Microvessels from Alzheimer's disease brains kill neurons in vitro

American Journal of Pathology

Volumn 154, Issue 2, 1999, Pages 337-342

  Grammas, Paula ^a,b   Moore, Pete ^a,b   Weigel, Paul H ^a,b  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DEMENTIA; HUMAN; HUMAN TISSUE; MICROCIRCULATION; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT;

EID: 0032915154     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65280-7     Document Type: Article

References (25)

1. Terry RD, Katzman R, Bick KL: Alzheimer Disease. New York, Raven Press, 1994
2. Goate A, Chartier-Harlin M-C, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L Haynes A, Irving N, James L, Mant R, Newton P, Rooke K, Roques P, Talbot C, Pericak-Vance M, Roses A, Williamson R, Rossor M, Owen M, Hardy J: Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991, 349:704-706
3. Schellenberg GD, Bird TD, Wijsman EM, Orr HT Anderson L, Nemens E, While JA, Bonnycastle L, Heston LL, Martin GM: Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science 1992, 258:668-671
4. Levy-Lahad E, Wijsman EM, Nemens E, Anderson L, Goddard KAB, Weber JL, Bird TD, Schellenberg GD: A familial Alzheimer's disease locus on chromosome 1. Science 1995, 269:970-973
5. Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD: Apolipoprotein E: High-activity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer's disease. Proc Natl Acad Sci USA 1993, 90:1977-1981
6. Skoog I, Lernfelt B, Landahl S, Palmertz B, Andreasson L-A, Nilsson L, Persson G, Odén A, Svanbort A: 15-year longitudinal study of blood pressure and dementia. Lancet 1996 347:1141-1145
7. Hofman A, Ott A, Breteler MMB, Bots ML, Slooter AJC, van Harskamp F, van Duijn CN, Van Broeckhoven C, Grobbee DE: Atherosclerosis, apolipoprotein E, and prevalence of dementia, and Alzheimer's disease in the Rotterdam study. Lancet 1997, 349:151-154
8. Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR: Brain infarction and the clinical expression of Alzheimer disease. JAMA 1997, 277:813-817
9. Davies DC, Hardy JA: Blood-brain barrier in aging and Alzheimer's disease. Neurobiol Aging 1988, 9:46-48
10. Masters CL, Beyreuther K: The blood-brain barrier in Alzheimer's disease and normal aging. Neurobiol Aging 1988, 9:43-44
11. de la Torre JC, Mussivand T: Can disturbed brain microcirculation cause Alzheimer's disease? Neurol Res 1993, 15:146-153
12. Kalaria RN: Cerebral vessels in ageing and Alzheimer's disease. Pharmacol Ther 1996, 72:193-214
13. Kalaria RN, Hank SI: Reduced glucose transporter at the blood-brain barrier in cerebral cortex in Alzheimer's disease. J Neurochem 1989, 53:1083-1088
14. Grammas P, Roher AE, Ball MJ: Decreased α-adrenergic receptors at the blood-brain barrier in Alzheimer's disease Alzheimer's Disease: Basic Mechanisms, Diagnosis and Therapeutic Strategies. Edited by K Iqbal, DRC McLachlan, B Winblad, HM Wisnieski, New York, John Wiley & Sons. Ltd, 1991, pp 129-136
15. Grammas P, Roher A, Ball MJ: Increased accumulation of cAMP in cerebral microvessels in Alzheimer's disease. Neurobiol Aging 1994, 15:113-116
16. Cashman RE, Grammas P: cAMP-dependent protein kinase in cerebral microvessels in aging and Alzheimer's disease. Mol Chem Neuropathol 1995, 26:247-258
17. Grammas P, Moore P, Botchlet T, Hanson-Painton O, Cooper DR, Ball MJ, Roher A: Cerebral microvessels in Alzheimer's have reduced protein kinase C activity. Neurobiol Aging 1995, 16:563-569
18. Dorheim MA, Tracey WR, Pollock JS, Grammas P: Nitric oxide is elevated in Alzheimer's brain microvessels. Biochem Biophys Res Commun 1994, 205:659-665
19. Pereira HA, Kumar P, Grammas P: Expression of CAP37, a novel inflammatory mediator in Alzheimer's disease. Neurobiol Aging 1996, 17:753-759
20. Grammas P, Moore P, Weigel PH: Production of neurotoxic factors by brain endothelium in AD. Ann NY Acad Sci 1997, 826:47-55
21. Greene LA, Tischler AS: Establishment of a noradreneryic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 1976, 73:2424-2428
22. Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA: Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell culture. Proc Natl Acad Sci USA 1995, 92:7162
23. Nakazano K, Watanabe N, Matsuno K, Sasaki J, Jato T, Inoue M: Does superoxide underlie the pathogenesis of hypertension. Proc Natl Acad Sci USA 1991, 88:10045-10048
24. Kumar M, Liu G-J, Floyd RA, Grammas P: Anoxic injury of endothelial cells increases production of nitric oxide and hydroxyl radicals. Biochem Biophys Res Commun 1996, 219:497-501
25. Majno G, Joris I: Apoptosis, oncosis, and necrosis: an overview of cell death. Am J Pathol 1995, 146:3-15