n-3 Polyunsaturated fatty acids and cancer

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 2, Issue 2, 1999, Pages 121-126

  Bougnoux, Philippe ^a,b  

^a UNIVERSITÉ DE TOURS   (France)

^b CHU BRETONNEAU   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIOXIDANT; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; UNSATURATED FATTY ACID;

APOPTOSIS; CELL DIVISION; DRUG EFFECT; HUMAN; IMMUNITY; IMMUNOLOGY; NEOPLASM; REVIEW;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; CELL DIVISION; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; FATTY ACIDS, UNSATURATED; HUMANS; IMMUNITY; NEOPLASMS;

EID: 0033091190     PISSN: 13631950     EISSN: None     Source Type: Journal    
DOI: 10.1097/00075197-199903000-00005     Document Type: Article

References (50)

1. Doll R. The lessons of life. Keynote address to the nutrition and cancer conference. Cancer Res 1992; 52:2024s-2029s.
2. Calder PC. N-3 polyunsaturated fatty acids and immune cell function. Adv Enzyme Regul 1997; 37:197-237.
3. Jiang WG, Bryce RP, Horrobin DF. Essential fatty acids: molecular and cellular basis of their anti-cancer action and clinical implications. Crit Rev Oncol Hematol 1998; 27:179-209.
4. Kato I, Akhmedkhanov A, Koenig K, Toniolo PG, Shore RE, Riboli E. Prospective study of diet and female colorectal cancer: the New York University Women's Health Study. Nutr Cancer 1997; 28:276-281.
5. Kim DY, Chung KH, Lee JH. Stimulatory effects of high-fat diets on colon cell proliferation depend on the type of dietary fat and site of the colon. Nutr Cancer 1998; 30:118-123. An original study of the effects of different types of very high fat diet in an experimental rat system without tumor initiation.
6. Paulsen JE, Stamm T, Alexander J. A fish oil-derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl esters inhibits the formation and growth of aberrant crypt foci in rat colon. Pharmacol Toxicol 1998; 82:28-33.
7. Chang WL, Chapkin RS, Lupton JR. Fish oil blocks azoxymethane-induced rat colon tumorigenesis by increasing cell differentiation and apoptosis rather than decreasing cell proliferation. Nutrition 1998; 128:491-497.
8. Calder PC, Davis J, Yaqoob P, Pala H, Thies F, Newsholme EA. Dietary fish oil suppresses human colon tumour growth in athymic mice. Clin Sci 1998; 94:303-311. The first study to describe the influence of the time and type of dietary fat administration pn human colon growth in athymic mice.
9. Okuno M, Tanaka T, Komaki C, Nagase S, Shiratori Y, Muto Y, et al. Suppressive effect of low amounts of safflower and perilla oils on diethylnitrosamine-induced hepatocarcinogenesis in male F344 rats. Nutr Cancer 1998; 30:186-193. A study describing the effects of a dietary intervention at nutritional doses on experimental carcinogenesis, along with the study of fatty acid composition of liver phospholipids.
10. Calviello G, Palozza P, Piccioni E, Maggiano N, Frattucci A, Franceschelli P, Bartoli GM. Dietary supplementation with eicosapentaenoic and docosahexaenoic acid inhibits growth of Morris hepatocarcinoma 3924A in rats: effects on proliferation and apoptosis. Int J Cancer 1998; 75:699-705. By considering individually purified n-3 PUFA, this study permitted the individualization of a preferential antiproliferative effect of EPA and a pro-apoptotic effect of DHA in vivo.
11. Chajès V, Hultèn K, Van Kappel AL, Winkvist A, Kaaks R, Hallmans G, et al. Fatty acid composition in serum phospholipids and risk of breast cancer: a prospective cohort study in northern Sweden [abstract]. Lipids (in press).
12. Noguchi M, Minami M, Yagasaki R, Kinoshita K, Earashi M, Kitagawa H, et al. Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA. Br J Cancer 1997; 75:348-353.
13. Fay MP, Freedman LS, Clifford CK, Midthune DN. Effect of different types and amounts of fat on the development of mammary tumors in rodents: a review. Cancer Res 1997; 57:3979-3988. This meta-analysis provides unique conclusions from papers covering a 28-year period and incorporating 97 experiments.
14. Senzaki H, Iwamoto S, Ogura E, Kiyozuka Y, Arita S, Kurebayashi J, et al. Dietary effects of fatty acids on growth and metastasis of KPL-1 human breast cancer cells in vivo and in vitro. Anticancer Res 1998; 18:1621-1627.
15. Connolly JM, Liu XH, Rose DP. Effects of dietary menhaden oil, soy, and a cyclooxygenase inhibitor on human breast cancer cell growth and metastasis in nude mice. Nutr Cancer 1997; 29:48-54.
