Depsides and depsidones as inhibitors of HIV-1 integrase: Discovery of novel inhibitors through 3D database searching

Journal of Medicinal Chemistry

Volumn 40, Issue 6, 1997, Pages 942-951

  Neamati, Nouri ^a   Hong, Huixiao ^a   Mazumder, Abhijit ^a   Wang, Shaomeng ^a   Sunder, Sanjay ^a   Nicklaus, Marc C ^a   Milne, George W A ^a   Proksa, Bohumil ^b   Pommier, Yves ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SLOVAK UNIVERSITY OF TECHNOLOGY   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

DEPSIDE; DEPSIDONE; DNA TOPOISOMERASE; GLYCOPROTEIN GP 120; INTEGRASE; NSC 646008; NSC 657327; NSC 685587; NSC 87511; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; ENZYME INACTIVATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; VIRUS REPLICATION;

ANTI-HIV AGENTS; BINDING SITES; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DATABASES, FACTUAL; DEPSIDES; DNA TOPOISOMERASES, TYPE I; DRUG DESIGN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HIV-2; HYDROXYBENZOIC ACIDS; LACTONES; LICHENS; MOLECULAR STRUCTURE; OLIGODEOXYRIBONUCLEOTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030891930     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960759e     Document Type: Article

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