-
1
-
-
0022432305
-
The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAs
-
Beckmann, R.J., et al., The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAs, Nucleic Acids Res., 13, 5233-5247, 1985.
-
(1985)
Nucleic Acids Res.
, vol.13
, pp. 5233-5247
-
-
Beckmann, R.J.1
-
2
-
-
0023500177
-
Propeptide of human protein C is necessary for gamma-carboxylation
-
Foster, D.C., et al., Propeptide of human protein C is necessary for gamma-carboxylation, Biochemistry, 26, 7003-7011, 1987.
-
(1987)
Biochemistry
, vol.26
, pp. 7003-7011
-
-
Foster, D.C.1
-
3
-
-
0008321303
-
α-Hydroxyaspartic acid in vitamin K-dependent protein C
-
Drakenberg, T., et al., α-Hydroxyaspartic acid in vitamin K-dependent protein C., Proc. Natl. Acad. Sci. USA, 80, 1802-1806, 1983.
-
(1983)
Proc. Natl. Acad. Sci. USA
, vol.80
, pp. 1802-1806
-
-
Drakenberg, T.1
-
4
-
-
0025883206
-
Glycosylation of human protein C affects its secretion, processing, functional activities and activation by thrombin
-
Grinnell, B.W., Walls, J.D., and Gerlitz, B., Glycosylation of human protein C affects its secretion, processing, functional activities and activation by thrombin, J. Biol. Chem., 226, 9778-9785, 1991.
-
(1991)
J. Biol. Chem.
, vol.226
, pp. 9778-9785
-
-
Grinnell, B.W.1
Walls, J.D.2
Gerlitz, B.3
-
5
-
-
0025297484
-
Beta protein C is not glycosylated at asparagine 329
-
Miletich, J.P. and Broze, G.J., Beta protein C is not glycosylated at asparagine 329, J. Biol. Chem., 265, 11397-11404, 1990.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 11397-11404
-
-
Miletich, J.P.1
Broze, G.J.2
-
6
-
-
0027205366
-
O-linked fucose and other post-translational modifications unique to EGF modules
-
Harris, R.J. and Spellman, M.W., O-linked fucose and other post-translational modifications unique to EGF modules, Glycobiology, 3, 219-224, 1993.
-
(1993)
Glycobiology
, vol.3
, pp. 219-224
-
-
Harris, R.J.1
Spellman, M.W.2
-
7
-
-
0026760593
-
Post-translational processing events in the secretion pathway of human protein C, a complex vitamin K-dependent antithrombotic factor
-
McClure, D.B., Walls, J.D., and Grinnell, B.W., Post-translational processing events in the secretion pathway of human protein C, a complex vitamin K-dependent antithrombotic factor, J. Biol. Chem., 267, 19710-19717, 1992.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 19710-19717
-
-
McClure, D.B.1
Walls, J.D.2
Grinnell, B.W.3
-
8
-
-
0024336105
-
Post-translational modifications of protein: Some problems left to solve
-
Yan, S.C.B., Grinnell, B.W., and Wold, F., Post-translational modifications of protein: Some problems left to solve, Trends Biochem. Sci., 14, 264-268, 1989.
-
(1989)
Trends Biochem. Sci.
, vol.14
, pp. 264-268
-
-
Yan, S.C.B.1
Grinnell, B.W.2
Wold, F.3
-
9
-
-
0025053103
-
Characterization and novel purification of recombinant human protein C from three mammalian cell lines
-
Yan, S.B., et al., Characterization and novel purification of recombinant human protein C from three mammalian cell lines, Bio/Technology, 8, 655-661, 1990.
-
(1990)
Bio/Technology
, vol.8
, pp. 655-661
-
-
Yan, S.B.1
-
10
-
-
0004522542
-
Effect of mutation of Asp71 on human protein C activation and function
-
Gerlitz, B., et al., Effect of mutation of Asp71 on human protein C activation and function, J. Cell. Biochem., 14E, 201, 1990.
-
(1990)
J. Cell. Biochem.
, vol.14E
, pp. 201
-
-
Gerlitz, B.1
-
11
-
-
0002146847
-
Native and modified recombinant human protein C: Function secretion and posttranslational modifications
-
Bruley, D. and Drohan, W., Eds., Gulf Publishing Co., Houston
-
Grinnell, B.W., et al., Native and modified recombinant human protein C: Function secretion and posttranslational modifications, in Protein C and Related Anticoagulants, Bruley, D. and Drohan, W., Eds., Gulf Publishing Co., Houston, 1990, pp. 13-46.
-
(1990)
Protein C and Related Anticoagulants
, pp. 13-46
-
-
Grinnell, B.W.1
-
12
-
-
0028299926
-
Human protein C inhibits selectin-mediated cell adhesion: Role of unique fucosylated oligosaccharide
-
Grinnell, B.W., Hermann, R.B., and Yan, S.B., Human protein C inhibits selectin-mediated cell adhesion: Role of unique fucosylated oligosaccharide, Glycobiology, 4, 221-225, 1994.
-
(1994)
Glycobiology
, vol.4
, pp. 221-225
-
-
Grinnell, B.W.1
Hermann, R.B.2
Yan, S.B.3
-
13
-
-
0023636780
-
Trans-activated expression of fully gamma-carboxylated recombinant human protein C, an antithrombotic factor
-
Grinnell, B.W., et al., Trans-activated expression of fully gamma-carboxylated recombinant human protein C, an antithrombotic factor, Bio/Technology, 5, 1189-1192, 1987.
-
(1987)
Bio/Technology
, vol.5
, pp. 1189-1192
-
-
Grinnell, B.W.1
-
14
-
-
0343553885
-
Expression and characterization of fully functional recombinant human protein C from the human kidney cell line 293
-
Suttie, J.W., Ed., Elsevier, New York
-
Grinnell, B.W., et al., Expression and characterization of fully functional recombinant human protein C from the human kidney cell line 293, in Current Advances in Vitamin K Research, Suttie, J.W., Ed., Elsevier, New York, 1988, pp. 191-198.
-
(1988)
Current Advances in Vitamin K Research
, pp. 191-198
-
-
Grinnell, B.W.1
-
15
-
-
0025185265
-
Effects of intact fibrin and partially plasmin-degraded fibrin on kinetic properties of one-chain tissue plasminogen activator
-
Fisher, B.E., and Will, H., Effects of intact fibrin and partially plasmin-degraded fibrin on kinetic properties of one-chain tissue plasminogen activator, Biochem. Biophys. Acta, 1041, 48-54, 1990.
-
(1990)
Biochem. Biophys. Acta
, vol.1041
, pp. 48-54
-
-
Fisher, B.E.1
Will, H.2
-
16
-
-
0022801056
-
Report of workshop on expression of vitamin K-dependent proteins in bacterial and mammalian cells
-
Suttie, J.W., Report of workshop on expression of vitamin K-dependent proteins in bacterial and mammalian cells, Thromb. Res., 44, 129-134, 1986.
-
(1986)
Thromb. Res.
, vol.44
, pp. 129-134
-
-
Suttie, J.W.1
-
17
-
-
0343553885
-
-
Suttie, J.W., Ed., Elsevier, New York
-
Oppenheimer, C. and Wydro, R., Cellular Processing of Vitamin K-Dependent Proteins, Suttie, J.W., Ed., Elsevier, New York, 1988.
-
(1988)
Cellular Processing of Vitamin K-Dependent Proteins
-
-
Oppenheimer, C.1
Wydro, R.2
-
18
-
-
0022416736
-
Expression of active human clotting factor IX from recombinant DNA clones in mammalian cells
-
Anson, D.S., Austen, D.E.G., and Brownlee, G.G., Expression of active human clotting factor IX from recombinant DNA clones in mammalian cells, Nature, 315, 683-685, 1985.
-
(1985)
Nature
, vol.315
, pp. 683-685
-
-
Anson, D.S.1
Austen, D.E.G.2
Brownlee, G.G.3
-
19
-
-
0021847266
-
Active gamma-carboxylated human factor IX expressed using recombinant DNA techniques
-
de la Salle, H., et al., Active gamma-carboxylated human factor IX expressed using recombinant DNA techniques, Nature, 316, 268-270, 1985.
-
(1985)
Nature
, vol.316
, pp. 268-270
-
-
de la Salle, H.1
-
20
-
-
0021847267
-
Expression of active human factor IX in transfected cells
-
Busby, S., et al., Expression of active human factor IX in transfected cells, Nature, 316, 271-273, 1985.
-
(1985)
Nature
, vol.316
, pp. 271-273
-
-
Busby, S.1
-
21
-
-
85179245267
-
-
Ginsberg, H.S., Ed., Plenum Press, New York
-
Graham, F.L., Transformation by and Oncogenicity of Human Adenoviruses, Ginsberg, H.S., Ed., Plenum Press, New York, 1984, pp. 631-639.
-
(1984)
Transformation by and Oncogenicity of Human Adenoviruses
, pp. 631-639
-
-
Graham, F.L.1
-
22
-
-
0026070515
-
Viral transformation increases vitamin K-dependent gamma-carboxylation of glutamate
-
Berg, D.T., et al., Viral transformation increases vitamin K-dependent gamma-carboxylation of glutamate, Exp. Cell Res., 192, 32-40, 1991.
-
(1991)
Exp. Cell Res.
, vol.192
, pp. 32-40
-
-
Berg, D.T.1
-
23
-
-
0023687086
-
A variant enhancer/regulatory region from a cloned human prototype BK virus genome
-
Berg, D.T., Walls, J., and Grinnell, B.W., A variant enhancer/regulatory region from a cloned human prototype BK virus genome, Nucleic Acids Res., 16, 9057, 1988.
-
(1988)
Nucleic Acids Res.
, vol.16
, pp. 9057
-
-
Berg, D.T.1
Walls, J.2
Grinnell, B.W.3
-
24
-
-
0024428644
-
E1A-induced enhancer activity of the poly(dG-dT).poly(dA-dC) element (GT element) and interactions with a GT-specific nuclear factor
-
Berg, D.T., et al., E1A-induced enhancer activity of the poly(dG-dT).poly(dA-dC) element (GT element) and interactions with a GT-specific nuclear factor, Mol. Cell. Biol., 9, 5248-5253, 1989.
-
(1989)
Mol. Cell. Biol.
, vol.9
, pp. 5248-5253
-
-
Berg, D.T.1
-
25
-
-
0026658714
-
E1a-responsive mammalian host/vector system for the stable high-level expression of secreted proteins
-
Berg, D.T., McClure, D.B., and Grinnell, B.W., E1a-responsive mammalian host/vector system for the stable high-level expression of secreted proteins, Nucleic Acids Res., 20, 5485-5486, 1992.
-
(1992)
Nucleic Acids Res.
, vol.20
, pp. 5485-5486
-
-
Berg, D.T.1
McClure, D.B.2
Grinnell, B.W.3
-
26
-
-
0027263191
-
High-level expression of secreted proteins from cell adapted to serum-free suspension culture
-
Berg, D.T., McClure, D.B., and Grinnell, B.W., High-level expression of secreted proteins from cell adapted to serum-free suspension culture, Biotech., 6, 972-978, 1993.
-
(1993)
Biotech.
