Is the yeast Anaphase Promoting Complex needed to prevent re-replication during G2 and M phases?

EMBO Journal

Volumn 16, Issue 19, 1997, Pages 5988-5997

  Pichler, Silke ^a,c   Piatti, Simonetta ^b   Nasmyth, Kim ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^b Dipartimento di Biologia   (Italy)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

APC; Cyclin B Cdk1; DNA replication; Mitosis; Pre replication complex

Indexed keywords

CYCLINE; FUNGAL DNA; MITOCHONDRIAL DNA;

ANAPHASE; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL MUTANT; CHROMOSOME; CHROMOSOME REPLICATION; CONTROLLED STUDY; CYTOPLASM; DNA CONTENT; DNA REPLICATION; DNA REPLICATION ORIGIN; DNA SYNTHESIS; FUNGAL GENETICS; MITOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; YEAST;

BROMODEOXYURIDINE; DNA REPLICATION; DNA, FUNGAL; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; FUNGAL PROTEINS; G2 PHASE; LIGASES; MITOSIS; TEMPERATURE; UBIQUITIN-PROTEIN LIGASE COMPLEXES; UBIQUITIN-PROTEIN LIGASES;

EID: 0030824369     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.19.5988     Document Type: Article

References (61)

1. 1 cyclins in the next cell cycle. Cell, 77, 1037-1050.
2. Anachkova,B. and Hamlin,J.L. (1989) Replication in the amplified Dihydrofolate Reductase domain in CHO cells may initiate at two distinct sites, one of which is a repetitive sequence element. Mol. Cell Biol., 9, 532-540.
3. Suc1 of Schizosaccharomyces pombe regulates two distinct forms of the mitotic cdc2 kinase. Mol. Cell. Biol., 15, 2028-2036.
4. Baum,P., Yip,C., Goetsch,L. and Byers,B. (1988) A yeast gene essential for regulation of spindle pole duplication. Mol. Cell. Biol., 8, 5386-5397.
5. Booher,R.N., Alfa,C.E., Hyams,J.S. and Beach,D.H. (1989) The fission yeast cdc2/cdc13/suc1 protein kinase: regulation of catalytic activity and nuclear localization. Cell, 58, 485-497.
6. cdc2 in establishing the dependency of S phase on mitosis. Nature, 349, 388-393.
7. Bueno,A. and Russel,P. (1992) Dual function of CDC6: a yeast protein required for DNA replication also inhibits nuclear division. EMBO J., 11, 2167-2176.
8. Cohen-Fix,O., Peters,J.M., Kirschner,M.W. and Koshland,D. (1996) Anaphase initiation in S. cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes Dev., 10, 3081-3093.
9. Dahmann,C. (1995) Mechanisms that restrict DNA replication to once per cell cycle in the budding yeast Saccharomyces cerevisiae. PhD Thesis, University of Vienna, Austria.
10. Dahmann,C., Diffley,J.F.X. and Nasmyth,K. (1995) S-phase promoting cyclin dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state. Curr. Biol., 5, 1257-1269.
11. Diffley,J.F.X., Cocker,J.H., Dowell,S.J. and Rowley,A. (1994) Two steps in the assembly of complexes at yeast replication origins in vivo. Cell, 78, 303-316.
12. Doheny,K.F., Sorger,P., Hyman,A.A., Tugendreich,F.S. and Hieter,P. (1993) Identification of essential components of the Saccharomyces cerevisiae kinetochore. Cell, 73, 761-774.
13. Engle,D.B., Osmani,S.A., Osmani,A.H., Rosborough,S., Xiang,X. and Morris,N.R. (1990) A negative regulator of mitosis in Aspergillus is a putative membrane spanning protein. J. Biol. Chem., 265, 16132-16137.
14. Epstein,C.B. and Cross,F.R. (1992) CLB5: a novel B cyclin from budding yeast with a role in S-phase. Genes Dev., 6, 1695-1706.
