메뉴 건너뛰기




Volumn 187, Issue 6, 1998, Pages 949-959

The unenlarged lymph nodes of HIV-1-infected, asymptomatic patients with high CD4 T cell counts are sites for virus replication and CD4 T cell proliferation. The impact of highly active antiretroviral therapy

Author keywords

[No Author keywords available]

Indexed keywords

BASILIXIMAB; CD4 ANTIGEN; CD8 ANTIGEN; DIDANOSINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD 20; MONOCLONAL ANTIBODY CD 23; MONOCLONAL ANTIBODY CD 57; MONOCLONAL ANTIBODY CD 68; MONOCLONAL ANTIBODY CD1A; MONOCLONAL ANTIBODY CD45; OKT 4; OKT 8; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS RNA; ZALCITABINE; ZIDOVUDINE;

EID: 0032536835     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.6.949     Document Type: Article
Times cited : (175)

References (40)
  • 2
    • 0029967721 scopus 로고    scopus 로고
    • HIV-1 dynamics in vivo: Virion clearance rate, infected cell life span, and viral generation time
    • Perelson, A.S., A.U. Neumann, M. Markowitz, J.M. Leonard, and D.D. Ho. 1996. HIV-1 dynamics in vivo: virion clearance rate, infected cell life span, and viral generation time. Science. 271:1582-1586.
    • (1996) Science , vol.271 , pp. 1582-1586
    • Perelson, A.S.1    Neumann, A.U.2    Markowitz, M.3    Leonard, J.M.4    Ho, D.D.5
  • 3
    • 0029164577 scopus 로고
    • Follicular dendritic cells initiate and maintain infection of the germinal centers by human immunodeficiency virus
    • Tenner-Racz, K., and P. Racz. 1995. Follicular dendritic cells initiate and maintain infection of the germinal centers by human immunodeficiency virus. Curr. Top. Microbiol. Immunol. 201:141-159.
    • (1995) Curr. Top. Microbiol. Immunol. , vol.201 , pp. 141-159
    • Tenner-Racz, K.1    Racz, P.2
  • 4
    • 0022979039 scopus 로고
    • HTLV-III expression in infected lymph nodes and relevance to pathogenesis of lymphadenopathy
    • Biberfeld, P., K.J. Chayt, L.M. Marselle, G. Biberfeld, R.C. Gallo, and M. Harper. 1986. HTLV-III expression in infected lymph nodes and relevance to pathogenesis of lymphadenopathy. Am. J. Pathol. 125:436-442.
    • (1986) Am. J. Pathol. , vol.125 , pp. 436-442
    • Biberfeld, P.1    Chayt, K.J.2    Marselle, L.M.3    Biberfeld, G.4    Gallo, R.C.5    Harper, M.6
  • 5
    • 0023687048 scopus 로고
    • Immunohistochemical, electron microscopic and in situ hybridization evidence for the involvement of lymphatics in the spread of HIV-1
    • Tenner-Racz, K., P. Racz, H. Schmidt, M. Dietrich, P. Kern, A. Louie, S. Gartner, and M. Popovic. 1988. Immunohistochemical, electron microscopic and in situ hybridization evidence for the involvement of lymphatics in the spread of HIV-1. AIDS (Lond.). 2:299-309.
    • (1988) AIDS (Lond.) , vol.2 , pp. 299-309
    • Tenner-Racz, K.1    Racz, P.2    Schmidt, H.3    Dietrich, M.4    Kern, P.5    Louie, A.6    Gartner, S.7    Popovic, M.8
  • 6
    • 0024325512 scopus 로고
    • Detection by in situ hybridization of HIV-1 RNA in spleens of HIV-1 seropositive patients with thrombocytopenic purpura
    • Prevot, S., J.G. Fournier, I. Tardivel, J. Audouin, and J. Diebold. 1989. Detection by in situ hybridization of HIV-1 RNA in spleens of HIV-1 seropositive patients with thrombocytopenic purpura. Pathol. Res. Pract. 185:187-193.
    • (1989) Pathol. Res. Pract. , vol.185 , pp. 187-193
    • Prevot, S.1    Fournier, J.G.2    Tardivel, I.3    Audouin, J.4    Diebold, J.5
  • 8
    • 0025789621 scopus 로고
    • Lymphoid germinal centers are reservoirs of human immunodeficiency virus type 1 RNA
    • Fox, C.H., K. Tenner-Racz, P. Racz, A. Fripo, P.A. Pizzo, and A.S. Fauci. 1991. Lymphoid germinal centers are reservoirs of human immunodeficiency virus type 1 RNA. J. Infect. Dis. 164:1051-1057.
    • (1991) J. Infect. Dis. , vol.164 , pp. 1051-1057
    • Fox, C.H.1    Tenner-Racz, K.2    Racz, P.3    Fripo, A.4    Pizzo, P.A.5    Fauci, A.S.6
  • 9
    • 0026601248 scopus 로고
