Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain

Journal of Immunology

Volumn 156, Issue 3, 1996, Pages 1284-1295

  Nottet, Hans S L M ^a   Persidsky, Yury ^a   Sasseville, Vito G ^c   Nukuna, Adeline N ^a   Bock, Paul ^a   Zhai, Qi Hui ^d   Sharer, Leroy R ^e   McComb, Rodney D ^a   Swindells, Susan ^a   Soderland, Carl ^f   Gendelman, Howard E ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d CREIGHTON UNIVERSITY MEDICAL CENTER   (United States)

^e RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^f Cell Systems Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GENE PRODUCT; LIPOPOLYSACCHARIDE; VASCULAR CELL ADHESION MOLECULE 1;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CELL ADHESION; CELL INFILTRATION; CELL MIGRATION; DISEASE ASSOCIATION; ENCEPHALITIS; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MONOCYTE; PRIORITY JOURNAL; SERODIAGNOSIS;

BASE SEQUENCE; BRAIN; CELL ADHESION; CELL MOVEMENT; CELLS, CULTURED; E-SELECTIN; ENDOTHELIUM, VASCULAR; HIV INFECTIONS; HIV-1; HUMANS; MACROPHAGE ACTIVATION; MOLECULAR SEQUENCE DATA; MONOCYTES; VASCULAR CELL ADHESION MOLECULE-1;

EID: 9044226527     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Price, R., B. Brew, J. Sidtis, M. Rosenblum, A. Scheck, and P. Cleary. 1988. The brain and AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science 239:586.
2. Epstein, L. G., and H. E. Gendelman. 1993. Human immunodeficiency virus type 1 infection of the nervous system: pathogenic mechanisms. Ann. Neurol 33:429.
3. Nottet, H. S L. M., and H. E. Gendelman. 1995. Unraveling the neuroimmune mechanisms for the HTV-1-associated cognitive/motor complex. Immunol. Today 16:441.
4. Gendelman, H. E., S. A. Lipton, M. Tardieu, M I Bukrinsky, and H. S. L. M. Nottet. 1994. The neuropathogenesis of HIV-1 infection J. Leukocyte Biol. 56: 389.
5. Nottet, H. S. L. M., M. Jett, C. R Flanagan, Q.-H. Zhai, Y. Persidsky, A. Rizzino, E. W Bernton, P. Genis, T. Baldwin, J. Schwartz, C. LaBenz, and H. E. Gendelman. 1995. A regulatory role for astrocytes in HIV-1 encephalitis: an overexpression of eicosanoids, platelet-activating factor, and tumor necrosis factor-α by activated HIV-1-infected monocytes is attenuated by primary human astrocytes. J. Immunol. 154:3567.
6. Lipton, S. A., and H. E. Gendelman. 1995 Pathophysiology and potential therapy of HIV-1 infection in the central nervous system N. Engl J. Med. 332 931.
7. Genis, P., M. Jett, E. W. Bernton, T. Boyle, H A. Gelbard, K. Dzenko, R W. Keane, L. Resnick, Y. Mizrachi, D. J. Volsky, L. G. Epstein, and H. E. Gendelman. 1992. Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease. J. Exp Med. 176:1703.
8. Tyor, W. R., J. D. Glass, J. W. Griffin, P. S. Becker, J. C. McArthur, L. Bezman, and D. E. Griffin. 1992. Cytokine expression in the brain during the acquired immune deficiency syndrome. Ann. Neurol. 31:349.
9. Wesselingh, S. L., C. Power, J. D. Glass, W R. Tyor, J. C. McArthur, J. M Farber, J. W. Griffin, and D. E Griffin. 1993. Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia. Ann. Neurol. 33:576.
10. Koenig, S., H. E. Gendelman, J. M. Orenstein, M C. Dal Canto, G. M. Pezeshkpour, M. Yungbluth, F Janotta, A. Aksamit, M. A. Martin, and A. S. Fauci. 1986. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 233:1089.
11. Wiley, C. A., R. D. Schrier, J A. Nelson, P W. Lampert, and M. B. A Oldstone. 1986. Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl. Acad. Sci USA 83:7089.
