-
1
-
-
0002915381
-
Retroviruses.
-
D. Berg M. Howe Am. Soc. Microbiol. Washington, DC
-
Varmus, H., Brown, P., Retroviruses. Berg, D., Howe, M., (eds.) Mobile DNA, 1989, Am. Soc. Microbiol., Washington, DC, 53–108.
-
(1989)
Mobile DNA
, pp. 53-108
-
-
Varmus, H.1
Brown, P.2
-
3
-
-
0001363865
-
Integration.
-
J.M. Coffin S.H. Hughes H.E. Varmus Cold Spring Harbor Press Cold Spring Harbor, N.Y.
-
Brown, P.O., Integration. Coffin, J.M., Hughes, S.H., Varmus, H.E., (eds.) Retroviruses, 1998, Cold Spring Harbor Press, Cold Spring Harbor, N.Y., 161–203.
-
(1998)
Retroviruses
, pp. 161-203
-
-
Brown, P.O.1
-
4
-
-
0031214288
-
In vitro assays for activities of retroviral integrase.
-
Chow, S.A., In vitro assays for activities of retroviral integrase. Methods: Companion to Methods Enzymol. 12 (1997), 306–317.
-
(1997)
Methods: Companion to Methods Enzymol.
, vol.12
, pp. 306-317
-
-
Chow, S.A.1
-
5
-
-
0008293521
-
Retroviral integrase: A novel target in antiviral development; basic in vitro assays with the purified enzyme.
-
D. Kinchington R. Schinazi Humana Press Totowa, NJ
-
Mazumder, A., Neamati, N., Sunder, S., Owen, J., Pommier, Y., Retroviral integrase: A novel target in antiviral development; basic in vitro assays with the purified enzyme. Kinchington, D., Schinazi, R., (eds.) Methods in Cellular and Molecular Biology: Antiviral Evaluation, 1998, Humana Press, Totowa, NJ.
-
(1998)
Methods in Cellular and Molecular Biology: Antiviral Evaluation
-
-
Mazumder, A.1
Neamati, N.2
Sunder, S.3
Owen, J.4
Pommier, Y.5
-
6
-
-
0031434606
-
Molecular mechanisms in retrovirus DNA integration.
-
Asante-Appiah, E., Skalka, A.M., Molecular mechanisms in retrovirus DNA integration. Antiviral Res. 36 (1997), 139–156.
-
(1997)
Antiviral Res.
, vol.36
, pp. 139-156
-
-
Asante-Appiah, E.1
Skalka, A.M.2
-
7
-
-
0030865411
-
HIV-1 integrase as a target for antiviral drugs.
-
Pommier, Y., Pilon, A.A., Bajaj, K., Mazumder, A., Neamati, N., HIV-1 integrase as a target for antiviral drugs. Antiviral Chem. Chemother. 8 (1997), 463–483.
-
(1997)
Antiviral Chem. Chemother.
, vol.8
, pp. 463-483
-
-
Pommier, Y.1
Pilon, A.A.2
Bajaj, K.3
Mazumder, A.4
Neamati, N.5
-
8
-
-
0030855938
-
Design and discovery of HIV-1 integrase inhibitors.
-
Neamati, N., Sunder, S., Pommier, Y., Design and discovery of HIV-1 integrase inhibitors. Drug Discovery Today 2 (1997), 487–498.
-
(1997)
Drug Discovery Today
, vol.2
, pp. 487-498
-
-
Neamati, N.1
Sunder, S.2
Pommier, Y.3
-
10
-
-
0029166510
-
Processing of deoxyuridine mismatches and abasic sites by human immunodeficiency virus type I integrase.
-
Mazumder, A., Pommier, Y., Processing of deoxyuridine mismatches and abasic sites by human immunodeficiency virus type I integrase. Nucleic Acids Res. 23 (1995), 2865–2871.
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 2865-2871
-
-
Mazumder, A.1
Pommier, Y.2
-
11
-
-
0026095906
-
Human immunodeficiency virus integrase protein requires a subterminal position for its viral DNA recognition sequence for efficient cleavage.
-
Vink, C, van Gent, D.C., Elgersma, Y., Plasterk, R.H.A., Human immunodeficiency virus integrase protein requires a subterminal position for its viral DNA recognition sequence for efficient cleavage. J. Virol. 65 (1991), 4636–4644.
-
(1991)
J. Virol.
, vol.65
, pp. 4636-4644
-
-
Vink, C.1
van Gent, D.C.2
Elgersma, Y.3
Plasterk, R.H.A.4
-
12
-
-
0031935582
-
Mapping viral DNA specificity to the central region of integrase by using functional human immunodeficiency virus type 1/Visna virus chimeric proteins.
-
Katzman, M., Sudol, M., Mapping viral DNA specificity to the central region of integrase by using functional human immunodeficiency virus type 1/Visna virus chimeric proteins. J. Virol. 72 (1998), 1744–1753.
-
(1998)
J. Virol.
, vol.72
, pp. 1744-1753
-
-
Katzman, M.1
Sudol, M.2
-
13
-
-
0029861955
-
Influence of subterminal viral DNA nucleotide on differential susceptibility to cleavage by human immunodeficiency virus type 1 and visna virus integrases.
-
Katzman, M., Sudol, M., Influence of subterminal viral DNA nucleotide on differential susceptibility to cleavage by human immunodeficiency virus type 1 and visna virus integrases. J. Virol. 70 (1996), 9069–9073.
-
(1996)
J. Virol.
, vol.70
, pp. 9069-9073
-
-
Katzman, M.1
Sudol, M.2
-
14
-
-
0032576722
-
Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands.
-
White, S., Szewczyk, J.W., Turner, J.M., Baird, E.E., Dervan, P.B., Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands. Nature (London) 391 (1998), 468–470.
-
(1998)
Nature (London)
, vol.391
, pp. 468-470
-
-
White, S.1
Szewczyk, J.W.2
Turner, J.M.3
Baird, E.E.4
Dervan, P.B.5
-
15
-
-
0031820936
-
Highly potent synthetic polyamines, bisdistamycins and lexitropsins as inhibitors of human immunodeficiency virus type 1 integrase.
-
Neamati, N., Mazumder, A., Sunder, S., Owen, J.M., Tandon, M., Lown, J.W., Pommier, Y., Highly potent synthetic polyamines, bisdistamycins and lexitropsins as inhibitors of human immunodeficiency virus type 1 integrase. Mol. Pharmacol. 54 (1998), 280–290.
-
(1998)
Mol. Pharmacol.
, vol.54
, pp. 280-290
-
-
Neamati, N.1
Mazumder, A.2
Sunder, S.3
Owen, J.M.4
Tandon, M.5
Lown, J.W.6
Pommier, Y.7
-
16
-
-
0028142815
-
Triplex-mediated inhibition of HIV DNA integration in vitro.
-
Mouscadet, J.-F., Carteau, S., Goulaouic, H., Subra, F., Auclair, C., Triplex-mediated inhibition of HIV DNA integration in vitro. J. Biol. Chem. 269 (1994), 21634–21638.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 21634-21638
-
-
Mouscadet, J.-F.1
Carteau, S.2
Goulaouic, H.3
Subra, F.4
Auclair, C.5
-
17
-
-
0028288222
-
Triple helix formation with short oligonucleotide-intercalator conjugates matching the HIV-1 U3 LTR end sequence.
-
Mouscadet, J.-F., Ketterlé, C., Goulaouic, H., Carteau, S., Subra, F., Le Bret, M., Auclair, C., Triple helix formation with short oligonucleotide-intercalator conjugates matching the HIV-1 U3 LTR end sequence. Biochemistry 33 (1994), 4187–4196.
-
(1994)
Biochemistry
, vol.33
, pp. 4187-4196
-
-
Mouscadet, J.-F.1
Ketterlé, C.2
Goulaouic, H.3
Carteau, S.4
Subra, F.5
Le Bret, M.6
Auclair, C.7
-
18
-
-
0028239062
-
A stable complex between integrase and viral DNA ends mediates human immunodeficiency virus integration in vitro.
-
Ellison, V., Brown, P.O., A stable complex between integrase and viral DNA ends mediates human immunodeficiency virus integration in vitro. Proc. Natl. Acad. Sci. U.S.A. 91 (1994), 7316–7320.
-
(1994)
Proc. Natl. Acad. Sci. U.S.A.
, vol.91
, pp. 7316-7320
-
-
Ellison, V.1
Brown, P.O.2
-
19
-
-
0032562165
-
Displacement of viral DNA termini from stable HIV-1 integrase nucleoprotein complexes induced by secondary DNA-binding interactions.
-
Pemberton, I.K., Buc, H., Buckle, M., Displacement of viral DNA termini from stable HIV-1 integrase nucleoprotein complexes induced by secondary DNA-binding interactions. Biochemistry 37 (1998), 2682–2690.
-
(1998)
Biochemistry
, vol.37
, pp. 2682-2690
-
-
Pemberton, I.K.1
Buc, H.2
Buckle, M.3
-
20
-
-
0030051081
-
The role of manganese in promoting multimerization and assembly of human immunodeficiency type 1 integrase as a catalytically active complex on immobilized long terminal repeat substrates.
-
Wolfe, A.L., Felock, P.J., Hastings, H.C., Uncapher Blau, C., Hazuda, D., The role of manganese in promoting multimerization and assembly of human immunodeficiency type 1 integrase as a catalytically active complex on immobilized long terminal repeat substrates. J. Virol. 70 (1996), 1424–1432.
-
(1996)
J. Virol.
, vol.70
, pp. 1424-1432
-
-
Wolfe, A.L.1
Felock, P.J.2
Hastings, H.C.3
Uncapher Blau, C.4
Hazuda, D.5
-
21
-
-
85023063958
-
Characterization of a stable HIV integrase-viral DNA complex: an early intermediate in the integration pathway.
-
Ellison, V., Vincent, K.A., Brown, P.O., Characterization of a stable HIV integrase-viral DNA complex: an early intermediate in the integration pathway. J. Cell. Biochem., 18B, 1994, 19.
-
(1994)
J. Cell. Biochem.
, vol.18B
, pp. 19
-
-
Ellison, V.1
Vincent, K.A.2
Brown, P.O.3
-
22
-
-
0025337327
-
Human immunodeficiency in a cell-free system.
-
Ellison, V., Abrams, H., Roe, T., Lifson, J., Brown, P., Human immunodeficiency in a cell-free system. J. Virol. 64 (1990), 2711–2715.