15. 1 cyclins. EMBO J., 15, 850-860.
16. Fitch,I., Dahmann,C., Surana,U., Amon,A., Nasmyth,K., Goetsch,L., Byers,B. and Futcher,B. (1992) Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae. Mol. Biol. Cell, 3, 805-818.
17. Funabiki,H., Yamano,H., Kumada,K., Nagao,K., Hunt,T. and Yanagida,M. (1996) Cut2 proteolysis required for sister-chromatid separation in fission yeast. Nature, 381, 438-441.
18. Glotzer,M., Murray,A.W. and Kirschner,M.W. (1991) Cyclin is degraded by the ubiquitin pathway. Nature, 349, 132-138.
19. Goh,P.-Y. and Kilmartin,J.V. (1993) NDC10: a gene involved in chromosome segregation in S. cerevisiae. J. Cell Biol., 121, 503-512.
20. cdc2_mitotic B cyclin complex Cell, 78, 813-822.
21. Heichman,K. (1996) Cdc6 and DNA replication: limited to humble origins. BioEssays, 18, 859-862.
22. Heichman,K.A. and Roberts,J.M. (1996) The yeast CDC16 and CDC27 genes restrict DNA replication to once per cell cycle. Cell, 85, 39-48.
23. Hirano,T., Hiraoka,Y. and Yanagida,M. (1988) A temperature-sensitive mutation of the Schizosaccharomyces pombe gene nuc2 that encodes a nuclear scaffold-like protein blocks spindle elongation in mitotic anaphase. J. Cell Biol., 106, 1171-1183.
24. +. Cell, 60, 319-328.
25. Irniger,S., Piatti,S., Michaelis,C. and Nasmyth,K. (1995) Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. Cell, 81, 269-277.
26. CIP. J. Cell Biol., 130, 755-769.
27. Jiang,W., Lechner,J. and Carbon,J. (1993) Isolation and characterization of a gene (CBF2) specifying an essential protein component of the budding yeast kinetochore. J Cell Biol., 121, 513-519.
28. Juang,Y.-L., Huang,J., Peters,J.M., McLaughlin,M.E., Tai,C.-Y. and Pellman,D. (1997) APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle. Science, 275, 1311-1314.
29. + gene product couples S phase to START and mitosis. Cell, 74, 371-382.
30. King,R.W., Peters,J.-M., Tugendreich,S., Rolfe,M., Hieter,P. and Kirschner,M.W. (1995) A 20 S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell, 81, 279-288.
31. King,R.W., Deshaies,R.J., Peters,J.-M. and Kirschner,M.W. (1996) How proteolysis drives the cell cycle. Science, 274, 1652-1658.
32. Krude,T., Jackman,M., Pines,J. and Laskey,R.A. (1997) Cyclin/Cdk-dependent initiation of DNA replication in a human cell-free system. Cell, 88, 109-119.
33. Maniatis,T., Fritsch,E.F. and Sambrook,J. (1982) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
34. Mondesert,O., McGowan,C.H. and Russel,P. (1996) Cig2, a B-type cyclin, promotes the onset of S in Schizosaccharomyces pombe. Mol. Cell. Biol., 16, 1527-1533.
35. cdc2 protein kinase during mitosis. Cell, 58, 361-372.
36. Mortimer,R.K. and Hawthorne,D.C (1969) Yeast genetics. In Rose,A.M. and Harrison,J.S. (eds). The Yeasts. Academic Press, New York, Vol. 1, pp. 385-460.
37. Nasmyth,K. (1993) Control of the yeast cell cycle by the Cdc28 protein kinase. Curr. Opin. Cell Biol., 5, 166-179.
38. Neff,M.W. and Burke,D.J. (1991) Random segregation of chromatids at mitosis in Saccharomyces cerevisiae. Genetics, 127, 463-473.
39. Nurse,P. (1994) Ordering S phase and M phase in the cell cycle. Cell, 79, 547-550.
40. O'Donnell,K.L., Osmani,A.H., Osmani,S.A. and Morris,N.R. (1991) bimA encodes a member of the tetratricopeptide repeat family of proteins and is required for the completion of mitosis in Aspergillus nidulans. J. Cell Sci., 99, 711-719.
