-
1
-
-
0021207461
-
Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
-
Glenner GG, Wong CW. Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun 1984;122:1131-1135.
-
(1984)
Biochem Biophys Res Commun
, vol.122
, pp. 1131-1135
-
-
Glenner, G.G.1
Wong, C.W.2
-
2
-
-
0023105114
-
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
-
Kang J, Lemaire H-G, Unterbeck A, et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 1987;325:733-736.
-
(1987)
Nature
, vol.325
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.-G.2
Unterbeck, A.3
-
3
-
-
0024237246
-
Diffuse type of senile plaques in the brains of Alzheimer-type dementia
-
Yamaguchi H, Hirai S, Morimatsu M, Shoji M, Harigaya Y. Diffuse type of senile plaques in the brains of Alzheimer-type dementia. Acta Neuropathol 1988;77:113-119.
-
(1988)
Acta Neuropathol
, vol.77
, pp. 113-119
-
-
Yamaguchi, H.1
Hirai, S.2
Morimatsu, M.3
Shoji, M.4
Harigaya, Y.5
-
4
-
-
0023798449
-
Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals
-
Tagliavini F, Giaccone G, Frangione B, Bugiani O. Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals. Neurosci Lett 1988;93:191-196.
-
(1988)
Neurosci Lett
, vol.93
, pp. 191-196
-
-
Tagliavini, F.1
Giaccone, G.2
Frangione, B.3
Bugiani, O.4
-
5
-
-
0028169925
-
Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: Evidence that an initially deposited species is A beta 42(43)
-
Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina H, Ihara Y. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron 1994;13:45-53.
-
(1994)
Neuron
, vol.13
, pp. 45-53
-
-
Iwatsubo, T.1
Odaka, A.2
Suzuki, N.3
Mizusawa, H.4
Nukina, H.5
Ihara, Y.6
-
6
-
-
0030464914
-
β-Amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease
-
Cummings BJ, Pike CJ, Shankle R, Cotman CW. β-Amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease. Neurobiol Ageing 1996;17:921-933.
-
(1996)
Neurobiol Ageing
, vol.17
, pp. 921-933
-
-
Cummings, B.J.1
Pike, C.J.2
Shankle, R.3
Cotman, C.W.4
-
7
-
-
10644229179
-
Preface
-
Verbeek MM, de Wall RMV, Vinters HV, editors. Dordrecht, The Netherlands: Kleuwer
-
Selkoe DJ. Preface. In: Verbeek MM, de Wall RMV, Vinters HV, editors. Cerebral Amyloid Angiopathy in Alzheimer's disease and related disorders, Dordrecht, The Netherlands: Kleuwer, 2000. pp. 357.
-
(2000)
Cerebral Amyloid Angiopathy in Alzheimer's Disease and Related Disorders
, pp. 357
-
-
Selkoe, D.J.1
-
8
-
-
0002941489
-
The neurofibrillary pathology of Alzheimer's disease
-
Rosenberg RN, Prusiner SB, DiMauro S, Barchi RL, editors.
-
Goedert M, Trojanowski JQ, Lee VM-Y, et al. The neurofibrillary pathology of Alzheimer's disease. In: Rosenberg RN, Prusiner SB, DiMauro S, Barchi RL, editors. The molecular and genetic basis of neurological disease, 2nd Ed. 1996. pp. 613-627.
-
(1996)
The Molecular and Genetic Basis of Neurological Disease, 2nd Ed.
, pp. 613-627
-
-
Goedert, M.1
Trojanowski, J.Q.2
Lee, V.M.-Y.3
-
9
-
-
0022723508
-
One of the antigenic determinants of paired helical filaments is related to tau protein
-
Nukina N, Ihara Y. One of the antigenic determinants of paired helical filaments is related to tau protein. J Biochem 1986;99:1541-1544.
-
(1986)
J Biochem
, vol.99
, pp. 1541-1544
-
-
Nukina, N.1
Ihara, Y.2
-
10
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein t (tau) in Alzheimer cytoskeletal pathology
-
Grundke-Iqbal I, Iqbal K, Tung Y-C, Quinlan M, Wisniewski HM, Binder LI. Abnormal phosphorylation of the microtubule-associated protein t (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA 1986;83:4913-4917.
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Tung, Y.-C.3
Quinlan, M.4
Wisniewski, H.M.5
Binder, L.I.6
-
11
-
-
0009364134
-
Microtubule-associated protein, tau, is a major antigenic component of paired helical filaments in Alzheimer's disease
-
Kosik KS, Joachim CL, Selkoe DJ. Microtubule-associated protein, tau, is a major antigenic component of paired helical filaments in Alzheimer's disease, Proc Natl Acad Sci USA 1986;83: 4044-4048.