12. Vazeux, R., N. Brousse, A. Jarry, D. Henin, C. Marche, C. Vedrenne, M. Mikol, M. Wolff, C. Michon, W. Rozenbaum, J.-F. Bureau, L. Montagnier, and M. Brahic. 1987. AIDS subacute encephalitis; identification of HIV-1-infected cells. Am J. Pathol. 126:403.
13. Stoler, M. H., T. A. Eskin, S. Benn, R C Angerer, and L. M. Angerer. 1986. Human T-cell lymphotropic virus type III infection of the central nervous system: a preliminary in situ analysis. JAMA 256:2360.
14. Gabuzda, D. H., D. D. Ho, S. M. de la Monte, M. S. Hirsch, T. R. Rota, and R A Sobel. 1986. Immunohistochemical identification of HTLV-III antigen in brains of patients with AIDS. Ann. Neurol 20:289.
15. Davis, L E., B L. Hjelle, V. E. Miller, D L. Palmer, A. L. Llewellyn, T L. Merlin, S. A. Young, R. G. Mills, W. Wachsman, and C A. Wiley. 1992. Early viral brain invasion in iatrogenic human immunodeficiency virus infection. Neurology 42:1736
16. Griffin, D. E., J. C. McArthur, and D. R. Cornblath. 1991. Neopterin and interferon-γ in serum and cerebrospinal fluid of patients with HIV associated neurologic disease Neurology 4:69
17. McArthur, J C., B. A Cohen, H. Farzedegan, D. R. Cornblath, O. A. Selnes, D. Ostrow, R T. Johnson, J. Phair, and B F. Polk. 1988. Cerebrospinal fluid abnormalities in homosexual men with and without neuropsychiatric findings Ann. Neurol. 23(Suppl):34
18. Goudsmit, J., E. C. Wolters, M. Bakker, L. Smit, J. van der Noorda, E. A. H. Hische, J A. Tutuarima, and H. J. van der Helm. 1986. Intrathecal synthesis of antibodies to HTLV-III in patients without AIDS or AIDS related complex. Br. Med J. 292:1231.
19. Cooper, D. A., J. Gold, P. Maclean, B. Donovan, R. Finlayson, T. G. Barnes, H. M. Michelmore, P. Brooke, and R. Penny. 1985. Acute AIDS retrovirus infection: definition of a clinical illness associated with seroconversion. Lancet i:537.
20. Resnick, L , J. R. Berger, P. Shapshak, and W. W Tourtellotte. 1988. Early penetration of the blood-brain barrier by HIV. Neurology 38:9.
21. Wiley, C. A., and C. Achim. 1994. Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome. Ann. Neurol. 36:673.
22. Glass, J. D., H. Fedor, S. L. Wesselingh, and J. C. McArthur. 1995. Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann. Neurol 38:755.
23. Tyor, W. R., J. D. Glass, N. Baumrind, J. C. McArthur, J. W. Griffin, P. S Becker, and D. E. Griffin. 1993. Cytokine expression of macrophages in HIV-1-associated vacuolar myelopathy. Neurology 43:1002.
24. Dustin, M. L., and T. A. Springer. 1991 Role of lymphocyte adhesion receptors in transient interactions and cell locomotion Annu. Rev Immunol. 9:27.
25. Bevilacqua, M. P , and R. M. Nelson. 1993. Selectins. J. Clin. Invest. 91:379
26. Varki, A. 1994. Selectin ligands. Proc. Natl. Acad. Sci. USA 91:7390.
27. Staunton, D. E., S. D. Marlin, C Stratowa, M. L. Dustin, and T. A. Springer 1988. Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integral supergene families. Cell 52:925.
28. Osborn, L., C. Hession, R. Tizard, C. Vassallo, S. Luhowskyj, G. Chi-Rosso, and R. Lobb. 1989. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell 59:1203.
29. Bevilacqua, M. P , S. Stengelin, M A Gimbrone, Jr., and B. Seed. 1989. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science 243:1160.
30. Hession, C , L. Osborn, D. Goff, G. Chi-Rosso, C. Vassallo, M. Pasek, C Pittack, R. Tizard, S. Goelz, K. McCarthy, S. Hopple, and R. Lobb. 1990. Endothelial leukocyte adhesion molecule 1. direct expression cloning and functional interactions. Proc. Natl. Acad. Sci. USA 87:1673.