, vol.6
, pp. 972-978
-
-
Berg, D.T.1
McClure, D.B.2
Grinnell, B.W.3
-
27
-
-
0025189327
-
A rapid and versatile method for the detection and isolation of mammalian cell lines secreting recombinant proteins
-
Walls, J.D. and Grinnell, B.W., A rapid and versatile method for the detection and isolation of mammalian cell lines secreting recombinant proteins, Biotechniques, 8, 138-142, 1990.
-
(1990)
Biotechniques
, vol.8
, pp. 138-142
-
-
Walls, J.D.1
Grinnell, B.W.2
-
28
-
-
0024431441
-
Amplification of multicistronic plasmids in the human 293 cell line and secretion of correctly processed recombinant human protein C
-
Walls, J.D., et al., Amplification of multicistronic plasmids in the human 293 cell line and secretion of correctly processed recombinant human protein C, Gene, 81, 139-149, 1989.
-
(1989)
Gene
, vol.81
, pp. 139-149
-
-
Walls, J.D.1
-
29
-
-
0030136063
-
Review of conformation-specific affinity purification methods for plasma vitamin Kdependent proteins
-
Yan, S.B., Review of conformation-specific affinity purification methods for plasma vitamin Kdependent proteins, J. Mol. Recognition, 9, 211-218, 1996.
-
(1996)
J. Mol. Recognition
, vol.9
, pp. 211-218
-
-
Yan, S.B.1
-
30
-
-
0025056635
-
Endoproteolytic processing of the dibasic cleavage site in the human protein C precursor in transfected mammalian cells: Effects of sequence alterations on efficiency of cleavage
-
Foster, D.C., et al., Endoproteolytic processing of the dibasic cleavage site in the human protein C precursor in transfected mammalian cells: Effects of sequence alterations on efficiency of cleavage, Biochemistry, 29, 347-354, 1990.
-
(1990)
Biochemistry
, vol.29
, pp. 347-354
-
-
Foster, D.C.1
-
31
-
-
0018672331
-
Human plasma protein C: Isolation, characterization, and mechanism of activation by alpha-thrombin
-
Kisiel, W., Human plasma protein C: Isolation, characterization, and mechanism of activation by alpha-thrombin, J. Clin. Invest., 64, 761-769, 1979.
-
(1979)
J. Clin. Invest.
, vol.64
, pp. 761-769
-
-
Kisiel, W.1
-
32
-
-
0025981417
-
Glycosylation of recombinant protein therapeutics: Control and functional implications
-
Cumming, D.A., Glycosylation of recombinant protein therapeutics: Control and functional implications, Glycobiology, 1, 115-130, 1991.
-
(1991)
Glycobiology
, vol.1
, pp. 115-130
-
-
Cumming, D.A.1
-
33
-
-
0027718176
-
Novel Asn-linked oligosaccharides terminating in GalNAc(1-4)[Fucα(1-3)]GalNAc(1-2) are present in recombinant human protein C expressed in human kidney 293 cells
-
Yan, S.B., Chao, Y.B., and van Halbeek, H., Novel Asn-linked oligosaccharides terminating in GalNAc(1-4)[Fucα(1-3)]GalNAc(1-2) are present in recombinant human protein C expressed in human kidney 293 cells, Glycobiology, 3, 597-608, 1993.
-
(1993)
Glycobiology
, vol.3
, pp. 597-608
-
-
Yan, S.B.1
Chao, Y.B.2
van Halbeek, H.3
-
34
-
-
0026090578
-
A novel sialylated N-acetylgalactosamine-containing oligosaccharide is the major complex-type structure present in Bowes melanoma tissue plasminogen activator
-
Chan, A.L., et al., A novel sialylated N-acetylgalactosamine-containing oligosaccharide is the major complex-type structure present in Bowes melanoma tissue plasminogen activator, Glycobiology, 1, 173-185, 1991.
-
(1991)
Glycobiology
, vol.1
, pp. 173-185
-
-
Chan, A.L.1
-
35
-
-
0026619051
-
Human urokinase contains GalNAc(1-4)[Fucα(1-3)]GlcNAc(1-2) as a novel terminal element in N-linked carbohydrate chains
-
Bergwerff, A.A., et al., Human urokinase contains GalNAc(1-4)[Fucα(1-3)]GlcNAc(1-2) as a novel terminal element in N-linked carbohydrate chains, FEBS Lett., 314, 389-394, 1992.
-
(1992)
FEBS Lett.
, vol.314
, pp. 389-394
-
-
Bergwerff, A.A.1
-
36
-
-
0027463627
-
Structural elucidation of a variety of GalNAc-containing N-linked oligosaccharides from human urinary kallidinogenase
-
Tomiya, N., et al., Structural elucidation of a variety of GalNAc-containing N-linked oligosaccharides from human urinary kallidinogenase, J. Biol. Chem., 268, 113-126, 1993.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 113-126
-
-
Tomiya, N.1
-
37
-
-
0028885690
-
Structural analysis of the oligosaccharide derived from glycodelin, a human glycoprotein with potent immunosuppresive and contraceptive activities
-
Dell, A., et al., Structural analysis of the oligosaccharide derived from glycodelin, a human glycoprotein with potent immunosuppresive and contraceptive activities, J. Biol. Chem., 270, 24116-24126, 1995.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 24116-24126
-
-
Dell, A.1
-
38
-
-
0025030398
-
Inhibition of thrombus formation by activated recombinant protein C in a primate model of arterial athrombosis
-
Gruber, A., et al., Inhibition of thrombus formation by activated recombinant protein C in a primate model of arterial athrombosis, Circulation, 82, 578-585, 1990.
-
(1990)
Circulation
, vol.82
, pp. 578-585
-
-
Gruber, A.1
-
39
-
-
10544251443
-
Gender-specific glycosylation of human glycodelin affects its contraceptive activity
-
Morris, H., et al., Gender-specific glycosylation of human glycodelin affects its contraceptive activity, J. Biol. Chem., 271, 32159-32167, 1996.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 32159-32167
-
-
Morris, H.1
-
40
-
-
0033863867
-
Recombinant glycodelin carrying the same type of glycan structure as contraceptive glycodelin-A can be produced in human kidney 293 cells but not in Chinese hamster ovary cells
-
van den Nieuwenhof, I., et al., Recombinant glycodelin carrying the same type of glycan structure as contraceptive glycodelin-A can be produced in human kidney 293 cells but not in Chinese hamster ovary cells, Eur. J. Biochem., 267, 4753-4762, 2000.
-
(2000)
Eur. J. Biochem.
, vol.267
, pp. 4753-4762
-
-
van den Nieuwenhof, I.1
-
41
-
-
0027410273
-
Inflammation-induced expression of sialyl Lewis X-containing Glycan structures on α1-acid glycoprotein (orosomucoid) in human sera
-
De Graaf, T.W., et al., Inflammation-induced expression of sialyl Lewis X-containing Glycan structures on α1-acid glycoprotein (orosomucoid) in human sera, J. Exp. Med., 177, 657-666, 1993.
-
(1993)
J. Exp. Med.
, vol.177
, pp. 657-666
-
-
De Graaf, T.W.1
-
42
-
-
0025572708
-
Recognition by ELAM-1 of the sialys-LeX determinant on myeloid and tumor cell
-
Walz, G., et al., Recognition by ELAM-1 of the sialys-LeX determinant on myeloid and tumor cell, Science, 250, 1132-1135, 1990.
-
(1990)
Science
, vol.250
, pp. 1132-1135
-
-
Walz, G.1
-
43
-
-
84968570490
-
Novel oligosaccharide structures on recombinant human protein C expressed in human kidney 293 cells
-
Yan, S.B., Chao, B.Y., and van Halbeek, H., Novel oligosaccharide structures on recombinant human protein C expressed in human kidney 293 cells, J. Cell Biochem., 16D, 151, 1992.
-
(1992)
J. Cell Biochem.
, vol.16D
, pp. 151
-
-
Yan, S.B.1
Chao, B.Y.2
van Halbeek, H.3
-
44
-
-
0000519967
-
Recombinant human protein C, protein S and thrombomodulin as antithrombotics
-
Yan, S.B. and Grinnell, B.W., Recombinant human protein C, protein S and thrombomodulin as antithrombotics, Perspective Drug Discovery Des., 1, 503-520, 1994.
-
(1994)
Perspective Drug Discovery Des.
, vol.1
, pp. 503-520
-
-
Yan, S.B.1
Grinnell, B.W.2
-
45
-
-
0001748803
-
Antithrombotic and anti-inflammatory agents of the protein C anticoagulant pathway
-
Yan, S.B. and Grinnell, B.W., Antithrombotic and anti-inflammatory agents of the protein C anticoagulant pathway, Ann. Rep. Med. Chem., 11, 103-112, 1994.
-
(1994)
Ann. Rep. Med. Chem.
, vol.11
, pp. 103-112
-
-
Yan, S.B.1
Grinnell, B.W.2
-
46
-
-
0035164538
-
Safety and dose-relationship of recombinant human activated protein C (rhAPC) on coagulopathy in severe sepsis
-
Bernard, G., et al., Safety and dose-relationship of recombinant human activated protein C (rhAPC) on coagulopathy in severe sepsis, Crit. Care Med., 29, 2051-2059, 2001.
-
(2001)
Crit. Care Med.
, vol.29
, pp. 2051-2059
-
-
Bernard, G.1
-
47
-
-
0035826096
-
Efficacy and safety of recombinant human activated protein C for severe sepsis
-
Bernard, G., et al., Efficacy and safety of recombinant human activated protein C for severe sepsis, New Engl. J. Med., 344, 699-705, 2001.
-
(2001)
New Engl. J. Med.
, vol.344
, pp. 699-705
-
-
Bernard, G.1
-
48
-
-
0024346952
-
Direct expression of recombinant activated human protein C, a serine protease
-
Ehrlich, H.J., et al., Direct expression of recombinant activated human protein C, a serine protease, J. Biol. Chem., 264, 14298-14304, 1989.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 14298-14304
-
-
Ehrlich, H.J.1
-
49
-
-
0028052297
-
Charge reversal at the P3' position in protein C optimally enhances thrombin affinity and activation rate
-
Richardson, M.A., Gerlitz, B., and Grinnell, B.W., Charge reversal at the P3' position in protein C optimally enhances thrombin affinity and activation rate, Protein Sci., 3, 711-712, 1994.
-
(1994)
Protein Sci.
, vol.3
, pp. 711-712
-
-
Richardson, M.A.1
Gerlitz, B.2
Grinnell, B.W.3
-
50
-
-
0025291082
-
Recombinant human protein C derivatives: Altered response to calcium resulting in enhanced activation by thrombin
-
Ehrlich, H.J., et al., Recombinant human protein C derivatives: Altered response to calcium resulting in enhanced activation by thrombin, EMBO J., 9, 2367-2373, 1990.
-
(1990)
EMBO J.
, vol.9
, pp. 2367-2373
-
-
Ehrlich, H.J.1
-
51
-
-
0026478750
-
Enhancing protein C interaction with thrombin results in a clot-activated antcoagulant
-
Richardson, M.A., Gerlitz, B., and Grinnell, B.W., Enhancing protein C interaction with thrombin results in a clot-activated antcoagulant, Nature, 360, 261-264, 1992.
