Salicylhydrazine-containing inhibitors of HIV-1 integrase: Implication for a selective chelation in the integrase active site

Journal of Medicinal Chemistry

Volumn 41, Issue 17, 1998, Pages 3202-3209

  Neamati, Nouri ^a   Hong, Huixiao ^a   Owen, Joshua M ^a   Sunder, Sanjay ^a   Winslow, Heather E ^a   Christensen, John L ^a   Zhao, He ^a   Burke Jr , Terrence R ^a   Milne, George W A ^a   Pommier, Yves ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRASE; INTEGRASE INHIBITOR; N N' BIS(SALICYLHYDRAZINE); NSC 157337; NSC 209034; NSC 209076; NSC 408200; NSC 60386; NSC 691994; NSC 87963; NSC 88155; NSC 88156; NSC 88159; NSC 88166; NSC 88167; NSC 88168; NSC 88169; NSC 88633; NSC 88634; NSC 91568; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CHELATION; DNA BINDING; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; STRUCTURE ACTIVITY RELATION;

BINDING SITES; COMPUTER GRAPHICS; DRUG DESIGN; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; HYDRAZINES; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OLIGODEOXYRIBONUCLEOTIDES; SALICYLAMIDES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 14444276046     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9801760     Document Type: Article

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