메뉴 건너뛰기




Volumn 3, Issue 1, 1997, Pages 28-29

Presenilins, amyloid-β and Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; PRESENILIN 1; PRESENILIN 2;

EID: 0031031120     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0197-28     Document Type: Short Survey
Times cited : (34)

References (22)
  • 1
    • 0029087026 scopus 로고
    • Candidate gene for the chromosome 1 familial Alzheimer's disease locus
    • Levy-Lahad, E. et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269, 973-977 (1995).
    • (1995) Science , vol.269 , pp. 973-977
    • Levy-Lahad, E.1
  • 2
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    • Sherrington, R. et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760 (1995).
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1
  • 3
    • 0029101491 scopus 로고
    • Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
    • Rogaev, E.I. et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376, 775-778 (1995).
    • (1995) Nature , vol.376 , pp. 775-778
    • Rogaev, E.I.1
  • 4
    • 0030174981 scopus 로고    scopus 로고
    • The gene defects responsible for familial Alzheimer's disease
    • Tanzi, R.E. et al. The gene defects responsible for familial Alzheimer's disease. Neurobiol. Disease 3, 159-168 (1996).
    • (1996) Neurobiol. Disease , vol.3 , pp. 159-168
    • Tanzi, R.E.1
  • 5
    • 0028985574 scopus 로고
    • Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
    • Games, D. et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 373, 523-527 (1995).
    • (1995) Nature , vol.373 , pp. 523-527
    • Games, D.1
  • 6
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Aβ elevation and amyloid plaques in transgenic mice
    • Hsiao, K. et al. Correlative memory deficits, Aβ elevation and amyloid plaques in transgenic mice. Science 274, 99-102 (1996).
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1
  • 7
    • 10544229795 scopus 로고    scopus 로고
    • Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues
    • Lee, M.K. et al. Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues. J. Neurosci. 16, 7513-7525 (1996).
    • (1996) J. Neurosci. , vol.16 , pp. 7513-7525
    • Lee, M.K.1
  • 8
    • 0029115555 scopus 로고
    • The structure of the presenilin I (S182) gene and identification of six novel mutations in early onset AD families
    • Alzheimer's Disease Collaborative Group. The structure of the presenilin I (S182) gene and identification of six novel mutations in early onset AD families. Nature Genet. 11, 219-222 (1995).
    • (1995) Nature Genet. , vol.11 , pp. 219-222
  • 9
    • 13344282063 scopus 로고    scopus 로고
    • Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells
    • Kovacs, D.M. et al. Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nature Med. 2, 224-229 (1996).
    • (1996) Nature Med. , vol.2 , pp. 224-229
    • Kovacs, D.M.1
  • 10
    • 8044231311 scopus 로고    scopus 로고
    • The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located within the endoplasmic reticulum
    • Walter, J. et al. The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located within the endoplasmic reticulum. Molec. Med. 2, 673-691 (1996).
    • (1996) Molec. Med. , vol.2 , pp. 673-691
    • Walter, J.1
  • 11
    • 16944362157 scopus 로고    scopus 로고
    • Mutant presenilins of Alzheimer's disease increase the production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
    • Citron, M. et al. Mutant presenilins of Alzheimer's disease increase the production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nature Med. 3, 67-72 (1997).
    • (1997) Nature Med. , vol.3 , pp. 67-72
    • Citron, M.1
  • 12
    • 16044366039 scopus 로고    scopus 로고
    • Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
    • Duff, K. et al. Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1. Nature 383, 710-713 (1996).
    • (1996) Nature , vol.383 , pp. 710-713
    • Duff, K.1
  • 13
    • 0030293676 scopus 로고    scopus 로고
    • Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo
    • Borchelt, D.R. et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron 17, 1005-1013 (1996).
    • (1996) Neuron , vol.17 , pp. 1005-1013
    • Borchelt, D.R.1
  • 14
    • 0030575338 scopus 로고    scopus 로고
    • Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing
    • Mercken, M. et al. Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing. FEBS Lett. 389, 297-303 (1996).
    • (1996) FEBS Lett. , vol.389 , pp. 297-303
    • Mercken, M.1
  • 15
    • 15844425969 scopus 로고    scopus 로고
    • Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
    • Thinakaran, G. et al. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17, 181-190 (1996).
    • (1996) Neuron , vol.17 , pp. 181-190
    • Thinakaran, G.1
  • 16
    • 0030293854 scopus 로고    scopus 로고
    • Protein topology of presenilin 1
    • Doan, A. et al. Protein topology of presenilin 1. Neuron 17, 1023-1030 (1996).
    • (1996) Neuron , vol.17 , pp. 1023-1030
    • Doan, A.1
  • 17
    • 16044373524 scopus 로고    scopus 로고
    • Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease in increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
    • Scheuner, D. et al. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease in increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med. 2, 864-870 (1996).
    • (1996) Nature Med. , vol.2 , pp. 864-870
    • Scheuner, D.1
  • 18
    • 16044365171 scopus 로고    scopus 로고
    • The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology
    • Lemere, C.A. et al. The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology. Nature Med. 2, 1146-1150 (1996).
    • (1996) Nature Med. , vol.2 , pp. 1146-1150
    • Lemere, C.A.1
  • 19
    • 10544224542 scopus 로고    scopus 로고
    • Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation
    • Wolozin, B. et al. Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation. Science 274, 1710-1712 (1996).
    • (1996) Science , vol.274 , pp. 1710-1712
    • Wolozin, B.1
  • 20
    • 16944362435 scopus 로고    scopus 로고
    • Assessment of normal and mutant human presenilin function in Caenorhabditis elegans
    • in the press
    • Levitan, D. et al. Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA (in the press).
    • Proc. Natl. Acad. Sci. USA
    • Levitan, D.1
  • 21
    • 16044362074 scopus 로고    scopus 로고
    • Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
    • Joutel, A. et al. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature 383, 707-710 (1996).
    • (1996) Nature , vol.383 , pp. 707-710
    • Joutel, A.1
  • 22
    • 0030293894 scopus 로고    scopus 로고
    • Membrane topology of the C. elegans SEL-12 presenilin
    • Li, X. & Greenwald, I. Membrane topology of the C. elegans SEL-12 presenilin. Neuron 17, 1015-1021 (1996).
    • (1996) Neuron , vol.17 , pp. 1015-1021
    • Li, X.1    Greenwald, I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.