-
(1992)
Nature
, vol.360
, pp. 261-264
-
-
Richardson, M.A.1
Gerlitz, B.2
Grinnell, B.W.3
-
52
-
-
0028169690
-
Mutation of Glu 80 to Lys results in a protein C mutant, that no longer requires Ca2for rapid activation by the thrombin-thrombomodulin complex
-
Rezaie, A.R., et al., Mutation of Glu 80 to Lys results in a protein C mutant, that no longer requires Ca2for rapid activation by the thrombin-thrombomodulin complex, J. Biol. Chem., 269, 3151-3154, 1994.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 3151-3154
-
-
Rezaie, A.R.1
-
53
-
-
0027078511
-
The function of calcium in protein C activation by thrombin and thrombin-thrombomodulin complex can be distinguished by mutational analysis of protein C derivatives
-
Rezaie, A.R. and Esmon, C.T., The function of calcium in protein C activation by thrombin and thrombin-thrombomodulin complex can be distinguished by mutational analysis of protein C derivatives, J. Biol. Chem., 267, 26104-26109, 1992.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 26104-26109
-
-
Rezaie, A.R.1
Esmon, C.T.2
-
54
-
-
0031028066
-
Antithrombotic efficacy in the guinea pig of a derivative of human protein C with enhanced activation by thrombin
-
Kurz, K.D., et al., Antithrombotic efficacy in the guinea pig of a derivative of human protein C with enhanced activation by thrombin, Blood, 89, 534-540, 1997.
-
(1997)
Blood
, vol.89
, pp. 534-540
-
-
Kurz, K.D.1
-
55
-
-
1242341318
-
Basic residues in the 37-loop of activated protein C modulate inhibition by protein C inhibitor but not by alpha (1)-antitrypsin
-
Glasscock, N.L., et al., Basic residues in the 37-loop of activated protein C modulate inhibition by protein C inhibitor but not by alpha (1)-antitrypsin, Biochim. Biophys. Acta, 1647, 106-117, 2003.
-
(2003)
Biochim. Biophys. Acta
, vol.1647
, pp. 106-117
-
-
Glasscock, N.L.1
-
56
-
-
0037447246
-
Engineering the proteolytic specificity of activated protein C improves its pharmacological properties
-
Berg, D.T., et al., Engineering the proteolytic specificity of activated protein C improves its pharmacological properties, Proc. Natl. Acad. Sci. USA, 100, 4423-4428, 2003.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 4423-4428
-
-
Berg, D.T.1
-
57
-
-
84888783104
-
Comparison in an arteriovenous (AV) shunt model of thrombosis in the guinea pig of the antithrombotic and anticoagulant activities of a gla-domain variant of human activated Protein C (APC) with native APC and with a low molecular weight heparin (LMWH)
-
Kurz, K.D., et al., Comparison in an arteriovenous (AV) shunt model of thrombosis in the guinea pig of the antithrombotic and anticoagulant activities of a gla-domain variant of human activated Protein C (APC) with native APC and with a low molecular weight heparin (LMWH), Blood, 100, 281a, 2002.
-
(2002)
Blood
, vol.100
, pp. 281a
-
-
Kurz, K.D.1
-
58
-
-
0032553444
-
Enhancement of human protein C function by site-directed mutagenesis of the gamma-carboxyglutamic acid domain
-
Shen, L., et al., Enhancement of human protein C function by site-directed mutagenesis of the gamma-carboxyglutamic acid domain, J. Biol. Chem., 273, 31086-31091, 1998.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 31086-31091
-
-
Shen, L.1
-
59
-
-
0032762628
-
Enhancement of vitamin-K-dependent protein function by modification of the gamma-carboxyglutamic acid domain: Studies of protein C and factor VII
-
Nelsestuen, G., Enhancement of vitamin-K-dependent protein function by modification of the gamma-carboxyglutamic acid domain: Studies of protein C and factor VII, Trends Cardiovasc. Med., 9, 162-167, 1999.
-
(1999)
Trends Cardiovasc. Med.
, vol.9
, pp. 162-167
-
-
Nelsestuen, G.1
-
60
-
-
0026591793
-
The protein C anticoagulant pathway
-
Esmon, C.T., The protein C anticoagulant pathway, Arterioscler. Thromb., 12, 135-145, 1992.
-
(1992)
Arterioscler. Thromb.
, vol.12
, pp. 135-145
-
-
Esmon, C.T.1
-
61
-
-
0027161205
-
Molecular events that control the protein C anticoagulant pathway
-
Esmon, C.T., Molecular events that control the protein C anticoagulant pathway, Thromb. Haemostas., 70, 29-35, 1993.
-
(1993)
Thromb. Haemostas.
, vol.70
, pp. 29-35
-
-
Esmon, C.T.1
-
62
-
-
0029119879
-
An update on clinical and basic aspects of the protein C anticoagulant pathway
-
Esmon, C.T. and Schwarz, H.P., An update on clinical and basic aspects of the protein C anticoagulant pathway, Trends Cardiovasc. Med., 5, 141-148, 1995.
-
(1995)
Trends Cardiovasc. Med.
, vol.5
, pp. 141-148
-
-
Esmon, C.T.1
Schwarz, H.P.2
-
63
-
-
0030756899
-
The protein C pathway: New insights
-
Esmon, C.T., et al., The protein C pathway: New insights, Thromb. Haemostas., 78, 70-74, 1997.
-
(1997)
Thromb. Haemostas.
, vol.78
, pp. 70-74
-
-
Esmon, C.T.1
-
64
-
-
0033815369
-
The protein C pathway
-
Esmon, C., The protein C pathway, Crit. Care Med., 28 (Suppl. 9), S44-48, 2000.
-
(2000)
Crit. Care Med.
, vol.28
, pp. S44-S48
-
-
Esmon, C.1
-
65
-
-
0032879431
-
Inflammation, sepsis, and coagulation
-
Esmon, C.T., et al., Inflammation, sepsis, and coagulation, Haematologica, 84, 254-259, 1999.
-
(1999)
Haematologica
, vol.84
, pp. 254-259
-
-
Esmon, C.T.1
-
66
-
-
15144361590
-
Novel antithrombotics based on modulation of the protein C pathway
-
Grinnell, B.W. and Yan, S.B., Novel antithrombotics based on modulation of the protein C pathway, Coron. Artery Dis., 9, 89-97, 1998.
-
(1998)
Coron. Artery Dis.
, vol.9
, pp. 89-97
-
-
Grinnell, B.W.1
Yan, S.B.2
-
67
-
-
0033562558
-
Vascular endothelial genes that are responsive to tumor necrosis factoralpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes
-
Horrevoets, A.J., et al., Vascular endothelial genes that are responsive to tumor necrosis factoralpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes, Blood, 93, 3418-3431, 1999.
-
(1999)
Blood
, vol.93
, pp. 3418-3431
-
-
Horrevoets, A.J.1
-
68
-
-
0034917319
-
Recombinant human activated protein C: A system modulator of vascular function for treatment of severe sepsis
-
Grinnell, B. and Joyce, D.E., Recombinant human activated protein C: A system modulator of vascular function for treatment of severe sepsis, Crit. Care Med., 29, S53-S61, 2001.
-
(2001)
Crit. Care Med.
, vol.29
, pp. S53-S61
-
-
Grinnell, B.1
Joyce, D.E.2
-
69
-
-
0036250817
-
Recombinant human activated protein C attenuates the inflammatory response in endothelium and monocytes by modulating nuclear factor-kappaB
-
Joyce, D.E. and Grinnell, B.W., Recombinant human activated protein C attenuates the inflammatory response in endothelium and monocytes by modulating nuclear factor-kappaB, Crit. Care Med., 30, S288-293, 2002.
-
(2002)
Crit. Care Med.
, vol.30
, pp. S288-S293
-
-
Joyce, D.E.1
Grinnell, B.W.2
-
70
-
-
0035815747
-
Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis
-
Joyce, D.E., et al., Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis, J. Biol. Chem., 276, 11199-11203, 2001.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 11199-11203
-
-
Joyce, D.E.1
-
71
-
-
0037036069
-
Activation of endothelial cell protease activated receptor 1 by the protein C pathway
-
Riewald, M., et al., Activation of endothelial cell protease activated receptor 1 by the protein C pathway, Science, 296, 1880-1882, 2002.
-
(2002)
Science
, vol.296
, pp. 1880-1882
-
-
Riewald, M.1
-
72
-
-
0031929812
-
Derangements of coagulation and fibrinolysis in critically ill patients with sepsis and septic shock
-
Vervloet, M., Thijs, L., and Hack, C., Derangements of coagulation and fibrinolysis in critically ill patients with sepsis and septic shock, Semin. Thromb. Hemostas., 24, 33-44., 1998.
-
(1998)
Semin. Thromb. Hemostas.
, vol.24
, pp. 33-44
-
-
Vervloet, M.1
Thijs, L.2
Hack, C.3
-
73
-
-
0029044322
-
Purification and characterization of TAFI, a throminactivable fibrinolysis inhibitor
-
Bajzar, L., Manuel, R., and Nesheim, M.E., Purification and characterization of TAFI, a throminactivable fibrinolysis inhibitor, J. Biol. Chem., 270, 14477-14484, 1995.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 14477-14484
-
-
Bajzar, L.1
Manuel, R.2
Nesheim, M.E.3
-
74
-
-
0025184934
-
The activated protein C-mediated enhancement of tissue-type plasminogen activator-induced fibrinolysis in a cell-free system
-
Bajzar, L., Fredenburgh, J.C., and Nesheim, M., The activated protein C-mediated enhancement of tissue-type plasminogen activator-induced fibrinolysis in a cell-free system, J. Biol. Chem., 265, 16948-16954, 1990.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 16948-16954
-
-
Bajzar, L.1
Fredenburgh, J.C.2
Nesheim, M.3
-
75
-
-
0029793068
-
The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent
-
Bajzar, L., Nesheim, M., and Tracy, P.B., The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent, Blood, 88, 2093-2100, 1996.
-
(1996)
Blood
, vol.88
, pp. 2093-2100
-
-
Bajzar, L.1
Nesheim, M.2
Tracy, P.B.3
-
76
-
-
0033712641
-
Pharmacological profile of recombinant, human activated protein C (LY203638) in a canine model of coronary artery thrombosis
-
Jackson, C., Bailey, B., and Shetler, T., Pharmacological profile of recombinant, human activated protein C (LY203638) in a canine model of coronary artery thrombosis, J. Pharmacol. Exp. Ther., 295, 967-971, 2000.
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.295
, pp. 967-971
-
-
Jackson, C.1
Bailey, B.2
Shetler, T.3
-
77
-
-
0001283044
-
Recombinant human activated protein C (LY203638) induced reperfusion in a canine model of occlusive coronary artery thrombosis
-
Jackson, C.V., et al., Recombinant human activated protein C (LY203638) induced reperfusion in a canine model of occlusive coronary artery thrombosis, Circulation, 98, I454, 1998.
-
(1998)
Circulation
, vol.98
, pp. I454
-
-
Jackson, C.V.1
-
78
-
-
0032845209
-
Regulation and functions of the protein C anticoagulant pathway
-
Esmon, C.T., et al., Regulation and functions of the protein C anticoagulant pathway, Haematologica, 84, 363-368, 1999.
-
(1999)
Haematologica
, vol.84
, pp. 363-368
-
-
Esmon, C.T.1
-
79
-
-
0026577704
-
Characterization of a functional thrombin receptor: Issues and opportunities
-
Coughlin, S.R., et al., Characterization of a functional thrombin receptor: Issues and opportunities, J. Clin. Invest., 89, 351-355, 1992.
