Folate and cancer prevention: A new medical application of folate beyond hyperhomocysteinemia and neural tube defects

Nutrition Reviews

Volumn 57, Issue 10, 1999, Pages 314-321

  Kim, Young In ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID;

BREAST CANCER; CANCER PREVENTION; CANCER RISK; CARDIOVASCULAR DISEASE; DIETARY INTAKE; FEMALE; FOLIC ACID BLOOD LEVEL; HUMAN; HYPERHOMOCYSTEINEMIA; MACROCYTIC ANEMIA; NEURAL TUBE DEFECT; PANCREAS CANCER; SHORT SURVEY; VITAMIN SUPPLEMENTATION;

ANIMALIA;

EID: 0032704132     PISSN: 00296643     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1753-4887.1999.tb06905.x     Document Type: Short Survey

References (42)

1. Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med 1998;338:1042-50
2. MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991;338:131-7
3. Food standards: amendment of standards of identity for enriched grain products to require addition of folic acid. Federal Register 1996;61(44):8781-97
4. Jacques PF, Selhub J, Bostom AG, et al. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med 1999;340:1449-54
5. Mason JB, Levesque T. Folate: effects on carcinogenesis and the potential for cancer chemoprevention. Oncology 1996;10:1727-43
6. Kim Y-I. Folate and carcinogenesis: evidence, mechanisms, and implications. J Nutr Biochem 1999;10:66-88
7. Wagner C. Biochemical role of folate in cellular metabolism. In: Bailey LB, ed. Folate in health and disease. New York: Marcel Dekker, 1995;23-42
8. Kamen B. Folate and antifolate pharmacology. Semin Oncol 1997;24(suppl 18):30-9
9. Bills ND, Hinrichs SH, Morgan R, Clifford AJ. Delayed tumor onset in transgenic mice fed a low-folate diet. J Natl Cancer Inst 1992;84:332-7
10. Giovannucci E, Stampfer MJ, Colditz GA, et al. Multivitamin use, folate, and colon cancer in women in the Nurses Health Study. Ann Intern Med 1998;129:517-24
11. Cravo ML, Mason JB, Dayal Y, et al. Folate deficiency enhances the development of colonic neoplasia in dimethylhydrazine-treated rats. Cancer Res 1992;52:5002-6
12. Kim Y-I, Salomon RN, Graeme-Cook F, et al. Dietary folate protects against the development of macroscopic colonic neoplasia in a dose responsive manner in rats. Gut 1996;39:732-40
13. Cravo M, Fidalgo P, Pereira AD, et al. DNA methylation as an intermediate biomarker in colorectal cancer: modulation by folic acid supplementation. Eur J Cancer Prev 1994;3:473-9
14. Paspatis GA, Karamanolis DG. Folate supplementation and adenomatous colonic polyps. Dis Colon Rectum 1994;37:1340-1
15. Cravo ML, Pinto AG, Chaves P, et al. Effect of folate supplementation on DNA methylation of rectal mucosa in patients with colonic adenomas: correlation with nutrient intake. Clin Nutr 1998;17:45-9
16. 12: report of a preliminary randomized, double-blind intervention trial. JAMA 1988;259:1525-30
17. Saito M, Kato H, Tsuchida T, Konaka C. Chemoprevention effects of bronchial squamous metaplasia by folate and vitamin B12 in heavy smokers. Chest 1994;106:496-9
18. Butterworth CE Jr, Hatch KD, Gore H, et al. Improvement in cervical dysplasia associated with folic acid therapy in users of oral contraceptives. Am J Clin Nutr 1982:35:73-82
19. Butterworth CE Jr, Hatch KD, Soong S-J, et al. Oral folic acid supplementation for cervical dysplasia: a clinical intervention trial. Am J Obstet Gynecol 1992;166:803-9
20. Childers JM, Chu J, Voigt LF, et al. Chemoprevention of cervical cancer with folic acid: a phase III Southwest Oncology Group intergroup study. Cancer Epidemiol Biomarkers Prev 1995;4:155-9
21. Zhang S, Hunter DJ, Hankinson SE, et al. A prospective study of folate intake and the risk of breast cancer. JAMA 1999;281:1632-7
22. Stolzenberg-Solomon RZ, Albanes D, Nieto FJ, et al. Pancreatic cancer risk and nutrition-related methyl-group availability indicators in male smokers. J Natl Cancer Inst 1999;91:535-41
23. Willett WC, Sampson L, Stampfer MJ, et al. Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol 1985; 122:51-65
24. Willett WC, Stampfer MJ, Colditz GA, et al. Moderate alcohol consumption and the risk of breast cancer. N Engl J Med 1987;316:1174-80
25. Smith-Warner SA, Spiegelman D, Yaun S-S, et al. Alcohol and breast cancer in women: a pooled analysis of cohort studies. JAMA 1998;279:535-40
26. Hillman RS, Steinberg SE. The effects of alcohol on folate metabolism. Annu Rev Med 1982;33:345-54
27. Giovannucci E, Stampfer MJ, Colditz GA, et al. Folate, methionine, alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst 1993;85: 875-84
28. Giovannucci E, Rimm EB, Ascherio A, et al. Alcohol, low-methionine-low-folate diets, and risk of colon cancer in men. J Natl Cancer Inst 1995;87: 265-73
29. 6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA 1998;279:359-64
30. Graham S, Hellmann R, Marshall J, et al. Nutritional epidemiology of postmenopausal breast cancer in western New York. Am J Epidemiol 1991; 134:552-66
31. Freudenheim JL, Marshall JR, Vena JE, et al. Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients. J Natl Cancer Inst 1996;88:340-8
32. Wu K, Helzlsouer KJ, Comstock GW, et al. A prospective study on folate, B12, and pyridoxal 5′-phosphate (B6) and breast cancer. Cancer Epidemiol Biomarkers Prev 1999;8:209-17
33. Lewisohn R, Leuchtenberger C, Leuchtenberger R, Keresztesy JC. The influence of liver L casei factor on spontaneous breast cancer in mice. Science 1946;104:436-7
34. Baggott JE, Vaughn WH, Juliana MM, et al. Effects of folate deficiency and supplementation on methylnitrosourea-induced rat mammary tumors. J Natl Cancer Inst 1992;84:1740-4
35. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;33:1029-35
36. Baghurst PA, McMichael AJ, Slavotinek AH, et al. A case-control study of diet and cancer of the pancreas. Am J Epidemiol 1991;134:167-79
37. Kim Y-I, Pogribny IP, Salomon RN, et al. Exon-specific DNA hypomethylation of the p53 gene of rat colon induced by dimethylhydrazine: modulation by dietary folate. Am J Pathol 1996;149:1129-37
38. Kim Y-I, Pogribny IP, Basnakian AG, et al. Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene. Am J Clin Nutr 1997;65:46-52
39. Choi S-W, Kim Y-I, Weitzel JN, Mason JB. Folate depletion impairs DNA excision repair in the colon of the rat. Gut 1998;43:93-9
40. Campbell NRC. How safe are folic acid supplements? Arch Intern Med 1996;156:1638-44
41. Wargovich MJ, Chen CD, Jimenez A, et al. Aberrant crypts as a biomarker for colon cancer: evaluation of potential chemopreventive agents in the rat. Cancer Epidemiol Biomarkers Prev 1996;5: 355-60
42. Song J, Kim H, Hay K, et al. Chemopreventive effects of dietary folate on intestinal tumorigenesis in Ape+/- Msh2-/- mice: the importance of timing of intervention. Proc Am Assoc Cancer Res 1999;40:3490