Relationships among TCR ligand potency, thresholds for effector function elicitation, and the quality of early signaling events in human T cells

Journal of Immunology

Volumn 160, Issue 12, 1998, Pages 5807-5814

  Hemmer, Bernhard ^a   Stefanova, Irena ^b   Vergelli, Marco ^a   Germain, Ronald N ^b   Martin, Roland ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN EXPRESSION; ARTICLE; CELL POLARITY; CELLULAR IMMUNITY; DOSE RESPONSE; EFFECTOR CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATORY CELL; LIGAND BINDING; MOLECULAR CLONING; PRIORITY JOURNAL; RECEPTOR DENSITY; T LYMPHOCYTE ACTIVATION;

CELLS, CULTURED; HUMANS; LIGANDS; MEMBRANE PROTEINS; PEPTIDES; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 0032526345     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Germain, R. N. 1994. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation, Cell 76:287.
2. Janeway, C. A., and K. Bottomly. 1994. Signals and signs for lymphocyte responses. Cell 76:275.
3. Evavold, B. D., J. Sloan-Lancaster, and P. M. Allen. 1993. Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands. Immunol. Today 14:602.
4. Jameson, S. C., and M. J. Bevan, 1995. T cell receptor antagonists and partial agonists. Immunity 2:1.
5. Janeway, C. A. 1995. Ligands for the T-cell receptor: hard times for avidity models. Immunol. Today 16:223.
6. Kersh, G. J., and P. M. Allen. 1996. Essential flexibility in the T cell recognition of antigen. Nature 380:495.
7. Madrenas, J., and R. N. Germain. 1996. Variant TCR ligands: new insights into the molecular basis of antigen-dependent signal transduction and T-cell activation. Semin. Immunol. 8:83.
8. Evavold, B. D., and P. M. Allen. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252:1308.
9. De Magistris, M. T., J. Alexander, M. Coggeshall, A. Altman, F. C. A. Gaeta, H. M. Grey, and A. Sette. 1992. Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor. Cell 68:625.
10. Evavold, B. D., S. G. Williams, B. L. Hsu, S. Buus, and P. M. Allen. 1992. Complete dissection of the Hb(64-76) determinant using T helper 1, T helper 2 clones, and T cell hybridomas. J. Immunol. 148:347.
11. Evavold, B. D., J. Sloan-Lancaster, B. L. Hsu, and P. M. Allen. 1993. Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides. J. Immunol. 150:3131.
12. Jameson, S. C., F. R. Carbone, and M. J. Bevan. 1993. Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells. J. Exp. Med. 177:1541.
13. Racioppi, L., F. Ronchese, L. A. Matis, and R. N. Germain. 1993. Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. J. Exp. Med. 177:1047.
14. Sloan-Lancaster, J., B. D. Evavold, and P. M. Allen. 1993. Induction of T-cell anergy by altered T cell receptor ligand on live antigen-presenting cells. Nature 363:156.
15. Klenerman, P., S. Rowland-Jones, S. McAdam, J. Edwards, S. Daenke, D. Lalloo, B. Köppe, W. Rosenberg, D. Boyd, A. Edwards, P. Glangrande, R. E. Phillips, and A. J. McMichael. 1994. Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 gag variants. Nature 369:403.
16. Höllsberg, P., W. E. J. Weber, F. Dangond, V. Batra, A. Sette, and D. A. Hafler. 1995. Differential activation of proliferation and cytotoxicity in human T-cell lymphotrophic virus type I Tax-specific CDS T cells by an altered peptide ligand. Proc. Natl. Acad. Sci. USA 92:4036.
17. Windhagen, A., C. Scholz, P. Höllsberg, H. Fukaura, A. Sette, and D. A. Hafler. 1995. Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand. Immunity 2:373.