-
(1992)
J. Clin. Invest.
, vol.89
, pp. 351-355
-
-
Coughlin, S.R.1
-
80
-
-
0030755533
-
Immunobiology and therapeutic applications of protein C/protein S/thrombomodulin in human and experimental allotransplantation and xenotransplantation
-
Hancock, W.W., and Bach, F.H., Immunobiology and therapeutic applications of protein C/protein S/thrombomodulin in human and experimental allotransplantation and xenotransplantation, Trends Cardiovasc. Med., 7, 174-183, 1997.
-
(1997)
Trends Cardiovasc. Med.
, vol.7
, pp. 174-183
-
-
Hancock, W.W.1
Bach, F.H.2
-
81
-
-
4243752864
-
Inhibition of LPS-induced activation of human monocytes by activated protein C (APC) occurs through a novel mechanism
-
Grey, S.T. and Hancock, W.W., Inhibition of LPS-induced activation of human monocytes by activated protein C (APC) occurs through a novel mechanism, J. Leukocyte Biol., 114 A487, 1993.
-
(1993)
J. Leukocyte Biol.
, vol.114
, pp. A487
-
-
Grey, S.T.1
Hancock, W.W.2
-
82
-
-
0027367126
-
Selective effects of protein C on activation of human monocytes by lipopolysaccharide, interferon-gamma or PMA: Modulation of effects on CD11b and CD14 but not CD25 or CD54 induction
-
Grey, S., et al., Selective effects of protein C on activation of human monocytes by lipopolysaccharide, interferon-gamma or PMA: Modulation of effects on CD11b and CD14 but not CD25 or CD54 induction, Transplant. Proc., 25, 2913-2914, 1993.
-
(1993)
Transplant. Proc.
, vol.25
, pp. 2913-2914
-
-
Grey, S.1
-
83
-
-
0027998013
-
Selective inhibitory effects of the anticoagulant activated protein C on the responses of human monocuclear phagocytes to LPS, IFN-, or phorbol ester
-
Grey, S.T., et al., Selective inhibitory effects of the anticoagulant activated protein C on the responses of human monocuclear phagocytes to LPS, IFN-, or phorbol ester, J. Immunol., 153, 3664-3672, 1994.
-
(1994)
J. Immunol.
, vol.153
, pp. 3664-3672
-
-
Grey, S.T.1
-
84
-
-
0023122016
-
Protein C prevents the coagulopathic and lethal effects of E. coli infusion in the baboon
-
Taylor, F.B., et al., Protein C prevents the coagulopathic and lethal effects of E. coli infusion in the baboon, J. Clin. Invest., 79, 918-925, 1987.
-
(1987)
J. Clin. Invest.
, vol.79
, pp. 918-925
-
-
Taylor, F.B.1
-
85
-
-
0026671606
-
The anticoagulants protein C and protein S display potent antiinflammatory and immunosuppressive effects relevant to transplant biology and therapy
-
Hancock, W.W., et al., The anticoagulants protein C and protein S display potent antiinflammatory and immunosuppressive effects relevant to transplant biology and therapy, Transplantation Proc., 24, 2302-2303, 1992.
-
(1992)
Transplantation Proc.
, vol.24
, pp. 2302-2303
-
-
Hancock, W.W.1
-
86
-
-
12444249948
-
Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulopathy response in patients with severe sepsis
-
Dhainaut, J.F., et al., Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulopathy response in patients with severe sepsis, Thromb. Haemostas., 90 (4), 642-653, 2003.
-
(2003)
Thromb. Haemostas.
, vol.90
, Issue.4
, pp. 642-653
-
-
Dhainaut, J.F.1
-
87
-
-
0141567620
-
Recombinant human activated protein C (rhAPC; drotrecogin alfa [activated]) has minimal effect on markers of coagulation, fibrinolysis, and inflammation in acute human endotoxemia
-
Derhaschnig, U., et al., Recombinant human activated protein C (rhAPC; drotrecogin alfa [activated]) has minimal effect on markers of coagulation, fibrinolysis, and inflammation in acute human endotoxemia, Blood, 102, 2093-2098, 2003.
-
(2003)
Blood
, vol.102
, pp. 2093-2098
-
-
Derhaschnig, U.1
-
88
-
-
3042571475
-
Effects of drotrecogin alfa (activated) in human endotoxemia
-
Kalil, A., et al., Effects of drotrecogin alfa (activated) in human endotoxemia, Shock, 21, 222-229, 2004.
-
(2004)
Shock
, vol.21
, pp. 222-229
-
-
Kalil, A.1
-
89
-
-
0034456899
-
Activated protein C inhibits tumor necrosis factor and macrophage migration inhibitory factor production in monocytes
-
Schmide-Supprian, M., et al., Activated protein C inhibits tumor necrosis factor and macrophage migration inhibitory factor production in monocytes, Eur. Cytokine Network, 11, 407-413, 2000.
-
(2000)
Eur. Cytokine Network
, vol.11
, pp. 407-413
-
-
Schmide-Supprian, M.1
-
90
-
-
0033880884
-
Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line
-
White, B., et al., Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line, Br. J. Haematol., 110, 130-134, 2000.
-
(2000)
Br. J. Haematol.
, vol.110
, pp. 130-134
-
-
White, B.1
-
91
-
-
0038682435
-
Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease activated receptor-1 and endothelial cell protein C receptor
-
Mosnier, L.O. and Griffin, J.H., Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease activated receptor-1 and endothelial cell protein C receptor, Biochem. J., 8, 65-70, 2003.
-
(2003)
Biochem. J.
, vol.8
, pp. 65-70
-
-
Mosnier, L.O.1
Griffin, J.H.2
-
92
-
-
0037352279
-
Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
-
Cheng, T., et al., Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective, Nat. Med., 9, 338-342, 2003.
-
(2003)
Nat. Med.
, vol.9
, pp. 338-342
-
-
Cheng, T.1
-
93
-
-
0030776168
-
Human protein C receptor is present primarily on endothelium of large blood vessels: Implications for the control of the protein C pathway
-
Laszik, Z., et al., Human protein C receptor is present primarily on endothelium of large blood vessels: Implications for the control of the protein C pathway, Circulation, 96, 3633-3640, 1997.
-
(1997)
Circulation
, vol.96
, pp. 3633-3640
-
-
Laszik, Z.1
-
94
-
-
1342269932
-
Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3
-
Guo, H., et al., Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3, Neuron, 41, 563-572, 2004.
-
(2004)
Neuron
, vol.41
, pp. 563-572
-
-
Guo, H.1
-
95
-
-
2942738936
-
Leukocyte and endothelial interactions in sepsis:Relevance of the Protein C pathway
-
Joyce, D.E., Nelson, D.R., and Grinnell, B.W., Leukocyte and endothelial interactions in sepsis:Relevance of the Protein C pathway, Crit. Care Med., 32 (Suppl.5), S280-S286, 2004.
-
(2004)
Crit. Care Med.
, vol.32
, pp. S280-S286
-
-
Joyce, D.E.1
Nelson, D.R.2
Grinnell, B.W.3
-
96
-
-
0043240071
-
Expression and function of the endothelial protein C receptor in human neutrophils
-
Sturn, D.H., et al., Expression and function of the endothelial protein C receptor in human neutrophils, Blood, 102, 1499-1505, 2003.
-
(2003)
Blood
, vol.102
, pp. 1499-1505
-
-
Sturn, D.H.1
-
97
-
-
0042530424
-
Endothelial protein C receptor-dependent inhibition of human eosinophil chemotaxis by protein C
-
Feistritzer, C., et al., Endothelial protein C receptor-dependent inhibition of human eosinophil chemotaxis by protein C, J. Allergy Clin. Immunol., 112, 375-381, 2003.
-
(2003)
J. Allergy Clin. Immunol.
, vol.112
, pp. 375-381
-
-
Feistritzer, C.1
-
98
-
-
0024556368
-
Inhibition of platelet-dependent thrombus formation by human activated protein C in a primate model
-
Gruber, A., et al., Inhibition of platelet-dependent thrombus formation by human activated protein C in a primate model, Blood, 73, 639-642, 1989.
-
(1989)
Blood
, vol.73
, pp. 639-642
-
-
Gruber, A.1
-
99
-
-
0027435111
-
Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates
-
Hanson, S.R., et al., Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates, J. Clin. Invest., 92, 2003-2012, 1993.
-
(1993)
J. Clin. Invest.
, vol.92
, pp. 2003-2012
-
-
Hanson, S.R.1
-
100
-
-
0025731750
-
Inhibitory effects of activated protein C and heparin on thrombotic arterial occlusion in rat mesenteric arteries
-
Araki, H., et al., Inhibitory effects of activated protein C and heparin on thrombotic arterial occlusion in rat mesenteric arteries, Thromb. Res., 62, 209-216, 1991.
-
(1991)
Thromb. Res.
, vol.62
, pp. 209-216
-
-
Araki, H.1
-
101
-
-
4243697943
-
Inhibition of microarterial thrombosis by bovine activated protein C in a rabbit model
-
Abstr
-
Arnlijots, B., Bergqvist, D., and Dahlback, B., Inhibition of microarterial thrombosis by bovine activated protein C in a rabbit model, Thromb. Haemostas., 69, (Abstr.), 589, 1993.
-
(1993)
Thromb. Haemostas.
, vol.69
, pp. 89
-
-
Arnlijots, B.1
Bergqvist, D.2
Dahlback, B.3
-
102
-
-
0000887757
-
Preclinical pharmacology of activated protein C
-
J.S. Holcenberg and J.L. Winkelhake, Eds., Anal R. Liss, Inc., New York
-
Emerick, S.C., et al., Preclinical pharmacology of activated protein C, in The Pharmacology and Toxicology of Proteins, J.S. Holcenberg and J.L. Winkelhake, Eds., Anal R. Liss, Inc., New York, 1987, pp. 351-367.
-
(1987)
The Pharmacology and Toxicology of Proteins
, pp. 351-367
-
-
Emerick, S.C.1
-
103
-
-
0026331758
-
Deep venous thrombosis in the baboon: An experimental model
-
Wakefield, T.W., et al., Deep venous thrombosis in the baboon: An experimental model, J. Vasc. Surg., 14, 588-598, 1991.
-
(1991)
J. Vasc. Surg.
, vol.14
, pp. 588-598
-
-
Wakefield, T.W.1
-
104
-
-
0029148565
-
Antithrombotic action of endogenous porcine protein C activated with a latent porcine thrombin preparation
-
McBane, R., et al., Antithrombotic action of endogenous porcine protein C activated with a latent porcine thrombin preparation, Thromb. Haemostas., 74, 879-885, 1995.
-
(1995)
Thromb. Haemostas.
, vol.74
, pp. 879-885
-
-
McBane, R.1
-
105
-
-
0028240809
-
Prevention of arterial reocclusion after thrombolysis with activated protein C: Comparison with heparin in a canine model of coronary artery thrombosis
-
Sakamoto, T., et al., Prevention of arterial reocclusion after thrombolysis with activated protein C: Comparison with heparin in a canine model of coronary artery thrombosis, Circulation, 90, 427-432, 1994.
-
(1994)
Circulation
, vol.90
, pp. 427-432
-
-
Sakamoto, T.1
-
106
-
-
0028236252
-
The antithrombotic effect of human activated protein C on He-Ne laserinduced thrombosis in rat mesenteric microvessels
-
Yamashita, T., et al., The antithrombotic effect of human activated protein C on He-Ne laserinduced thrombosis in rat mesenteric microvessels, Thromb. Res., 75, 33-40, 1994.