16. Hubbard NE, Lim D, Erickson KL. Alteration of murine mammary tumorigenesis by dietary enrichment with n-3 fatty acids in fish oil. Cancer Lett 1998; 124:1-7.
17. Iwamoto S, Senzaki H, Kiyozuka Y, Ogura E, Takada H, Hioki K, Tsubura A. Effects of fatty acids on liver metastasis of ACL-15 rat colon cancer cells. Nutr Cancer 1998; 31:143-150.
18. Griffini P, Fehres O, Klieverik L, Vogels IM, Tigchelaar W, Smorenburg SM, Van Noorden CJ. Dietary omega-3 polyunsaturated fatty acids promote colon carcinoma metastasis in rat liver. Cancer Res 1998; 58:3312-3319.
19. Coulombe J, Pelletier G, Tremblay P, Mercier G, Oth D. Influence of lipid diets on the number of metastases and ganglioside content of H59 variant tumors. Clin Exp Metastasis 1997; 15:410-417.
20. Iigo M, Nakagawa T, Ishikawa C, Iwahori Y, Asamoto M, Yazawa K, et al. Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung. Br J Cancer 1997; 75:650-655.
21. Ip C, Ip MM, Sylvester P. Relevance of trans fatty acids and fish oil in animal tumorigenesis studies. Prog Clin Biol Res 1986; 222:283-294.
22. Cohen LA, Chen-Backlund JY, Sepkovic DW, Sugie S. Effect of varying proportions of dietary menhaden and corn oil on experimental rat mammary tumor promotion. Lipids 1993; 28:449-456.
23. Sasaki T, Kobayashi Y, Shimizu J, Wada M, In'nami S, Kanke Y, Takita T. Effects of dietary n-3-to-n-6 polyunsaturated fatty acid ratio on mammary carcinogenesis in rats. Nutr Cancer 1998; 30:137-143. A careful study of the effects of n-3 PUFA according to their interactions with the main classes of fatty acids, from oils fed at physiologic levels.
24. Simonsen N, van't Veer P, Strain JJ, Martin-Moreno JM, Huttunen JK, Navajas JF, et al. Adipose tissue omega-3 and omega-6 fatty acid content and breast cancer in the EURAMIC study. European Community Multicenter Study on Antioxidants, Myocardial Infarction, and Breast Cancer. Am J Epidemiol 1998; 147:342-352. A European epidemiologic study based on adipose tissue as biomarkers of past PUFA intake.
25. Gonzalez MJ, Schemmel RA, Gray JI, Dugan L, Sheffield LF, Welsch CW. Effect of dietary fat on growth of MCF-7 and MDA-MB231 human breast carcinomas in athymic mice: relationship between carcinoma growth and lipid peroxydation product levels. Carcinogenesis 1991; 12:1231-1235.
26. Gonzalez MJ, Schemmel RA, Dugan L Jr, Gray JI, Welsch CW. Dietary fish oil inhibits human breast carcinoma growth: a function of increased lipid peroxidation. Lipids 1993; 28:827-832.
27. Welsch C. The role of lipid peroxidation in growth suppression of human breast carcinoma by dietary fish oil. Adv Exp Med Biol 1997; 4008:849-860.
28. Hardman WE, Barnes CJ, Knight CW, Cameron IL. Effects of iron supplementation and ET-18-OCH3 on MDA-MB 231 breast carcinomas in nude mice consuming a fish oil diet. Br J Cancer 1997; 76:347-354.
29. Lhuillery C, Cognault S, Germain E, Jourdan ML, Bougnoux P. Suppression of the promoter effect of polyunsaturated fatty acids by the absence of dietary vitamin E in experimental mammary carcinoma. Cancer Lett 1997; 114:233-234. This was the first experiment on chemically induced mammary tumors, showing the determinant role of antioxidants in the effects of PUFA on tumor growth.
30. Noding R, Schonberg SA, Krokan HE, Bjerve KS. Effects of polyunsaturated fatty acids and their n-6 hydroperoxides on growth of five malignant cell lines and the significance of culture media. Lipids 1998; 33:285-293. This is a direct investigation of the role of lipid peroxidation products in the effects of PUFA.
31. Ramesh G, Das UN. Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo. Cancer Lett 1998; 123:207-214. A study of the relationship between free radical generation, lipid peroxidation and their importance on the proliferation of tumor cells in vivo.
32. Finstad HS, Myhrstad MC, Heimli H, Lomo J, Blomhoff HK, Kolset SO, Drevon CA. Multiplication and death-type of leukemia cell lines exposed to very long-chain polyunsaturated fatty acids. Leukemia 1998; 12:921-929. A careful study of the type of cell death induced by PUFA and of the role of lipoperoxides, taking advantage of differential properties of 14 types of leukemia cell lines.
33. Hawkins RA, Sangster K, Arends MJ. Apoptotic death of pancreatic cancer cells induced by polyunsaturated fatty acids varies with double bond number and involves an oxidative mechanism. J Pathol 1998; 185:61-70. This study describes an interesting correlation between the number of fatty acid double bonds, or the extent of PUFA-induced lipid peroxidation in cancer cells, and the proportion of cells undergoing apoptosis.