31. Carlos, T., N. Kovach, B. Schwartz, M. Rosa, B. Newman, E. Wayner, C. Benjamin, L. Osborn, R. Lobb, and J. Harlan. 1991. Human monocytes bind to two cytokine-induced adhesive ligands on cultured human endothelial cells, endothelial-leukocyte adhesion molecule-1: direct expression cloning and functional interactions. Blood 77:2266.
32. Hakkert, B. C., T. W. Kuipers, J. P. M. Leeuwenberg, J. A. van Mourik, and D Roos. 1991. Neutrophil and monocyte adherence to and migration across monolayers of cytokine-activated endothelial cells: the contribution of CD18, ELAM-1, and VLA-4. Blood 78, 2721.
33. Chuluyan, H. E , and A. C. Issekutz 1993. VLA-4 integrin can mediate CD11/ CD18-independent transendothelial migration of human monocytes. J. Clin. Invest. 92:2768.
34. Peluso, R., A. Haase, L Stowring, M. Edwards, and P. Ventura. 1986. A Trojan horse mechanism for the spread of visna virus in monocytes. Virology 147:231.
35. Moses, A. V., F. E. Bloom, D. Pauza, and J. A. Nelson. 1993. Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism- Proc. Natl. Acad Sci. USA 90:10474
36. Moses, A. V., and J. A. Nelson. 1994. HIV infection of human brain capillary endothelial cells: implications for AIDS dementia. In Advances in Neuroimmunology G. B. Stefano, and E. M. Smith, eds. Elsevier Science Ltd., Amsterdam, p. 239.
37. Power, C., J. C. McArthur, R. T. Johson, D. E. Griffin, J. D. Glass, S. Perryman, and B Chesebro. 1994. Demented and nondemented patients with AIDS differ in brain-derived human immunodeficiency virus type 1 envelope sequences. J. Virol 68:4643.
38. Korber, B. T M , K J Kunstman, B. K. Patterson, M Furtado, M M. McEvilly, R. Levy, and S. M. Wolinsky. 1994. Genetic differences between blood- and brain-derived viral sequences from human immunodeficiency virus type 1-infected patients: evidence of conserved elements in the V3 region of the envelope protein of brain-derived sequences. J Virol. 68:7467.
39. Gendelman, H. E., J M. Orenstein, M. A. Martin, C. Ferrua, R. Mitra, T. Phipps, L. A Wahl, H. C Lane, A. S. Fauci, D. S. Burke, D. R Skillman, and M. S. Meltzer. 1988. Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes. J. Exp. Med. 167:1428.
40. Dhawan, S., B S. Weeks, C. Soderland, H. W. Schnaper, L A. Toro, S P. Asthana, I. K. Hewlett, W. G Stetler-Stevenson, S. S Yamada, K. M. Yamada, and M. S. Meltzer. 1995. HIV-1 infection alters monocyte interactions with human microvascular endothelial cells. J. Immunol 154:422.
41. Dorovini-Zis, K., R Prameya, and P. D. Bowman. 1991. Culture and characterization of microvascular endothelial cells derived from human brain. Lab. Invest. 64:425.
42. Kalter, D. C., M. Nakamura, J. A. Turpin, L. M Baca, C. Dieffenbach, P. Ralph, H. E. Gendelman, and M. S. Meltzer. 1991. Enhanced HIV replication in MCSF-treated monocytes. J. Immunol. 146:298.
43. Bukrinsky, M. I., N. Sharova, T. L McDonald, T. Pushkarskaya, W. G. Tarpley, and M. Stevenson. 1993. Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection. Proc. Natl. Acad. Sci. USA 90:6125.
44. Baca-Regen, L., N. Heinzinger, M. Stevenson, and H E Gendelman. 1994. α interferon-induced antiretroviral activities: restriction of viral nucleic acid synthesis and progeny virion production in human immunodeficiency virus type 1-infected monocytes. J Virol. 68:7559.