-
(1994)
Thromb. Res.
, vol.75
, pp. 33-40
-
-
Yamashita, T.1
-
107
-
-
0025305844
-
Low doses of activated protein C delay arterial thrombosis in rats
-
Smirnov, M., et al., Low doses of activated protein C delay arterial thrombosis in rats, Thromb. Res., 57, 645-650, 1991.
-
(1991)
Thromb. Res.
, vol.57
, pp. 645-650
-
-
Smirnov, M.1
-
108
-
-
0025745178
-
Activated protein C: Antithrombotic properties and influence on fibrinolysis in an animal model
-
Romisch, J., et al., Activated protein C: Antithrombotic properties and influence on fibrinolysis in an animal model, Fibrinolysis, 5, 191-196, 1991.
-
(1991)
Fibrinolysis
, vol.5
, pp. 191-196
-
-
Romisch, J.1
-
109
-
-
0026333595
-
Enhancement of tissue plasminogen activator-induced fibrinolysis by activated protein C in endotoxin-treated rabbits
-
Krishnamurti, C., et al., Enhancement of tissue plasminogen activator-induced fibrinolysis by activated protein C in endotoxin-treated rabbits, J. Lab. Clin. Med., 118, 523-530, 1991.
-
(1991)
J. Lab. Clin. Med.
, vol.118
, pp. 523-530
-
-
Krishnamurti, C.1
-
110
-
-
0025833721
-
Antithrombotic effects of combining activated protein C and urokinase in nonhuman primates
-
Gruber, A., et al., Antithrombotic effects of combining activated protein C and urokinase in nonhuman primates, Circulation, 84, 2454-2462, 1991.
-
(1991)
Circulation
, vol.84
, pp. 2454-2462
-
-
Gruber, A.1
-
111
-
-
0022616976
-
The regulation of hemostasis: The protein C system
-
Clouse, L.H. and Comp, P.C., The regulation of hemostasis: The protein C system, New Engl. J. Med., 314, 1298-1304, 1986.
-
(1986)
New Engl. J. Med.
, vol.314
, pp. 1298-1304
-
-
Clouse, L.H.1
Comp, P.C.2
-
112
-
-
0026529348
-
Evaluation of a new protein C concentrate and comparison of protein C assays in a child with congenital protein C deficiency
-
Auberger, K., Evaluation of a new protein C concentrate and comparison of protein C assays in a child with congenital protein C deficiency, Ann. Hematol., 64, 146-151, 1992.
-
(1992)
Ann. Hematol.
, vol.64
, pp. 146-151
-
-
Auberger, K.1
-
113
-
-
0027186461
-
Replacement therapy with a purified protein C concentrate during initiation of oral anticoagulation in severe protein C congenital deficiency
-
De Stefano, V., et al., Replacement therapy with a purified protein C concentrate during initiation of oral anticoagulation in severe protein C congenital deficiency, Thromb. Haemostas., 70, 247-249, 1993.
-
(1993)
Thromb. Haemostas.
, vol.70
, pp. 247-249
-
-
De Stefano, V.1
-
114
-
-
0026409651
-
Treatment of homozygous protein C deficiency and neonatal purpura fulminans with purified protein C concentrate
-
Dreyfus, M., et al., Treatment of homozygous protein C deficiency and neonatal purpura fulminans with purified protein C concentrate, New Engl. J. Med., 325, 1565-1568, 1991.
-
(1991)
New Engl. J. Med.
, vol.325
, pp. 1565-1568
-
-
Dreyfus, M.1
-
115
-
-
85179237004
-
New approach to the treatment of warfarin-induced skin necrosis in the protein C deficiency
-
Abstr
-
Lewandowski, K. and Zawilska, K., New approach to the treatment of warfarin-induced skin necrosis in the protein C deficiency, Thromb. Haemostas., 69, (Abstr.), 725, 1993.
-
(1993)
Thromb. Haemostas.
, vol.69
, pp. 725
-
-
Lewandowski, K.1
Zawilska, K.2
-
116
-
-
0026607644
-
Protein C concentrate prevents peripartum thrombosis
-
Manco-Johnson, M. and Nuss, R., Protein C concentrate prevents peripartum thrombosis, Am. J. Hematol., 40, 69-70, 1992.
-
(1992)
Am. J. Hematol.
, vol.40
, pp. 69-70
-
-
Manco-Johnson, M.1
Nuss, R.2
-
117
-
-
0027164283
-
Treatment of coumarin-induced skin necrosis with a monoclonal antibody purified Protein C concentrate
-
Schramm, W., et al., Treatment of coumarin-induced skin necrosis with a monoclonal antibody purified Protein C concentrate, Arch. Dermatol., 129, 753-759, 1993.
-
(1993)
Arch. Dermatol.
, vol.129
, pp. 753-759
-
-
Schramm, W.1
-
118
-
-
84888796654
-
Acute and long-term treatment of severe congenital protein C deficiency with protein C concentrate
-
Abstr
-
Schwarz, H.P., et al., Acute and long-term treatment of severe congenital protein C deficiency with protein C concentrate, Thromb. Haemostas., 69, (Abstr.), 1020, 1993.
-
(1993)
Thromb. Haemostas.
, vol.69
, pp. 1020
-
-
Schwarz, H.P.1
-
119
-
-
0029617466
-
Replacement therapy with a monoclonal antibody purified protein C concentrate in newborns with severe congenital Protein C deficiency
-
Dreyfus, M., et al., Replacement therapy with a monoclonal antibody purified protein C concentrate in newborns with severe congenital Protein C deficiency, Semin. Thromb. Haemostas., 21, 371-381, 1995.
-
(1995)
Semin. Thromb. Haemostas.
, vol.21
, pp. 371-381
-
-
Dreyfus, M.1
-
120
-
-
0030044808
-
Purpura fulminans in severe congenital protein C deficiency: Monitoring of treatment with protein C concentrate
-
Muller, F.M., et al., Purpura fulminans in severe congenital protein C deficiency: Monitoring of treatment with protein C concentrate, Eur. J. Pediatr., 155, 20-25, 1996.
-
(1996)
Eur. J. Pediatr.
, vol.155
, pp. 20-25
-
-
Muller, F.M.1
-
121
-
-
0027484320
-
Successful treatment of deep vein thrombosis in homozygous protein C deficiency with activated protein C
-
Wada, H., Deguch, K., and Shirakawa, S., Successful treatment of deep vein thrombosis in homozygous protein C deficiency with activated protein C, Am. J. Hematol., 44, 218-219, 1993.
-
(1993)
Am. J. Hematol.
, vol.44
, pp. 218-219
-
-
Wada, H.1
Deguch, K.2
Shirakawa, S.3
-
122
-
-
84888800246
-
Multicenter trail of plasma-derived activated protein C concentrate (CTC-111) in patients with venous thrombosis associated with inherited protein C deficiency
-
Wada, H., Shirakawa, S., and Shiku, H., Multicenter trail of plasma-derived activated protein C concentrate (CTC-111) in patients with venous thrombosis associated with inherited protein C deficiency, Blood, 94, 111, 1999.
-
(1999)
Blood
, vol.94
, pp. 111
-
-
Wada, H.1
Shirakawa, S.2
Shiku, H.3
-
123
-
-
0033781467
-
A case of purpura fulminans is caused by homozygous 8857 mutation (protein C-Nagoya) and successfully treated with activated protein C concentrate
-
Nakayama, T., et al., A case of purpura fulminans is caused by homozygous 8857 mutation (protein C-Nagoya) and successfully treated with activated protein C concentrate, Br. J. Haematol., 110, 727-730, 2000.
-
(2000)
Br. J. Haematol.
, vol.110
, pp. 727-730
-
-
Nakayama, T.1
-
124
-
-
0347634503
-
Activated protein C concentrate reverses purpura fulminans in severe genetic protein C deficiency
-
Manco-Johnson, M. and Knapp-Clevenger, R., Activated protein C concentrate reverses purpura fulminans in severe genetic protein C deficiency, J. Pediatric Hematology/Oncology, 26 (1), 25-27, 2004.
-
(2004)
J. Pediatric Hematology/Oncology
, vol.26
, Issue.1
, pp. 25-27
-
-
Manco-Johnson, M.1
Knapp-Clevenger, R.2
-
125
-
-
84888786875
-
A phase III clinical study of a plasma derived human activated protein C for the treatment of DIC
-
Aoki, N., A phase III clinical study of a plasma derived human activated protein C for the treatment of DIC, J. New Remedies Clinics, 47, 448-482, 1998.
-
(1998)
J. New Remedies Clinics
, vol.47
, pp. 448-482
-
-
Aoki, N.1
-
126
-
-
0032883550
-
Activated protein C is effective for disseminated intravascular coagulation associated with placental abruption
-
Kobayashi, T., et al., Activated protein C is effective for disseminated intravascular coagulation associated with placental abruption, Thromb. Haemostas., 82, 1363, 1999.
-
(1999)
Thromb. Haemostas.
, vol.82
, pp. 1363
-
-
Kobayashi, T.1
-
127
-
-
0025210140
-
Treatment of patients with disseminated intravascular coagulation by protein C
-
Okajima, K., et al., Treatment of patients with disseminated intravascular coagulation by protein C, Am. J. Hematol., 33, 277-278, 1990.
-
(1990)
Am. J. Hematol.
, vol.33
, pp. 277-278
-
-
Okajima, K.1
-
128
-
-
0025174960
-
Effect of protein C and activated protein C on coagulation and fibrinolysis in normal human subjects
-
Okajima, K., et al., Effect of protein C and activated protein C on coagulation and fibrinolysis in normal human subjects, Thromb. Haemostas., 63, 48-53, 1990.
-
(1990)
Thromb. Haemostas.
, vol.63
, pp. 48-53
-
-
Okajima, K.1
-
129
-
-
0142012083
-
Effect of activated protein C on plasma plasminogen activator inhibitor activity in patients with acute myocardial infarction treated with alteplase
-
Sakamoto, T., et al., Effect of activated protein C on plasma plasminogen activator inhibitor activity in patients with acute myocardial infarction treated with alteplase, J. Am. Coll. Cardiol., 42, 1389-1394, 2003.
-
(2003)
J. Am. Coll. Cardiol.
, vol.42
, pp. 1389-1394
-
-
Sakamoto, T.1
-
130
-
-
84888775592
-
Activated protein C (APC) for the prevention and treatment of veno-occlusive disease (VOD) of the liver after bone marrow transplantation (BMT)
-
Oh, H., et al., Activated protein C (APC) for the prevention and treatment of veno-occlusive disease (VOD) of the liver after bone marrow transplantation (BMT), Blood, 92, 325b, 1998.
-
(1998)
Blood
, vol.92
, pp. 325b
-
-
Oh, H.1
-
131
-
-
0004465841
-
Inhibitory effect of activated protein C on the experimental cerebral infarction in rabbits
-
Abstr
-
Oda, Y., Tsumoto, K., and Mizokami, H., Inhibitory effect of activated protein C on the experimental cerebral infarction in rabbits, Thromb. Haemostas., 69, (Abstr.), 724, 1993.
-
(1993)
Thromb. Haemostas.