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 4044-4048
-
-
Kosik, K.S.1
Joachim, C.L.2
Selkoe, D.J.3
-
12
-
-
0023175756
-
Senile dementia of the Alzheimer type without neocortical neurofibrillary tangles
-
Terry RD, Hansen LA, DeTeresa R, Davies P, Tobias H, Katzman R. Senile dementia of the Alzheimer type without neocortical neurofibrillary tangles. J Neuropath Exp Neurol 1987;46:262-268.
-
(1987)
J Neuropath Exp Neurol
, vol.46
, pp. 262-268
-
-
Terry, R.D.1
Hansen, L.A.2
DeTeresa, R.3
Davies, P.4
Tobias, H.5
Katzman, R.6
-
13
-
-
0027517625
-
Plaque-only Alzheimer disease is usually the Lewy body variant, and vice versa
-
Hansen LA, Masliah E, Galasko D, Terry RD. Plaque-only Alzheimer disease is usually the Lewy body variant, and vice versa. J Neuropathol Exp Neurol 1993;52:648-654.
-
(1993)
J Neuropathol Exp Neurol
, vol.52
, pp. 648-654
-
-
Hansen, L.A.1
Masliah, E.2
Galasko, D.3
Terry, R.D.4
-
14
-
-
0021256895
-
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
-
Glenner GG, Wong CW. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 1984;120:885-890.
-
(1984)
Biochem Biophys Res Commun
, vol.120
, pp. 885-890
-
-
Glenner, G.G.1
Wong, C.W.2
-
15
-
-
0033600274
-
Translating cell biology into therapeutic advances in Alzheimer's disease
-
Selkoe DJ. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 1999;399:A23-A31.
-
(1999)
Nature
, vol.399
-
-
Selkoe, D.J.1
-
16
-
-
0028988801
-
β-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
-
Zheng H, Jiang M, Trumbauer ME, et al. β-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 1995;81:525-531.
-
(1995)
Cell
, vol.81
, pp. 525-531
-
-
Zheng, H.1
Jiang, M.2
Trumbauer, M.E.3
-
17
-
-
0031453752
-
The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity
-
Perez RG, Zheng H, Van der Ploeg LH, Koo EH. The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity. J Neurosci 1997;17:9407-9414.
-
(1997)
J Neurosci
, vol.17
, pp. 9407-9414
-
-
Perez, R.G.1
Zheng, H.2
Van Der Ploeg, L.H.3
Koo, E.H.4
-
18
-
-
0026442891
-
Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid β-protein precursor
-
Wasco W, Bupp K, Magendantz M, Gusella J, Tanzi RE, Solomon F. Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid β-protein precursor. Proc Natl Acad Sci USA 1992;89:10758-10762.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 10758-10762
-
-
Wasco, W.1
Bupp, K.2
Magendantz, M.3
Gusella, J.4
Tanzi, R.E.5
Solomon, F.6
-
19
-
-
0028059841
-
Expression of a ubiquitous, cross-reactive homologue of the mouse β-amyloid precursor protein (APP)
-
Slunt HH, Thinakaran G, Von Koch C, Lo ACY, Tanzi RE, Sisodia SS. Expression of a ubiquitous, cross-reactive homologue of the mouse β-amyloid precursor protein (APP). J Biol Chem 1994;269:2637-2644.
-
(1994)
J Biol Chem
, vol.269
, pp. 2637-2644
-
-
Slunt, H.H.1
Thinakaran, G.2
Von Koch, C.3
Lo, A.C.Y.4
Tanzi, R.E.5
Sisodia, S.S.6
-
20
-
-
0026646604
-
Amyloid β-peptide is produced by cultured cells during normal metabolism
-
Haass C, Schlossmacher M, Hung AY, et al. Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature 1992;359:322-325.
-
(1992)
Nature
, vol.359
, pp. 322-325
-
-
Haass, C.1
Schlossmacher, M.2
Hung, A.Y.3
-
21
-
-
0026760261
-
Production of the Alzheimer amyloid β protein by normal proteolytic processing
-
Shoji M, Golde TE, Ghiso J, et al. Production of the Alzheimer amyloid β protein by normal proteolytic processing. Science 1992;258:126-129.
-
(1992)
Science
, vol.258
, pp. 126-129
-
-
Shoji, M.1
Golde, T.E.2
Ghiso, J.3
-
22
-
-
0026646605
-
Isolation and quantitation of soluble Alzheimer's β-peptide from biological fluids
-
Seubert P, Vigo-Pelfrey C, Esch F, et al. Isolation and quantitation of soluble Alzheimer's β-peptide from biological fluids. Nature 1992;359:325-327.
