Magnesium supplementation attenuates, but does not prevent, development of hypertension in spontaneously hypertensive rats

American Journal of Hypertension

Volumn 12, Issue 8 I, 1999, Pages 757-765

  Touyz, R M ^a   Milne, F J ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Calcium; Cations; Erythrocytes; Hypertension; Magnesium; Potassium; Sodium

Indexed keywords

CALCIUM ION; MAGNESIUM; POTASSIUM ION; SODIUM ION;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BLOOD VESSEL TONE; DIET SUPPLEMENTATION; ERYTHROCYTE; HYPERTENSION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SPONTANEOUSLY HYPERTENSIVE RAT;

EID: 0032849981     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0895-7061(99)00064-3     Document Type: Article

References (55)

1. 2+ movements Can J Physiol 60 1982 459 482
2. M Faragó C Szabó E Dóra Contractile and endothelium-dependent dilatory responses of cerebral arteries at various extracellular magnesium concentrations J Cereb Blood Flow Metab 11 1991 161 164
3. M.A Noguera M.P D’Ocon Modulatory role of magnesium on the contractile response of rat aorta to several agonists in normal and calcium-free medium J Pharm Pharmacol 45 1993 697 700
4. 2+ J Clin Invest 89 1992 1988 1994
5. R.M Touyz P Laurant E.L Schiffrin Role of magnesium on calcium responses to vasopressin in vascular smooth muscle of spontaneously hypertensive rats J Pharmacol Exp Ther 284 1998 998 1005
6. 2+ transients Biochim Biophys Acta 1265 1995 89 92
7. 2+ concentrations in a subgroup of hypertensives. Membrane model for the pathogenesis of primary hypertension Am J Hypertens 11 1998 1390 1393
8. L.M Resnick O Bardicef B.T Altura Serum ionized magnesium relation to blood pressure and racial factors Am J Hypertens 10 1997 1420 1424
9. R.M Touyz F.J Milne H.C Seftel S.G Reinach Magnesium, calcium, sodium and potassium status in normotensive and hypertensive Johannesburg residents S Afr Med J 72 1987 377 381
10. R.M Touyz F.J Milne Alterations in intracellular cations and cell membrane ATPase activity in patients with malignant hypertension J Hypertens 13 1995 867 874
11. P.T Delva C Pastori M Degan Intralymphocyte free magnesium in a group of subjects with essential hypertension Hypertension 28 1996 433 439
12. L.M Resnick Ionic basis of hypertension, insulin resistance, vascular disease and related disorders mechanisms of Syndrome X Am J Hypertens 6 1993 123S 134S
13. T.A Millane S.H Jennison J.M Mann Myocardial magnesium depletion associated with prolonged hypomagnesemia; a longitudinal study in heart transplant recipients J Am Coll Cardiol 20 1992 806 812
14. A Berthelot J Esposito Effects of dietary magnesium on the development of hypertension in SHR J Am Coll Nutr 4 1983 343 353
15. N Krari P Allain Altered element concentrations in tissues of Dahl salt-sensitive rats Biol Trace Elem Res 31 1991 199 207
16. N Saito G.C Abbu Y Konishi Magnesium, calcium and trace elements in SHR Clin Exp Pharmacol Physiol 22 suppl 1 1995 S212 S214
17. R.M Touyz E.L Schiffrin Differential effects of vasopressin and endothelin-1 on vascular contractile and calcium responses in small arteries from SHR J Hypertens 14 1996 983 991
18. A Berthelot C Luthringer E Meyers A Exinger Disturbances of magnesium metabolism in the spontaneously hypertensive rat J Am Coll Nutr 6 1987 329 332
19. M.R Jones J.E Martins R.A Clemens Mineral balance and blood pressure in the young spontaneously hypertensive rat J Nutr 118 1988 114 120
20. J.P Wolf C Luthringer A Berthelot S Berthelay Blood pressure and plasma renin activity after magnesium supplementation in the spontaneously hypertensive rat a study during developing and established hypertension Magnesium 6 1987 243 248
21. R.M Touyz F.J Milne P.R Marshall Altered cations and muscle membrane ATPase activity in SHR with benign and malignant hypertension J Hypertens 9 1991 737 750
22. Y Kawano H Matsuoka S Takishita T Omae Effects of magnesium supplementation in hypertensive patients. Assessment by office, home and ambulatory blood pressures Hypertension 32 1998 260 265
23. E.S Ford Race, education and dietary cations findings from the third national health and nutrition examination survey Ethhnicity Dis 8 1998 10 20
24. J.C Witteman W.C Willet M.J Stampfer A prospective study of nutritional factors and hypertension among US women Circulation 80 1989 1320 1327
25. T Mahboob M Mumtaz M.A Haleem Electrolyte content of serum, erythrocyte, kidney and heart tissue in salt induced hypertensive rats Life Sci 59 1996 731 737
26. L.L Ng J.E Davies M Ameen Intracellular free magnesium levels in vascular smooth and striated muscle cells of SHR Metab Clin Exp 41 1992 772 777