18. Vergelli, M., B. Hemmer, U. Utz, A. Vogt, M. Kalbus, L. Tranquill, P. Conlon, N. Ling, L. Steinman, H. F. McFarland, and R. Martin. 1996. Differential T cell activation by altered peptide ligands derived from myelin basic protein peptide (87-99). Eur. J. Immunol. 26:2624.
19. Madrenas, J., R. L. Wange, J. L. Wang, N. Isakov, L. Samelson, and R. N. Germain. 1995. ζ phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 167:515.
20. + T cells in response to antagonist ligands. J. Exp. Med. 184:149.
21. Sloan-Lancaster, J., A. S. Shaw, J. B. Rothbard, and P. M. Allen. 1994. Partial T cell signaling: altered phospho-ζ and lack of zap70 recruitment in APL-induced T cell anergy. Cell 79:913.
22. Madrenas, J., R. H. Schwanz, and R. N. Germain. 1996. Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation. controls anergy induction by both agonists and partial agonists. Proc. Natl. Acad. Sci. USA 93:9736.
23. Bretscher, P. A., G. Wei, J. N. Menon, and H. Bielefeldt-Ohmann. 1992. Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major. Science 257:539.
24. + T cells. J. Exp. Med. 182:1591.
25. + T helper cell phenotype development in a T cell receptor-α β-transgenic model. J. Exp. Med. 182:1579.
26. Parish, C. R., and F. Y. Liew. 1972. Immune response to chemically modified flagellin. III. Enhanced cell-mediated immunity during high and low zone antibody tolerance to flagellin. J. Exp. Med. 135:298.
27. Valitutti, S., S. Müller, M. Cella, E. Padovan, and A. Lanzavecchia. 1995. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375:148.
28. Chen, Y. Z., S. Matsushita, and Y. Nishimura. 1996. Response of a human T cell clone to a large panel of altered peptide ligands carrying single residue substitutions in an antigenic peptide: characterization and frequencies of TCR agonism and TCR antagonism with or without partial activation. J. Immunol. 157:3783.
29. Matsuoka, T., H. Kohrogi, M. Ando, Y. Nishimura, and S. Matsushita. 1996. Altered TCR ligands affect antigen-presenting cell responses: up-regulation of IL-12 by an analogue peptide, J. Immunol. 157:4837.
30. Tsitoura, D. C., W. Holter, A. Cerwenka, C. M. Gelder, and J. R. Lamb, 1996. Induction of anergy in human T helper 0 cells by stimulation with altered T cell antigen receptor ligands. J. Immunol. 156:2801.
31. Valitutti, S., S. Müller, M. Dessing, and A. Lanzavecchia. 1996. Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy. J. Exp. Med. 183:1917.
32. Vergelli, M., B. Hemmer, M. Kalbus. A. Vogt, N. Ling, P. Conlon, J. E. Coligan, H. F. McFarland, and R. Martin. 1997. Modifications of peptide ligands enhancing T cell responsiveness imply large numbers of stimulatory ligands for auto-reactive T cells. J. Immunol. 158:3746.
33. Hemmer, B., B. Fleckenstein, M. Vergelli, G. Jung, H. McFarland, R. Martin, and K.-H. Wiesmueller. 1997. Identification of high potency microbial and self ligands for a human autoreactive class II restricted T cell clone. J. Exp. Med. 185:1651.
34. + cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106. J. Immunol. 148:1359.
35. Ling, N., F. Esch, P. Böhlen, P. Brazeau, W. B. Wehrenherg, and R. Guillemin. 1984. Isolation, primary structure, and synthesis of human hypothalamic somatocrinin: growth hormone-re leasing factor. Proc. Natl. Acad. Sci. USA 81:4302.
36. Burkhardt, A. L., B. Stealey, R. B. Rowley, S. Mahajan, M. Prendergast, J. Fargnoli, and J. B. Bolen. 1994. Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T cell antigen receptor engagement. J. Biol. Chem. 269:23642.
