Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke

Circulation

Volumn 103, Issue 13, 2001, Pages 1799-1805

  Shibata, Masayoshi ^a,b,c   Kumar, S Ram ^a,b,c   Amar, Arun ^a,b,c   Fernandez, Jose A ^a,b,c   Hofman, Florence ^a,b,c   Griffin, John H ^a,b,c   Zlokovic, Berislav V ^a,b,c,d  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d Box 645   (United States)

Author keywords

Blood cells; Cerebrovascular disorders; Ischemia; Nervous system; Proteins; Thrombosis

Indexed keywords

FIBRIN; PROTEIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN EDEMA; BRAIN HEMORRHAGE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; FIBRIN DEPOSITION; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVOUS SYSTEM; NEUROPATHOLOGY; NEUROPROTECTION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL TIME; THROMBOSIS; TISSUE PERFUSION;

EID: 0035799374     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.103.13.1799     Document Type: Article

References (37)

1. The thrombin paradox
2. Cell mediated events that control blood coagulation and vascular injury
3. Endothelial protein C receptor
4. Regulation of brain capillary endothelial thrombomodulin mRNA expression
5. Thrombomodulin expression in bovine brain capillaries: Anticoagulant function of the blood-brain barrier, regional differences, and regulatory mechanisms
6. Rat brain capillary thrombomodulin: Structure and function
7. High-density lipoprotein enhancement of anticoagulant activities of plasma protein S and activated protein C
8. Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon
9. DEGR-factor Xa blocks disseminated intravascular coagulation initiated by Escherichia coli without preventing shock or organ damage
10. Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation
11. Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats
12. Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN, or phorbol ester
13. Prospective study of markers of hemostatic function with risk of ischemic stroke
14. Impairments of the protein C system and fibrinolysis in infection-associated stroke
15. Activated protein C resistance in ischemic stroke not due to factor V arginine506-glutamine mutation
16. Reduced response to activated protein C is associated with increased risk for cerebrovascular disease
17. Brain specific protein C activation during carotid artery occlusion in humans
18. Cardiopulmonary bypass and activation of antithrombotic plasma protein C
19. tPA: A neuron buster, too?
20. Factors determining the therapeutic window for stroke
21. Post-ischemic administration of an anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats
22. Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion: Role of neutrophil adhesion in the pathogenesis of stroke
23. Inflammatory responses in the cerebral cortex after ischemia in the P7 neonatal rat
24. Microvascular response to cerebral ischemia/inflammation
25. Anticoagulant synergism of heparin and activated protein C in vitro: Role of a novel anticoagulant mechanism of heparin, enhancement of inactivation of factor V by activated protein C
26. Inhibition of microarterial thrombosis by activated protein C in a rabbit model
27. Antithrombotic effects of activated protein C and protein S in a rabbit model of microarterial thrombosis
28. Inhibition of platelet-dependent thrombus formation by activated protein C in a primate model
29. Inhibition of thrombus formation by activated recombinant protein C in a primate model of arterial thrombosis
30. Manipulation of coagulation factors in acute stroke
31. Predictors of hemorrhagic transformation occurring spontaneously and on anticoagulants in patients with acute ischemic stroke
32. Hemorrhagic transformation following tissue plasminogen activator in experimental cerebral infarction
33. Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke
34. Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model
35. Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury
36. A targeted point mutation in thrombomodulin generates viable mice with a pre-thrombotic state
37. Use of spectrophotometric hemoglobin assay to objectively quantify intracerebral hemorrhage in mice