-
(1992)
Nature
, vol.359
, pp. 325-327
-
-
Seubert, P.1
Vigo-Pelfrey, C.2
Esch, F.3
-
23
-
-
0026721943
-
β-Amyloid precursor protein cleavage by a membrane-bound protease
-
Sisodia SS. β-Amyloid precursor protein cleavage by a membrane-bound protease. Proc Natl Acad Sci USA 1992;89:6075-6079.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 6075-6079
-
-
Sisodia, S.S.1
-
24
-
-
8044257704
-
A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells
-
Black RA, Rauch CT, Kozlosky CJ, et al. A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature 1997;385:729-733.
-
(1997)
Nature
, vol.385
, pp. 729-733
-
-
Black, R.A.1
Rauch, C.T.2
Kozlosky, C.J.3
-
25
-
-
14444272986
-
Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor
-
Buxbaum JD, Liu KN, Luo Y, et al. Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J Biol Chem 1998;273:27765-27767.
-
(1998)
J Biol Chem
, vol.273
, pp. 27765-27767
-
-
Buxbaum, J.D.1
Liu, K.N.2
Luo, Y.3
-
26
-
-
0027459686
-
Secretion of β-amyloid precursor protein cleaved at the amino-terminus of the β-amyloid peptide
-
Seubert P, Oltersdorf T, Lee MG, et al. Secretion of β-amyloid precursor protein cleaved at the amino-terminus of the β-amyloid peptide. Nature 1993;361:260-263.
-
(1993)
Nature
, vol.361
, pp. 260-263
-
-
Seubert, P.1
Oltersdorf, T.2
Lee, M.G.3
-
27
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R, Bennett BD, Babu-Khan S, et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999;286:735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
-
28
-
-
0033518251
-
Purification and cloning of amyloid precursor protein beta-secretase from human brain
-
Sinha S, Anderson JP, Barbour R, et al. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 1999;402:537-540.
-
(1999)
Nature
, vol.402
, pp. 537-540
-
-
Sinha, S.1
Anderson, J.P.2
Barbour, R.3
-
29
-
-
0033518264
-
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
-
Yan R, Bienkowski MJ, Shuck ME, et al. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 1999;402:533-537.
-
(1999)
Nature
, vol.402
, pp. 533-537
-
-
Yan, R.1
Bienkowski, M.J.2
Shuck, M.E.3
-
30
-
-
0027407565
-
Apolipoprotein E: High-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
-
Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: high-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 1993;90:1977-1981.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 1977-1981
-
-
Strittmatter, W.J.1
Saunders, A.M.2
Schmechel, D.3
-
31
-
-
0027327267
-
Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease
-
Saunders AM, Strittmatter WJ, Schmechel D, et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993;43:1467-1472.
-
(1993)
Neurology
, vol.43
, pp. 1467-1472
-
-
Saunders, A.M.1
Strittmatter, W.J.2
Schmechel, D.3
-
32
-
-
0029004341
-
Cloning of a novel gene bearing missense mutations in early onset familial Alzheimer disease
-
Sherrington R, Rogaev EI, Liang Y, et al. Cloning of a novel gene bearing missense mutations in early onset familial Alzheimer disease. Nature 1995;375:754-760.
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
-
33
-
-
0029087026
-
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
-
Levy-Lahad E, Wasco W, Poorkaj P, et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 1995;269:973-977.
-
(1995)
Science
, vol.269
, pp. 973-977
-
-
Levy-Lahad, E.1
Wasco, W.2
Poorkaj, P.3
-
34
-
-
0029101491
-
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
-
Rogaev EI, Sherrington R, Rogaeva EA, et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 1995;376:775-778.
-
(1995)
Nature
, vol.376
, pp. 775-778
-
-
Rogaev, E.I.1
Sherrington, R.2
Rogaeva, E.A.3
-
35
-
-
17344362232
-
Alpha-2 macroglobulin is genetically associated with Alzheimer disease
-
Blacker D, Wilcox MA, Laird NM, et al. Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nat Genet 1998;19:357-360.
-
(1998)
Nat Genet
, vol.19
, pp. 357-360
-
-
Blacker, D.1
Wilcox, M.A.2
Laird, N.M.3
-
36
-
-
0032560487
-
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
-
Spillantini MG, Murrell JR, Goedert M, Farlow MR, Klug A, Ghetti B. Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. Proc Natl Acad Sci USA 1998;95:7737-7741.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 7737-7741
-
-
Spillantini, M.G.1
Murrell, J.R.2
Goedert, M.3
Farlow, M.R.4
Klug, A.5
Ghetti, B.6
-
37
-
-
0032543684
-
Association of missense and 5′-splice-site mutations in tau with the inherited FTDP-17
-
Hutton M, Lendon C, Rizzu P, et al. Association of missense and 5′-splice-site mutations in tau with the inherited FTDP-17. Nature 1998;393:702-705.