34. Timmer-Bosscha H, de Vries EG, Meijer C, Oosterhuis JW, Mulder NH. Differential effects of all-trans-retinoic acid, docosahexaenoic acid, and hexadecylphosphocholine on cisplatin-induced cytotoxicity and apoptosis in a cisplatin-sensitive and resistant human embryonal carcinoma cell line. Cancer Chemother Pharmacol 1998; 41:469-476.
35. Tsai WS, Nagawa H, Muto T. Differential effects of polyunsaturated fatty acids on chemosensitivity of NIH3T3 cells and its transformants. Int J Cancer 1997; 70:357-361. An in-vitro study of the selectivity of EPA towards malignant cells.
36. Shao Y, Pardini L, Pardini RS. Dietary menhaden oil enhances mitomycin C antitumor activity toward human mammary carcinoma MX-1. Lipids 1995; 30:1035-1045.
37. Germain E, Bonnet P, Lavandier F, Lhuillery C, Bougnoux P. Increased efficacy of epirubicin on NMU-induced mammary tumor in rats by dietary n-3 PUFA and oxidants without change in cardiac toxicity. Proc Am Ass Cancer Res 1998; 39:311.
38. Bougnoux P., Germain E, Chajès V, Hubert B, Lhuillery C, Le Floch O, et al. Cytotoxic drug efficacy correlates with adipose tissue docosahexaenoic acid level in locally advanced breast carcinoma. Br J Cancer (in press).
39. Germain E, Chajès V, Cognault S, Lhuillery C, Bougnoux P. Enhancement of doxorubicin cytotoxicity by polyunsaturated fatty acids in the human breast tumor cell line MDA-MB-231: relationship to lipid peroxidation. Int J Cancer 1998; 75:578-583. A comprehensive study of the additional cytotoxicity obtainable with different PUFA provided as substrates for lipoperoxidation, according to the oxidant stress induced by anthracyclins at therapeutic concentrations.
40. Begin ME, Ells G, Das UN, Horrobin DF. Differential killing of human carcinoma cells supplemented with n-3 and n-6 polyunsaturated fatty acids. J Natl Cancer Inst 1986; 77:1053-1062.
41. Schjott J, Brurok H, Jynge P, Bjerve KS. Effects of eicosapentaenoic acid and docosahexaenoic acid diet supplement on tolerance to the cardiotoxicity of epirubicin and to ischaemia reperfusion in the isolated rat heart. Pharmacol Toxicol 1996; 79:65-72.
42. Shao Y, Pardini L, Pardini RS. Intervention of transplantable human mammary carcinoma MX-1 chemotherapy with dietary menhaden oil in athymic mice: increased therapeutic effects and decreased toxicity of cyclophosphamide. Nutr Cancer 1998; 28:63-73. This is a determinant study of the action of n-3 PUFA in vivo on enzymes involved in anticancer drug activity.
43. Spector AA, North JA, Cornelius AS, Buettner GR. Possible applications of polyunsaturated fatty acids in cancer therapy. World Rev Nutr Diet 1994; 76:81-65.
44. Kokura S, Yoshikawa T, Kaneko T, linuma S, Nishimura S, Matsuyama K, et al. Efficacy of hyperthermia and polyunsaturated fatty acids on experimental carcinoma. Cancer Res 1997; 57:2200-2202.
45. Vartak S, Robbins ME, Spector AA. Polyunsaturated fatty acids increase the sensitivity of 36B10 rat astrocytoma cells to radiation-induced cell kill. Lipids 1997; 32:283-292. A demonstration that PUFA can alter the sensitivity to radiation of a radioresistant cell line.
46. Vartak S, McCaw R, Davis CS, Robbins ME, Spector AA. Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes. Br J Cancer 1998; 77:1612-1620.
47. Calviello G, Palozza P, Franceschelli P, Bartoli GM. Low-dose eicosapentaenoic or docosahexaenoic acid administration modifies fatty acid composition and does not affect susceptibility to oxidative stress in rat erythrocytes and tissues. Lipids 1997; 32:1075-1083.
48. Abel S, Gelderblom WC, Smuts CM, Kruger M. Thresholds and kinetics of fatty acid replacement in different cellular compartments in rat liver as a function of dietary n-6/n-3 fatty acid content. Prostaglandins Leukot Essent Fatty Acids 1997; 56:29-39.
49. Palozza P, Luberto C, Calviello G, Ricci P, Bartoli GM. Antioxidant and prooxidant role of beta-carotene in murine normal and tumor thymocytes: effects of oxygen partial pressure. Free Radic Biol Med 1997; 22:1065-1073.
50. Bagga D, Capone S, Wang HJ, Heber D, Lill M, Chap L, Glaspy JA. Dietary modulation of omega-3/omega-6 polyunsaturated fatty acid ratios in patients with breast cancer. J Natl Cancer Inst 1997; 89:1123-1131. This very useful study details adipose tissue changes after a dietary intervention with fish oil in patients with breast cancer.