27. I.C Wells D.K Agrawal Abnormal magnesium metabolism in two rat models of genetic hypertension Can J Physiol Pharmacol 70 1991 1225 1229
28. P Laurant J.P Kantelip A Berthelot Dietary magnesium supplementation modifies blood pressure and cardiovascular function in mineralocorticoid-salt hypertensive but not in normotensive rats J Nutr 125 1995 830 841
29. A.F Sanjuliani V.G de Abreu Fagundes E.A Francischetti Effect of magnesium on blood pressure and intracellular ion levels of Brazilian hypertensive patients Int J Cardiol 56 1996 177 183
30. L Widman P.O Wester B.K Stegmayr M Wirell The dose-dependent reduction in blood pressure through administration of magnesium. A double blind placebo controlled cross-over study Am J Hypertens 6 1993 41 45
31. F.P Cappuccio N.D Markandu G.W Beynon Lack of effect of oral magnesium on high blood pressure a double blind study Br Med J 291 1985 235 238
32. G.E Evans C.M Weaver Dietary magnesium does not affect blood pressure in spontaneously hypertensive rats Clin Exper Hypertens [A] A11 1989 619 632
33. H Makynen M Kahonen P Arvola Dietary calcium and magnesium supplements in spontaneously hypertensive rats and isolated arterial reactivity Br J Pharmacol 115 1995 1455 1462
34. L.A Ferrara R Iannuzzi A Castaldo Long-term magnesium supplementation in essential hypertension Cardiology 81 1992 25 33
35. L Lind H Lithell T Pollare S Ljunghall Blood pressure response during long-term treatment with magnesium is dependent on magnesium status. A double-blind, placebo-controlled study in essential hypertension and in subjects with high-normal blood pressure Am J Hypertens 4 1991 674 679
36. B.M Altura B.T Altura A Gebrewold Magnesium deficiency and hypertension correlation between magnesium-deficient diets and microcirculatory changes Science 223 1984 1315 1317
37. Y Itokawa C Tanaka M Fujiwara Changes in body temperature and blood pressure in rats with calcium and magnesium deficiencies J Appl Physiol 37 1974 835 839
38. M Adachi Y Nara M Mano Y Yamori Effect of dietary magnesium supplementation on intralymphocytic free calcium and magnesium in stroke-prone hypertensive rats Clin Exp Hypertens 16 1994 317 326
39. E.M.A Mervaala A.-K Pere L Lindgren Effects of dietary sodium and magnesium on cyclosporin A-induced hypertension and nephrotoxicity in spontaneously hypertensive rats Hypertension 29 1997 822 827
40. T.L Smith P.M Hutchins Central hemodynamics in the developmental stages of spontaneous hypertension in the unanesthetized rat Hypertension 1 1979 508 517
41. + pump function in the heart of rats J Nutr 117 1987 2091 2095
42. K.D Fortes Mayer B.J Starkey Simpler flame photometric determination of erythrocyte sodium and potassium the reference range for apparently healthy adults Clin Chem 23 1977 275 278
43. R.M Touyz F.J Milne A method for determining the total magnesium, calcium, sodium and potassium contents of human platelets Min Electrolyte Metab 17 1991 173 178
44. B.M Altura B.T Altura New perspectives on the role of magnesium in the pathophysiology of the cardiovascular system. Experimental aspects Magnesium 4 1985 245 271
45. H.W Overbeck R.M Daughtery Jr F.J Haddy Continuous infusion indicator dilution measurement of limb blood flow and vascular response to magnesium sulfate in normotensive and hypertensive men J Clin Invest 48 1969 1944 1956
46. 2+ in young patients with borderline hypertension Circulation 82 1990 384 393
47. B.M Altura B.T Altura Influence of magnesium on vascular smooth muscle cell and serum biochemical parameters from diabetic and hypertensive rats Magnesium 2 1983 253 266
48. Y.V Postnov An approach to the explanation of cell membrane alteration in primary hypertension Hypertension 15 1990 332 337
49. 2+ permeable non-selective cation currents in aortic smooth muscle cells Eur J Pharmacol 320 1997 81 86
50. L.T Iseri J.H French Magnesium nature’s physiologic calcium blocker Am Heart J 108 1984 188 194
51. P Laurant R.M Touyz E.L Schiffrin Effect of magnesium on vascular tone and reactivity in pressurized mesenteric arteries from SHR Can J Physiol Pharmacol 75 1997 293 300
52. R.V Sharma R.C Bhalla Calcium and abnormal reactivity of vascular smooth muscle cells in hypertension Cell Calcium 9 1989 267 274
53. 2+ responses to angiotensin II but not to endothelin-1 J Hypertens 12 1994 663 673
54. R.M Touyz E.L Schiffrin The effect of angiotensin II on platelet intracellular free magnesium and calcium ionic concentrations in essential hypertension J Hypertens 11 1993 551 558
55. L.M Resnick R.J Gupta R.E Sosa Effects of altered dietary calcium intake in experimental hypertension role of intracellular free magnesium J Hypertens 4 suppl 5 1986 S182 S185