Nutraceutical interventions may delay aging and the age-related diseases

Experimental Gerontology

Volumn 35, Issue 9-10, 2000, Pages 1405-1417

  Villeponteau, B ^a,c   Cockrell, R ^a,b   Feng, J ^a  

^a HealthSpan Sciences   (United States)

^b Fountain Valley Regional Hospital and Medical Center   (United States)

^c NONE   (United States)

Author keywords

Age related disease; Aging; Antioxidants; Cancer; Cardiovascular disease; Clinical trials; Free radicals; Mitochondria; Nutritional supplements; Oxidative stress

Indexed keywords

ANTIOXIDANT; CENTRUM VITAMIN E; MULTIVITAMIN; THIOMAX; UNCLASSIFIED DRUG; VI MIX GRAPE; VI MIX THIOGEN; YOUTHGUARD;

AGING; ALZHEIMER DISEASE; ARTHRITIS; CANCER; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETES MELLITUS; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; HEALTH PROMOTION; HUMAN; LIFE EXPECTANCY; NUTRIENT; NUTRITIONAL DEFICIENCY; OSTEOPOROSIS; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; QUALITY OF LIFE; RETINA MACULA DEGENERATION; TREATMENT OUTCOME; URINALYSIS;

AGING; ANTIOXIDANTS; CARDIOVASCULAR DISEASES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; HUMANS; MINERALS; NEOPLASMS; NEURODEGENERATIVE DISEASES; OXIDANTS; OXIDATIVE STRESS; TREATMENT OUTCOME; VITAMINS;

EID: 0033654199     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(00)00182-0     Document Type: Conference Paper

References (69)

1. Numerical density of cardiac myocytes in aged rats fed a cholesterol-rich diet and a canola oil diet (n-3 fatty acid rich)
2. Manganese superoxide dismutase (MnSOD) genetic polymorphisms, dietary antioxidants, and risk of breast cancer
3. Micronutrients prevent cancer and delay aging
4. Micronutrient deficiencies. A major cause of DNA damage
5. Oxidants are a major contributor to aging
6. Oxidants, antioxidants, and the degenerative diseases of aging
7. Mitochondrial decay in aging
8. Effect of omega-3 fatty acids on rectal mucosal cell proliferation in subjects at risk for colon cancer
9. Intake of potassium, magnesium, calcium, and fiber and risk of stroke among US men
10. The cytoprotective effect of magnesium in global myocardial ischemia
11. Gender specific alterations in antioxidant status of aging Zaprionus paravittiger fed on propyl gallate
12. Effect of propyl gallate feeding on glutathione content in ageing Zaprionus paravittiger (Diptera)
13. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury
14. Mitochondrial free radical production and aging in mammals and birds
15. Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals
16. The free radical theory of aging matures
17. Hydrogen peroxide mediates amyloid beta protein toxicity
18. Attenuation of reperfusion injury by the antioxidant n-propyl gallate
19. DNA damage in folate deficiency
20. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage
21. n-3 polyunsaturated fatty acids and cancer
22. Effects of supplementation with folic acid and antioxidant vitamins on homocysteine levels and LDL oxidation in coronary patients
23. The biology of replicative senescence
24. Oxidative stress and Alzheimer disease
25. A review of magnesium intake in the elderly. A cause for concern?
26. Magnesium and cardiovascular drugs: Interactions and therapeutic role
27. Influence of the phospholipid n-6/n-3 polyunsaturated fatty acid ratio on the mitochondrial oxidative metabolism before and after myocardial ischemia
28. Magnesium depletion and pathogenesis of Alzheimer's disease
29. Are age-related neurodegenerative diseases linked with various types of magnesium depletion?
30. Effects of antioxidants on vascular health
31. Antioxidant vitamins and cardiovascular disease
32. Dementias: The role of magnesium deficiency and an hypothesis concerning the pathogenesis of Alzheimer's disease
33. (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate
34. Aging: A theory based on free radical and radiation chemistry
35. Free radicals in aging
36. Antihypertensive effect of all-cis-5,8,11,14,17-icosapentaenoate of aged rats is associated with an increase in the release of ATP from the caudal artery
37. Longevity, genes, and aging
38. Effects of magnesium supplementation in hypertensive patients: Assessment by office, home, and ambulatory blood pressures
39. Folate and cancer prevention: A new medical application of folate beyond hyperhomocysteinemia and neural tube defects
40. Accumulation of defective mitochondria through delayed degradation of damaged organelles and its possible role in the ageing of post-mitotic and dividing cells
41. Superiority of magnesium cardioplegia in neonatal myocardial protection
42. Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin
43. Antioxidant vitamins and prevention of cardiovascular disease: Laboratory, epidemiological and clinical trial data
44. Pro-oxidating properties of melatonin in the in vitro interaction with the singlet oxygen
45. Homocyst(e)ine induces calcium second messenger in vascular smooth muscle cells
46. Effects of EUK-8, a synthetic catalytic superoxide scavenger, on hypoxia- and acidosis-induced damage in hippocampal slices
47. Genetic regulation of aging
48. Brown fat thermogenesis in rats fed high-fat diets enriched with n-3 polyunsaturated fatty acids
49. Neuroprotection by the metabolic antioxidant alpha-lipoic acid
50. Alpha-lipoic acid as a biological antioxidant
51. Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons
52. Thyroid hormone status and membrane n-3 fatty acid content influence mitochondrial proton leak
53. The rate of free radical production as a determinant of the rate of aging: Evidence from the comparative approach
54. EUK-8 a synthetic catalytic scavenger of reactive oxygen species protects isolated iron-overloaded rat heart from functional and structural damage induced by ischemia/reperfusion
55. Dietary magnesium deficiency in rats enhances free radical production in skeletal muscle
56. Calorie restriction in primates: Will it work and how will we know?
57. Magnesium and calcium in drinking water and death from acute myocardial infarction in women
58. Nitroxide SOD-mimics: Modes of action
59. Mitochondria, oxidative stress and aging
60. Dietary intake of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest
61. The ambivalence of vitamin E in atherogenesis
62. Dietary magnesium supplementation affects bone metabolism and dynamic strength of bone in ovariectomized rats
63. Magnesium supplementation attenuates, but does not prevent, development of hypertension in spontaneously hypertensive rats
64. A possible role for vitamin C in age-related cataract
65. n-3 fatty acids and the prevention of coronary atherosclerosis
66. Magnesium sulfate therapy in preeclampsia and eclampsia
67. Evidence of Trolox and some gallates as synergistic protectors of erythrocytes against peroxyl radicals
68. Propyl gallate as a hepatoprotector in vitro and in vivo
69. Calcium and magnesium in drinking water and risk of death from cerebrovascular disease