Regulation and function of the CD3γ/DxxxLL motif: A binding site for adaptor protein-1 and adaptor protein-2 in vitro

Journal of Cell Biology

Volumn 138, Issue 2, 1997, Pages 271-281

  Dietrich, Jes ^a,c   Kastrup, Jesper ^a,b   Nielsen, Bodil L ^a   Ødum, Niels ^a,d   Geisler, Carsten ^a,d  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d Biotech Ctr for Cell Comm   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; T LYMPHOCYTE RECEPTOR; ALPHA ADAPTIN; AMINO ACID; CD4 ANTIGEN; HYBRID PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ARTICLE; BINDING SITE; DOWN REGULATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; AMINO ACID SEQUENCE; CHEMISTRY; COATED VESICLE; GENETICS; LEUKEMIA CELL LINE; METABOLISM; MOLECULAR GENETICS; MUTATION; PHOSPHORYLATION; PROTEIN CONFORMATION;

ADAPTOR PROTEIN COMPLEX ALPHA SUBUNITS; ADAPTOR PROTEINS, VESICULAR TRANSPORT; AMINO ACID SEQUENCE; AMINO ACIDS; ANTIGENS, CD3; ANTIGENS, CD4; BINDING SITES; COATED VESICLES; DOWN-REGULATION; HUMANS; JURKAT CELLS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PROTEIN CONFORMATION; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT FUSION PROTEINS;

EID: 0030611594     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.138.2.271     Document Type: Article

References (55)