-
(1990)
J. Virol.
, vol.64
, pp. 2711-2715
-
-
Ellison, V.1
Abrams, H.2
Roe, T.3
Lifson, J.4
Brown, P.5
-
23
-
-
0030875813
-
Mapping features of HIV-1 integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photo-cross-linking.
-
Heuer, T.S., Brown, P.O., Mapping features of HIV-1 integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photo-cross-linking. Biochemistry 36 (1997), 10655–10665.
-
(1997)
Biochemistry
, vol.36
, pp. 10655-10665
-
-
Heuer, T.S.1
Brown, P.O.2
-
24
-
-
0030828521
-
Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking.
-
Jenkins, T.M., Esposito, D., Engelman, A., Craigie, R., Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking. EMBO J. 16 (1997), 6849–6859.
-
(1997)
EMBO J.
, vol.16
, pp. 6849-6859
-
-
Jenkins, T.M.1
Esposito, D.2
Engelman, A.3
Craigie, R.4
-
25
-
-
0032516064
-
Identification of a nucleotide binding site in HIV-1 integrase.
-
Drake, R., Neamati, N., Hong, H., Pilon, A.A., Sunthankar, P., Hume, S.D., Milne, G.W.A., Pommier, Y., Identification of a nucleotide binding site in HIV-1 integrase. Proc. Natl. Acad. Sci. U.S.A. 95 (1998), 4170–4175.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 4170-4175
-
-
Drake, R.1
Neamati, N.2
Hong, H.3
Pilon, A.A.4
Sunthankar, P.5
Hume, S.D.6
Milne, G.W.A.7
Pommier, Y.8
-
26
-
-
0029964978
-
Inhibition of human immunodeficiency virus type 1 integrase by guanosine quartet structures.
-
Mazumder, A., Neamati, N., Ojwang, J.O., Sunder, S., Rando, R.F., Pommier, Y., Inhibition of human immunodeficiency virus type 1 integrase by guanosine quartet structures. Biochemistry 43 (1996), 13762–13771.
-
(1996)
Biochemistry
, vol.43
, pp. 13762-13771
-
-
Mazumder, A.1
Neamati, N.2
Ojwang, J.O.3
Sunder, S.4
Rando, R.F.5
Pommier, Y.6
-
27
-
-
0028824505
-
T30177, an oligonucleotide stabilized by an intramolecular guanosine octet, is a potent inhibitor of laboratory strains and clinical isolates of human immunodeficiency virus type 1.
-
Ojwang, J.O., Buckheit, R.W., Pommier, Y., Mazumder, A., De Vreese, K., Esté, J.A., Reymen, D., Pallansch, L.A., Lackman-Smith, C., Wallace, T.L., De Clercq, E., McGrath, M.S., Rando, R.F., T30177, an oligonucleotide stabilized by an intramolecular guanosine octet, is a potent inhibitor of laboratory strains and clinical isolates of human immunodeficiency virus type 1. Antimicrob. Agents Chemother. 39 (1995), 2426–2435.
-
(1995)
Antimicrob. Agents Chemother.
, vol.39
, pp. 2426-2435
-
-
Ojwang, J.O.1
Buckheit, R.W.2
Pommier, Y.3
Mazumder, A.4
De Vreese, K.5
Esté, J.A.6
Reymen, D.7
Pallansch, L.A.8
Lackman-Smith, C.9
Wallace, T.L.10
De Clercq, E.11
McGrath, M.S.12
Rando, R.F.13
-
28
-
-
0028242724
-
Inhibition of human immunodeficiency virus type 1 integrase by 3′-azido-3′-deoxythymi-dylate.
-
Mazumder, A., Cooney, D., Agbaria, R., Gupta, M., Pommier, Y., Inhibition of human immunodeficiency virus type 1 integrase by 3′-azido-3′-deoxythymi-dylate. Proc. Natl. Acad. Sci. U.S.A. 91 (1994), 5771–5775.
-
(1994)
Proc. Natl. Acad. Sci. U.S.A.
, vol.91
, pp. 5771-5775
-
-
Mazumder, A.1
Cooney, D.2
Agbaria, R.3
Gupta, M.4
Pommier, Y.5
-
29
-
-
0028171531
-
Nucleotide binding by the HIV-1 integrase protein in vitro.
-
Lipford, J.R., Worland, S.T., Farnet, C.M., Nucleotide binding by the HIV-1 integrase protein in vitro. J. AIDS 7 (1994), 1215–1223.
-
(1994)
J. AIDS
, vol.7
, pp. 1215-1223
-
-
Lipford, J.R.1
Worland, S.T.2
Farnet, C.M.3
-
30
-
-
0029871472
-
Effects of nucleotide analogs on human immunodeficiency virus type 1 integrase.
-
Mazumder, A., Neamati, N., Sommadossi, J.-P., Gosselin, G., Schinazi, R., Imbach, J.-L., Pommier, Y., Effects of nucleotide analogs on human immunodeficiency virus type 1 integrase. Mol. Pharmacol. 49 (1996), 621–628.
-
(1996)
Mol. Pharmacol.
, vol.49
, pp. 621-628
-
-
Mazumder, A.1
Neamati, N.2
Sommadossi, J.-P.3
Gosselin, G.4
Schinazi, R.5
Imbach, J.-L.6
Pommier, Y.7
-
31
-
-
0030902155
-
Probing interactions between viral DNA and human immunodeficiency virus type 1 integrase using dinucleotides.
-
Mazumder, A., Uchida, H., Neamati, N., Sunder, S., Jaworska-Maslanka, M., Wickstrom, E., Zeng, F., Jones, R.A., Mandes, R.F., Chenault, H.K., Pommier, Y., Probing interactions between viral DNA and human immunodeficiency virus type 1 integrase using dinucleotides. Mol. Pharmacol. 51 (1997), 567–575.
-
(1997)
Mol. Pharmacol.
, vol.51
, pp. 567-575
-
-
Mazumder, A.1
Uchida, H.2
Neamati, N.3
Sunder, S.4
Jaworska-Maslanka, M.5
Wickstrom, E.6
Zeng, F.7
Jones, R.A.8
Mandes, R.F.9
Chenault, H.K.10
Pommier, Y.11
-
32
-
-
0026659014
-
Inhibition of HIV-1 integration protein by aurintricarboxylic acid monomers, monomer analogs, and polymer fractions.
-
Cushman, M., Sherman, P., Inhibition of HIV-1 integration protein by aurintricarboxylic acid monomers, monomer analogs, and polymer fractions. Biochem. Biophys. Res. Commun. 185 (1992), 85–90.
-
(1992)
Biochem. Biophys. Res. Commun.
, vol.185
, pp. 85-90
-
-
Cushman, M.1
Sherman, P.2
-
33
-
-
0029065930
-
Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase.
-
Cushman, M., Golebiewski, W.M., Pommier, Y., Mazumder, A., Reymen, D., De Clercq, E., Grahm, L., Rice, W.G., Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase. J. Med. Chem. 38 (1995), 443–452.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 443-452
-
-
Cushman, M.1
Golebiewski, W.M.2
Pommier, Y.3
Mazumder, A.4
Reymen, D.5
De Clercq, E.6
Grahm, L.7
Rice, W.G.8
-
34
-
-
0027222149
-
Inhibitory effect of the polyanionic drug suramin on the in vitro HIV DNA integration reaction.
-
Carteau, S., Mouscadet, J.-F., Goulaouic, H., Subra, F., Auclair, C., Inhibitory effect of the polyanionic drug suramin on the in vitro HIV DNA integration reaction. Arch. Biochem. Biophys. 305 (1993), 606–610.
-
(1993)
Arch. Biochem. Biophys.
, vol.305
, pp. 606-610
-
-
Carteau, S.1
Mouscadet, J.-F.2
Goulaouic, H.3
Subra, F.4
Auclair, C.5
-
35
-
-
0030891601
-
HIV-1 integrase pharmacophore: Discovery of inhibitors through 3D database searching.
-
Nicklaus, M., Neamati, N., Hong, H., Mazumder, A., Sunder, Y., Chen, J., Milne, G.W.A., Pommier, Y., HIV-1 integrase pharmacophore: Discovery of inhibitors through 3D database searching. J. Med. Chem. 40 (1997), 920–929.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 920-929
-
-
Nicklaus, M.1
Neamati, N.2
Hong, H.3
Mazumder, A.4
Sunder, Y.5
Chen, J.6
Milne, G.W.A.7
Pommier, Y.8
-
36
-
-
0031060473
-
Equivalent inhibition of half-site and full-site retroviral strand transfer reactions by structurally diverse compounds.
-
Hazuda, D., Felock, P., Hastings, J., Pramanik, B., Wolfe, A., Goodarzi, G., Vora, A., Brackmann, K., Grandgenett, D., Equivalent inhibition of half-site and full-site retroviral strand transfer reactions by structurally diverse compounds. J. Virol. 71 (1997), 807–811.
-
(1997)
J. Virol.
, vol.71
, pp. 807-811
-
-
Hazuda, D.1
Felock, P.2
Hastings, J.3
Pramanik, B.4
Wolfe, A.5
Goodarzi, G.6
Vora, A.7
Brackmann, K.8
Grandgenett, D.9
-
37
-
-
0026330796
-
HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer.
-
Engelman, A., Mizuuchi, K., Craigie, R., HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer. Cell (Cambridge, Mass.) 67 (1991), 1211–1221.
-
(1991)
Cell (Cambridge, Mass.)
, vol.67
, pp. 1211-1221
-
-
Engelman, A.1
Mizuuchi, K.2
Craigie, R.3
-
38
-
-
0026348879
-
Site-specific hydrolysis and alcoholysis of human immunodeficiency virus DNA termini mediated by the viral integrase protein.
-
Vink, C., Yeheskiely, E., van der Marel, G.A., Van Boom, J.H., Plasterk, R.H.A., Site-specific hydrolysis and alcoholysis of human immunodeficiency virus DNA termini mediated by the viral integrase protein. Nucleic Acids Res. 19 (1991), 6691–6698.
-
(1991)
Nucleic Acids Res.
, vol.19
, pp. 6691-6698
-
-
Vink, C.1
Yeheskiely, E.2
van der Marel, G.A.3
Van Boom, J.H.4
Plasterk, R.H.A.5
-
39
-
-
0029993527
-
Nonspecific alcoholysis, a novel endonuclease activity of human immunodeficiency virus type 1 and other retroviral integrases.