-
(1998)
Nature
, vol.393
, pp. 702-705
-
-
Hutton, M.1
Lendon, C.2
Rizzu, P.3
-
38
-
-
0032484089
-
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17
-
Hong M, Zhukareva V, Vogelsberg-Ragaglia V, et al. Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17. Science 1998;282:1914-1917.
-
(1998)
Science
, vol.282
, pp. 1914-1917
-
-
Hong, M.1
Zhukareva, V.2
Vogelsberg-Ragaglia, V.3
-
39
-
-
0032214501
-
Tau mutations cause frontotemporal dementias
-
Goedert M. Tau mutations cause frontotemporal dementias. Neuron 1998;21:955-958.
-
(1998)
Neuron
, vol.21
, pp. 955-958
-
-
Goedert, M.1
-
40
-
-
0031056184
-
Plasma levels of amyloid beta proteins Abetal-40 and Abetal-42(43) are elevated in Down's syndrome
-
Tokuda T, Fukushima T, Ikeda S, et al. Plasma levels of amyloid beta proteins Abetal-40 and Abetal-42(43) are elevated in Down's syndrome. Ann Neurol 1997;41:271-273.
-
(1997)
Ann Neurol
, vol.41
, pp. 271-273
-
-
Tokuda, T.1
Fukushima, T.2
Ikeda, S.3
-
41
-
-
0030007964
-
Sequence of deposition of heterogeneous amyloid β-peptides and Apo E in Down syndrome: Implications for initial events in amyloid plaque formation
-
Lemere CA, Blustzjan JK, Yamaguchi H, Wisniewski T, Saido TC, Selkoe DJ. Sequence of deposition of heterogeneous amyloid β-peptides and Apo E in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiol Dis 1996;3:16-32.
-
(1996)
Neurobiol Dis
, vol.3
, pp. 16-32
-
-
Lemere, C.A.1
Blustzjan, J.K.2
Yamaguchi, H.3
Wisniewski, T.4
Saido, T.C.5
Selkoe, D.J.6
-
42
-
-
0028863201
-
Microglial cells and amyloid beta protein (A beta) deposition; association with A beta 40-containing plaques
-
Berl
-
Mann DM, Iwatsubo T, Fukumoto H, Ihara Y, Odaka A, Suzuki N. Microglial cells and amyloid beta protein (A beta) deposition; association with A beta 40-containing plaques. Acta Neuropathol (Berl) 1995;90:472-477.
-
(1995)
Acta Neuropathol
, vol.90
, pp. 472-477
-
-
Mann, D.M.1
Iwatsubo, T.2
Fukumoto, H.3
Ihara, Y.4
Odaka, A.5
Suzuki, N.6
-
43
-
-
0025296269
-
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage. Dutch-type
-
Levy E, Carman MD, Fernandez-Madrid IJ, et al. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage. Dutch-type, Science 1990;248:1124-1126.
-
(1990)
Science
, vol.248
, pp. 1124-1126
-
-
Levy, E.1
Carman, M.D.2
Fernandez-Madrid, I.J.3
-
44
-
-
0026879650
-
Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β-amyloid precursor protein gene
-
Hendriks L, van Duijn CM, Cras P, et al. Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β-amyloid precursor protein gene. Nat Genet 1992;1:218-221.
-
(1992)
Nat Genet
, vol.1
, pp. 218-221
-
-
Hendriks, L.1
Van Duijn, C.M.2
Cras, P.3
-
45
-
-
0028246308
-
Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid β-protein precursor
-
Haass C, Hung AY, Selkoe DJ, Teplow DB. Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid β-protein precursor. J Biol Chem 1994;269:17741-17748.
-
(1994)
J Biol Chem
, vol.269
, pp. 17741-17748
-
-
Haass, C.1
Hung, A.Y.2
Selkoe, D.J.3
Teplow, D.B.4
-
46
-
-
0029311686
-
Co-expression of β-amyloid precursor protein (βAPP) and apolipoprotein E in cell culture: Analysis of βAPP processing
-
Biere AL, Ostaszewski B, Zhao H, Gillespie S, Younkin SG, Selkoe DJ. Co-expression of β-amyloid precursor protein (βAPP) and apolipoprotein E in cell culture: analysis of βAPP processing. Neurobiol Dis 1995;2:177-187.
