton. 1987. Association of phosphorylation of the T3 antigen with immune activation of T lymphocytes. Nature 325:540.
29. Dietrich, J., X. Hou, A.-M. K. Wegener, L. O. Pedersen, N. Odum, and C. Geisler. 1996. Molecular characterization of the di-leucine based internalization motif of the T cell receptor. J. Biol. Chem. 271:11441.
30. Dietrich, J., J. Kastrup, B. L. Nielsen, N. Odum, and C. Geisler. 1997. Regulation and function of the CD3γ DxxxLL motif: a binding site for adaptor protein-1 and adaptor protein-2 in vitro. J. Cell. Biol. 138:271.
31. Luton, F., M. Buferne, V. Legendre, E. Chauvert, C. Boyer, and A.-M. Schmitt-Verhulst. 1997. Role of CD3γ and CD3δ cytoplasmic domains in cytolytic T lymphocyte functions and TCR/CD3 down-modulation. J. Immunol. 158:4162.
32. Geisler, C. 1992. Failure to synthesize the CD3-γ chain: consequences for T cell antigen receptor assembly, processing, and expression. J. Immunol. 148:2437.
33. Dietrich, J., A. Neisig, X. Hou, A.-M. K. Wegener, M. Gajhede, and C. Geisler. 1996. Role of CD3γ in T cell receptor assembly. J. Cell. Biol. 132:299.
34. Goldsmith, M. A., and A. Weiss. 1987. Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor. Proc. Natl. Acad. Sci. USA 84:6879.
35. Koretzky, G. A., J. Picus, T. Schultz, and A. Weiss. 1991. Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production. Proc. Natl. Acad. Sci. USA 88:2037.
36. Geisler, C., T. Plesner, G. Pallesen, K. Skjodt, N. Odum, and J. K. Larsen. 1988. Characterization and expression of the human T cell receptor-T3 complex by monoclonal antibody F101.01. Scand. J. Immunol. 27:685.
37. Hou, X., J. Dietrich, N. Odum, and C. Geisler. 1996. The cytoplasmic tail of FcγRIIIAα is involved in signalling by the low affinity receptor for IgG. J. Biol. Chem. 271:22815.
38. Straus, D. B., and A. Weiss. 1992. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 70:585.
39. Koretzky, G. A., M. A. Kohmetscher, T. Kadleck, and A. Weiss. 1992. Restoration of T cell receptor-mediated signal transduction by transfection of CD45 cDNA into a CD45-deficient variant of the Jurkat T cell line. J. Immunol. 149:1138.
40. Letourneur, F., and R. D. Klausner. 1992. A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains. Cell 69:1143.
41. Luton, F., M. Buferne, J. Davoust, A. M. Schmitt-Verhulst, and C. Boyer. 1994. Evidence for protein tyrosine kinase involvement in ligand- induced TCR/CD3 internalization and surface redistribution. J. Immunol. 153:63.
42. Pure, E., and L. Tardelli. 1992. Tyrosine phosphorylation is required for ligand-induced internalization of the antigen receptor on B lymphocytes. Proc. Natl. Acad. Sci. USA 89:114.
43. Lamaze, C., and S. L. Schmid. 1995. Recruitment of epidermal growth factor receptors into coated pits requires their activated tyrosine kinase. J. Cell. Biol. 129:47.
44. Carpentier, J. L., J. P. Paccaud, J. Backer, A. Gilbert, L. Orci, C. R. Kahn, and J. c. t. B. J. Baecker. 1993. Two steps of insulin receptor internalization depend on different domains of the beta-subunit. J. Cell. Biol. 122:1243.
45. Secrist, J. P., L. A. Burns, L. Karnitz, G. A. Koretzky, and R. T. Abraham. 1993. Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events. J. Biol. Chem. 268:5886.
46. Imbert, V., J. F. Peyron, F. D. Farahi, B. Mari, P. Auberger, and B. Rossi. 1994. Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, an inhibitor of protein tyrosine phosphatases. Biochem. J. 297:163.
47. Cenciarelli, C., K. G. Wilhelm, Jr., A. Guo, and A. M. Weissman. 1996. T cell antigen receptor ubiquitination is a consequence of receptor-mediated tyrosine kinase activation. J. Biol. Chem. 271:8709.
48. Imbert, V., D. Farahifar, P. Auberger, D. Mary, B. Rossi, and J. F. Peyron. 1996. Stimulation of the T-cell antigen receptor-CD3 complex signaling pathway by the tyrosine phosphatase inhibitor pervanadate is mediated by inhibition of CD45: evidence for two interconnected Lck/Fyn- or zap-70-dependent signaling pathways. J. Inflamm. 46:65.
