Design and discovery of HIV-1 integrase inhibitors

Drug Discovery Today

Volumn 2, Issue 11, 1997, Pages 487-498

  Neamati, Nouri ^a   Sunder, Sanjay ^a   Pommier, Yves ^a  

^a Laboratory of Molecular Pharmacology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; ANTIVIRUS AGENT; AROMATIC COMPOUND; COUMARIN DERIVATIVE; GUANOSINE DERIVATIVE; INTEGRASE; NUCLEOSIDE DERIVATIVE; PEPTIDE DERIVATIVE; SULFONAMIDE; SULFONIC ACID DERIVATIVE; SYNTHETIC PEPTIDE;

ANTIVIRAL ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; REVIEW;

EID: 0030855938     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(97)01105-7     Document Type: Review

References (57)

1. Katz, R.A. and Skalka, A.M. (1994) Annu. Rev. Biochem. 63, 133-173
2. Rice, P., Craigie, R. and Davies, D.R. (1996) Curr. Opin. Struct. Biol. 6, 76-83
3. Pommier, Y. et al. Antiviral Chem. Chemother. (in press)
4. Mazumder, A. et al. in Methods in Cellular and Molecular Biology: Antiviral Evaluation (Kinchington, D. and Schinazi, R., eds), Humana Press (in press)
5. Dyda, F. et al. (1994) Science 266, 1981-1986
6. Bujacz, G. et al. (1995) J. Mol. Biol. 253, 333-346
7. Nicklaus, M.C. et al. (1997) J. Med. Chem. 40, 920-929
8. Neamati, N. et al. (1997) J. Med. Chem. 40, 942-951
9. Hong, H. et al. (1997) J. Med. Chem. 40, 930-936
10. Raghavan, K. et al. (1995) J. Med. Chem. 38, 890-897
11. Mazumder, A. et al. (1996) Biochemistry 35, 13762-13771
12. Mazumder, A et al. (1996) Mol. Pharmacol. 49, 621-628
13. Burke, T.R. et al. (1995) J. Med. Chem. 38, 4171-4178
14. Fesen, M.R. et al. (1994) Biochem. Pharmacol. 48, 595-608
15. Zhao, H. et al. (1997) J. Med. Chem. 40, 1186-1194
16. Zhao, H. et al. (1997) J. Med. Chem. 40, 242-249
17. Zhao, H. et al. (1997) J. Med. Chem. 40, 937-941
18. Mazumder, A et al. (1997) Mol. Pharmacol. 51, 567-575
19. Drake, R. et al. (1997) Antiviral Res. 34, A42
20. Farnet, C.M. et al. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 9742-9747
21. Farnet, C.M. and Bushman, F.D. (1996) AIDS 10 (Suppl. A), S3-S11
22. Mazumder, A. et al. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 5771-5775
23. Lipford, J.R., Worland, S.T. and Farnet, C.M. (1994) J. Acquired Immune Defic. Syndr. 7, 1215-1223
24. Allen, P., Worland, S. and Gold, L. (1995) Virology 209, 327-336
25. Fesen, M.R. et al. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 2399-2403
26. Billich, A. et al. (1992) Antiviral Chem. Chemother. 3, 113-119
27. Carteau, S. et al. (1993) Biochem. Biophys. Res. Commun. 192, 1409-1414
28. Mazumder, A. et al. (1995) AIDS Res. Hum. Retroviruses 11, 115-125
29. Neamati, N. et al. (1997) in Keystone Symposia on Molecular and Cellular Biology, p. 32, Keystone Symposia
30. Carteau, S. et al. (1994) Biochem. Pharmacol. 47, 1821-1826
31. Mouscadet, J.F. et al. (1994) J. Biol. Chem. 269, 21635-21638
32. Wang, W. and Lown, L. (1992) J. Med. Chem. 35, 2890-2897
33. Rice-Evans, C. (1995) Biochem. Soc. Symp. 61, 103-116
34. Mahmood, N. et al. (1996) Biochem. Biophys. Res. Commun. 229, 73-79
35. Critchfield, J.W., Butera, S.T. and Folks, T.M. (1996) AIDS Res. Hum. Retroviruses 12, 39-46
36. Mazumder, A. et al. (1995) Biochem. Pharmacol. 49, 1165-1170
37. Pfeifer, K. et al. (1992) J. Pharm. Med. 2, 75-97
38. Eich, E. et al. (1996) J. Med. Chem. 39, 86-95
39. LaFemina, R.L. et al. (1995) Antimicrob. Agents Chemother. 39, 320-324
40. Mazumder, A. et al. (1995) Biochemistry 34, 15111-15122
41. Robinson, W.E., Jr et al. (1996) Mol. Pharmacol. 50, 846-855
42. Robinson, W.E., Jr et al. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 6326-6331
43. Mazumder, A. et al. J. Med. Chem. (in press)
44. Stanwell, C. et al. (1996) Biochem. Pharmcol. 52, 475-480
45. Liehr, J.G. and Roy, D. (1990) Free Radical Biol. Med. 8, 415-423
46. Mazumder, A. et al. (1996) J. Med. Chem. 39, 2472-2481
47. Cushman, M. and Sherman, P. (1992) Biochem. Biophys. Res. Commun. 185, 85-90
48. Cushman, M. et al. (1995) J. Med. Chem. 38, 443-452
49. Carteau, S. et al. (1993) Arch. Biochem. Biophys. 305, 606-610
50. Neamati, N. et al. (1997) Antimicrob. Agents Chemother. 41, 385-393
51. Lutzke, R.A.P. et al. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 11456-11460
52. Sourgen, F. et al. (1996) Eur. J. Biochem. 240, 765-773
53. Lee-Huang, S. et al. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 8818-8822
54. Nilsen, B.M. et al. (1996) J. Virol. 70, 1580-1587
55. Barsov, E.V. et al. (1996) J. Virol. 70, 4484-4494
56. Bizub-Bender, D., Kulkosky, J. and Skalka, A.M. (1994) AIDS Res. Hum. Retroviruses 10, 1105-1115
57. Levy-Mintz, P. et al. (1996) J. Virol. 70, 8821-8832