Effects of supplementation with folic acid and antioxidant vitamins on homocysteine levels and LDL oxidation in coronary patients

Nutrition

Volumn 16, Issue 2, 2000, Pages 107-110

  Bunout, Daniel ^c   Garrido, Argelia ^b   Suazo, Myriam ^b   Kauffman, Ronald ^b   Venegas, Paz ^a   De La Maza, Pia ^b   Petermann, Margarita ^b   Hirsch, Sandra ^a,b  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

^c NONE

Author keywords

Tocopherol; Atherosclerosis; Folic acid; Homocysteine; Low density lipoprotein (LDL) oxidation

Indexed keywords

ALPHA TOCOPHEROL; BETA CAROTENE; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; LOW DENSITY LIPOPROTEIN; MULTIVITAMIN;

ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CLINICAL TRIAL; CORONARY ARTERY DISEASE; DIET SUPPLEMENTATION; FEMALE; HUMAN; MALE; OXIDATION; PRIORITY JOURNAL;

ANTIOXIDANTS; ASCORBIC ACID; BETA CAROTENE; CORONARY DISEASE; DIETARY SUPPLEMENTS; FOLIC ACID; HOMOCYSTEINE; HUMANS; LIPID PEROXIDATION; LIPIDS; LIPOPROTEINS, LDL; VITAMIN B 12; VITAMIN E; VITAMINS;

EID: 0033953601     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0899-9007(99)00248-8     Document Type: Article

References (34)