37. Stefanova, I., M. L. Corcoran, E. M. Horak, L. M. Wahl, J. B. Bolen, and I. D. Horak. 1993. Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn. J. Biol. Chem. 268:20725.
38. Rabinowitz. J. D., C. Beeson, C. Wülfing, K. Tate, P. M. Allan, and H. M. McConnel. 1996. Altered T cell receptor ligands trigger a subset of early T cell signals. Immunity 5:125.
39. Lyons, D. S., S. A. Lieberman, J. Hampl, J. J. Boniface, Y.-h. Chien, L. J. Berg, and M. M. Davis. 1996. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than agonists. Immunity 5:53.
40. Viola, A., and A. Lanzavecchia. 1996. T cell activation determined by T cell receptor number and tunable thresholds. Science 273:104.
41. + T cells. Annu. Rev. Immunol. 12:635.
42. Karin, N., D. J. Mitchell, S. Brocke, N. Ling, and L. Steinman. 1994. Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon γ and tumor necrosis factor α production. J. Exp. Med. 180:2227.
43. Kuchroo, V. K., J. M. Greer, D. Kaul, G. Ishioka, A. Franco, A. Sette, R. A. Sobel, and M. B. Lees. 1994. A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire. J. Immunol. 153:3326.
44. Nicholson, L. B., J. M. Greer, R. A. Sobel, M. B. Lees, and V. K. Kuchroo. 1995. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 3:397.
45. Brocke, S., K. Gijbels, M. Allegretta, I. Ferber, C. Piercy, T. Blankenstein, R. Martin, U. Utz, N. Karin, D. Mitchell, T. Veromaa, P. J. Fairchild, D. C. Wraith, A. O'Garra, C. G. Fathman, and L. Steinman. 1996. Dynamics of autoimmune T cell infiltration: reversal of paralysis and disappearance of inflammation following treatment of experimental encephalomyelitis with a myelin basic protein peptide analog. Nature 379:343.
46. Valitutti, S., S. Muller, M. Dessing, and A. Lanzavecchia. 1996. Signal extinction and T cell repolarization in T helper cell-antigen-presenting cell conjugates. Eur. J. Immunol. 26:2012.
47. Boyer, C., N. Auphan, F. Luton, J. M. Malburel, M. Barad, J. P. Bizozzero, H. Reggio, and A. M. Schmitt-Verhulst. 1991. T cell receptor/CD3 complex internalization following activation of a cytolytcc T cell clone: evidence for a protein kinase C-independent staurosporine-sensitive step. Eur. J. Immunol. 21: 1623.
48. Luton, F., M. Buferne, J. Davoust, A. M. Schmitt-Verhulst, and C. Boyer. 1994. Evidence for protein tyrosine kinase involvement in ligand-induced TCR/CD3 intemalization and surface redistribution. J. Immunol. 153:63.
49. Alam, S. M., P. J. Travers, J. L. Wung, W. Nasholds, S. Redpath, S. C. Jameson, and N. R. Gascoigne. 1996. T-cell-receptor affinity and thymocyte positive selection. Nature 381:616.
50. Madrenas, J., L. A. Chau, J. Smith, J. A. Bluestone, and R. Germain. 1997. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. J. Exp. Med. 185:219.
51. Hampl, J., Y. H. Chien, and M. M. Davis. 1997. CD4 augments the response of a T cell to agonist but not to antagonist ligands. Immunity 7:379.
52. Hogquist, K. A., S. Jameson, W. R. Heath, J. L. Howard, M. J. Bevan, and F. R. Carbone. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76:17.
53. + T cells. Immunity 1995:79.
54. Sebzda, E., T. M. Kundig, C. T. Thomson, K. Aoki, S. Y. Mak, J. P. Mayer, T. Zamborelli, S. G. Nathenson, and P. S. Ohashi. 1996. Mature T cell reactivity altered by peptide agonist that induces positive selection. J. Exp. Med. 183:1093.