-
Katzman, M., Sudol, M., Nonspecific alcoholysis, a novel endonuclease activity of human immunodeficiency virus type 1 and other retroviral integrases. J. Virol. 70 (1996), 2598–2604.
-
(1996)
J. Virol.
, vol.70
, pp. 2598-2604
-
-
Katzman, M.1
Sudol, M.2
-
40
-
-
0027457192
-
Inhibitors of human immunodeficiency virus integrase.
-
Fesen, M.R., Kohn, K.W., Leteurtre, F., Pommier, Y., Inhibitors of human immunodeficiency virus integrase. Proc. Natl. Acad. Sci. U.S.A. 90 (1993), 2399–2403.
-
(1993)
Proc. Natl. Acad. Sci. U.S.A.
, vol.90
, pp. 2399-2403
-
-
Fesen, M.R.1
Kohn, K.W.2
Leteurtre, F.3
Pommier, Y.4
-
41
-
-
0028070994
-
Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds.
-
Fesen, M.R., Pommier, Y., Leteurtre, F., Hiroguchi, S., Yung, J., Kohn, K.W., Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochem. Pharmacol. 48 (1994), 595–608.
-
(1994)
Biochem. Pharmacol.
, vol.48
, pp. 595-608
-
-
Fesen, M.R.1
Pommier, Y.2
Leteurtre, F.3
Hiroguchi, S.4
Yung, J.5
Kohn, K.W.6
-
42
-
-
0026549933
-
Reversal of integration and DNA splicing mediated by integrase of human immunodeficiency virus.
-
Chow, S.A., Vincent, K.A., Ellison, V., Brown, P.O., Reversal of integration and DNA splicing mediated by integrase of human immunodeficiency virus. Science 255 (1992), 723–726.
-
(1992)
Science
, vol.255
, pp. 723-726
-
-
Chow, S.A.1
Vincent, K.A.2
Ellison, V.3
Brown, P.O.4
-
43
-
-
0031032592
-
3′-End processing and kinetics of 5′-end joining during retroviral integration in vivo.
-
Roe, T., Chow, S.A., Brown, P.O., 3′-End processing and kinetics of 5′-end joining during retroviral integration in vivo. J. Virol. 71 (1997), 1334–1340.
-
(1997)
J. Virol.
, vol.71
, pp. 1334-1340
-
-
Roe, T.1
Chow, S.A.2
Brown, P.O.3
-
44
-
-
0031887358
-
Efficient gap repair catalyzed in vitro by an intrinsic DNA polymerase activity of human immunodeficiency virus type 1 integrase.
-
Acel, A., Udashkin, B.E., Wainberg, M.A., Faust, E.A., Efficient gap repair catalyzed in vitro by an intrinsic DNA polymerase activity of human immunodeficiency virus type 1 integrase. J. Virol. 72 (1998), 2062–2071.
-
(1998)
J. Virol.
, vol.72
, pp. 2062-2071
-
-
Acel, A.1
Udashkin, B.E.2
Wainberg, M.A.3
Faust, E.A.4
-
45
-
-
0029845980
-
Differential inhibition of HIV-1 preintegration complexes and purified integrase protein by small molecules.
-
Farnet, C.M., Wang, B., Lipford, J.R., Bushman, F.D., Differential inhibition of HIV-1 preintegration complexes and purified integrase protein by small molecules. Proc. Natl. Acad. Sci. U.S.A. 93 (1996), 9742–9747.
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 9742-9747
-
-
Farnet, C.M.1
Wang, B.2
Lipford, J.R.3
Bushman, F.D.4
-
46
-
-
0030972160
-
Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition.
-
Miller, M.D., Farnet, C.M., Bushman, F.D., Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition. J. Virol. 71 (1997), 5382–5390.
-
(1997)
J. Virol.
, vol.71
, pp. 5382-5390
-
-
Miller, M.D.1
Farnet, C.M.2
Bushman, F.D.3
-
47
-
-
0027376309
-
A nuclear localization signal within HIV-1 matrix protein that governs infection of nondividing cells.
-
Bukrinsky, M.I., Haggerty, S., Dempsey, M.P., Sharova, N., Adzhubel, A., Spitz, L., Lewis, P., Goldfarb, D., Emerman, M., Stevenson, M., A nuclear localization signal within HIV-1 matrix protein that governs infection of nondividing cells. Nature (London) 365 (1993), 666–669.
-
(1993)
Nature (London)
, vol.365
, pp. 666-669
-
-
Bukrinsky, M.I.1
Haggerty, S.2
Dempsey, M.P.3
Sharova, N.4
Adzhubel, A.5
Spitz, L.6
Lewis, P.7
Goldfarb, D.8
Emerman, M.9
Stevenson, M.10
-
48
-
-
0028283854
-
HIV-1 infection ofnon-dividing cells.
-
Freed, E.O., Martin, M.A., HIV-1 infection ofnon-dividing cells. Nature (London) 369 (1994), 107–108.
-
(1994)
Nature (London)
, vol.369
, pp. 107-108
-
-
Freed, E.O.1
Martin, M.A.2
-
49
-
-
0031472241
-
Phosphorylation of residue 131 of HIV-1 matrix is not required for macrophage infection.
-
Freed, E.O., Englund, G., Maldarelli, F., Martin, M.A., Phosphorylation of residue 131 of HIV-1 matrix is not required for macrophage infection. Cell (Cambridge, Mass.) 88 (1997), 171–174.
-
(1997)
Cell (Cambridge, Mass.)
, vol.88
, pp. 171-174
-
-
Freed, E.O.1
Englund, G.2
Maldarelli, F.3
Martin, M.A.4
-
50
-
-
0028851734
-
Interface peptides as structure-based human immunodeficiency virus reverse transcriptase inhibitors.
-
Divita, G., Baillon, J.G., Rittinger, K., Chermann, J.-C., Goody, R.S., Interface peptides as structure-based human immunodeficiency virus reverse transcriptase inhibitors. J. Biol. Chem. 270 (1995), 28642–28646.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 28642-28646
-
-
Divita, G.1
Baillon, J.G.2
Rittinger, K.3
Chermann, J.-C.4
Goody, R.S.5
-
51
-
-
0030662656
-
Inhibitors of the nuclear translocation of the HIV-1 preintegration complex.
-
Bukrinsky, M., Inhibitors of the nuclear translocation of the HIV-1 preintegration complex. Drugs Future 22 (1997), 875–883.
-
(1997)
Drugs Future
, vol.22
, pp. 875-883
-
-
Bukrinsky, M.1
-
52
-
-
0029171804
-
Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention.
-
Dubrovsky, L., Ulrich, P., Nuovo, G.J., Manogue, K.R., Cerami, A., Bukrinsky, M., Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention. Mol. Med. 1 (1995), 217–230.
-
(1995)
Mol. Med.
, vol.1
, pp. 217-230
-
-
Dubrovsky, L.1
Ulrich, P.2
Nuovo, G.J.3
Manogue, K.R.4
Cerami, A.5
Bukrinsky, M.6
-
53
-
-
18844468523
-
Viral protein R regulates nuclear import of the HIV-1 pre-integration complex.
-
Papov, S., Rexach, M., Zybarth, G., Reiling, N., Lee, M.-A., Ratner, L., Lane, C.M., Moore, M.S., Blobel, G., Bukrinsky, M., Viral protein R regulates nuclear import of the HIV-1 pre-integration complex. EMBO J. 17 (1998), 909–917.
-
(1998)
EMBO J.
, vol.17
, pp. 909-917
-
-
Papov, S.1
Rexach, M.2
Zybarth, G.3
Reiling, N.4
Lee, M.-A.5
Ratner, L.6
Lane, C.M.7
Moore, M.S.8
Blobel, G.9
Bukrinsky, M.10
-
54
-
-
0031079648
-
Leptomycin B is an inhibitor of nuclear export: Inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA.
-
Wolff, B., Sanglier, J.J., Wang, Y., Leptomycin B is an inhibitor of nuclear export: Inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem. Biol. 4 (1997), 139–147.
-
(1997)
Chem. Biol.
, vol.4
, pp. 139-147
-
-
Wolff, B.1
Sanglier, J.J.2
Wang, Y.3
-
55
-
-
85023026963
-
2+-dependent 3′-processing activity of human immunodeficiency virus type 1 integrase in vitro.
-
2+-dependent 3′-processing activity of human immunodeficiency virus type 1 integrase in vitro. Biochemistry 36 (1996), 173–180.
-
(1996)
Biochemistry
, vol.36
, pp. 173-180
-
-
Lee, S.P.1
Han, M.K.2
-
56
-
-
0030478950
-
Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity.
-
Zheng, R., Jenkins, T.M., Craigie, R., Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity. Proc. Natl. Acad. Sci. U.S.A. 93 (1996), 13659–13664.
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 13659-13664
-
-
Zheng, R.1
Jenkins, T.M.2
Craigie, R.3
-
58
-
-
0027456715
-
Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding.
-
Bushman, F.D., Engelman, A., Palmer, I., Wingfield, P., Craigie, R., Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding. Proc. Natl. Acad. Sci. U.S.A. 90 (1993), 3428–3432.
-
(1993)
Proc. Natl. Acad. Sci. U.S.A.
, vol.90
, pp. 3428-3432
-
-
Bushman, F.D.1
Engelman, A.2
Palmer, I.3
Wingfield, P.4
Craigie, R.5
-
59
-
-
0027210608
-
Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type I integrase protein.
-
Vink, C., Oude Groeneger, A.A.M., Plasterk, R.H.A., Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type I integrase protein. Nucleic Acids Res. 21 (1993), 1419–1425.
-
(1993)
Nucleic Acids Res.
, vol.21
, pp. 1419-1425
-
-
Vink, C.1
Oude Groeneger, A.A.M.2
Plasterk, R.H.A.3
-
60
-
-
0029954581
-
Virus-encoded zinc fingers as targets for antiviral chemotherapy.
-
Rice, W.G., Turpin, J.A., Virus-encoded zinc fingers as targets for antiviral chemotherapy. Rev. Med. Virol. 6 (1996), 187–199.
-
(1996)
Rev. Med. Virol.
, vol.6
, pp. 187-199
-
-
Rice, W.G.1
Turpin, J.A.2
-
61
-
-
0026035178
-
Retroviral integrase domains: DNA binding and the recognition of LTR sequences.