1. Kang S.S., Wong P.W.K., Malinow R. Hyperhomocysteinemia as a risk factor for occlusive vascular disease. Annu Rev Nut. 12:1992;279.
2. Clarke R., Daly L., Robinson K., et al. Hyperhomcysteinemia an independent risk factor for vascular disease . N Engl J Med. 324:1991;1149.
3. Boushey C.J., Beresford S.A., Omenn G.S., Motulsky A.G. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease probable benefits of increasing folic acid intakes . JAMA. 274:1995;1049.
4. Azam Mansoor M., Ueland P.M., Svardal A.M. Redox status and protein binding of plasma homocysteine and other aminothiols in patients with hyperhomocysteinemia due to cobalamin deficiency. Am J Clin Nutr. 59:1994;631.
5. Ubbink J.B., Hayward Vermaak W.J., van der Merwe A., et al. Vitamin requirements for the treatment of hyperhomocysteinemia in humans. J Nutr. 124:1994;1927.
6. Den Heijer M., Koster T., Blom H.J., et al. Hyperhomocysteinemia as a risk factor for deep vein thrombosis. N Engl J Med. 334:1996;759.
7. Lubec B., Arbeiter K., Hoeger H., Lubec C. Increased cyclin dependent kinase in aortic tissue of rats fed homocysteine. Thromb Haemost. 75:1996;542.
8. Loscalzo J. The oxidant stress of hyperhomocysteinemia. J Clin Invest. 98:1996;5.
9. Steinberg D., Parthasarathy S., Carew T.E., Khoo J.C., Witztum J.L. Beyond cholesterol. Modifications of low density lipoprotein that increase its atherogenicity. New Engl J Med. 320:1989;915.
10. Esterbauer H, Dieber-Rotheneder M, Striegl G, Waeg G. Role of vitamin E in preventing the oxidation of low density lipoprotein. Am J Clin Nutr 1991;53(suppl 1):314S.
11. Ubbink J.B., Vermaak J.H., Bissbort S. Rapid high performance liquid chromatographic assay for total homocysteine levels in human serum. J Chromatogr. 565:1991;441.
12. Lehmann J., Martin H.L. Improved direct determination of alpha and gamma tocopherols in plasma and platelets by liquid chromatography, with fluorescence detection. Clin Chem. 28:1982;1784.
13. Valenzuela A. The biological significance of malondialdehyde determination in the assessment of tissue oxidative stress. Life Sci. 48:1991;301.
14. Jacob R.A., Wu M.M., Henning S.M., Swendseid M.E. Homocysteine increases as folate decreases in plasma of healthy men during short term dietary folate and methyl group restriction. J Nutr. 124:1994;1072.
15. Meydani S.N., Meydani M., Blumberg J.B., et al. Vitamin E supplementation enhances in vivo immune response in healthy elderly subjects a randomized controlled trial . JAMA. 277:1997;1380.
16. Henneken C.H., Buring J.E., Manson J.E., et al. Lack of effect of long term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med. 334:1996;1145.
17. Ward M., McNulty H., McPartlin J., et al. Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid. QJM. 90:1997;519.
18. Malinow M.R., Duell P.B., Hess D.L., et al. Reduction of plasma homocysteine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease. N Engl J Med. 338:1998;1009.
19. Verhoef P., Kok F.J., Kruyssen D., et al. Plasma total homocysteine, B vitamins and risk of coronary atherosclerosis. Arterioscler Thromb Vasc Biol. 17:1997;989.
20. Schwartz S.M., Siscovick D.S., Malinow M.R., et al. Myocardial infarction in young women in relation to plasma total homocysteine, folate and a common variant in the methylenetetrahydrofolate reductase gene. Circulation. 96:1997;412.
21. Verhaar M.C., Wever R.M.F., Kastelein J.P.J., et al. 5-Methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia. Circulation. 97:1998;237.
22. Rasmussen K., Moller J., Lyngbak M., Holm Pedersen A.M., Dybkjaer L. Age and gender specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation. Clin Chem. 42:1996;630.
23. Woo K.S., Chook P., Lolin Y.I., et al. Hyperhomocysteinemia is a risk factor for arterial dysfunction in humans. Circulation. 96:1997;2542.
24. Lentz S.R., Sobey C.G., Piegors D.J., et al. Vascular dysfunction in monkeys with diet induced hyperhomocysteinemia. J Clin Invest. 98:1996;24.
25. Donner M.G., Klein G.K., Mathes P.B., Schwandt P., Richter W.O. Plasma total homocysteine levels in patients with early onset coronary heart disease and a low cardiovascular risk profile. Metabolism. 47:1998;273.
26. Summer A.E., Chin M.M., Abraham J.L., et al. Elevated methylmalonic acid and total homocysteine levels show high prevalence of vitamin B12 deficiency after gastric surgery. Ann Intern Med. 124:1996;469.
27. Lindenbaum J., Healton E.B., Savage D.G., et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med. 318:1988;1720.
28. Babior BM, Bunn F. Megaloblastic anemias. In: Fauci AS, Braunwald E, Isselbacher KJ, et al., eds. Harrison's principles of internal medicine, 14th ed. New York: McGraw-Hill, 1998:653.
29. Ruef J., Rao G.N., Li F., et al. Induction of rat aortic smooth muscle cell growth by the lipid peroxidation product 4-hydroxy-2-nonenal. Circulation. 97:1998;1071.
30. Jialal I., Devaraj S. Low density lipoprotein oxidation, antioxidants and atherosclerosis a clinical biochemistry perspective . Clin Chem. 42:1996;498.
31. Reaven P., Parthasarathy S., Grasse B.J., et al. Effects of oleate-rich diets on the susceptibility of low density lipoprotein to oxidative modification in mildly hypercholesterolemic subjects. J Clin Invest. 91:1993;668.
32. Jialal I., Fuller C.J., Huet B.A. The effect of alpha tocopherol supplementation on LDL oxidation. A dose response study. Arterioscler Thromb Vasc Biol. 15:1995;190.
33. Anderson T.J., Meredith I.T., Yeung A.C., et al. The effect of cholesterol lowering and antioxidant therapy on endothelium dependent coronary vasomotion. N Engl J Med. 332:1995;488.
34. Stephens N.G., Parsons A., Schofield P.M., et al. Randomized controlled trial of vitamin E in patients with coronary disease Cambridge Heart Antioxidant Study (CHAOS) . Lancet. 347:1996;781.