49. Kolesnick, R., and D. W. Golde. 1994. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell 77:325.
50. Hannun, Y. A. 1994. The sphingomyelin cycle and the second messenger function of ceramide. J. Biol. Chem. 269:3125.
51. Viola, A., and A. Lanzavecchia. 1996. T cell activation determined by T cell receptor number and tunable thresholds. Science 273:104.
52. Castagna, M., Y. Takai, K. Kaibuchi, K. Sano, U. Kikkawa, and Y. Nishizuka. 1982. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J. Biol. Chem. 257:7847.
53. Yamanishi, J., Y. Takai, K. Kaibuchi, K. Sano, M. Castagna, and Y. Nishizuka. 1983. Synergistic functions of phorbol ester and calcium in serotonin release from human platelets. Biochem. Biophys. Res. Commun. 112:778.
54. Krangel, M. S. 1987. Endocytosis and recycling of the T3-T cell receptor complex: the role of T3 phosphorylation. J. Exp. Med. 165:1141.
55. Minami, Y., L. E. Samelson, and R. D. Klausner. 1987. Internalization and cycling of the T cell antigen receptor. J. Biol. Chem. 262:13342.
56. Schonhorn, J. E., and M. Wessling-Resnick. 1994. Brefeldin A down-regulates the transferrin receptor in K562 cells. Mol. Cell. Biochem. 135:159.
57. Valitutti, S., S. Muller, M. Salio, and A. Lanzavecchia. 1997. Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation. J. Exp. Med. 185:1859.
58. Luton, F., V. Legendre, J. P. Gorvel, A. M. Schmitt-Verhulst, and C. Boyer. 1997. Tyrosine and serine protein kinase activities associated with ligand-induced internalized TCR/CD3 complexes. J. Immunol. 158:3140.
59. Yamasaki, S., M. Tachibana, N. Shinohara, and M. Iwashima. 1997. Lck-independent triggering of T-cell antigen receptor signal transduction by staphylococcal enterotoxins. J. Biol. Chem. 272:14787.
60. Pearse, B. M. F. 1988. Receptors compete for adaptors found in plasma membrane coated pits. EMBO J. 7:3331.
61. Glickman, J. N., E. Conibear, and B. M. Pearse. 1989. Specificity of binding of clathrin adaptors to signals on the mannose-6-phosphate/insulin-like growth factor II receptor. EMBO J. 8:1041.
62. Beltzer, J. P., and M. Spiess. 1991. In vitro binding of the asialoglycoprotein receptor to the beta adaptin of plasma membrane-coated vesicles. EMBO J. 10:3735.
63. Sosa, M. A., B. Schmidt, K. von Figura, and A. Hille-Rehfeld. 1993. In vitro binding of plasma membrane-coated vesicle adaptors to the cytoplasmic domain of lysosomal acid phosphatase. J. Biol. Chem. 268:12537.
64. Sorkin, A., and G. Carpenter. 1993. Interaction of activated EGF receptors with coated pit adaptins. Science 261:612.
65. Nesterov, A., R. C. Kurten, and G. N. Gill. 1995. Association of epidermal growth factor receptors with coated pit adaptins via a tyrosine phosphorylation-regulated mechanism. J. Biol. Chem. 270:6320.
66. Ohno, H., J. Stewart, M. C. Fournier, H. Bosshart, I. Rhee, S. Miyatake, T. Saito, A. Gallusser, T. Kirchhausen, and J. S. Bonifacino. 1995. Interaction of tyrosine-based sorting signals with clathrin- associated proteins. Science 269:1872.
67. Cenciarelli, C., D. Hou, K. C. Hsu, B. L. Rellahan, D. L. Wiest, H. T. Smith, Fried, VA, and A. M. Weissman. 1992. Activation-induced ubiquitination of the T cell antigen receptor. Science 257:795.
68. Strous, G. J., P. van Kerkhof, R. Govers, A. Ciechanover, and A. L. Schwartz. 1996. The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor. EMBO J. 15:3806.
69. Hicke, L., and H. Riezman. 1996. Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis. Cell 84:277.
70. Weissman, A. M. 1997. Regulating protein degradation by ubiquitination. Immunol. Today 18:189.
71. Koretzky, G. A. 1997. The role of Grb2-associated proteins in T-cell activation. Immunol. Today 18:401.
72. Wang, Z., and M. F. Moran. 1996. Requirement for the adapter protein GRB2 in EGF receptor endocytosis. Science 272:1935.
73. Bernot, A., and C. Auffray. 1991. Primary structure and ontogeny of an avian CD3 transcript. Proc. Natl. Acad. Sci. USA 88:2550.
74. Sussman, J. J., J. S. Bonifacino, J. Lippincott-Schwartz, A. M. Weissman, T. Saito, R. D. Klausner, and J. D. Ashwell. 1988. Failure to synthesize the T cell CD3-ζ chain: structure and function of a partial T cell receptor complex. Cell 52:85.