-
errata: Nucleic Acids Res., p. 1358
-
Khan, E., Mack, J.P., Katz, R.A., Kulkosky, J., Skalka, A.M., Retroviral integrase domains: DNA binding and the recognition of LTR sequences. Nucleic Acids Res. 19 (1991), 851–860 errata: Nucleic Acids Res., p. 1358.
-
(1991)
Nucleic Acids Res.
, vol.19
, pp. 851-860
-
-
Khan, E.1
Mack, J.P.2
Katz, R.A.3
Kulkosky, J.4
Skalka, A.M.5
-
62
-
-
0026459411
-
Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells.
-
La Femina, R.L., Schneider, C.L., Robbins, H.L., Callahan, P.L., Le Grow, K., Roth, E., Schleif, W.A., Emini, E.A., Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells. J. Virol. 66 (1992), 7414–7419.
-
(1992)
J. Virol.
, vol.66
, pp. 7414-7419
-
-
La Femina, R.L.1
Schneider, C.L.2
Robbins, H.L.3
Callahan, P.L.4
Le Grow, K.5
Roth, E.6
Schleif, W.A.7
Emini, E.A.8
-
63
-
-
0026649557
-
Identification of conserved amino acid residues critical for human immunodeficiency virus type I integrase function in vitro.
-
Engelman, A., Craigie, R., Identification of conserved amino acid residues critical for human immunodeficiency virus type I integrase function in vitro. J. Virol. 66 (1992), 6361–6369.
-
(1992)
J. Virol.
, vol.66
, pp. 6361-6369
-
-
Engelman, A.1
Craigie, R.2
-
64
-
-
0026668776
-
Mutational analysis of the integrase protein of human immunodeficiency virus type 2.
-
Van Gent, D.C., Oude Groeneger, A.A.M., Plasterk, R.H.A., Mutational analysis of the integrase protein of human immunodeficiency virus type 2. Proc. Natl. Acad. Sci. U.S.A. 89 (1992), 9598–9602.
-
(1992)
Proc. Natl. Acad. Sci. U.S.A.
, vol.89
, pp. 9598-9602
-
-
Van Gent, D.C.1
Oude Groeneger, A.A.M.2
Plasterk, R.H.A.3
-
65
-
-
0028097285
-
Monoclonal antibodies against HIV type 1 integrase: clues to molecular structure.
-
Bizub-Bender, D., Kulkosky, J., Skalka, A.M., Monoclonal antibodies against HIV type 1 integrase: clues to molecular structure. AIDS Res. Hum. Retrovirus 10 (1994), 1105–1115.
-
(1994)
AIDS Res. Hum. Retrovirus
, vol.10
, pp. 1105-1115
-
-
Bizub-Bender, D.1
Kulkosky, J.2
Skalka, A.M.3
-
66
-
-
0029670765
-
Monoclonal antibodies against human immunodeficiency virus type 1 integrase: Epitope mapping and differential effects on integrase activities in vitro.
-
Nilsen, B.M., Haugan, I.R., Berg, K., Olsen, L., Brown, P.O., Helland, D.E., Monoclonal antibodies against human immunodeficiency virus type 1 integrase: Epitope mapping and differential effects on integrase activities in vitro. J. Virol. 70 (1996), 1580–1587.
-
(1996)
J. Virol.
, vol.70
, pp. 1580-1587
-
-
Nilsen, B.M.1
Haugan, I.R.2
Berg, K.3
Olsen, L.4
Brown, P.O.5
Helland, D.E.6
-
67
-
-
0030003130
-
Inhibition of human immunodeficiency virus type 1 integrase by the Fab fragment of a specific monoclonal antibody suggests that different multimerization states are required for different enzymatic functions.
-
Barsov, E.V., Huber, W.E., Marcotrigiano, J., Clark, P.K., Clark, A.D., Arnold, E., Hughes, S.H., Inhibition of human immunodeficiency virus type 1 integrase by the Fab fragment of a specific monoclonal antibody suggests that different multimerization states are required for different enzymatic functions. J. Virol. 70 (1996), 4484–4494.
-
(1996)
J. Virol.
, vol.70
, pp. 4484-4494
-
-
Barsov, E.V.1
Huber, W.E.2
Marcotrigiano, J.3
Clark, P.K.4
Clark, A.D.5
Arnold, E.6
Hughes, S.H.7
-
68
-
-
0025765803
-
SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins.
-
Koch, C.A., Anderson, D., Moran, M.F., Ellis, C., Pawson, T., SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science 252 (1991), 668–674.
-
(1991)
Science
, vol.252
, pp. 668-674
-
-
Koch, C.A.1
Anderson, D.2
Moran, M.F.3
Ellis, C.4
Pawson, T.5
-
69
-
-
0029881450
-
The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase.
-
Grzesiek, S., Bax, A., Clore, M., Gronenborn, A.M., Hu, J.-S., Kaufman, J., Palmer, I., Stahl, S.J., Wingfield, P.T., The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase. Nat. Struct. Biol. 3 (1996), 340–345.
-
(1996)
Nat. Struct. Biol.
, vol.3
, pp. 340-345
-
-
Grzesiek, S.1
Bax, A.2
Clore, M.3
Gronenborn, A.M.4
Hu, J.-S.5
Kaufman, J.6
Palmer, I.7
Stahl, S.J.8
Wingfield, P.T.9
-
70
-
-
0028895156
-
SH2 and SH3 domains: Potential targets for anti-cancer drug design.
-
Smithgall, T.E., SH2 and SH3 domains: Potential targets for anti-cancer drug design. J. Pharmacol. Toxicol. Methods 34 (1995), 125–132.
-
(1995)
J. Pharmacol. Toxicol. Methods
, vol.34
, pp. 125-132
-
-
Smithgall, T.E.1
-
71
-
-
0032515399
-
Exploring the leucine-proline binding pocket of the src SH3 domain using structure-based, split-pool synthesis and affinity-based selection.
-
Morken, J.P., Kapoor, T.M., Feng, S., Shirai, F., Schreiber, S.L., Exploring the leucine-proline binding pocket of the src SH3 domain using structure-based, split-pool synthesis and affinity-based selection. J. Am. Chem. Soc. 120 (1998), 30–36.
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 30-36
-
-
Morken, J.P.1
Kapoor, T.M.2
Feng, S.3
Shirai, F.4
Schreiber, S.L.5
-
72
-
-
0032515410
-
Exploring the specificity pockets of two homologous SH3 domains using structure-based, split-pool synthesis and affinity-based selection.
-
Kapoor, T.M., Andreotti, A.H., Schreiber, S.L., Exploring the specificity pockets of two homologous SH3 domains using structure-based, split-pool synthesis and affinity-based selection. J. Am. Chem. Soc. 120 (1998), 23–29.
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 23-29
-
-
Kapoor, T.M.1
Andreotti, A.H.2
Schreiber, S.L.3
-
73
-
-
0028125329
-
Formation of a stable complex between the human immunodeficiency virus integrase protein and viral DNA.
-
Vink, C., Lutzke, R.A.P., Plasterk, R.H.A., Formation of a stable complex between the human immunodeficiency virus integrase protein and viral DNA. Nucleic Acids Res. 22 (1994), 4103–4110.
-
(1994)
Nucleic Acids Res.
, vol.22
, pp. 4103-4110
-
-
Vink, C.1
Lutzke, R.A.P.2
Plasterk, R.H.A.3
-
74
-
-
0030922072
-
A metal-induced conformational change and activation of HIV-1 integrase.
-
Asante-Appiah, E., Skalka, A.M., A metal-induced conformational change and activation of HIV-1 integrase. J. Biol. Chem. 272 (1997), 16196–16205.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 16196-16205
-
-
Asante-Appiah, E.1
Skalka, A.M.2
-
75
-
-
0028984923
-
2+-dependent 3′-processing activity for human immunodeficiency virus type 1 integrase in vitro: Real-time kinetic studies using fluorescence resonance energy transfer.
-
2+-dependent 3′-processing activity for human immunodeficiency virus type 1 integrase in vitro: Real-time kinetic studies using fluorescence resonance energy transfer. Biochemistry 34 (1995), 10205–10214.
-
(1995)
Biochemistry
, vol.34
, pp. 10205-10214
-
-
Lee, S.P.1
Kim, H.G.2
Censullo, M.L.3
Han, M.K.4
-
76
-
-
0029083428
-
Efficient magnesium-dependent human immunodeficiency virus type 1 integrase activity.
-
Engelman, A., Craigie, R., Efficient magnesium-dependent human immunodeficiency virus type 1 integrase activity. J. Virol. 69 (1995), 5908–5911.
-
(1995)
J. Virol.
, vol.69
, pp. 5908-5911
-
-
Engelman, A.1
Craigie, R.2
-
77
-
-
0030746054
-
Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity.
-
Bujacz, G., Alexandratos, J., Wlodawer, A., Merkel, G., Andrake, M., Katz, R.A., Skalka, A.M., Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity. J. Biol. Chem. 272 (1997), 18161–18168.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 18161-18168
-
-
Bujacz, G.1
Alexandratos, J.2
Wlodawer, A.3
Merkel, G.4
Andrake, M.5
Katz, R.A.6
Skalka, A.M.7
-
78
-
-
0030566832
-
The catalytic domain of human immunodeficiency virus integrase: Ordered active site in the F185H mutant.
-
Bujacz, G., Alexandratos, J., Qing, Z.L., Clement-Mella, C., Wlodawer, A., The catalytic domain of human immunodeficiency virus integrase: Ordered active site in the F185H mutant. FEBS Lett. 398 (1996), 175–178.
-
(1996)
FEBS Lett.
, vol.398
, pp. 175-178
-
-
Bujacz, G.1
Alexandratos, J.2
Qing, Z.L.3
Clement-Mella, C.4
Wlodawer, A.5
-
79
-
-
0029643952
-
Recombining the structures of HIV integrase, RuvC and RNase H.
-
Yang, W., Steitz, T.A., Recombining the structures of HIV integrase, RuvC and RNase H. Curr. Biol. 3 (1995), 131–134.
-
(1995)
Curr. Biol.
, vol.3
, pp. 131-134
-
-
Yang, W.1
Steitz, T.A.2
-
80
-
-
0030792182
-
Complementation of integrase function in HIV-1 virions.