    • Follicular dendritic cells are a major reservoir for human immunodeficiency virus type 1 in lymphoid tissues facilitating infection of CD4+ T-helper cells
    • Spiegel, H., H. Herbst, G. Niedobitek, H.D. Voss, and H. Stein. 1991. Follicular dendritic cells are a major reservoir for human immunodeficiency virus type 1 in lymphoid tissues facilitating infection of CD4+ T-helper cells. Am. J. Pathol. 140:15-22.
    • (1991) Am. J. Pathol. , vol.140 , pp. 15-22
    • Spiegel, H.1    Herbst, H.2    Niedobitek, G.3    Voss, H.D.4    Stein, H.5
  • 11
    • 0027516822 scopus 로고
    • Massive coven infection of helper T lymphocytes and macrophages by human immunodeficiency virus during the incubation period of AIDS
    • Embretson, J., M. Zupancic, J.L. Ribas, A. Burke, P. Racz, K. Tenner-Racz, and A.T. Haase. 1993. Massive coven infection of helper T lymphocytes and macrophages by human immunodeficiency virus during the incubation period of AIDS. Nature. 362:359-362.
    • (1993) Nature , vol.362 , pp. 359-362
    • Embretson, J.1    Zupancic, M.2    Ribas, J.L.3    Burke, A.4    Racz, P.5    Tenner-Racz, K.6    Haase, A.T.7
  • 13
    • 0001892542 scopus 로고
    • Lymphadenopathy and lymphoid neoplasms associated with the acquired immunodeficiency syndrome (AIDS)
    • D.M. Knowles, editor. Williams and Wilkins, Baltimore
    • Knowles, D.M., and A. Chadburn. 1992. Lymphadenopathy and lymphoid neoplasms associated with the acquired immunodeficiency syndrome (AIDS). In Neoplastic Hematopathology. D.M. Knowles, editor. Williams and Wilkins, Baltimore. 773-783.
    • (1992) Neoplastic Hematopathology , pp. 773-783
    • Knowles, D.M.1    Chadburn, A.2
  • 14
    • 0027980256 scopus 로고
    • Brief, high-temperature heat denaturation (pressure cooking): A simple and effective method of antigen retrieval for routinely processed tissues
    • Norton, A.J., S. Jordan, and P. Yeomans. 1994. Brief, high-temperature heat denaturation (pressure cooking): a simple and effective method of antigen retrieval for routinely processed tissues. J. Pathol. 173:371-379.
    • (1994) J. Pathol. , vol.173 , pp. 371-379
    • Norton, A.J.1    Jordan, S.2    Yeomans, P.3
  • 15
    • 0027057589 scopus 로고
    • Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections
    • Cattoretti, G., M.H. Becker, G. Key, M. Duchrow, C. Schluter, J. Galle, and J. Gerdes. 1993. Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J. Pathol. 168:357-363.
    • (1993) J. Pathol. , vol.168 , pp. 357-363
    • Cattoretti, G.1    Becker, M.H.2    Key, G.3    Duchrow, M.4    Schluter, C.5    Galle, J.6    Gerdes, J.7
  • 17
    • 0028069547 scopus 로고
    • Rapid and simple PCR assay for quantification of human immunodeficiency virus type 1 RNA in plasma: Application to acute retroviral infection
    • Mulder, J., N. McKinney, C. Christopherson, J. Sninsky, L. Greenfield, and S. Kwok. 1994. Rapid and simple PCR assay for quantification of human immunodeficiency virus type 1 RNA in plasma: application to acute retroviral infection. J. Clin. Microbiol. 32:292-300.
    • (1994) J. Clin. Microbiol. , vol.32 , pp. 292-300
    • Mulder, J.1    McKinney, N.2    Christopherson, C.3    Sninsky, J.4    Greenfield, L.5    Kwok, S.6
  • 19
    • 0024207320 scopus 로고
    • Expression of RNA and antigens of human immunodeficiency virus type-1 (HIV-1) in lymph nodes from HIV-1 infected individuals
    • Schuurman, H.J., W.J.A. Krone, R. Broekhuizen, and J. Goudsmit. 1988. Expression of RNA and antigens of human immunodeficiency virus type-1 (HIV-1) in lymph nodes from HIV-1 infected individuals. Am. J. Pathol. 133:516-524.
    • (1988) Am. J. Pathol. , vol.133 , pp. 516-524
    • Schuurman, H.J.1    Krone, W.J.A.2    Broekhuizen, R.3    Goudsmit, J.4
  • 21
    • 2642679046 scopus 로고
    • The human lymph node. Component cells and functional anatomy; principles of lymph node diagnosis
    • Miller Heyden Ltd., London