1. Arnold, B., O. Schonrich, and G.J. Hammerling. 1993. Multiple levels of peripheral tolerance. Immunol. Today. 14:12-14.
2. Beltzer, J.P., and M. Spiess. 1991. In vitro binding of the asialoglycoprotein receptor to the beta adaptin of plasma membrane coated vesicles. EMBO (Eur. Mol. Biol. Organ.) J. 10:3735-3742.
3. Bernot, A., and C. Auffray. 1991. Primary structure and ontogeny of an avian CD3 transcript. Proc. Natl. Acad. Sci. USA. 88:2550-2554.
4. Bremnes, B., T. Madsen, M. Gedde-Dahl, and O. Bakke. 1994. An LI and ML motif in the cytoplasmic tail of the MHC-associated invariant chain mediate rapid internalization. J. Cell. Sci. 107:2021-2032.
5. Davies, J.D., D. Mueller, D.B. Wilson, and D.P. Gold. 1990. Nucleotide sequence of a cDNA encoding the rat T3 delta chain. Nucleic Acids Res. 18: 4617.
6. Dietrich, J., X. Hou, A.K. Wegener, and C. Geisler. 1994. CD3γ contains a phosphoserine-dependent di-leucine motif involved in downregulation of the T cell receptor. EMBO (Eur. Mol. Biol. Organ.) J. 13:2156-2166.
7. Dietrich, J., X. Hou, A.K. Wegener, L.O. Pedersen, N. Odum, and C. Geisler. 1996. Molecular characterization of the di-leucine based internalization motif of the T cell receptor. J. Biol. Chem. 271:11441-11448.
8. Dietrich, J., A. Neisig, X. Hou, A.K. Wegener, M. Gajhede, and C. Geisler. 1996. Role of CD3γ in T cell receptor assembly. J. Cell. Biol. 132:299-310.
9. Dittrich, E., CR. Haft, L. Muys, P.C. Heinrich, and L. Graeve. 1996. A dileucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and downregulation of the IL-6 receptor. J. Biol. Chem. 271:5487-5494.
10. Ferber, L. G. Schonrich, J. Schenkel, A.L. Mellor, G.J. Hammerling, and B. Arnold. 1994. Levels of peripheral T cell tolerance induced by different doses of tolerogen. Science (Wash. DC). 263:674-676.
11. Geisler, C. 1992. Failure to synthesize the CD3-γ chain: Consequences for T cell antigen receptor assembly, processing, and expression. J. Immunol. 148:2437-2445.
12. Geisler, C., T. Plesner, G. Pallesen, K. Skjodt, N. Odum, and J.K. Larsen. 1988. Characterization and expression of the human T cell receptor-T3 complex by monoclonal antibody F101.01. Scand. J. Immunol. 27:685-696.
13. Glickman, J.N., E. Conibear, and B.M. Pearse. 1989. Specificity of binding of clathrin adaptors to signals on the mannose-6-phosphate/insulin-like growth factor II receptor. EMBO (Eur. Mol. Biol. Organ.) J. 8:1041-1047.
14. Hahn, W.C., E. Menzin, T. Saito, R.N. Germain, and B.E. Bierer. 1993. The complete sequences of plasmids pFNeo and pMH-Neo: convenient expression vectors for high-level expression of eukaryotic genes in hematopoietic cell lines. Gene (Amst.). 127:267-268.
15. Heilker, R., U. Manning-Krieg, J.F. Zuber, and M. Spiess. 1996. In vitro binding of clathrin adaptors to sorting signals correlates with endocytosis and basolateral sorting. EMBO (Eur. Mol. Biol. Organ.) J. 15:2893-2899.
16. Hein, W.R., and A. Tunnacliffe. 1990. Characterization of the CD3 γand δ invariant subunits of the sheep T cell antigen receptor. Eur. J. Immunol. 20:1505-1511.
17. Hou, X., J. Dietrich, N. Odum, and C. Geisler. 1996. The cytoplasmic tail of FcγRIIIAα is involved in signaling by the low affinity receptor for IgG.J. Biol. Chem. 271:22815-22822.
18. Huang, L., and I.N. Crispe. 1993. Superantigen-driven peripheral deletion of T cells. Apoptosis occurs in cells that have lost the alpha/beta T cell receptor. J. Immunol. 151:1844-1851.
19. Johnson, K.F., and S. Kornfeld. 1992. The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi. J. Cell. Biol. 119:249-257.
20. Krissansen, G.W., M.J. Owen, W. Verbi, and M.J. Crumpton. 1986. Primary structure of the T3 γ subunit of the T3/T cell antigen receptor complex deduced from cDNA sequences: evolution of the T3 γ and δ subunits. EMBO (Eur. Mol. Biol. Organ.) J. 5:1799-1808.
21. Krissansen, G.W., M.J. Owen, P.J. Fink, and M.J. Crumpton. 1987. Molecular cloning of the cDNA encoding the T3γ subunit of the mouse T3/T cell antigen receptor complex. J. Immunol. 138:3513-3518.
22. Kruisbeek, A.M., and D. Amsen. 1996. Mechanisms underlying T-cell tolerance. Curr. Opin. Immunol. 8:233-244.
23. Letourneur, F., and R.D. Klausner. 1992. A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains. Cell. 69:1143-1157.
24. Levins, B., and C.A.L.S. Colaco. 1992. The CD3 γ-chain, transmembrane signaling or recognition? Immunogenetics. 35:140-143.
25. Littman, D.R., and S.N. Gettner. 1987. Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene. Nature (Lond.). 325:453-455.
26. Lohse, M.J. 1993. Molecular mechanisms of membrane receptor desensitization. Biochim. Biophys. Acta. 1179:171-188.
27. Marks, M.S., H. Ohno, T. Kirchhausen, and J.S. Bonifacino. 1997. Protein sorting by tyrosine-based signals: adapting to the Ys and wherefores. Trends Cell Biol. 7:124-128.
28. Masui, H., A. Wells, C.S. Lazar, M.G. Rosenfeld, and G.N. Gill. 1991. Enhanced tumorigenesis of NR6 cells which express non-down-regulating epidermal growth factor receptors. Cancer Res. 51:6170-6175.
