In vivo evidence for carrier-mediated efflux transport of 3'-azido-3'- deoxythymidine and 2',3'-dideoxyinosine and 2',3'-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system

Journal of Pharmacology and Experimental Therapeutics

Volumn 281, Issue 1, 1997, Pages 369-375

  Takasawa, Katsuko ^a   Terasaki, Tetsuya ^a,b   Suzuki, Hiroshi ^a   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOHIPPURIC ACID; DEOXYINOSINE; DIDANOSINE; INOSINE DERIVATIVE; PENICILLIN G; PROBENECID; ZIDOVUDINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD CEREBROSPINAL FLUID BARRIER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG TRANSPORT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTRACEREBRAL DRUG ADMINISTRATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSPORT KINETICS;

ANIMALS; ANTI-HIV AGENTS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; DIDANOSINE; DOSE-RESPONSE RELATIONSHIP, DRUG; INULIN; MALE; PROBENECID; RATS; RATS, WISTAR; ZIDOVUDINE;

EID: 0030977086     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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