-
(1995)
Neurobiol Dis
, vol.2
, pp. 177-187
-
-
Biere, A.L.1
Ostaszewski, B.2
Zhao, H.3
Gillespie, S.4
Younkin, S.G.5
Selkoe, D.J.6
-
47
-
-
0027365822
-
Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease
-
Schmechel DE, Saunders AM, Strittmatter WJ, et al. Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci USA 1993;90:9649-9653.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 9649-9653
-
-
Schmechel, D.E.1
Saunders, A.M.2
Strittmatter, W.J.3
-
48
-
-
0027374047
-
Apolipoprotein E, in sporadic Alzheimer's disease: Allelic variation and receptor inter-actions
-
Rebeck GW, Reiter JS, Strickland DK, Hyman BT. Apolipoprotein E, in sporadic Alzheimer's disease: allelic variation and receptor inter-actions. Neuron 1993;11:575-580.
-
(1993)
Neuron
, vol.11
, pp. 575-580
-
-
Rebeck, G.W.1
Reiter, J.S.2
Strickland, D.K.3
Hyman, B.T.4
-
49
-
-
0028173205
-
The amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote the assembly of the Alzheimer β-protein into filaments
-
Ma J, Yee A, Brewer Jr. HB, Das S, Potter H. The amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote the assembly of the Alzheimer β-protein into filaments. Nature 1994;372:92-94.
-
(1994)
Nature
, vol.372
, pp. 92-94
-
-
Ma, J.1
Yee, A.2
Brewer Jr., H.B.3
Das, S.4
Potter, H.5
-
50
-
-
0028872558
-
Apolipoprotein E, is a kinetic but not a thermodynamic inhibitor of amyloid formation: Implications for the pathogenesis and treatment of Alzheimer disease
-
Evans KC, Berger EP, Cho C-G, Weisgraber KH, Lansbury Jr PT. Apolipoprotein E, is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease. Proc Natl Acad Sci USA 1995;92:763-767.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 763-767
-
-
Evans, K.C.1
Berger, E.P.2
Cho, C.-G.3
Weisgraber, K.H.4
Lansbury Jr., P.T.5
-
51
-
-
0031278270
-
Lack of apolipprotein E dramatically reduces amyloid β-peptide deposition
-
Bales KR, Verina T, Dodel RC, et al. Lack of apolipprotein E dramatically reduces amyloid β-peptide deposition. Nat Genet 1997;17:263-264.
-
(1997)
Nat Genet
, vol.17
, pp. 263-264
-
-
Bales, K.R.1
Verina, T.2
Dodel, R.C.3
-
52
-
-
16044373524
-
Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D, Eckman C, Jensen M, et al. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 1996;2:864-870.
-
(1996)
Nat Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
-
53
-
-
0031914718
-
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
-
Holcomb L, Gordon MN, McGowan E, et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 1998;4:97-100.
-
(1998)
Nat Med
, vol.4
, pp. 97-100
-
-
Holcomb, L.1
Gordon, M.N.2
McGowan, E.3
-
54
-
-
16044365171
-
The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology
-
Lemere CA, Lopera F, Kosik KS, et al. The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology. Nat Med 1996;2:1146-1150.
-
(1996)
Nat Med
, vol.2
, pp. 1146-1150
-
-
Lemere, C.A.1
Lopera, F.2
Kosik, K.S.3
-
55
-
-
9444276544
-
Amyloid beta protein (A-beta) deposition in chromosome 14-linked Alzheimer's disease - Predominance of A-beta (42(43))
-
Mann DMA, Iwatsubo T, Cairns NJ, et al. Amyloid beta protein (A-beta) deposition in chromosome 14-linked Alzheimer's disease - predominance of A-beta (42(43)). Ann Neurol 1996;40:149-156.
-
(1996)
Ann Neurol
, vol.40
, pp. 149-156
-
-
Mann, D.M.A.1
Iwatsubo, T.2
Cairns, N.J.3
-
56
-
-
0033014046
-
Evidence for a physical interaction between presenilin and Notch
-
Ray WJ, Yao M, Nowotny P, et al. Evidence for a physical interaction between presenilin and Notch. Proc Natl Acad Sci USA 1999;96:3263-3268.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3263-3268
-
-
Ray, W.J.1
Yao, M.2
Nowotny, P.3
-
57
-
-
0029906585
-
Assessment of normal and mutant human presenilin function in Caenorhabditis elegans
-
Levitan D, Doyle TG, Brousseau D, et al. Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc Natl Acad Sci USA 1996;93:14940-14944.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 14940-14944
-
-
Levitan, D.1
Doyle, T.G.2
Brousseau, D.3
-
58
-
-
0033535504
-
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
-
De Strooper B, Annaert W, Cupers P, et al. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 1999;398:518-522.