-
Fletcher, T.M.I., Soares, M.A., McPhearson, S., Hui, H., Wiskerchen, M., Muesing, M.A., Shaw, G.M., Leavitt, A.D., Boeke, J.D., Hahn, B.H., Complementation of integrase function in HIV-1 virions. EMBO J. 16 (1997), 5123–5138.
-
(1997)
EMBO J.
, vol.16
, pp. 5123-5138
-
-
Fletcher, T.M.I.1
Soares, M.A.2
McPhearson, S.3
Hui, H.4
Wiskerchen, M.5
Muesing, M.A.6
Shaw, G.M.7
Leavitt, A.D.8
Boeke, J.D.9
Hahn, B.H.10
-
81
-
-
0028566214
-
Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5.
-
Kalpana, G.V., Marmon, S., Wang, W., Crabtree, G.R., Goff, S.P., Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5. Science 266 (1994), 2002–2006.
-
(1994)
Science
, vol.266
, pp. 2002-2006
-
-
Kalpana, G.V.1
Marmon, S.2
Wang, W.3
Crabtree, G.R.4
Goff, S.P.5
-
82
-
-
0032477738
-
Structure-function analysis of integrase interactor 1/hSNF5L1 reveals differential properties of two repeat motifs present in the highly conserved region.
-
Morozov, A., Yung, E., Kalpana, G.V., Structure-function analysis of integrase interactor 1/hSNF5L1 reveals differential properties of two repeat motifs present in the highly conserved region. Proc. Natl. Acad. Sci. U.S.A. 95 (1998), 1120–1125.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 1120-1125
-
-
Morozov, A.1
Yung, E.2
Kalpana, G.V.3
-
83
-
-
0028839344
-
HIV nuclear import is governed by the phophotyrosine-mediated binding of the matrix to the core domain of integrase.
-
Gallay, P., Swingler, S., Song, J., Bushman, F., Trono, D., HIV nuclear import is governed by the phophotyrosine-mediated binding of the matrix to the core domain of integrase. Cell (Cambridge, Mass.) 83 (1995), 569–576.
-
(1995)
Cell (Cambridge, Mass.)
, vol.83
, pp. 569-576
-
-
Gallay, P.1
Swingler, S.2
Song, J.3
Bushman, F.4
Trono, D.5
-
84
-
-
19244375366
-
The inhibition of human immunodeficiency virus proteases by interface peptides.
-
Schramm, H.J., Boetzel, J., Buttner, J., Fritsche, E., Gohring, W., Jaeger, E., Konig, S., Thumfart, O., Wenger, T., Nagel, N.E., Schramm, W., The inhibition of human immunodeficiency virus proteases by interface peptides. Antiviral Res. 30 (1996), 155–170.
-
(1996)
Antiviral Res.
, vol.30
, pp. 155-170
-
-
Schramm, H.J.1
Boetzel, J.2
Buttner, J.3
Fritsche, E.4
Gohring, W.5
Jaeger, E.6
Konig, S.7
Thumfart, O.8
Wenger, T.9
Nagel, N.E.10
Schramm, W.11
-
85
-
-
0030583586
-
Triterpenes as potential dimerization inhibitoon of HIV-1 protease.
-
Quere, L., Wenger, T., Schramm, H.J., Triterpenes as potential dimerization inhibitoon of HIV-1 protease. Biochem. Biophys. Res. Commun. 227 (1996), 484–488.
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.227
, pp. 484-488
-
-
Quere, L.1
Wenger, T.2
Schramm, H.J.3
-
86
-
-
0029966228
-
Engineering human immunodeficiency virus 1 protease heterodimers as macromolecular inhibitors of viral maturation.
-
McPhee, F., Good, A.C., Kuntz, I.D., Craik, C.S., Engineering human immunodeficiency virus 1 protease heterodimers as macromolecular inhibitors of viral maturation. Proc. Natl. Acad. Sci. U.S.A. 93 (1996), 11477–11481.
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 11477-11481
-
-
McPhee, F.1
Good, A.C.2
Kuntz, I.D.3
Craik, C.S.4
-
87
-
-
0026720467
-
Intracellular immunization-transdominant mutants of HIV gene-products as tools for the study and interruption of viral replication.
-
Feinberg, M.B., Trono, D., Intracellular immunization-transdominant mutants of HIV gene-products as tools for the study and interruption of viral replication. AIDS Res. Hum. Retroviruses 8 (1992), 1013–1022.
-
(1992)
AIDS Res. Hum. Retroviruses
, vol.8
, pp. 1013-1022
-
-
Feinberg, M.B.1
Trono, D.2
-
88
-
-
0028842828
-
Trans-dominant inhibitory human immunodeficiency virus type 1 protease monomers prevent protease activation and virion maturation.
-
Babe, L.M., Rose, J., Craik, C.S., Trans-dominant inhibitory human immunodeficiency virus type 1 protease monomers prevent protease activation and virion maturation. Proc. Natl. Acad. Sci. U.S.A. 92 (1995), 10069–10073.
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 10069-10073
-
-
Babe, L.M.1
Rose, J.2
Craik, C.S.3
-
89
-
-
0029839487
-
Intracellular expression of human immunodeficiency virus type 1(HIV-1) protease variants inhibits replication of wild-type and protease inhibitor-resistant HIV-1 strains in human T-cell lines.
-
Junker, U., Escaich, S., Plavec, I., Baker, J., McPhee, F., Rose, J.R., Craik, C.S., Bohnlein, E., Intracellular expression of human immunodeficiency virus type 1(HIV-1) protease variants inhibits replication of wild-type and protease inhibitor-resistant HIV-1 strains in human T-cell lines. J. Virol. 70 (1996), 7765–7772.
-
(1996)
J. Virol.
, vol.70
, pp. 7765-7772
-
-
Junker, U.1
Escaich, S.2
Plavec, I.3
Baker, J.4
McPhee, F.5
Rose, J.R.6
Craik, C.S.7
Bohnlein, E.8
-
90
-
-
0028213920
-
A Rev-inducible mutant gag gene stably transferred into T lymphocytes: An approach to gene therapy against human immunodeficiency virus type 1 infection.
-
Smythe, J., Sun, D., Thomson, M., Markham, P., Reitz, M.S.J., Gallo, R.C., Lisziewicz, J., A Rev-inducible mutant gag gene stably transferred into T lymphocytes: An approach to gene therapy against human immunodeficiency virus type 1 infection. Proc. Natl. Acad. Sci. U.S.A. 91 (1994), 3657–3661.
-
(1994)
Proc. Natl. Acad. Sci. U.S.A.
, vol.91
, pp. 3657-3661
-
-
Smythe, J.1
Sun, D.2
Thomson, M.3
Markham, P.4
Reitz, M.S.J.5
Gallo, R.C.6
Lisziewicz, J.7
-
91
-
-
0025986843
-
Dissociative inhibition of dimeric enzymes: Kinetic characterization of the inhibition of HIV-1 protease by its COOH-terminal tetrapeptide.
-
Zhang, Z.Y., Poorman, R.A., Maggiora, L.L., Heinrikson, R.L., Kezdy, F.J., Dissociative inhibition of dimeric enzymes: Kinetic characterization of the inhibition of HIV-1 protease by its COOH-terminal tetrapeptide. J. Biol. Chem. 266 (1991), 15591–15594.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 15591-15594
-
-
Zhang, Z.Y.1
Poorman, R.A.2
Maggiora, L.L.3
Heinrikson, R.L.4
Kezdy, F.J.5
-
92
-
-
0027087479
-
Synthetic “interface” peptides alter dimeric assembly of the HIV 1 and 2 proteases.
-
Babe, L.M., Rose, J., Craik, C.S., Synthetic “interface” peptides alter dimeric assembly of the HIV 1 and 2 proteases. Protein Sci. 1 (1992), 1244–1253.
-
(1992)
Protein Sci.
, vol.1
, pp. 1244-1253
-
-
Babe, L.M.1
Rose, J.2
Craik, C.S.3
-
93
-
-
0030805774
-
Discovery and analysis of inhibitors of the human immunodeficiency integrase.
-
Hazuda, D., Felock, P.J., Hastings, J.C., Pramanik, B., Wolfe, A.L., Discovery and analysis of inhibitors of the human immunodeficiency integrase. Drug Des. Discovery 15 (1997), 17–24.
-
(1997)
Drug Des. Discovery
, vol.15
, pp. 17-24
-
-
Hazuda, D.1
Felock, P.J.2
Hastings, J.C.3
Pramanik, B.4
Wolfe, A.L.5
-
94
-
-
0025366844
-
Human immunodeficiency virus integration protein expressed in Escherichia coli possesses selective DNA cleaving activity.
-
Sherman, P.A., Fyfe, J.A., Human immunodeficiency virus integration protein expressed in Escherichia coli possesses selective DNA cleaving activity. Proc. Natl. Acad. Sci. U.S.A. 87 (1990), 5119–5123.
-
(1990)
Proc. Natl. Acad. Sci. U.S.A.
, vol.87
, pp. 5119-5123
-
-
Sherman, P.A.1
Fyfe, J.A.2
-
95
-
-
0025903619
-
A rapid in vitro assay for HIV DNA integration.
-
Craigie, R., Mizuuchi, K., Bushman, F.D., Engelman, A., A rapid in vitro assay for HIV DNA integration. Nucleic Acids Res. 19 (1991), 2729–2734.
-
(1991)
Nucleic Acids Res.
, vol.19
, pp. 2729-2734
-
-
Craigie, R.1
Mizuuchi, K.2
Bushman, F.D.3
Engelman, A.4
-
96
-
-
0024431589
-
The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration.
-
Katzman, M., Katz, R.A., Skalka, A.M., Leis, J., The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration. J. Virol. 63 (1989), 5319–5327.
-
(1989)
J. Virol.
, vol.63
, pp. 5319-5327
-
-
Katzman, M.1
Katz, R.A.2
Skalka, A.M.3
Leis, J.4
-
98
-
-
0026072804
-
Substrate specificity of recombinant human immunodeficiency virus integrase protein.
-
La Femina, R.L., Callahan, P.L., Cordingley, M.G., Substrate specificity of recombinant human immunodeficiency virus integrase protein. J. Virol. 65 (1991), 5624–5630.
-
(1991)
J. Virol.
, vol.65
, pp. 5624-5630
-
-
La Femina, R.L.1
Callahan, P.L.2
Cordingley, M.G.3
-
99
-
-
0026537415
-
Both substrate and target oligonucleotide sequences affect in vitro integration mediated by human immunodeficiency virus type 1 integrase protein produced in
-
Leavitt, A.D., Rose, R.B., Varmus, H.E., Both substrate and target oligonucleotide sequences affect in vitro integration mediated by human immunodeficiency virus type 1 integrase protein produced in. Saccharomyces cerevisiae. J. Virol. 66 (1992), 2359–2368.
