Differential T Cell Signaling Induced by Antagonist Peptide-MHC Complexes and the Associated Phenotypic Responses

Journal of Immunology

Volumn 158, Issue 5, 1997, Pages 2057-2064

  La Face, Drake M ^a,c   Couture, Clément ^a,d   Anderson, Karen ^a   Shih, Grace ^a   Alexander, Jeff ^b   Sette, Alessandro ^b   Mustelin, Tomas ^a   Altman, Amnon ^a   Grey, Howard M ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b CYTEL CORPORATION   (United States)

^c Immusol Inc   (United States)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 2; I E ANTIGEN; I-E-ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; PEPTIDE; PHOSPHOTYROSINE; PROTEIN TYROSINE KINASE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BIOSYNTHESIS; CHEMISTRY; COMPARATIVE STUDY; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVATION; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; MOUSE; PHENOTYPE; PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; DOWN-REGULATION; ENZYME ACTIVATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; MICE; MOLECULAR SEQUENCE DATA; PEPTIDES; PHENOTYPE; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0031091732     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Crabtree, G. R., and N. A. Clipstone. 1994. Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu. Rev. Biochem. 63:1045.
2. Iwashima, M., B. A. Irving, N. S. vanOers, A. C. Chan, and A. Weiss. 1994. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 263:1136.
3. Isakov, N., R. L. Wange, and L. E. Samelson. 1994. The role of tyrosine kinases and phosphotyrosine-containing recognition motifs in regulation of the T cell-antigen receptor-mediated signal transduction pathway. J. Leukocyte Biol. 55:265.
4. Wange, R. L., S. N. Malek, S. Desiderio, and L. E. Samelson. 1993. Tandem SH2 domains of Zap-70 bind to T cell antigen receptor ζ and CD3 ε from activated Jurkat T cells. J. Biol. Chem. 268:19797.
5. lck/CD4 to the activated T cell receptor/CD3/ζ complex. J. Exp. Med. 181:1997.
6. Chan, A. C., M. Iwashima, C. W. Turck, and A. Weiss. 1992. ZAP-70: a 70-kd protein-tyrosine kinase that associates with the TCR ζ chain. Cell 71:649.
7. Neumeister, E. N., Y. Zhu, S. Richard, C. Terhorst, A. C. Chan, and A. S. Shaw. 1995. Binding of ZAP-70 to phosphorylated T-cell receptor ζ and ε enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins. Mol. Cell. Biol. 15:3171.
8. Chan, A. C., M. Dalton, R. Johnson, G. H. Kong, T. Wang, R. Thoma, and T. Kurosaki. 1995. Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. EMBO J. 14:2499.
9. Osman, N., S. Lucas, and D. Cantrell. 1995. The role of tyrosine phosphorylation in the interaction of cellular tyrosine kinases with the T cell receptor ζ chain tyrosine-based activation motif. Eur. J. Immunol. 25:2863.
10. Nel, A. E., S. Gupta, L. Lee, J. A. Ledbetter, and S. B. Kanner. 1995. Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-γ 1, and other phosphoproteins with Grb2 and the ζ-chain of the TCR. J. Biol. Chem. 270:18428.
11. DeMagistris, M. T., J. Alexander, M. Coggeshall, A. Altman, F. C. A. Gaeta, H. M. Grey, and A. Seite. 1992. Antigen analog-major histocompatibility complexes act as antagonist of the T cell receptor. Cell 68:625.
12. Jameson, S. C., and M. J. Bevan. 1995. T cell receptor antagonists and partial agonists. Immunity 2:1.
13. Ruppert, J., J. Alexander, K. Snoke, M. Coggeshall, E. Herbert, D. McKenzie, H. M. Grey, and A. Sette. 1993. Effect of T-cell receptor antagonism on interaction between T cells and antigen-presenting cells and on T-cell signaling events. Pruc. Natl. Acad. Sci. USA 90:2671.
14. Sette, A., J. Alexander, J. Ruppert, K. Snoke, A. Franco, G. Ishioka, and H. M. Grey. 1994. Antigen analogs/MHC complexes as specific T cell receptor antagonists. Annu. Rev. Immunol. 12:413.
15. Evavold, B. D., and P. M. Allen. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 253:1308.
16. Evavold, B. D., J. Sloan-Lancaster, B. L. Hsu, and P. M. Allen. 1993. Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides. J. Immunol. 150:3131.
17. Sloan-Lancaster, J., B. D. Evavold, and P. M. Allen. 1993. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature 363:156.
18. Valitutti, S., S. Müller, M. Cella, E. Padovan, and A. Lanzavecchia. 1995. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375:148.
19. Ehrich, E. W., B. Devaux, E. P. Rock, J. L. Jorgensen, M. M. Davis, and Y. H. Chien. 1993. T cell receptor interaction with peptide/major histo-compatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen. J. Exp. Med. 178:713.
20. Chien, Y.-H., and M. M. Davis. 1993. How αβ T-cell receptors 'see' peptide/ MHC complexes. Immunol. Today 14:597.
21. Evavold, B. D., J. Sloan-Lancaster, and P. M. Allen. 1993. Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands. Immunol. Today 14:602.
22. Sette, A., S. Southwood, D. O'Sullivan, F. C. A. Gaeta, J. Sidney, and H. M. Grey. 1992. The effect of pH on class II-peptide interactions. J. Immunol. 148:844.
23. Hedrick, S. M., I. Engel, D. L. McElligott, P. J. Fink, M.-L. Hsu, D. Hansburg, and L. A. Matis. 1988. Selection of amino acid sequences in the β chain of the T cell antigen receptor. Science 239:1541.
24. Madrenas, J., R. L. Wange, J. L. Wang, N. Isakov, L. E. Samelson, and R. N. Germain. 1995. ζ Phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 267:515.
25. Sloan-Lancaster, J., A. S. Shaw, J. B. Rothbard, and P. M. Allen. 1994. Partial T cell signaling: altered phospho-ζ and lack of Zap 70 recruitment in APL-induced T cell anergy. Cell 79:913.
26. c-cbl in T lymphocytes. J. Exp. Med. 183:301.
27. Valitutti, S., M. Dessing, K. Aktories, H. Gallati, and A. Lanzavecchia. 1995. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton. J. Exp. Med. 181:577.
28. Racioppi, L., F. Ronchese, L. A. Matis, and R. N. Germain. 1993. Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. J. Exp. Med. 177:1047.
29. Boussiotis, V. A., D. L. Barber, B. J. Lee, J. G. Gribben, G. J. Freeman, and L. M. Nadler. 1996. Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation. J. Exp. Med. 184:365.
30. + T cells in response to antagonist ligands. J. Exp. Med. 184:149.