-
(1999)
Nature
, vol.398
, pp. 518-522
-
-
De Strooper, B.1
Annaert, W.2
Cupers, P.3
-
59
-
-
0033966452
-
Notch and presenilins in vertebrates and invertebrates: Implications for neuronal development and degeneration
-
Selkoe DJ. Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration. Curr Opin Neurobiol 2000;10:50-57.
-
(2000)
Curr Opin Neurobiol
, vol.10
, pp. 50-57
-
-
Selkoe, D.J.1
-
60
-
-
17744401440
-
Presenilin 1 is required for Notch 1 and Dill expression in the paraxial mesoderm
-
Wong P, Zhen H, Chen H, et al. Presenilin 1 is required for Notch 1 and Dill expression in the paraxial mesoderm. Nature 1997;397:288.
-
(1997)
Nature
, vol.397
, pp. 288
-
-
Wong, P.1
Zhen, H.2
Chen, H.3
-
61
-
-
0030779784
-
Skeletal and CNS defects in presnilin-1 deficient mice
-
Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S. Skeletal and CNS defects in presnilin-1 deficient mice. Cell 1997;89:629-639.
-
(1997)
Cell
, vol.89
, pp. 629-639
-
-
Shen, J.1
Bronson, R.T.2
Chen, D.F.3
Xia, W.4
Selkoe, D.J.5
Tonegawa, S.6
-
62
-
-
15844425969
-
Endoprotreolysis of presenilin 1 and accumulation of processed derivatives in vivo
-
Thinakaran G, Borchelt DR, Lee MK, et al. Endoprotreolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 1996;17:181-190.
-
(1996)
Neuron
, vol.17
, pp. 181-190
-
-
Thinakaran, G.1
Borchelt, D.R.2
Lee, M.K.3
-
63
-
-
0031920383
-
Stable association of presenilin derivatives and absence of presenilin interactions with APP
-
Thinakaran G, Regard JB, Bouton CML, et al. Stable association of presenilin derivatives and absence of presenilin interactions with APP. Neurobiol Dis 1998;4:438-453.
-
(1998)
Neurobiol Dis
, vol.4
, pp. 438-453
-
-
Thinakaran, G.1
Regard, J.B.2
Bouton, C.M.L.3
-
64
-
-
0000138540
-
Effects of PS1 deficiency on membrane protein trafficking in neurons
-
Naruse S, Thinakaran G, Luo JJ, et al. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron 1998;21:1213-1221.
-
(1998)
Neuron
, vol.21
, pp. 1213-1221
-
-
Naruse, S.1
Thinakaran, G.2
Luo, J.J.3
-
65
-
-
0031054505
-
Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and β-amyloid precursor protein
-
Weidemann A, Paliga K, Durrwang U, et al. Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and β-amyloid precursor protein. Nat Med 1997;3:328-332.
-
(1997)
Nat Med
, vol.3
, pp. 328-332
-
-
Weidemann, A.1
Paliga, K.2
Durrwang, U.3
-
66
-
-
0030753089
-
Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer's disease
-
Xia W, Zhang J, Perez R, Koo EH, Selkoe DJ. Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer's disease. Proc Natl Acad Sci USA 1997;94:8208-8213.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 8208-8213
-
-
Xia, W.1
Zhang, J.2
Perez, R.3
Koo, E.H.4
Selkoe, D.J.5
-
67
-
-
0032564388
-
Presenilin 1 regulates the processing APP C-terminal fragments and the generation of amyloid β-protein in ER and Golgi
-
Xia W, Zhang J, Ostaszewski BL, et al. Presenilin 1 regulates the processing APP C-terminal fragments and the generation of amyloid β-protein in ER and Golgi. Biochemistry 1998;37:16465-16471.
-
(1998)
Biochemistry
, vol.37
, pp. 16465-16471
-
-
Xia, W.1
Zhang, J.2
Ostaszewski, B.L.3
-
68
-
-
0000792598
-
The transmembrane aspartates in presenilin 1 and 2 are obligatory for γ-secretase activity and amyloid β-protein generation
-
Kimberly WT, Xia W, Rahmati R, Wolfe MS, Selkoe DJ. The transmembrane aspartates in presenilin 1 and 2 are obligatory for γ-secretase activity and amyloid β-protein generation. J Biol Chem 2000;275:3173-3178.