-
(1992)
Saccharomyces cerevisiae. J. Virol.
, vol.66
, pp. 2359-2368
-
-
Leavitt, A.D.1
Rose, R.B.2
Varmus, H.E.3
-
100
-
-
0025775488
-
DNA binding properties of the integrase proteins of human immunodeficiency viruses types 1 and 2.
-
Van Gent, D.C., Elgersma, Y., Bolk, M.W., Vink, C., Plasterk, R.H.A., DNA binding properties of the integrase proteins of human immunodeficiency viruses types 1 and 2. Nucleic Acids Res. 19 (1991), 3821–3827.
-
(1991)
Nucleic Acids Res.
, vol.19
, pp. 3821-3827
-
-
Van Gent, D.C.1
Elgersma, Y.2
Bolk, M.W.3
Vink, C.4
Plasterk, R.H.A.5
-
101
-
-
0027136287
-
Rapid solution assays for retroviral integration reactions and their use in kinetic analyses of wild-type and mutant Rous sarcoma virus integrases.
-
Müller, B., Jones, K.S., Merkel, G.W., Skalka, A.M., Rapid solution assays for retroviral integration reactions and their use in kinetic analyses of wild-type and mutant Rous sarcoma virus integrases. Proc. Natl. Acad. Sci. U.S.A. 90 (1993), 11633–11637.
-
(1993)
Proc. Natl. Acad. Sci. U.S.A.
, vol.90
, pp. 11633-11637
-
-
Müller, B.1
Jones, K.S.2
Merkel, G.W.3
Skalka, A.M.4
-
102
-
-
0028238134
-
A high-throughput, non-radioactive microtiter plate assay for activity of the human immnodeficiency virus integrase protein.
-
Vink, C., Banks, M., Bethell, R., Plasterk, R.H.A., A high-throughput, non-radioactive microtiter plate assay for activity of the human immnodeficiency virus integrase protein. Nucleic Acids Res. 22 (1994), 2176–2177.
-
(1994)
Nucleic Acids Res.
, vol.22
, pp. 2176-2177
-
-
Vink, C.1
Banks, M.2
Bethell, R.3
Plasterk, R.H.A.4
-
103
-
-
0028303481
-
A novel assay for the DNA strand-transfer reaction of HIV-1 integrase.
-
Hazuda, D.J., Hastings, J.C., Wolfe, A.L., Emini, E.A., A novel assay for the DNA strand-transfer reaction of HIV-1 integrase. Nucleic Acids Res. 22 (1994), 1121–1122.
-
(1994)
Nucleic Acids Res.
, vol.22
, pp. 1121-1122
-
-
Hazuda, D.J.1
Hastings, J.C.2
Wolfe, A.L.3
Emini, E.A.4
-
104
-
-
0029938801
-
Assaying the activity of HIV-1 integrase with DNA-coated plates.
-
Chang, Y.C., Ching, T.T., Syu, W.J., Assaying the activity of HIV-1 integrase with DNA-coated plates. J. Virol. Methods 59 (1996), 135–140.
-
(1996)
J. Virol. Methods
, vol.59
, pp. 135-140
-
-
Chang, Y.C.1
Ching, T.T.2
Syu, W.J.3
-
105
-
-
0025133394
-
Retroviral DNA integration directed by HIV integration protein in vitro.
-
Bushman, F.D., Fujiwara, T., Craigie, R., Retroviral DNA integration directed by HIV integration protein in vitro. Science 249 (1990), 1555–1558.
-
(1990)
Science
, vol.249
, pp. 1555-1558
-
-
Bushman, F.D.1
Fujiwara, T.2
Craigie, R.3
-
106
-
-
0026034790
-
Activities of human immunodeficiency virus (HIV) integration protein in vitro: Specific cleavage and integration of HIV DNA.
-
Bushman, F.D., Craigie, R., Activities of human immunodeficiency virus (HIV) integration protein in vitro: Specific cleavage and integration of HIV DNA. Proc. Natl. Acad. Sci. U.S.A. 88 (1991), 1339–1343.
-
(1991)
Proc. Natl. Acad. Sci. U.S.A.
, vol.88
, pp. 1339-1343
-
-
Bushman, F.D.1
Craigie, R.2
-
107
-
-
0026740842
-
Identification of amino acid residues critical for endonuclease and integration activities of HIV-1 protein in vitro.
-
Drelich, M., Wilhelm, R., Mous, J., Identification of amino acid residues critical for endonuclease and integration activities of HIV-1 protein in vitro. Virology 188 (1992), 459–468.
-
(1992)
Virology
, vol.188
, pp. 459-468
-
-
Drelich, M.1
Wilhelm, R.2
Mous, J.3
-
108
-
-
0029091789
-
Substrate-length-dependent activities of human immunodeficiency type 1 integrase in vitro: Differential DNA binding affinities associated with different lenghths of substrates.
-
Lee, S.P., Censullo, M.L., Kim, H.G., Han, M.K., Substrate-length-dependent activities of human immunodeficiency type 1 integrase in vitro: Differential DNA binding affinities associated with different lenghths of substrates. Biochemistry 34 (1995), 10215–10223.
-
(1995)
Biochemistry
, vol.34
, pp. 10215-10223
-
-
Lee, S.P.1
Censullo, M.L.2
Kim, H.G.3
Han, M.K.4
-
109
-
-
0028924311
-
Three-dimensional quantitative structure-activity relationship (QSAR) of HIV integrase inhibitors: A comparative molecular field analysis (CoMFA) study.
-
Raghavan, K., Buolamwini, J.K., Fesen, M.R., Pommier, Y., Kohn, K.W., Weinstein, J.N., Three-dimensional quantitative structure-activity relationship (QSAR) of HIV integrase inhibitors: A comparative molecular field analysis (CoMFA) study. J. Med. Chem. 38 (1995), 890–897.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 890-897
-
-
Raghavan, K.1
Buolamwini, J.K.2
Fesen, M.R.3
Pommier, Y.4
Kohn, K.W.5
Weinstein, J.N.6
-
110
-
-
0031469396
-
Potent inhibitors of human immunodeficiency virus type 1 integrase: Identification of a novel four-point pharmacophore and tetracyclines as novel inhibitors.
-
Neamati, N., Hong, H., Sunder, S., Milne, G.W.A., Pommier, Y., Potent inhibitors of human immunodeficiency virus type 1 integrase: Identification of a novel four-point pharmacophore and tetracyclines as novel inhibitors. Mol. Pharmacol. 52 (1997), 1041–1055.
-
(1997)
Mol. Pharmacol.
, vol.52
, pp. 1041-1055
-
-
Neamati, N.1
Hong, H.2
Sunder, S.3
Milne, G.W.A.4
Pommier, Y.5
-
111
-
-
0030933554
-
Discovery of human immunodeficiency virus type 1 integrase inhibitors by pharmacophore searching.
-
Hong, H., Neamati, N., Wang, S., Nicklaus, M., Mazumder, A., Zhao, H., Burke, T.R., Pommier, Y., Milne, G.W.A., Discovery of human immunodeficiency virus type 1 integrase inhibitors by pharmacophore searching. J. Med. Chem. 40 (1997), 930–936.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 930-936
-
-
Hong, H.1
Neamati, N.2
Wang, S.3
Nicklaus, M.4
Mazumder, A.5
Zhao, H.6
Burke, T.R.7
Pommier, Y.8
Milne, G.W.A.9
-
112
-
-
0028824133
-
Hydroxylated aromatic inhibitors of HIV-1 integrase.
-
Burke, T.R., Fesen, M., Mazumder, A., Yung, J., Wang, J., Carothers, A.M., Grunberger, D., Driscoll, J., Pommier, Y., Hydroxylated aromatic inhibitors of HIV-1 integrase. J. Med. Chem. 38 (1995), 4171–4178.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 4171-4178
-
-
Burke, T.R.1
Fesen, M.2
Mazumder, A.3
Yung, J.4
Wang, J.5
Carothers, A.M.6
Grunberger, D.7
Driscoll, J.8
Pommier, Y.9
-
113
-
-
0031013534
-
Coumarin-based inhibitors of HIV integrase.
-
Zhao, H., Neamati, N., Hong, H., Mazumder, A., Wang, S., Sunder, S., Milne, G.W.A., Pommier, Y., Burke, T.R. Jr., Coumarin-based inhibitors of HIV integrase. J. Med. Chem. 40 (1996), 242–249.
-
(1996)
J. Med. Chem.
, vol.40
, pp. 242-249
-
-
Zhao, H.1
Neamati, N.2
Hong, H.3
Mazumder, A.4
Wang, S.5
Sunder, S.6
Milne, G.W.A.7
Pommier, Y.8
Burke, T.R.9
-
114
-
-
0030936836
-
Arylamide inhibitors of HIV-1 integrase.
-
Zhao, H., Neamati, N., Mazumder, A., Sunder, S., Pommier, Y., Burke, T., Arylamide inhibitors of HIV-1 integrase. J. Med. Chem. 40 (1997), 1186–1194.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 1186-1194
-
-
Zhao, H.1
Neamati, N.2
Mazumder, A.3
Sunder, S.4
Pommier, Y.5
Burke, T.6
-
115
-
-
0030946320
-
Hydrazine-containing inhibitors of HIV-1 integrase.
-
Zhao, H., Neamati, N., Sunder, S., Hong, H., Wang, S., Milne, G.W.A., Pommier, Y., Burke, T., Hydrazine-containing inhibitors of HIV-1 integrase. J. Med. Chem. 40 (1997), 937–941.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 937-941
-
-
Zhao, H.1
Neamati, N.2
Sunder, S.3
Hong, H.4
Wang, S.5
Milne, G.W.A.6
Pommier, Y.7
Burke, T.8
-
116
-
-
0030805998
-
Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action.
-
Mazumder, A., Neamati, N., Sunder, S., Schulz, J., Pertz, H., Eich, E., Pommier, Y., Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action. J. Med. Chem. 40 (1997), 3057–3063.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 3057-3063
-
-
Mazumder, A.1
Neamati, N.2
Sunder, S.3
Schulz, J.4
Pertz, H.5
Eich, E.6
Pommier, Y.7
-
117
-
-
0342569810
-
Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor.