45. Folks, T. M., D. Powell, M. Lightfoote, S. Koenig, A. S. Fauci, S. Benn, A. Rabson, H. E. Gendelman, M. D. Hoggan, S. Venkatessan, and M. A. Martin 1986. Biological and biochemical characterization of a cloned Leu-3-cell surviving infection with the acquired immune deficiency syndrome retrovirus. J. Exp. Med. 164:280.
46. Gendelman, H. E., R. M. Friedman, S. Joe, L M Baca, J. A. Turpin, G. Dveksler, M S. Meltzer, and C. Dieffenbach. 1990. A selective defect of interferon α production in human immunodeficiency virus-infected monocytes J. Exp. Med. 172:1433.
47. Stamper, H. B., Jr., and J. J. Woodruff. 1976. Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules. J. Exp Med. 144:828.
48. 1 integrin interactions. Am J. Pathol. 144:27
49. Sasseville, V. G., W. A. Newman, A. W. Lackner, M. O. Smith, N C. G. Lausen, D. Beall, and D. J Ringler. 1992. Elevated vascular cell adhesion molecule-1 in AIDS encephalitis induced by simian immunodeficiency virus. Am J. Pathol. 141:1021.
50. Hemler, M. E., C. Huang, Y. Takada, L. Schwartz, J. L. Strominger, and M. L. Clabby. 1987. Characterization of the cell surface heterodimer VLA-4 and related peptides. J. Biol. Chem 262:11478
51. Elices, M. J., L. Osborn, Y. Takada, C. Crouse, S. Luhowskyj, M. E. Hemler, and A. D. Lobb. 1990. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from from the VLA-4/fibronectin binding site. Cell 60:577.
52. Bevilacqua, M. P , J. S Pober, D. L. Mendrick, R. S. Cotran, and M. A. Gimbrone, Jr. 1987. Identification of an inducible endothelial leukocyte adhesion molecule. Proc. Natl Acad. Sci USA 84:9238.
53. Shimizu, Y , S. Shaw, N. Graber, T. V. Gopal, K J Horgan, G A. van Seventer, and W. Newman. 1991. Activation-independent binding of human memory T cells to adhesion molecule ELAM-1 Nature 349:799.
54. Dobrina, A., R. Menegazzi, T. M. Carlos, E. Nardon, R. Cramer, T Zacchi, J M Harlan, and P. Patriarca. 1991. Mechanisms of eosinophil adherence to cultured vascular endothelial cells: eosinophils bind to the cytokine-induced endothelial ligand vascular adhesion molecule-1 via the very late activation antigen-4 integrin receptor. J. Clin. Invest. 88:20.
55. Bochner, B S , R. W Luscinskas, M. A. Gimbrone, Jr , W. Newman, S A. Sterbinsky, C. P. Derse-Anthony, D. Klunk, and R. P. Schleimer. 1991. Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules. J. Exp Med. 173:1553.
56. Black, K. L , and J T. Hoff. 1985. Leukotrienes and blood-brain barrier permeability following intraparenchymal injections in rats. Ann. Neurol. 18 349.
57. Wahl, S M , J. B. Allen, N. McCartney-Francis, M. C. Morganti-Kossmann, T. Kossmann, L Ellingsworth, U E. H Mai, S. E. Mergenhagen, and J M. Orenstein. 1991. Macrophage- and astrocyte-derived transforming growth factor β as a mediator of central nervous system dysfunction in acquired immune deficiency syndrome. J. Exp. Med. 173:981
58. Wahl, S. M., D. A. Hunt, L M. Wakefield, N. McCartney-Francis, L. M. Wahl, A. B. Roberts, and M B. Sporn. 1987. Transforming growth factor β (TGF-β) induces monocyte chemotaxis and growth factor production. Proc. Natl. Acad Sci USA 84:5788.
59. Rollins, B. J., T. Yoshimura, E. J. Leonard, and J. S. Pober 1990. Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP/JE. Am J. Pathol. 136:1229.
60. Lackner, A. A., P. Vogel, R. A. Rames, D. Kluge, and M Marthas. 1994 Early events in tissues during infection with pathogenic (SIVmac239) and nonpathogenic (SrVmac1A11) molecular clones of simian immunodeficiency virus. Am J. Pathol 145:428.