Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: Coupling glucose sensing to gene expression and the cell cycle

EMBO Journal

Volumn 16, Issue 18, 1997, Pages 5629-5638

  Li, Frank Ning ^a   Johnston, Mark ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

G1 cyclin turnover; Glucose signaling; Leucinerich repeats; Saccharomyces cerevisiae

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLINE; GLUCOSE; PROTEIN GRR1; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; YEAST CELL;

CARRIER PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; CYCLINS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENETIC COMPLEMENTATION TEST; GENOTYPE; GLUCOSE; LIGASES; PLASMIDS; RECOMBINANT FUSION PROTEINS; S-PHASE KINASE-ASSOCIATED PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES; UBIQUITINS;

SACCHAROMYCES CEREVISIAE;

EID: 0030874516     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.18.5629     Document Type: Article

References (43)

1. Bai, C., Sen, P., Hofmann, K., Ma, L., Goebl, M., Harper, J.W. and Elledge, S.J. (1996) SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell, 86, 263-274.
2. Bailey, R.B. and Woodword, A. (1984) Isolation and characterization of a pleiotropic glucose repression resistant mutant of Saccharomyces cerevisiae. Mol. Gen. Genet., 193, 507-512.
3. Baroni, M.D., Monti, P. and Alberghina, L. (1994) Repression of growth-regulated G1 cyclin expression by cyclic AMP in budding yeast. Nature, 371, 339-342.
4. Barral, Y., Jentsch, S. and Mann, C. (1995) G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast. Genes Dev., 9, 399-409.
5. Blondel, M. and Mann, C. (1996) G2 cyclins are required for the degradation of G1 cyclins in yeast. Nature, 384, 279-282.
6. Christianson, T.W., Sikorski, R.S., Dante, M., Shero, J.H and Hieter, P. (1992) Multifunctional yeast high-copy-number shuttle vectors. Gene, 110, 119-122.
7. Conklin, D.S., Kung, C. and Culbertson, M.R. (1993) The COT2 gene is required for glucose-dependent divalent cation transport in Saccharomyces cerevisiae. Mol. Cell. Biol., 13, 2041-2049.
8. Connelly, C. and Hieter, P. (1996) Budding yeast SKP1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression. Cell, 86, 275-285.
9. Deshaies, R.J., Chau, V. and Kirschner, M. (1995) Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway. EMBO J., 14, 303-312.
10. Durfee, T., Becherer, K., Chen, P.L., Yeh, S.H., Yang, Y.Z., Kilburn, A.E., Lee, W.H. and Elledge, S.J. (1993) The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev., 7, 555-569.
11. Erickson, J.R. and Johnston, M. (1994) Suppressors reveal two classes of glucose repression genes in the yeast Saccharomyces cerevisiae. Genetics, 136, 1271-1278.
12. Fields, S. and Song, O. (1989) A novel genetic system to detect protein-protein interactions. Nature, 340, 245-246.
13. Flick, J.S. and Johnston, M. (1991) GRR1 of Saccharomyces cerevisiae is required for glucose repression and encodes a protein with leucine-rich repeats. Mol. Cell. Biol., 11, 5101-5112.
14. Goebl, M.G., Yochem, J., Jentsch, S., McGrath, J.P., Varshavsky, A. and Byers, B. (1988) The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme. Science, 241, 1331-1335.
15. Hardy, C.F. and Pautz, A. (1996) A novel role for Cdc5p in DNA replication. Mol. Cell. Biol., 16, 6775-6782.
16. Harper, J.W., Adami, G.R., Wei, N., Keyomarsi, K. and Elledge, S.J. (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell, 75, 805-816.
17. Hicke, L. and Riezman, H. (1996) Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis. Cell, 84, 277-287.