41. 1-to-S phase transition. Mol. Cell. Biol., 15, 2612-2624.
42. Peters,J.M., King,R.W., Hooeg,C. and Kirschner,M.W. (1996) Identification of BIME as a subunit of the anaphase-promoting complex. Science, 274, 1199-1201.
43. 1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae. EMBO J., 14, 3788-3799.
44. 1 defines a 'point of no return' after which Cdc6 cannot promote DNA replication in yeast. Genes Dev., 10, 1516-1531.
45. Samejima,I. and Yanagida,M. (1994) Bypassing anaphase by fission yeast cut9 mutation: requirement of Cut9 to initiate anaphase. J. Cell Biol., 127, 1655-1670.
46. Schwob,E. and Nasmyth,K. (1993) CLB5 and CLB6, a new pair of B-type cyclins involved in S phase and mitotic spindle formation in S. cerevisiae. Genes Dev., 7, 1160-1175.
47. 1 to S transition in S. cerevisiae. Cell, 79, 233-244.
48. Starborg,M., Brundell,E., Gell,K. and Hooeg,C. (1994) A novel murine gene encoding a 216-kDa protein is related to a mitotic checkpoint regulator previously identified in Aspergillus nidulans. J. Biol. Chem., 269, 24133-24137.
49. Strausfeld,U.P., Howell,M., Descombes,P., Chevalier,S., Rempel,R.E., Adamczewski,J., Maller,J.L., Hunt,T. and Blow,J.J. (1996) Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts. J. Cell Sci., 109, 1555-1563.
50. Sudakin,V., Ganoth,D., Daha,A., Heller,H., Herschko,J., Luca,F.C., Ruderman,J.V. and Herschko,A. (1995) The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell, 6, 185-198.
51. Surana,U., Robitsch,H., Price,C., Fitch,I., Futcher,A.B. and Nasmyth,K. (1991) The role of Cdc28 and cyclins during mitosis in the budding yeast S. cerevisiae. Cell, 65, 145-161.
52. Surana,U., Amon,A., Dowzer,C., McGrew,J., Byers,B. and Nasmyth,K. (1993) Destruction of the Cdc28/Clb kinase is not required for metaphase/anaphase transition in yeast. EMBO J., 12, 1969-1978.
53. Tanaka,T., Knapp,D. and Nasmyth,K. (1997) Loading of an Mcm protein onto DNA replication origins is regulated by Cdcbp and CDks. Cell, in press.
54. Tugendreich,S., Tomkiel,J., Earnshaw,W. and Hieter,P. (1995) CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. Cell, 81, 261-268.
55. Vassilev,L. and Johnson,E.M. (1989) Mapping initiation sites of DNA replication in vivo using polymerase chain reaction amplification of nascent strand segments. Nucleic Acids Res., 17, 7693-7705.
56. Vassilev,L. and Johnson,E.M. (1990) An initiation zone of chromosomal DNA replication located upstream of the c-myc gene in proliferating HeLa cells. Mol. Cell. Biol., 10, 4899-4904.
57. Vassilev,L. and Russev,G. (1988) Purification of nascent DNA chains by immunoprecipitation with anti-BrdU antibodies. Nucleic Acids Res., 16, 10397.
58. Wuarin,J. and Nurse,P. (1996) Regulating S phase: CDKs, licensing and proteolysis. Cell, 85, 785-787.
59. Yamashita,Y.M., Nakaseko,Y., Samejima,I., Kumada,K., Yamada,H., Michaelson,D. and Yanagida,M. (1996) 20S cyclosome complex formation and proteolytic activity inhibited by the cAMP/PKA pathway. Nature, 384, 276-279.
60. Zachariae,W. and Nasmyth,K. (1996) TPR proteins required for anaphase progression mediate ubiquitination of the Clb2 B-type cyclin in yeast. Mol. Biol. Cell, 7, 791-801.
61. Zachariae,W., Shin,T.H., Galova,M., Obermaier,B. and Nasmyth,K. (1996) Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae. Science, 274, 1201-1204.