    • Robb-Smith, A.H.T., and C.R. Taylor. 1981. The human lymph node. Component cells and functional anatomy; principles of lymph node diagnosis. In Lymph Node Biopsy. Miller Heyden Ltd., London. 9-50.
    • (1981) Lymph Node Biopsy , pp. 9-50
    • Robb-Smith, A.H.T.1    Taylor, C.R.2
  • 22
    • 0022474962 scopus 로고
    • + germinal center cells with the helper cell phenotype and granular lymphocyte morphology
    • + germinal center cells with the helper cell phenotype and granular lymphocyte morphology. J. Clin. Immunol. 6:205-215.
    • (1986) J. Clin. Immunol. , vol.6 , pp. 205-215
    • Velardi, A.1    Tilden, A.B.2    Milo, R.3    Grossi, C.E.4
  • 24
  • 25
    • 0029150019 scopus 로고
    • Immunohistochemical analysis of T cell proliferation in normal tonsil and B cell lymphoma
    • Wang, J., P.G. Isaacson, and J. Spencer. 1995. Immunohistochemical analysis of T cell proliferation in normal tonsil and B cell lymphoma. J. Clin. Pathol. 48:873-875.
    • (1995) J. Clin. Pathol. , vol.48 , pp. 873-875
    • Wang, J.1    Isaacson, P.G.2    Spencer, J.3
  • 27
    • 0027764405 scopus 로고
    • Cytotoxic effector cell granules recognized by the monoclonal antibody TIA-1 are present in CD8+ lymphocytes in lymph nodes of human immunodeficiency virus-1-infected patients
    • Tenner-Racz, K., P. Racz, C. Thomé, G.G. Meyer, P.J. Anderson, S.F. Schlossman, and N.L. Letvin. 1993. Cytotoxic effector cell granules recognized by the monoclonal antibody TIA-1 are present in CD8+ lymphocytes in lymph nodes of human immunodeficiency virus-1-infected patients. Am. J. Pathol. 142:1750-1758.
    • (1993) Am. J. Pathol. , vol.142 , pp. 1750-1758
    • Tenner-Racz, K.1    Racz, P.2    Thomé, C.3    Meyer, G.G.4    Anderson, P.J.5    Schlossman, S.F.6    Letvin, N.L.7
  • 28
    • 0030603841 scopus 로고    scopus 로고
    • Changing the natural history of HIV disease
    • Feinberg, M.B. 1996. Changing the natural history of HIV disease. Lancet. 348:239-246.
    • (1996) Lancet , vol.348 , pp. 239-246
    • Feinberg, M.B.1
  • 30
    • 0030451775 scopus 로고    scopus 로고
    • Sensitivity to inhibition by β-chemokines correlates with biological phenotypes of primary HIV-1 isolates
    • Jansson, M., M. Popovic, A. Karlsson, F. Cocchi, P. Rossi, J. Albert, and H. Wigzell. 1996. Sensitivity to inhibition by β-chemokines correlates with biological phenotypes of primary HIV-1 isolates. Proc. Natl. Acad. Sci. USA. 93:15382-15387.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 15382-15387
    • Jansson, M.1    Popovic, M.2    Karlsson, A.3    Cocchi, F.4    Rossi, P.5    Albert, J.6    Wigzell, H.7
  • 31
    • 0024314961 scopus 로고
    • Follicular dendritic cells in HIV-induced lymphadenopathy and AIDS
    • Racz, P., K. Tenner-Racz, and H. Schmidt. 1989. Follicular dendritic cells in HIV-induced lymphadenopathy and AIDS. Acta Pathol. Microbiol. Scand. 97(Suppl. 8):16-23.
    • (1989) Acta Pathol. Microbiol. Scand. , vol.97 , Issue.8 SUPPL. , pp. 16-23
    • Racz, P.1    Tenner-Racz, K.2    Schmidt, H.3
  • 36
    • 0030052964 scopus 로고    scopus 로고
    • Alterations in the immune response of human immunodeficiency virus (HIV)-infected subjects treated with an HIV-specific protease inhibitor, ritonavir
    • Kelleher, A.D., A. Carr, J. Zaunders, and D.A. Cooper. 1996. Alterations in the immune response of human immunodeficiency virus (HIV)-infected subjects treated with an HIV-specific protease inhibitor, ritonavir. J. Infect. Dis. 173: 321-329.
    • (1996) J. Infect. Dis. , vol.173 , pp. 321-329
    • Kelleher, A.D.1    Carr, A.2    Zaunders, J.3    Cooper, D.A.4
  • 40
    • 0027433123 scopus 로고
    • T cells within germinal centers are specific for the immunizing antigen
    • Fuller, K.A., O. Kanagawa, and M.H. Nahm. 1993. T cells within germinal centers are specific for the immunizing antigen. J. Immunol. 151:4505-4512.
    • (1993) J. Immunol. , vol.151 , pp. 4505-4512
    • Fuller, K.A.1    Kanagawa, O.2    Nahm, M.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.