, vol.69
, pp. 724
-
-
Oda, Y.1
Tsumoto, K.2
Mizokami, H.3
-
132
-
-
0035799374
-
Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke
-
Shibata, M., et al., Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke, Circulation, 103, 1799-1805, 2001.
-
(2001)
Circulation
, vol.103
, pp. 1799-1805
-
-
Shibata, M.1
-
133
-
-
0030034186
-
Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats
-
Murakami, K., et al., Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats, Blood, 87, 642-647, 1996.
-
(1996)
Blood
, vol.87
, pp. 642-647
-
-
Murakami, K.1
-
134
-
-
0034660464
-
Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation
-
Mizutani, A., et al., Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation, Blood, 95, 3781-3787, 2000.
-
(2000)
Blood
, vol.95
, pp. 3781-3787
-
-
Mizutani, A.1
-
135
-
-
0026039105
-
Protein C activation following coronary artery occlusion in the in situ porcine heart
-
Snow, T.R., et al., Protein C activation following coronary artery occlusion in the in situ porcine heart, Circulation, 84, 293-299, 1991.
-
(1991)
Circulation
, vol.84
, pp. 293-299
-
-
Snow, T.R.1
-
136
-
-
0030746482
-
Anti-inflammatory therapies to treat sepsis and septic shock: A reassessment
-
Natanson, C., Anti-inflammatory therapies to treat sepsis and septic shock: A reassessment, Crit. Care Med., 25, 1095-1100, 1997.
-
(1997)
Crit. Care Med.
, vol.25
, pp. 1095-1100
-
-
Natanson, C.1
-
137
-
-
0030746482
-
Anti-inflammatory therapies to treat sepsis and septic shock: A reassessment
-
Zeni, F., Freeman, B., and Natanson, C., Anti-inflammatory therapies to treat sepsis and septic shock: A reassessment, Crit. Care Med., 25, 1095-1100, 1997.
-
(1997)
Crit. Care Med.
, vol.25
, pp. 1095-1100
-
-
Zeni, F.1
Freeman, B.2
Natanson, C.3
-
138
-
-
0029147346
-
Incidence, risk factors and outcome of severe sepsis and septic shock in adults
-
Brun-Buisson, C., et al., Incidence, risk factors and outcome of severe sepsis and septic shock in adults, JAMA, 274, 968-974, 1995.
-
(1995)
JAMA
, vol.274
, pp. 968-974
-
-
Brun-Buisson, C.1
-
139
-
-
0030982989
-
Therapies for sepsis emerging therapies for sepsis and septic shock
-
Abraham, E., Therapies for sepsis emerging therapies for sepsis and septic shock, West J. Med., 166, 195-200, 1997.
-
(1997)
West J. Med.
, vol.166
, pp. 195-200
-
-
Abraham, E.1
-
140
-
-
0030854780
-
Epidemiology of sepsis syndrome in 8 academic medical centers
-
Sands, K., et al., Epidemiology of sepsis syndrome in 8 academic medical centers, JAMA, 278, 234-240, 1997.
-
(1997)
JAMA
, vol.278
, pp. 234-240
-
-
Sands, K.1
-
141
-
-
0032433470
-
Has the mortality of septic shock changed with time?
-
Friedman, G., Silva, E., and Vincent, J.-L., Has the mortality of septic shock changed with time?, Crit. Care Med., 26, 2078-2086., 1998.
-
(1998)
Crit. Care Med.
, vol.26
, pp. 2078-2086
-
-
Friedman, G.1
Silva, E.2
Vincent, J.-L.3
-
142
-
-
0032443734
-
The sirens’ songs of confirmatory sepsis trials:Selection bias and sampling error
-
Natanson, C., Esposito, C., and Banks, S., The sirens’ songs of confirmatory sepsis trials:Selection bias and sampling error, Crit. Care Med., 26, 1927-1931, 1998.
-
(1998)
Crit. Care Med.
, vol.26
, pp. 1927-1931
-
-
Natanson, C.1
Esposito, C.2
Banks, S.3
-
143
-
-
0002048139
-
Age-specific incidence and outcome of sepsis in the US
-
Linde-Zwirble, W., et al., Age-specific incidence and outcome of sepsis in the US, Crit. Care. Med., 27, 33, 1999.
-
(1999)
Crit. Care. Med.
, vol.27
, pp. 33
-
-
Linde-Zwirble, W.1
-
144
-
-
0032841352
-
Clinical Gram-positive sepsis: Does it fundamentally differ from Gramnegative bacterial sepsis?
-
Opal, S. and Cohen, J., Clinical Gram-positive sepsis: Does it fundamentally differ from Gramnegative bacterial sepsis?, Crit. Care Med., 27, 1608-1616, 1999.
-
(1999)
Crit. Care Med.
, vol.27
, pp. 1608-1616
-
-
Opal, S.1
Cohen, J.2
-
145
-
-
0026048714
-
The pathogenesis of sepsis
-
Bone, R.C., The pathogenesis of sepsis, Ann. Intern. Med., 115, 457-469, 1991.
-
(1991)
Ann. Intern. Med.
, vol.115
, pp. 457-469
-
-
Bone, R.C.1
-
146
-
-
0033590515
-
Treating patients with severe sepsis
-
Wheeler, A.P. and Bernard, G.R., Treating patients with severe sepsis, New Engl. J. Med., 340, 207-214, 1999.
-
(1999)
New Engl. J. Med.
, vol.340
, pp. 207-214
-
-
Wheeler, A.P.1
Bernard, G.R.2
-
147
-
-
0026061609
-
Protein C, protein S and C4b-binding protein in severe infection and septic shock
-
Hesselvik, J.F., et al., Protein C, protein S and C4b-binding protein in severe infection and septic shock, Thromb. Haemostas., 65, 126-129, 1991.
-
(1991)
Thromb. Haemostas.
, vol.65
, pp. 126-129
-
-
Hesselvik, J.F.1
-
148
-
-
0030100155
-
Alterations in coagulation and fibrinolysis during sepsis
-
Kidokoro, A., et al., Alterations in coagulation and fibrinolysis during sepsis, Shock, 5, 223-228, 1996.
-
(1996)
Shock
, vol.5
, pp. 223-228
-
-
Kidokoro, A.1
-
149
-
-
0031057343
-
The cytokine-mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia
-
Levi, M., et al., The cytokine-mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia, Eur. J. Clin. Invest., 27, 3-9, 1997.
-
(1997)
Eur. J. Clin. Invest.
, vol.27
, pp. 3-9
-
-
Levi, M.1
-
150
-
-
0002912919
-
How coagulation defects alter outcome in sepsis: Survival may depend on reversing procoagulant conditions
-
Carvalho, A.C. and Freeman, N.J., How coagulation defects alter outcome in sepsis: Survival may depend on reversing procoagulant conditions, J. Crit. Illness, 9, 51-75, 1994.
-
(1994)
J. Crit. Illness
, vol.9
, pp. 51-75
-
-
Carvalho, A.C.1
Freeman, N.J.2
-
151
-
-
0033810792
-
Protein C levels as a prognostic indicator of outcome in sepsis and related diseases
-
Fisher, C.J. and Yan, S.B., Protein C levels as a prognostic indicator of outcome in sepsis and related diseases, Crit.Care Med., 28, S49-S56, 2000.
-
(2000)
Crit.Care Med.
, vol.28
, pp. S49-S56
-
-
Fisher, C.J.1
Yan, S.B.2
-
152
-
-
0035826080
-
Severe sepsis-a new treatment with both anticoagulant and antiinflammatory properties
-
Matthay, M., Severe sepsis-a new treatment with both anticoagulant and antiinflammatory properties, New Engl. J. Med., 344, 759-762, 2001.
-
(2001)
New Engl. J. Med.
, vol.344
, pp. 759-762
-
-
Matthay, M.1
-
153
-
-
0037426726
-
The pathophysiology and treament of sepsis
-
Hotchkiss, R. and Karl, I.E., The pathophysiology and treament of sepsis, New Engl. J. Med., 348, 138-150, 2003.
-
(2003)
New Engl. J. Med.
, vol.348
, pp. 138-150
-
-
Hotchkiss, R.1
Karl, I.E.2
-
154
-
-
0031956683
-
Sol Sherry lecture in thrombosis: How thrombin ‘talks’ to cells: Molecular mechanisms and roles in vivo
-
Coughlin, S.R., Sol Sherry lecture in thrombosis: How thrombin ‘talks’ to cells: Molecular mechanisms and roles in vivo, Arterioscler. Thromb. Vasc. Biol., 18, 514-518, 1998.
-
(1998)
Arterioscler. Thromb. Vasc. Biol.
, vol.18
, pp. 514-518
-
-
Coughlin, S.R.1
-
155
-
-
0037588986
-
The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
-
Aird, W.C., The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome, Blood, 101, 3765-3777, 2003.
-
(2003)
Blood
, vol.101
, pp. 3765-3777
-
-
Aird, W.C.1
-
156
-
-
0031971176
-
Inflammation and thrombosis. Mutual regulation by protein C
-
Esmon, C., Inflammation and thrombosis. Mutual regulation by protein C, Immunologist, 6, 84-89, 1998.
-
(1998)
Immunologist
, vol.6
, pp. 84-89
-
-
Esmon, C.1
-
157
-
-
0032537394
-
Septic shock
-
Astiz, M. and Rackow, E., Septic shock, Lancet, 351, 1501-1505, 1998.
-
(1998)
Lancet
, vol.351
, pp. 1501-1505
-
-
Astiz, M.1
Rackow, E.2
-
158
-
-
0027214771
-
Time course of hemostatic abnormalities in sepsis and its relation to outcome
-
Lorente, J., et al., Time course of hemostatic abnormalities in sepsis and its relation to outcome, Chest, 103, 1536-1542, 1993.
-
(1993)
Chest
, vol.103
, pp. 1536-1542
-
-
Lorente, J.1
-
159
-
-
0031665896
-
The role of the endothelium in changes in procoagulant activity in sepsis
-
Iba, T., Kidokoro, A., and Yagi, Y., The role of the endothelium in changes in procoagulant activity in sepsis, J. Am. Coll. Surg., 187, 321-329, 1998.
-
(1998)
J. Am. Coll. Surg.
, vol.187
, pp. 321-329
-
-
Iba, T.1
Kidokoro, A.2
Yagi, Y.3
-
160
-
-
0033584457
-
Disseminated intravascular coagulation
-
Levi, M. and ten Cate, H., Disseminated intravascular coagulation, New Engl. J. Med., 341, 586-592, 1999.
-
(1999)
New Engl. J. Med.
, vol.341
, pp. 586-592
-
-
Levi, M.1
ten Cate, H.2
-
161
-
-
0031908430
-
Role of the coagulation system in the local and systemic inflammatory response
-
McGilvray, I.D. and Rotstein, O.D., Role of the coagulation system in the local and systemic inflammatory response, World J. Surg., 22, 179-186, 1998.
-
(1998)
World J. Surg.
, vol.22
, pp. 179-186
-
-
McGilvray, I.D.1
Rotstein, O.D.2
-
162
-
-
0035338993
-
Sepsis-induced apoptosis causes progressive profound depletion of B and CD4T lymphocytes in humans
-
Hotchkiss, R., et al., Sepsis-induced apoptosis causes progressive profound depletion of B and CD4T lymphocytes in humans, J. Immunol., 166, 6952-6963, 2001.