18. Hochstrasser, M. (1995) Ubiquitin, proteasomes, and the regulation of intracellular protein degradation. Curr. Opin. Cell Biol., 7, 215-223.
19. Hochstrasser, M. (1996) Protein degradation or regulation: Ub the judge. Cell, 84, 813-815.
20. Jackson, P.K. (1996) Cell cycle: cull and destroy. Curr. Biol., 6, 1209-1212.
21. Johnston, M. and Carlson, M. (1993) Regulation of carbon and phosphate utilization. In Broach, J., Jones, E.W. and Pringle, J. (eds), The Biology of the Yeast Saccharomyces, vol. 2. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 193-281.
22. Kim, Y.J., Francisco, L., Chen, G.C., Marcotte, M. and Chan, C.S. (1994) Control of cellular morphogenesis by the Ip12/Bem2 GTPase-activating protein: possible role of protein phosphorylation. J. Cell Biol., 127, 1381-1394.
23. King, R.W., Deshaies, R.J., Peters, J.-M. and Kirschner, M.W. (1996) How proteolysis drives the cell cycle. Science, 274, 1652-1659.
24. Kobe, B. and Deisenhofer, J. (1994) The leucine-rich repeat: a versatile binding motif. Trends Biochem. Sci., 19, 415-421.
25. 1 cyclin Cln2 induced by CDK-dependent phosphorylation. Science, 271, 1597-1601.
26. Mathias, N., Johnson, S.L., Winey, M., Adams, A.E.M., Goetsch, L., Pringle, J.R., Byers, B. and Goebl, M. (1996) Cdc53 acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins. Mol. Cell. Biol., 16, 6634-6643.
27. Neer, E.J., Schmidt, C.J., Nambudripad, R. and Smith, T.F. (1994) The ancient regulatory-protein family of WD-repeat proteins. Nature, 371, 297-300.
28. Özcan, S. and Johnston, M. (1995) Three different regulatory mechanisms enable yeast hexose transporter (HXT) genes to be induced by different levels of glucose. Mol. Cell. Biol., 15, 1564-1572.
29. Özcan, S., Leong, T. and Johnston, M. (1996) Rgt1p of Saccharomyces cerevisiae, a key regulator of glucose-induced genes, is both an activator and a repressor of transcription. Mol. Cell. Biol., 16, 6419-6426.
30. Palombella, V.J., Rando, O.J., Goldberg, A.L. and Maniatis, T. (1994) The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell, 78, 773-785.
31. Printen, J.A. and Sprague, G.F., Jr. (1994) Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade. Genetics, 138, 609-619.
32. Ronne, H. (1995) Glucose repression in fungi. Trends Genet., 11, 12-17.
33. Salama, S.R., Hendricks, K.B. and Thorner, J. (1994) G1 cyclin degradation: the PEST motif of yeast Cln2 is necessary, but not sufficient, for rapid protein turnover. Mol. Cell. Biol., 14, 7953-7966.
34. sic1 controls the G1 to S transition in S.cerevisiae. Cell, 79, 233-244.
35. Tokiwa, G., Tyers, M., Volpe, T. and Futcher, B. (1994) Inhibition of G1 cyclin activity by the Ras/cAMP pathway in yeast. Nature, 371, 342-345.
36. Trumbly, R.J. (1992) Glucose repression in the yeast Saccharomyces cerevisiae. Mol. Microbiol., 6, 15-21.
37. Tyers, M., Tokiwa, G., Nash, R. and Futcher, B. (1992) The Cln3-Cdc28 kinase complex of S.cerevisiae is regulated by proteolysis and phosphorylation. EMBO J., 11, 1773-1784.
38. Vallier, L.G., Coons, D., Bisson, L.F. and Carlson, M. (1994) Altered regulatory responses to glucose are associated with a glucose transport defect in grr1 mutants of Saccharomyces cerevisiae. Genetics, 136, 1279-1285.
39. 1 cyclins for degradation by the ubiquitin proteolytic pathway. Cell, 86, 453-163.
40. CDC28 protein kinase. Cell, 62, 225-237.
41. CDC28-mediated control of Cln3 cyclin degradation. Mol. Cell. Biol., 15, 731-741.
42. Yochem, J. and Byers, B. (1987) Structural comparison of the yeast cell division cycle gene CDC4 and a related pseudogene. J. Mol. Biol., 195, 233-245.
43. Skp2 are essential elements of the cyclin A-CDK2 S-phase kinase. Cell, 82, 915-925.