-
Lubkowski, J., Yang, F., Alexandratos, J., Wlodawer, A., Zhao, H., Burke, T.R., Neamati, N., Pommier, Y., Merkel, G., Skalka, A.M., Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor. Proc. Natl. Acad. Sci. U.S.A. 95 (1998), 4831–4836.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 4831-4836
-
-
Lubkowski, J.1
Yang, F.2
Alexandratos, J.3
Wlodawer, A.4
Zhao, H.5
Burke, T.R.6
Neamati, N.7
Pommier, Y.8
Merkel, G.9
Skalka, A.M.10
-
118
-
-
0001996953
-
HIV cDNA integration: Molecular biology and inhibitor development.
-
Farnet, C.M., Bushman, F.D., HIV cDNA integration: Molecular biology and inhibitor development. AIDS 10:Suppl. A (1996), S3–S11.
-
(1996)
AIDS
, vol.10
, pp. S3-S11
-
-
Farnet, C.M.1
Bushman, F.D.2
-
119
-
-
0030902816
-
HIV integrase: A target for AIDS therapeutics.
-
Thomas, M., Brady, L., HIV integrase: A target for AIDS therapeutics. Trends Biotechnol. 15 (1997), 167–172.
-
(1997)
Trends Biotechnol.
, vol.15
, pp. 167-172
-
-
Thomas, M.1
Brady, L.2
-
120
-
-
0027227754
-
Effect of topoisomerase inhibitors on the in vitro HIV DNA integration reaction.
-
Carteau, S., Mouscadet, J.-F., Goulaouic, H., Subra, F., Auclair, C., Effect of topoisomerase inhibitors on the in vitro HIV DNA integration reaction. Biochem. Biophys. Res. Commun. 192 (1993), 1409–1414.
-
(1993)
Biochem. Biophys. Res. Commun.
, vol.192
, pp. 1409-1414
-
-
Carteau, S.1
Mouscadet, J.-F.2
Goulaouic, H.3
Subra, F.4
Auclair, C.5
-
121
-
-
0030969341
-
Human immunodeficiency virus type 2 preintegration complexes: Activities in vitro and response to inhibitors.
-
Hansen, M.S.T., Bushman, F.D., Human immunodeficiency virus type 2 preintegration complexes: Activities in vitro and response to inhibitors. J. Virol. 71 (1997), 3351–3356.
-
(1997)
J. Virol.
, vol.71
, pp. 3351-3356
-
-
Hansen, M.S.T.1
Bushman, F.D.2
-
122
-
-
0029062402
-
Inhibition of human immunodeficiency virus type 1 integrase by a hydrophobic cation: The phenanthroline-cuprous complex.
-
Mazumder, A., Gupta, M., Perrin, D.M., Sigman, D.S., Rabinovitz, M., Pommier, Y., Inhibition of human immunodeficiency virus type 1 integrase by a hydrophobic cation: The phenanthroline-cuprous complex. AIDS Res. Hum. Retroviruses 11 (1995), 115–125.
-
(1995)
AIDS Res. Hum. Retroviruses
, vol.11
, pp. 115-125
-
-
Mazumder, A.1
Gupta, M.2
Perrin, D.M.3
Sigman, D.S.4
Rabinovitz, M.5
Pommier, Y.6
-
123
-
-
0029990185
-
Alternate strand DNA triple helix-mediated inhibition of HIV-1 U5 long terminal repeat integration in vitro.
-
Bouziane, M., Cherny, D.I., Mouscadet, J.-F., Auclair, C., Alternate strand DNA triple helix-mediated inhibition of HIV-1 U5 long terminal repeat integration in vitro. J. Biol. Chem. 271 (1996), 10359–10364.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 10359-10364
-
-
Bouziane, M.1
Cherny, D.I.2
Mouscadet, J.-F.3
Auclair, C.4
-
124
-
-
0029870911
-
A molecular mechanics and dynamics study of alternate triple-helices involving the integrase-binding site of the HIV-1 virus and oligonucleotides having a 3′-3′ internucleotide junction.
-
Ouali, M., Bouziane, M., Ketterle, C., Gabarro-Arpa, J., Auclair, C., Le Bret, M., A molecular mechanics and dynamics study of alternate triple-helices involving the integrase-binding site of the HIV-1 virus and oligonucleotides having a 3′-3′ internucleotide junction. J. Biomol. Struct. Dyn. 13 (1996), 835–853.
-
(1996)
J. Biomol. Struct. Dyn.
, vol.13
, pp. 835-853
-
-
Ouali, M.1
Bouziane, M.2
Ketterle, C.3
Gabarro-Arpa, J.4
Auclair, C.5
Le Bret, M.6
-
125
-
-
0028303604
-
Inhibition of the in vitro integration of Moloney murine leukemia virus DNA by the DNA minor groove binder netropsin.
-
Carteau, S., Mouscadet, J.F., Goulaouic, H., Subra, F., Auclair, C., Inhibition of the in vitro integration of Moloney murine leukemia virus DNA by the DNA minor groove binder netropsin. Biochem. Pharmacol. 47 (1994), 1821–1826.
-
(1994)
Biochem. Pharmacol.
, vol.47
, pp. 1821-1826
-
-
Carteau, S.1
Mouscadet, J.F.2
Goulaouic, H.3
Subra, F.4
Auclair, C.5
-
126
-
-
0026637636
-
Anti-HIV-1 activity of linked lexitropsins.
-
Wang, W., Lown, L., Anti-HIV-1 activity of linked lexitropsins. J. Med. Chem. 35 (1992), 2890–2897.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 2890-2897
-
-
Wang, W.1
Lown, L.2
-
127
-
-
0006430045
-
Identification of the antiviral nucleoside drug binding site of HIV-1 integrase by proteolytic peptide mapping.
-
Drake, R., Neamati, N., Sunthankar, P., Mazumder, A., Pommier, Y., Identification of the antiviral nucleoside drug binding site of HIV-1 integrase by proteolytic peptide mapping. Antiviral Res., 34, 1997, A42.
-
(1997)
Antiviral Res.
, vol.34
, pp. A42
-
-
Drake, R.1
Neamati, N.2
Sunthankar, P.3
Mazumder, A.4
Pommier, Y.5
-
128
-
-
0029055551
-
Isolation of high-affinity RNA ligands to HIV1 integrase from a random pool.
-
Allen, P., Worland, S., Gold, L., Isolation of high-affinity RNA ligands to HIV1 integrase from a random pool. Virology 209 (1995), 327–336.
-
(1995)
Virology
, vol.209
, pp. 327-336
-
-
Allen, P.1
Worland, S.2
Gold, L.3
-
129
-
-
0031886388
-
Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir).
-
Este, J.A., Cabrera, C., Schols, D., Cherepanov, P., Gutierrez, A., Witvrouw, M., Pannecouque, C., Debyser, Z., Rando, R.F., Clotet, B., Desmyter, J., De Clercq, E., Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir). Mol. Pharmacol. 53 (1998), 340–345.
-
(1998)
Mol. Pharmacol.
, vol.53
, pp. 340-345
-
-
Este, J.A.1
Cabrera, C.2
Schols, D.3
Cherepanov, P.4
Gutierrez, A.5
Witvrouw, M.6
Pannecouque, C.7
Debyser, Z.8
Rando, R.F.9
Clotet, B.10
Desmyter, J.11
De Clercq, E.12
-
130
-
-
0028820595
-
Effects of tyrphostins, protein kinase inhibitors, on human immunodeficiency virus type 1 integrase.
-
Mazumder, A., Gazit, A., Levitzki, A., Nicklaus, M., Yung, J., Kohlhagen, G., Pommier, Y., Effects of tyrphostins, protein kinase inhibitors, on human immunodeficiency virus type 1 integrase. Biochemistry 34 (1995), 15111–15121.
-
(1995)
Biochemistry
, vol.34
, pp. 15111-15121
-
-
Mazumder, A.1
Gazit, A.2
Levitzki, A.3
Nicklaus, M.4
Yung, J.5
Kohlhagen, G.6
Pommier, Y.7
-
131
-
-
0030041593
-
(-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase.
-
Eich, E., Petz, H., Kaloga, M., Schulz, J., Fesen, M.R., Mazumder, A., Pommier, Y., (-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase. J. Med. Chem. 39 (1996), 86–95.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 86-95
-
-
Eich, E.1
Petz, H.2
Kaloga, M.3
Schulz, J.4
Fesen, M.R.5
Mazumder, A.6
Pommier, Y.7
-
132
-
-
0028798026
-
Inhibition of human immunodeficiency virus integrase by bis-catechols.
-
La Femina, R.L., Graham, P.L., Le Grow, K., Hastings, J.C., Wolfe, A., Young, S.D., Emini, E.A., Hazuda, D., Inhibition of human immunodeficiency virus integrase by bis-catechols. Antimicrob. Agents Chemother. 39 (1995), 320–324.
-
(1995)
Antimicrob. Agents Chemother.
, vol.39
, pp. 320-324
-
-
La Femina, R.L.1
Graham, P.L.2
Le Grow, K.3
Hastings, J.C.4
Wolfe, A.5
Young, S.D.6
Emini, E.A.7
Hazuda, D.8
-
133
-
-
10244260392
-
Dicaffeoylquinic acid inhibitors of human immunodeficiency virus integrase: Inhibition of the core catalytic domain of human immunodeficiency virus integrase.
-
Robinson, W.E., Cordeiro, M., Abdel-Malek, S., Jia, Q., Chow, S.A., Reinecke, M.G., Mitchell, W.M., Dicaffeoylquinic acid inhibitors of human immunodeficiency virus integrase: Inhibition of the core catalytic domain of human immunodeficiency virus integrase. Mol. Pharmacol. 50 (1996), 846–855.
-
(1996)
Mol. Pharmacol.
, vol.50
, pp. 846-855
-
-
Robinson, W.E.1
Cordeiro, M.2
Abdel-Malek, S.3
Jia, Q.4
Chow, S.A.5
Reinecke, M.G.6
Mitchell, W.M.7
-
134
-
-
0030891930
-
Depside and depsidones as inhibitors of HIV-1 integrase: Discovery of novel inhibitors through 3D database searching.