-
(2000)
J Biol Chem
, vol.275
, pp. 3173-3178
-
-
Kimberly, W.T.1
Xia, W.2
Rahmati, R.3
Wolfe, M.S.4
Selkoe, D.J.5
-
69
-
-
0033551099
-
Peptidomimetic probes and molecular modeling suggest Alzheimer's γ-secretase is an intramembrane-cleaving aspartyl protease
-
Wolfe MS, Xia W, Moore CL, et al. Peptidomimetic probes and molecular modeling suggest Alzheimer's γ-secretase is an intramembrane-cleaving aspartyl protease. Biochemistry 1999;38:4720-4727.
-
(1999)
Biochemistry
, vol.38
, pp. 4720-4727
-
-
Wolfe, M.S.1
Xia, W.2
Moore, C.L.3
-
70
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
-
Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity. Nature 1999;398:513-517.
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
-
71
-
-
0032507667
-
Caspasse-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling
-
Brockhaus M, Grunberg J, Rohrig S, et al. Caspasse-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling. NeuroReport 1998;9:1481-1486.
-
(1998)
NeuroReport
, vol.9
, pp. 1481-1486
-
-
Brockhaus, M.1
Grunberg, J.2
Rohrig, S.3
-
72
-
-
0031781642
-
Detection of a novel intraneuronal pool of insoluble amyloid α protein that accumulates with time in culture
-
Skovronsky DM, Doms RW, Lee VM-Y. Detection of a novel intraneuronal pool of insoluble amyloid α protein that accumulates with time in culture. J Cell Biol 1998;141:1031-1039.
-
(1998)
J Cell Biol
, vol.141
, pp. 1031-1039
-
-
Skovronsky, D.M.1
Doms, R.W.2
Lee, V.M.-Y.3
-
73
-
-
0034609516
-
-
Walsh, DM, Tseng, BP, Rydel, RE, Podlisny, MB, Selkoe, DJ, Detection of intracellular oligomers of amyloid β-protein in cells derived from human brain, 2000;39:10831-10839.
-
(2000)
Detection of Intracellular Oligomers of Amyloid β-Protein in Cells Derived from Human Brain
, vol.39
, pp. 10831-10839
-
-
Walsh, D.M.1
Tseng, B.P.2
Rydel, R.E.3
Podlisny, M.B.4
Selkoe, D.J.5
-
74
-
-
11544279355
-
Diffusible, nonfribrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins
-
Lambert MP, Barlow AK, Chromy BA, et al. Diffusible, nonfribrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins, Proc Natl Acad Sci USA 1998;95:6448-6453.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
-
76
-
-
0029610011
-
The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
-
McGeer PL, McGeer EG. The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res Rev 1995;21:195-218.
-
(1995)
Brain Res Rev
, vol.21
, pp. 195-218
-
-
McGeer, P.L.1
McGeer, E.G.2
-
77
-
-
0030250567
-
Inflammation and Alzheimer's disease pathogenesis
-
Rogers J, Webster S, Leu FL, et al. Inflammation and Alzheimer's disease pathogenesis. Neurobiol Aging 1996;17:681-686.
-
(1996)
Neurobiol Aging
, vol.17
, pp. 681-686
-
-
Rogers, J.1
Webster, S.2
Leu, F.L.3
-
78
-
-
0026447529
-
Complement activation by β-amyloid in Alzheimer disease
-
Rogers J, Cooper NR, Websger S, et al. Complement activation by β-amyloid in Alzheimer disease. Proc Natl Acad Sci USA 1992;89:10016-10020.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 10016-10020
-
-
Rogers, J.1
Cooper, N.R.2
Websger, S.3
-
79
-
-
0028217539
-
Ultrastructural localization of complement membrane attack complex (MAC)-like immunoreactivity in brains of patients with Alzheimer's disease
-
Itagaki S, Akiyama H, Saito H, McGeer PL. Ultrastructural localization of complement membrane attack complex (MAC)-like immunoreactivity in brains of patients with Alzheimer's disease. Brain Res 1994;645:78-84.
-
(1994)
Brain Res
, vol.645
, pp. 78-84
-
-
Itagaki, S.1
Akiyama, H.2
Saito, H.3
McGeer, P.L.4
-
80
-
-
0028233494
-
Hydrogen peroxide mediates amyloid β protein toxicity
-
Behl C, Davis JB, Lesley R, Schubert D. Hydrogen peroxide mediates amyloid β protein toxicity. Cell 1994;77:817-827.
-
(1994)
Cell
, vol.77
, pp. 817-827
-
-
Behl, C.1
Davis, J.B.2
Lesley, R.3
Schubert, D.4
-
81
-
-
0028908516
-
Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons
-
Harris ME, Hensley K, Butterfield DA, Leedle RA, Carney JM. Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons. Exp Neurol 1995;131:193-202.