29. Motta, A., B. Bremnes, M.A. Morelli, R.W. Frank, G. Saviano, and O. Bakke. 1995. Structure-activity relationship of the leucine-based sorting motifs in the cytosolic tail of the major histocompatibility complex-associated invariant chain. J. Biol. Chem. 270:27165-27171.
30. Nesterov, A., R.C. Kurten, and G.N. Gill. 1995. Association of epidermal growth factor receptors with coated pit adaptins via a tyrosine phosphorylation-regulated mechanism. J. Biol. Chem. 270:6320-6327.
31. Ohno, H., J. Stewart, M.C. Fournier, H. Bosshart, I. Rhee, S. Miyatake, T. Saito, A. Gallusser, T. Kirchhausen, and J.S. Bonifacino. 1995. Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science (Wash. DC). 269:1872-1875.
32. Pearse, B.M.F. 1988. Receptors compete for adaptors found in plasma membrane coated pits. EMBO (Eur. Mol. Biol. Organ.) J. 7:3331-3336.
33. Pearse, B.M., and M.S. Robinson. 1990. Clathrin, adaptors, and sorting. Annu. Rev. Cell Biol. 6:151-171.
34. Pieters, J., O. Bakke, and B. Dobberstein. 1993. The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail. J. Cell Sci. 106:831-846.
35. Pond, L., L.A. Kuhn, L. Teyton, M. Schutze, J.A. Tainer, M.R. Jackson, and P.A. Peterson. 1995. A role for acidic residues in di-leucine motif-based targeting to the endocytic pathway. J. Biol. Chem. 270:19989-19997.
36. Robinson, M.S. 1993. Adaptins. Trends Cell Biol. 2:293-297.
37. Rocha, B., and H. von Boehmer. 1991. Peripheral selection of the T cell repertoire. Science (Wash. DC). 251:1225-1228.
38. Sandoval, I.V., and O. Bakke. 1994. Targeting of membrane proteins to endosomes and lysosomes. Trend Cell Biol. 4:292-297.
39. Sandoval, I.V., J.J. Arredondo, J. Alcalde, A.C. Noriega, J. Vandekerchove, M.A. Jimenez, and M. Rico. 1994. The residue leu(ile)475-ile(leu, val, ala)476 contained in the extended carboxyl cytoplasmic tail, are critical for targeting of the resident lysosomal membrane protein LIMP II to lysosomes. J. Biol. Chem. 269:6622-6631.
40. Schonrich, G., U. Kalinke, F. Momburg, M. Malissen, A.M. Schmitt Verhulst, B. Malissen, G.J. Hammerling, and B. Arnold. 1991. Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction. Cell. 65:293-304.
41. Sheikh, H., and C.M. Isacke. 1996. A di-hydrophobic Leu-Val motif regulates the basolateral localization of CD44 in polarized Madin-Darby canine kidney epithelial cells. J. Biol. Chem. 271:12185-12190.
42. Shin, J., C. Doyle, Z. Yang, D. Kappes, and J.L. Strominger. 1990. Structural features of the cytoplasmic region of CD4 required for internalization. EMBO (Eur. Mol. Biol. Organ.) J. 9:425-134.
43. Shin, J., R.L. Dunbrack, S. Lee, and J.L. Strominger. 1991. Phosphorylation-dependent down-modulation of CD4 requires a specific structure within the cytoplasmic domain of CD4. J. Biol. Chem. 266:10658-10665.
44. Sorkin, A., and G. Carpenter. 1993. Interaction of activated EGF receptors with coated pit adaptins. Science (Wash. DC). 261:612-615.
45. Sosa, M.A., B. Schmidt, K. von Figura, and A. Hille-Rehfeld. 1993. In vitro binding of plasma membrane-coated vesicle adaptors to the cytoplasmic domain of lysosomal acid phosphatase. J. Biol. Chem. 268:12537-12543.
46. Sussman, J.J., S.S. Bonifacino, J. Lippincott-Schwartz, A.M. Weissman, T. Saito, R.D. Klausner, and J.P. Ashwell. 1988. Failure to synthesize the T cell CD3-ζ chain: structure and function of a partial T cell receptor complex. Cell. 52:85-95.
47. Tafuri, A., J. Alferink, P. Moller, G.J. Hammerling, and B. Arnold. 1995. T cell awareness of paternal alloantigens during pregnancy. Science (Wash. DC). 270:630-633.
48. Trowbridge, I.S., J.F. Collawn, and C.R. Hopkins. 1993. Signal-dependent membrane protein trafficking in the endocytic pathway. Annu. Rev. Cell. Biol. 9:129-161.
49. Valitutti, S., S. Muller, M. Cella, E. Padovan, and A. Lanzavecchia. 1995. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature (Lond.). 375:148-151.
50. Valitutti, S., S. Muller, M. Dessing, and A. Lanzavecchia. 1996. Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy. J. Exp. Med. 183:1917-1921.
51. Van den Elsen, P., B. Shepley, J. Borst, J.E. Coligan, A.F. Markham, S. Orkin, and C. Terhorst. 1984. Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex. Nature (Lond.). 312:413-418.
52. Van den Elsen, P., B. Shepley, M. Cho, and C. Terhorst. 1985. Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein. Nature (Lond.). 314:542-544.
53. Vaux, D. 1992. The structure of an endocytosis signal. Trends Cell Biol. 2:189-192.
54. Wegener, A.K., X. Hou, J. Dietrich, and C. Geisler. 1995. Distinct domains of the CD3-γ chain are involved in surface expression and function of the T cell antigen receptor. J. Biol. Chem. 270:4675-4680.
55. Wells, A., J.B. Welsh, C.S. Lazar, H.S. Wiley, G.N. Gill, and M.G. Rosenfeld. 1990. Ligand-induced transformation by a noninternalizing epidermal growth factor receptor. Science (Wash. DC). 247:962-964.