-
Neamati, N., Hong, H., Mazumder, A., Wang, S., Sunder, S., Nicklaus, M.C., Milne, G.W.A., Proska, B., Pommier, Y., Depside and depsidones as inhibitors of HIV-1 integrase: Discovery of novel inhibitors through 3D database searching. J. Med. Chem. 40 (1997), 942–951.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 942-951
-
-
Neamati, N.1
Hong, H.2
Mazumder, A.3
Wang, S.4
Sunder, S.5
Nicklaus, M.C.6
Milne, G.W.A.7
Proska, B.8
Pommier, Y.9
-
135
-
-
2642685126
-
Inhibitors of HIV-1 replication that inhibit HIV integrase.
-
Robinson, W.E., Reinecke, M.G., Abdel-Malek, S., Jia, Q., Chow, S.A., Inhibitors of HIV-1 replication that inhibit HIV integrase. Proc. Natl. Acad. Sci. U.S.A. 93 (1996), 6326–6331.
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 6326-6331
-
-
Robinson, W.E.1
Reinecke, M.G.2
Abdel-Malek, S.3
Jia, Q.4
Chow, S.A.5
-
136
-
-
0030576651
-
Cell protein-crosslinking by erbstatin and related compounds.
-
Stanwell, C., Ye, B., Yuspa, S.H., Burke, T.R., Cell protein-crosslinking by erbstatin and related compounds. Biochem. Pharmacol. 52 (1996), 475–480.
-
(1996)
Biochem. Pharmacol.
, vol.52
, pp. 475-480
-
-
Stanwell, C.1
Ye, B.2
Yuspa, S.H.3
Burke, T.R.4
-
137
-
-
0029439547
-
Plant polyphenols: Free radical scavenger or chain-breaking antioxidants?
-
Rice-Evans, C., Plant polyphenols: Free radical scavenger or chain-breaking antioxidants?. Biochem. Soc. Symp. 61 (1995), 103–116.
-
(1995)
Biochem. Soc. Symp.
, vol.61
, pp. 103-116
-
-
Rice-Evans, C.1
-
138
-
-
17744419436
-
The anti-HIV activity and mechanisms of action of pure compounds isolated from Rosa damascena.
-
Mahmood, N., Piacente, S., Pizza, C., Burke, A., Khan, A.I., Hay, A.J., The anti-HIV activity and mechanisms of action of pure compounds isolated from Rosa damascena. Biochem. Biophys. Res. Commun. 229 (1996), 73–79.
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.229
, pp. 73-79
-
-
Mahmood, N.1
Piacente, S.2
Pizza, C.3
Burke, A.4
Khan, A.I.5
Hay, A.J.6
-
139
-
-
0030061391
-
Inhibition of HIV activation in latently infected cells by flavonoid compounds.
-
Critchfield, J.W., Butera, S.T., Folks, T.M., Inhibition of HIV activation in latently infected cells by flavonoid compounds. AIDS Res. Hum. Retroviruses 12 (1996), 39–46.
-
(1996)
AIDS Res. Hum. Retroviruses
, vol.12
, pp. 39-46
-
-
Critchfield, J.W.1
Butera, S.T.2
Folks, T.M.3
-
140
-
-
0028928463
-
Inhibition of human immunodeficiency virus type-1 integrase by curcumin.
-
Mazumder, A., Raghavan, K., Weinstein, J., Kohn, K.W., Pommier, Y., Inhibition of human immunodeficiency virus type-1 integrase by curcumin. Biochem. Pharmacol. 49 (1995), 1165–1170.
-
(1995)
Biochem. Pharmacol.
, vol.49
, pp. 1165-1170
-
-
Mazumder, A.1
Raghavan, K.2
Weinstein, J.3
Kohn, K.W.4
Pommier, Y.5
-
141
-
-
15844424316
-
Antiretroviral agent as inhibitors of both human immunodeficiency virus type 1 integrase and protease.
-
Mazumder, A., Wang, S., Neamati, N., Nicklaus, M., Sunder, S., Chen, J., Milne, G., Rice, W.G., Burke, T.R., Pommier, Y., Antiretroviral agent as inhibitors of both human immunodeficiency virus type 1 integrase and protease. J. Med. Chem. 39 (1996), 2472–2481.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 2472-2481
-
-
Mazumder, A.1
Wang, S.2
Neamati, N.3
Nicklaus, M.4
Sunder, S.5
Chen, J.6
Milne, G.7
Rice, W.G.8
Burke, T.R.9
Pommier, Y.10
-
142
-
-
0006807931
-
Design and synthesis of photoactivatable coumarin-containing HIV-1 integrase inhibitors.
-
Zhao, H., Neamati, N., Pommier, Y., Burke, T.R., Design and synthesis of photoactivatable coumarin-containing HIV-1 integrase inhibitors. Heterocycles 45 (1997), 2277–2282.
-
(1997)
Heterocycles
, vol.45
, pp. 2277-2282
-
-
Zhao, H.1
Neamati, N.2
Pommier, Y.3
Burke, T.R.4
-
143
-
-
14444276046
-
Salicylhydrazinecontaining inhibitors of HIV-1 integrase: Implication for a selective chelation in the integrase active site.
-
Neamati, N., Hong, H., Owen, J.M., Sunder, S., Winslow, H.E., Christensen, J.L., Zhao, H., Burke, J.T.R., Milne, G.W.A., Pommier, Y., Salicylhydrazinecontaining inhibitors of HIV-1 integrase: Implication for a selective chelation in the integrase active site. J. Med. Chem. 41 (1998), 3202–3209.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 3202-3209
-
-
Neamati, N.1
Hong, H.2
Owen, J.M.3
Sunder, S.4
Winslow, H.E.5
Christensen, J.L.6
Zhao, H.7
Burke, J.T.R.8
Milne, G.W.A.9
Pommier, Y.10
-
144
-
-
0026590931
-
HIV-1 integrase: High-level production and screening assay for the endonucleolytic activity.
-
Billich, A., Schauer, M., Frank, S., Rosenwirth, B., Billich, S., HIV-1 integrase: High-level production and screening assay for the endonucleolytic activity. Antiviral Chem. Chemother. 3 (1992), 113–119.
-
(1992)
Antiviral Chem. Chemother.
, vol.3
, pp. 113-119
-
-
Billich, A.1
Schauer, M.2
Frank, S.3
Rosenwirth, B.4
Billich, S.5
-
145
-
-
0031046693
-
Diarylsulfones, a novel class of HIV-1 integrase inhibitors.
-
Neamati, N., Mazumder, A., Zhao, H., Sunder, S., Burke, T.R., Schultz, R.J., Pommier, Y., Diarylsulfones, a novel class of HIV-1 integrase inhibitors. Antimicrobiol. Agents Chemother. 41 (1997), 385–393.
-
(1997)
Antimicrobiol. Agents Chemother.
, vol.41
, pp. 385-393
-
-
Neamati, N.1
Mazumder, A.2
Zhao, H.3
Sunder, S.4
Burke, T.R.5
Schultz, R.J.6
Pommier, Y.7
-
146
-
-
0030867109
-
2-Mercaptobenzenesulfonamides as novel inhibitors of human immunodeficiency virus type 1 integrase and replication.
-
Neamati, N., Mazumder, A., Sunder, S., Owen, J.M., Schultz, R.J., Pommier, Y., 2-Mercaptobenzenesulfonamides as novel inhibitors of human immunodeficiency virus type 1 integrase and replication. Antiviral Chem. Chemother. 8 (1997), 485–495.
-
(1997)
Antiviral Chem. Chemother.
, vol.8
, pp. 485-495
-
-
Neamati, N.1
Mazumder, A.2
Sunder, S.3
Owen, J.M.4
Schultz, R.J.5
Pommier, Y.6
-
147
-
-
0029557124
-
Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library.
-
Lutzke, R.A.P., Eppens, N.A., Weber, P.A., Houghten, R.A., Plasterk, R.H.A., Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library. Proc. Natl. Acad. Sci. U.S.A. 92 (1995), 11456–11460.
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 11456-11460
-
-
Lutzke, R.A.P.1
Eppens, N.A.2
Weber, P.A.3
Houghten, R.A.4
Plasterk, R.H.A.5
-
148
-
-
0029743107
-
A synthetic peptide from the human immunodeficiency virus type-1 integrase exhibits coiled-coil properties and interferes with the in vitro integration activity of the enzyme. Correlated biochemical and spectroscopic results.
-
Sourgen, F., Maroun, R.G., Frere, V., Bouziane, M., Auclair, C., Troalen, F., Fermandjian, S., A synthetic peptide from the human immunodeficiency virus type-1 integrase exhibits coiled-coil properties and interferes with the in vitro integration activity of the enzyme. Correlated biochemical and spectroscopic results. Eur. J. Biochem. 240 (1996), 765–773.
-
(1996)
Eur. J. Biochem.
, vol.240
, pp. 765-773
-
-
Sourgen, F.1
Maroun, R.G.2
Frere, V.3
Bouziane, M.4
Auclair, C.5
Troalen, F.6
Fermandjian, S.7
-
149
-
-
0028225959
-
Human immunodeficiency virus type 1 integrase: Effect on viral replication of mutation at hightly conserved residues.
-
Cannon, P.M., Wilson, W., Byles, E., Kingsman, S.M., Kingsman, A.J.K., Human immunodeficiency virus type 1 integrase: Effect on viral replication of mutation at hightly conserved residues. J. Virol. 68 (1994), 4768–4775.
-
(1994)
J. Virol.
, vol.68
, pp. 4768-4775
-
-
Cannon, P.M.1
Wilson, W.2
Byles, E.3
Kingsman, S.M.4
Kingsman, A.J.K.5
-
150
-
-
10344256143
-
Intracellular expression of single-chain variable fragments to inhibit early stages of the viral life cycle by targeting human immunodeficiency virus type 1 integrase.
-
Levy-Mintz, P., Duan, L., Zhang, H., Hu, B., Dornadula, G., Zhu, M., Kulkosky, J., Bizub-Bender, D., Skalka, A.M., Pomerantz, R.J., Intracellular expression of single-chain variable fragments to inhibit early stages of the viral life cycle by targeting human immunodeficiency virus type 1 integrase. J. Virol. 70 (1996), 8821–8832.
-
(1996)
J. Virol.
, vol.70
, pp. 8821-8832
-
-
Levy-Mintz, P.1
Duan, L.2
Zhang, H.3
Hu, B.4
Dornadula, G.5
Zhu, M.6
Kulkosky, J.7
Bizub-Bender, D.8
Skalka, A.M.9
Pomerantz, R.J.10
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