-
(1995)
Exp Neurol
, vol.131
, pp. 193-202
-
-
Harris, M.E.1
Hensley, K.2
Butterfield, D.A.3
Leedle, R.A.4
Carney, J.M.5
-
82
-
-
0030967165
-
A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study
-
Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 1997;336:1216-1222.
-
(1997)
N Engl J Med
, vol.336
, pp. 1216-1222
-
-
Sano, M.1
Ernesto, C.2
Thomas, R.G.3
-
83
-
-
0026570528
-
β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
-
Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE. β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 1992;12:379-389.
-
(1992)
J Neurosci
, vol.12
, pp. 379-389
-
-
Mattson, M.P.1
Cheng, B.2
Davis, D.3
Bryant, K.4
Lieberburg, I.5
Rydel, R.E.6
-
84
-
-
0027447286
-
Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state
-
Pike CJ, Burdick D, Walencewicz AJ, Glabe CG, Cotman CW. Neurodegeneration induced by β-amyloid peptides in vitro: the role of peptide assembly state. J Neurosci 1993;13:1676-1687.
-
(1993)
J Neurosci
, vol.13
, pp. 1676-1687
-
-
Pike, C.J.1
Burdick, D.2
Walencewicz, A.J.3
Glabe, C.G.4
Cotman, C.W.5
-
85
-
-
0028172886
-
β-Amyloid neurotoxicity requires fibril formation and is inhibited by Congo red
-
Lorenzo A, Yankner B. β-Amyloid neurotoxicity requires fibril formation and is inhibited by Congo red. Proc Natl Acad Sci USA 1994;91:12243-12247.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 12243-12247
-
-
Lorenzo, A.1
Yankner, B.2
-
86
-
-
0033540060
-
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
-
Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 1999;402:615-622.
-
(1999)
Nature
, vol.402
, pp. 615-622
-
-
Patrick, G.N.1
Zukerberg, L.2
Nikolic, M.3
De La Monte, S.4
Dikkes, P.5
Tsai, L.H.6
-
87
-
-
0028985574
-
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
-
Games D, Adams D, Alessandrini R, et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 1995;373:523-527.
-
(1995)
Nature
, vol.373
, pp. 523-527
-
-
Games, D.1
Adams, D.2
Alessandrini, R.3
-
88
-
-
0029742199
-
Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
-
Hsiao K, Chapman P, Nilsen S, et al. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science 1996;274:99-102.
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
-
89
-
-
0011444914
-
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
-
Sturchler-Pierrat C, Abrahamowski D, Duke M, et al. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci USA 1997;94:13287-13292.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13287-13292
-
-
Sturchler-Pierrat, C.1
Abrahamowski, D.2
Duke, M.3
-
90
-
-
0033622324
-
Intraneuronal Aβ42 accumulation in human brain
-
Gouras GK, Tasi J, Naslund J, et al. Intraneuronal Aβ42 accumulation in human brain. Am J Pathol 2000;156:15-20.
-
(2000)
Am J Pathol
, vol.156
, pp. 15-20
-
-
Gouras, G.K.1
Tasi, J.2
Naslund, J.3
-
91
-
-
10544224542
-
Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation
-
Wolozin B, Iwasaki K, Vito P, et al. Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science 1996;274:1710-1713.
-
(1996)
Science
, vol.274
, pp. 1710-1713
-
-
Wolozin, B.1
Iwasaki, K.2
Vito, P.3
-
92
-
-
0000967277
-
Presenilin 1 P264L knock-in mutation: Effect on cortical neuronal vulnerability to degeneration
-
426.5
-
Siman R, Reaume A, Savage MJ, Scott RW, Flood DG. Presenilin 1 P264L knock-in mutation: effect on cortical neuronal vulnerability to degeneration. J Neurosci Abstr 1999;25(Pt 1):1046(426.5).
-
(1999)
J Neurosci Abstr
, vol.25
, Issue.1 PART
, pp. 1046
-
-
Siman, R.1
Reaume, A.2
Savage, M.J.3
Scott, R.W.4
Flood, D.G.5
-
93
-
-
0032574993
-
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
-
Schroeter EH, Kisslinger JA, Kopan R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 1998;393:382-386.
-
(1998)
Nature
, vol.393
, pp. 382-386
-
-
Schroeter, E.H.1
Kisslinger, J.A.2
Kopan, R.3
-
94
-
-
0033536163
-
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk D, Barbour R, Dunn W, et al. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999;400:173-177.
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
|