-
(2001)
J. Immunol.
, vol.166
, pp. 6952-6963
-
-
Hotchkiss, R.1
-
163
-
-
0034101765
-
Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients? A review and a theoretical framework
-
Papathanassoglou, E.D., Moynihan, J.A., and Ackerman, M.H., Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients? A review and a theoretical framework, Crit. Care Med., 28 (2), 537-549, 2000.
-
(2000)
Crit. Care Med.
, vol.28
, Issue.2
, pp. 537-549
-
-
Papathanassoglou, E.D.1
Moynihan, J.A.2
Ackerman, M.H.3
-
164
-
-
0034102920
-
Endothelial apoptosis: Could it have a role in the pathogenesis and treatment of disease?
-
Stefanec, T., Endothelial apoptosis: Could it have a role in the pathogenesis and treatment of disease?, Chest, 117, 841-854, 2000.
-
(2000)
Chest
, vol.117
, pp. 841-854
-
-
Stefanec, T.1
-
165
-
-
0034057558
-
Apoptosis in sepsis
-
Mahidhara, R. and Billiar, T.R., Apoptosis in sepsis, Crit. Care Med., 28 (Suppl. 4), N105-113, 2000.
-
(2000)
Crit. Care Med.
, vol.28
, pp. N105-N113
-
-
Mahidhara, R.1
Billiar, T.R.2
-
166
-
-
0030956584
-
Apoptotic vascular endothelial cells become procoagulant
-
Bombeli, T., et al., Apoptotic vascular endothelial cells become procoagulant, Blood, 89, 2429-2442, 1997.
-
(1997)
Blood
, vol.89
, pp. 2429-2442
-
-
Bombeli, T.1
-
167
-
-
0035833529
-
Dysfunction of endothelial protein C activation in severe meningococcal sepsis
-
Faust, S., et al., Dysfunction of endothelial protein C activation in severe meningococcal sepsis, New Engl. J. Med., 345, 408-416, 2001.
-
(2001)
New Engl. J. Med.
, vol.345
, pp. 408-416
-
-
Faust, S.1
-
168
-
-
0023755932
-
Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells
-
Conway, E.M. and Rosenberg, R.D., Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells, Mol. Cell. Biol., 8, 5588-5592, 1988.
-
(1988)
Mol. Cell. Biol.
, vol.8
, pp. 5588-5592
-
-
Conway, E.M.1
Rosenberg, R.D.2
-
169
-
-
0025241217
-
Plasma thrombomodulin in health and diseases
-
Takano, S., et al., Plasma thrombomodulin in health and diseases, Blood, 76, 2024-2029, 1990.
-
(1990)
Blood
, vol.76
, pp. 2024-2029
-
-
Takano, S.1
-
170
-
-
0024589205
-
Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture
-
Moore, K.L., Esmon, C.T., and Esmon, N.L., Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture, Blood, 73, 159-165, 1989.
-
(1989)
Blood
, vol.73
, pp. 159-165
-
-
Moore, K.L.1
Esmon, C.T.2
Esmon, N.L.3
-
171
-
-
0027312882
-
Pathogenesis of disseminated intravascular coagulation in sepsis
-
Levi, M., et al., Pathogenesis of disseminated intravascular coagulation in sepsis, JAMA, 270, 975-979, 1993.
-
(1993)
JAMA
, vol.270
, pp. 975-979
-
-
Levi, M.1
-
172
-
-
0029855166
-
Increase of plasminogen activator inhibitor levels predicts outcome of leukocytopenic patients with sepsis
-
Mesters, R.M., et al., Increase of plasminogen activator inhibitor levels predicts outcome of leukocytopenic patients with sepsis, Thromb. Haemostas., 75, 902-907, 1996.
-
(1996)
Thromb. Haemostas.
, vol.75
, pp. 902-907
-
-
Mesters, R.M.1
-
173
-
-
0029793068
-
The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent
-
Bajzar, L., Nesheim, M.E., and Tracy, P.B., The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent, Blood, 88, 2093-2100, 1996.
-
(1996)
Blood
, vol.88
, pp. 2093-2100
-
-
Bajzar, L.1
Nesheim, M.E.2
Tracy, P.B.3
-
174
-
-
0029895009
-
TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thromobmodulin complex
-
Bajzar, L., Morser, J., and Nesheim, M., TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thromobmodulin complex, J. Biol. Chem., 271, 16603-16608, 1996.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 16603-16608
-
-
Bajzar, L.1
Morser, J.2
Nesheim, M.3
-
175
-
-
0026625080
-
Protein C, protein S and C4b-binding protein in neonatal severe infection and septic shock
-
Roman, J., et al., Protein C, protein S and C4b-binding protein in neonatal severe infection and septic shock, J. Perinat. Med., 20, 111-116, 1992.
-
(1992)
J. Perinat. Med.
, vol.20
, pp. 111-116
-
-
Roman, J.1
-
176
-
-
0026534242
-
Septic shock, multiple organ failure and disseminated intravascular coagulation:Compared patterns of antithrombin III, protein C and protein S deficiencies
-
Fourrier, F., et al., Septic shock, multiple organ failure and disseminated intravascular coagulation:Compared patterns of antithrombin III, protein C and protein S deficiencies, Chest, 101, 816-823, 1992.
-
(1992)
Chest
, vol.101
, pp. 816-823
-
-
Fourrier, F.1
-
177
-
-
0026788072
-
Protein C and S deficiency in severe infectious purpura of children: A collaborative study of 40 cases
-
Leclerc, F., et al., Protein C and S deficiency in severe infectious purpura of children: A collaborative study of 40 cases, Intensive Care Med., 18, 202-205, 1992.
-
(1992)
Intensive Care Med.
, vol.18
, pp. 202-205
-
-
Leclerc, F.1
-
178
-
-
0029011240
-
Activation of the protein C pathway in acute sepsis
-
Alcaraz, A., et al., Activation of the protein C pathway in acute sepsis, Thromb. Res., 79, 83-93, 1995.
-
(1995)
Thromb. Res.
, vol.79
, pp. 83-93
-
-
Alcaraz, A.1
-
179
-
-
0028855106
-
Coagulation activation and tissue necrosis in meningococcal septic shock:Severely reduced protein C levels predict a high mortality
-
Fijnvandraat, K., et al., Coagulation activation and tissue necrosis in meningococcal septic shock:Severely reduced protein C levels predict a high mortality, Thromb. Haemostas., 73, 15-20, 1995.
-
(1995)
Thromb. Haemostas.
, vol.73
, pp. 15-20
-
-
Fijnvandraat, K.1
-
180
-
-
0027978071
-
Coagulation/fibrinolysis balance in septic shock related to cytokines and clinical state
-
Massignon, D., et al., Coagulation/fibrinolysis balance in septic shock related to cytokines and clinical state, Haemostas., 24, 36-48, 1994.
-
(1994)
Haemostas.
, vol.24
, pp. 36-48
-
-
Massignon, D.1
-
181
-
-
0029562092
-
Activation of the intrinsic pathway of coagulation in children with meningococcal septic shock
-
Wuillemin, W.A., et al., Activation of the intrinsic pathway of coagulation in children with meningococcal septic shock, Thromb. Haemostas., 74, 1436-1441, 1995.
-
(1995)
Thromb. Haemostas.
, vol.74
, pp. 1436-1441
-
-
Wuillemin, W.A.1
-
182
-
-
0033860427
-
Prognostic value of protein C levels in Neutropenic patients at high risk of severe septic complications
-
Mesters, R., et al., Prognostic value of protein C levels in Neutropenic patients at high risk of severe septic complications, Crit. Care Med., 28, 2209-2216, 2000.
-
(2000)
Crit. Care Med.
, vol.28
, pp. 2209-2216
-
-
Mesters, R.1
-
183
-
-
0034834039
-
Low levels of protein C are associated with poor outcome in severe sepsis
-
Yan, S., et al., Low levels of protein C are associated with poor outcome in severe sepsis, Chest, 120, 915-922, 2001.
-
(2001)
Chest
, vol.120
, pp. 915-922
-
-
Yan, S.1
-
184
-
-
0029743427
-
Factor VIIa and antithrombin III activity during severe sepsis and septic shock in neutropenic patients
-
Mesters, R., et al., Factor VIIa and antithrombin III activity during severe sepsis and septic shock in neutropenic patients, Blood, 88, 881-886, 1996.
-
(1996)
Blood
, vol.88
, pp. 881-886
-
-
Mesters, R.1
-
185
-
-
0031975435
-
The haematological manifestations of sepsis
-
Mammen, E., The haematological manifestations of sepsis, J. Antimicrob. Chemother., 41 (Suppl. A), 17-24, 1998.
-
(1998)
J. Antimicrob. Chemother.
, vol.41
, pp. 17-24
-
-
Mammen, E.1
-
186
-
-
0029743427
-
Factor VIIa and antithrombin III activity during severe sepsis and septic shock in neutropenic patients
-
Mesters, R.M., et al., Factor VIIa and antithrombin III activity during severe sepsis and septic shock in neutropenic patients, Blood, 88, 881-886, 1996.
-
(1996)
Blood
, vol.88
, pp. 881-886
-
-
Mesters, R.M.1
-
187
-
-
0040144794
-
Multiple organ dysfunction syndrome in bone marrow transplantation
-
Hairo, W.D., et al., Multiple organ dysfunction syndrome in bone marrow transplantation, JAMA, 274, 1289-1295, 1995.
-
(1995)
JAMA
, vol.274
, pp. 1289-1295
-
-
Hairo, W.D.1
-
188
-
-
0023122016
-
Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon
-
Taylor, F.B. Jr., et al., Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon, J. Clin. Invest., 79, 918-925, 1987.
-
(1987)
J. Clin. Invest.
, vol.79
, pp. 918-925
-
-
Taylor, F.B.1
-
189
-
-
0025807728
-
DEFR-Factor Xa blocks disseminated intravascular coagulation initiated by E. coli without preventing shock or organ damage
-
Taylor, F.B., et al., DEFR-Factor Xa blocks disseminated intravascular coagulation initiated by E. coli without preventing shock or organ damage, Blood, 78, 364-368, 1991.
-
(1991)
Blood
, vol.78
, pp. 364-368
-
-
Taylor, F.B.1
-
190
-
-
0028958909
-
Treatment of purpura fulminans in meningococcemia with protein C concentrate
-
Rivard, G.E., et al., Treatment of purpura fulminans in meningococcemia with protein C concentrate, J. Pediatr., 126, 646-652, 1995.
-
(1995)
J. Pediatr.
, vol.126
, pp. 646-652
-
-
Rivard, G.E.1
-
191
-
-
15844395458
-
Protein C in the treatment of coagulopathy in meningococcal disease
-
Rintala, E., et al., Protein C in the treatment of coagulopathy in meningococcal disease, Lancet, 347, 1767, 1996.
-
(1996)
Lancet
, vol.347
, pp. 1767
-
-
Rintala, E.1
-
192
-
-
0004485898
-
Successful treatment of meningococcal induced protein C deficiency/purpura fulminans in children with protein C concentrate and heparin
-
Smith, O.P., White, B., and Rafferty, M., Successful treatment of meningococcal induced protein C deficiency/purpura fulminans in children with protein C concentrate and heparin, Thromb. Haemostas., 97, 419, 1997.
-
(1997)
Thromb. Haemostas.
, vol.97
, pp. 419
-
-
Smith, O.P.1
White, B.2
Rafferty, M.3
-
193
-
-
0027248914
-
Epidemic meningococcemia and purpura fulminans with induced protein C deficiency
-
Powars, D., et al., Epidemic meningococcemia and purpura fulminans with induced protein C deficiency, Clin. Infectious Disease, 17, 254-261, 1993.
-
(1993)
Clin. Infectious Disease
, vol.17
, pp. 254-261
-
-
Powars, D.1
-
194
-
-
0031919338
-
Protein C in the treatment of coagulopathy in meningococcal disease
-
Rintala, E., et al., Protein C in the treatment of coagulopathy in meningococcal disease, Crit. Care Med., 26, 965-968, 1998.
-
(1998)
Crit. Care Med.
, vol.26
, pp. 965-968
-
-
Rintala, E.1
-
195
-
-
0034651718
-
Introduction: Are natural anticoagulants candidates for modulating the inflammatory response to endotoxin?
-
Esmon, C.T., Introduction: Are natural anticoagulants candidates for modulating the inflammatory response to endotoxin?, Blood, 95, 1113-1116, 2000.
-
(2000)
Blood
, vol.95
, pp. 1113-1116
-
-
Esmon, C.T.1
-
196
-
-
0000942913
-
Purpura fulminans and S. pneumonia sepsis with severe acquired protein C deficiency successfully treated with recombinant human activated protein C
-
Smith, K., et al., Purpura fulminans and S. pneumonia sepsis with severe acquired protein C deficiency successfully treated with recombinant human activated protein C, Thromb. Hemostas. (Suppl.82), 731, 1999.
-
(1999)
Thromb. Hemostas.
, vol.731
-
-
Smith, K.1
-
197
-
-
0033854677
-
Protein C substitution in sepsis-associated purpura fulminans
-
Rintala, E., et al., Protein C substitution in sepsis-associated purpura fulminans, Crit. Care Med., 28, 2373-2378, 2000.
-
(2000)
Crit. Care Med.
, vol.28
, pp. 2373-2378
-
-
Rintala, E.1
-
198
-
-
0027397621
-
Severe acquired protein C deficiency in purpura fulminans associated with disseminated intravascular coagulation: Treatment with protein C concentrate
-
Gerson, W.T., et al., Severe acquired protein C deficiency in purpura fulminans associated with disseminated intravascular coagulation: Treatment with protein C concentrate, Pediatrics, 91, 418-422, 1993.
-
(1993)
Pediatrics
, vol.91
, pp. 418-422
-
-
Gerson, W.T.1
-
199
-
-
0038128677
-
Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: A randomized, doubleblinded, placebo-controlled, dose-finding study
-
deKleijn, E., et al., Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: A randomized, doubleblinded, placebo-controlled, dose-finding study, Crit. Care Med., 31, 1839-1847, 2003.
-
(2003)
Crit. Care Med.
, vol.31
, pp. 1839-1847
-
-
deKleijn, E.1
-
200
-
-
85179272104
-
Only activated protein C treatment and not protein C has demonstrated an improvement in survival in severe sepsis
-
Yan, S. and Dhainaut, J.F., Only activated protein C treatment and not protein C has demonstrated an improvement in survival in severe sepsis, Crit Care Med 32, 2004.
-
Crit Care Med
, vol.32
, pp. 2004
-
-
Yan, S.1
Dhainaut, J.F.2
-
201
-
-
0025835466
-
Expression of endothelial leukocyte adhesion molecule-1 in septic but not traumatic/hypovolemic shock in the baboon
-
Redl, H., et al., Expression of endothelial leukocyte adhesion molecule-1 in septic but not traumatic/hypovolemic shock in the baboon, Am. J. Pathol., 139, 461-466, 1991.
-
(1991)
Am. J. Pathol.
, vol.139
, pp. 461-466
-
-
Redl, H.1
-
202
-
-
0027294656
-
Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock
-
Newman, W., et al., Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock, J. Immunol., 150, 644-654, 1993.
-
(1993)
J. Immunol.
, vol.150
, pp. 644-654
-
-
Newman, W.1
-
203
-
-
0027476093
-
Selectins
-
Bevilacqua, M.P. and Nelson, R.M., Selectins, J. Clin. Invest., 91, 379-387, 1993.
-
(1993)
J. Clin. Invest.
, vol.91
, pp. 379-387
-
-
Bevilacqua, M.P.1
Nelson, R.M.2
-
204
-
-
4244095544
-
Induction of myocardial ELAM-1 by ischemia and reperfusion
-
Kukielka, G.L., et al., Induction of myocardial ELAM-1 by ischemia and reperfusion, FASEB J., 6, 1060A, 1992.
-
(1992)
FASEB J.
, vol.6
, pp. 1060A
-
-
Kukielka, G.L.1
-
205
-
-
0033586986
-
Vascular-bed-specific hemostasis and hypercoagulable states
-
Rosenberg, R. and Aird, W., Vascular-bed-specific hemostasis and hypercoagulable states, New Engl. J. Med., 340, 1555-1564, 1999.
-
(1999)
New Engl. J. Med.
, vol.340
, pp. 1555-1564
-
-
Rosenberg, R.1
Aird, W.2
-
206
-
-
0033020625
-
Human endothelium as a source of multifunctional cytokines:Molecular regulation and possible role in human disease
-
Krishnaswamy, G., et al., Human endothelium as a source of multifunctional cytokines:Molecular regulation and possible role in human disease, J. Interferon Cytokine Res., 19, 91-104, 1999.
-
(1999)
J. Interferon Cytokine Res.
, vol.19
, pp. 91-104
-
-
Krishnaswamy, G.1
-
207
-
-
0033379264
-
Cell adhesion molecules: Selectins and integrens
-
Gonzalez-Amaro, A. and Sanchez-Madrid, F., Cell adhesion molecules: Selectins and integrens, Crit. Reviews Immunol., 19, 389-429, 1999.
-
(1999)
Crit. Reviews Immunol.
, vol.19
, pp. 389-429
-
-
Gonzalez-Amaro, A.1
Sanchez-Madrid, F.2
-
208
-
-
0034049428
-
Adaptive response of the endothelium to stress
-
Pohlman, T. and Harlan, J., Adaptive response of the endothelium to stress, J. Surg. Res., 89, 85-119, 2000.
-
(2000)
J. Surg. Res.
, vol.89
, pp. 85-119
-
-
Pohlman, T.1
Harlan, J.2
-
209
-
-
0034958947
-
Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
-
Angus, D., et al., Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care, Crit. Care Med., 29, 1303-1310, 2001.
-
(2001)
Crit. Care Med.
, vol.29
, pp. 1303-1310
-
-
Angus, D.1
-
210
-
-
0001647991
-
Recombinant human activated protein C (rhAPC) produces a trend toward improvement in morbidity and 28 day survival in patients with severe sepsis
-
Bernard, G.R., et al., Recombinant human activated protein C (rhAPC) produces a trend toward improvement in morbidity and 28 day survival in patients with severe sepsis, Crit. Care Med., 27, S4, 1999.
-
(1999)
Crit. Care Med.
, vol.27
, pp. S4
-
-
Bernard, G.R.1
-
211
-
-
0003134388
-
Recombinant human activated protein C (rhAPC) improves coagulation abnormalities, morbidity and 28 day mortality in patients with severe sepsis
-
Fisher, C.J., et al., Recombinant human activated protein C (rhAPC) improves coagulation abnormalities, morbidity and 28 day mortality in patients with severe sepsis, J. Antimicrob. Chemother., 44 (Suppl. A), 10, 1999.
-
(1999)
J. Antimicrob. Chemother.
, vol.44
, pp. 10
-
-
Fisher, C.J.1
-
212
-
-
0037251585
-
Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis
-
Ely, E.W., et al., Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis, Crit. Care Med., 31, 12-19, 2003.
-
(2003)
Crit. Care Med.
, vol.31
, pp. 12-19
-
-
Ely, E.W.1
-
213
-
-
0037352375
-
Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial
-
Vincent, J.L., et al., Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial, Crit. Care Med., 31, 834-840, 2003.
-
(2003)
Crit. Care Med.
, vol.31
, pp. 834-840
-
-
Vincent, J.L.1
-
214
-
-
3042669238
-
The development of drotrecogin alfa (activated) for the treatment of severe sepsis
-
Macias, W.L., Yan, S.B., and Grinnell, B.W., The development of drotrecogin alfa (activated) for the treatment of severe sepsis, Int. J. Artificial Organs, 27, 360-370, 2004.
-
(2004)
Int. J. Artificial Organs
, vol.27
, pp. 360-370
-
-
Macias, W.L.1
Yan, S.B.2
Grinnell, B.W.3
-
215
-
-
0037389471
-
Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis
-
Bernard, G.R., et al., Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis, Crit. Care (London), 7, 155-163, 2003.
-
(2003)
Crit. Care (London)
, vol.7
, pp. 155-163
-
-
Bernard, G.R.1
-
216
-
-
0035904368
-
Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: A randomized controlled trial
-
Warren, B.L., et al., Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: A randomized controlled trial, JAMA, 286, 1869-1878, 2001.
-
(2001)
JAMA
, vol.286
, pp. 1869-1878
-
-
Warren, B.L.1
-
217
-
-
0038690407
-
Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis; A randomized controlled trial
-
Abraham, E., Reinhart, K., and Opal, S., Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis; A randomized controlled trial, JAMA, 290, 238-247, 2003.
-
(2003)
JAMA
, vol.290
, pp. 238-247
-
-
Abraham, E.1
Reinhart, K.2
Opal, S.3
-
218
-
-
0036795261
-
Pharmacokinetic-pharmacodynamic analysis of drotrecogin alfa (activated) in patients with severe sepsis
-
Macias, W.L., et al., Pharmacokinetic-pharmacodynamic analysis of drotrecogin alfa (activated) in patients with severe sepsis, Clin. Pharmacol. Therapeut., 72, 391-402, 2002.
-
(2002)
Clin. Pharmacol. Therapeut.
, vol.72
, pp. 391-402
-
-
Macias, W.L.1
-
219
-
-
0142245617
-
Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia
-
Kerlin, B., et al., Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia, Blood, 102, 3085-3092, 2003.
-
(2003)
Blood
, vol.102
, pp. 3085-3092
-
-
Kerlin, B.1
-
220
-
-
84888814473
-
Thrombin paradox redux
-
Aird, W., Thrombin paradox redux, Blood, 102, 3077-3078, 2003.
-
(2003)
Blood
, vol.102
, pp. 3077-3078
-
-
Aird, W.1
-
221
-
-
3242775982
-
Surviving sepsis campaign guidelines for management of severe sepsis and septic shock
-
Dellinger, R., et al., Surviving sepsis campaign guidelines for management of severe sepsis and septic shock, Crit. Care Med., 32, 858-873, 2004.
-
(2004)
Crit. Care Med.
, vol.32
, pp. 858-873
-
-
Dellinger, R.1
-
222
-
-
0028299926
-
Human protein C inhibits selectin-mediated cell adhesion: Role of unique fucosylated oligosaccharide
-
Grinnell, B.W., Hermann, R.B., and Yan, S.B., Human protein C inhibits selectin-mediated cell adhesion: Role of unique fucosylated oligosaccharide, Glycobiology, 4, 221-225, 1994.
-
(1994)
Glycobiology
, vol.4
, pp. 221-225
-
-
Grinnell, B.W.1
Hermann, R.B.2
Yan, S.B.3
|