Review of conformation-specific affinity purification methods for plasma vitamin K-dependent proteins

Journal of Molecular Recognition

Volumn 9, Issue 3, 1996, Pages 211-218

  Yan, S Betty ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

carboxyglutamic acid; calcium binding proteins; factor IX; factor X; immunoaffinity; protein C; protein S; prothrombin; pseudoaffinity; vitamin K dependent proteins

Indexed keywords

4 CARBOXYGLUTAMIC ACID; BLOOD CLOTTING FACTOR; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 9; CALCIUM; EPIDERMAL GROWTH FACTOR; PLASMA PROTEIN; PLASMA PROTEIN Z; PROTEIN C; PROTEIN S; PROTHROMBIN; VITAMIN K GROUP;

AFFINITY CHROMATOGRAPHY; ANTIBODY SPECIFICITY; CHEMISTRY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; ISOLATION AND PURIFICATION; METHODOLOGY; PHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; REVIEW; STRUCTURE ACTIVITY RELATION;

1-CARBOXYGLUTAMIC ACID; ANTIBODY SPECIFICITY; BLOOD COAGULATION FACTORS; BLOOD PROTEINS; CALCIUM; CHROMATOGRAPHY, AFFINITY; EPIDERMAL GROWTH FACTOR; FACTOR IX; FACTOR VII; FACTOR X; HUMANS; IMMUNOSORBENT TECHNIQUES; PROTEIN C; PROTEIN CONFORMATION; PROTEIN S; PROTEIN STRUCTURE, TERTIARY; PROTHROMBIN; STRUCTURE-ACTIVITY RELATIONSHIP; VITAMIN K;

EID: 0030136063     PISSN: 09523499     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1352(199605)9:3<211::AID-JMR334>3.0.CO;2-7     Document Type: Review

References (62)

1. Andersson, L., Thuy, L. P. and Brown, J. E. (1981). Affinity chromatography of coagulation factors II, VIII, IX and X on matrix-bound phospholipid vesicles. Thromb. Res. 23, 481-489.
2. 2+ binding to the γ-carboxyglutamic acid and epidermal growth factor-like regions of factor IX. J. Biol. Chem. 266, 2430-2437.
3. Bajaj, S. P. and Birktoft, J. J. (1993). Human factor IX and factor IXa. Meth. Enzymol. 222, 96-128.
4. Baker, M. E., French, F. S. and Joseph, D. R. (1987). Vitamin K-dependent protein S is similar to rat androgen-binding protein. Biochem. J. 243, 293-296.
5. Borowski, M., Furie, B. C., Goldsmith, G. H. and Furie, B. (1985). Metal and phospholipid binding properties of partially carboxylated human prothrombin variants. J. Biol. Chem. 260, 9258-9264.
6. Bradford, M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
7. Chavez, L. G. and Scheraga, H. A. (1977). Immunological determination of the order of folding of portions of the molecule during air oxidation of reduced ribonuclease. Biochemostry 16, 1849-1856.
8. Church, W. R., Bhushan, F. H., Mann, K. G. and Bovill, E. G. (1989). Discrimination of normal and abnormal prothrombin and Protein C in plasma using a calcium ion-inhibited monoclonal antibody to a common epitope on several vitamin K-dependent proteins. Blood 74, 2418-2425.
9. Church, W. R., Messier, T., Howard, P. R., Amiral, J., Meyer, D. and Mann, K. G. (1988). A conserved epitope on several human vitamin K-dependent proteins. J. Biol. Chem. 263, 6259-6267.
10. Dahlback, B., Hildebrand, B. and Malm, J. (1990). Characterization of functionally important domains in human vitamin K-dependent protein S using monoclonal antibodies. J. Biol. Chem. 265, 8127-8135.
11. Davie, E. W., Fujikawa, K. and Kisiel, W. (1991). The coagulation cascade: initiation, maintenance, and regulation. Biochemistry 30, 10363-10370.
12. Dean, J. and Schechter, A. N. (1979). Conformation-specific antibodies to the a chain COOH terminus of hemoglobin A°. J. Biol. Chem. 254, 9185-9193.
13. Esmon, C. T., Esmon, N. L., Le Bonniec, B. F. and Johnson, A. E. (1993). Protein C activation. Meth. Enzymol. 222, 359-385.
14. Fischer, B., Mitterer, A. and Dorner, F. (1995). Purification of recombinant human coagulation factors II and IX and protein S expressed in recombinant Vaccinia virus-infected Vero cells. J. Biotechnol. 38, 129-136.
15. Furie, B. and Furie, B. C. (1979). Conformation-specific antibodies as probes of the γ-carboxyglutamic acid-rich region of bovine prothrombin. J. Biol. Chem. 254, 9766-9771.
16. Furie, B., Provost, K. L., Blanchard, R. A. and Furie, B. C. (1978). Antibodies directed against a γ-carboxyglutamic acid-rich region of bovine prothrombin. J. Biol. Chem. 253, 8980-8987.
17. Furie, B., Schechter, A. N., Sachs, D. H. and Anfinsen, C. B. (1975). An immunological approach to the conformational equilibrium of Staphylococcal Nuclease. J. Mol. Biol. 92, 497-506.
18. Gilchrist, J. S. C. and Pierce, G. N. (1993). Identification and purification of a calcium-binding protein in hepatic nuclear membranes. J. Biol. Chem. 268, 4291-4299.
19. Glenney, J. R. (1991). Purification of calpactins I and II and isolation of N-terminal tail of calpactin I. Meth. Enzymol. 196, 65-69.
20. Goodall, A. H., Kemble, G., O'Brien, D. P., Rawlings, E., Rotblat, F., Russell, G. C., Janossy, G. and Tuddenham, G. D. (1982). Preparation of factor IX deficient human plasma by immunoaffinity chromatography using a monoclonal antibody. Blood 59, 664-670.
21. Grinnell, B. W., Berg, D. T., Walls, J. and Yan, S. B. (1987). Transactivated expression of fully gamma-carboxylated recombinant human protein C, an antithrombotic factor. Bio/Technology 5, 1189-1192.
22. Grinnell, B. W., Walls, J. D., Marks, C., Glasebrook, A. L., Berg, D. T., Yan, S. B. and Bang, N. U. (1990). γ-carboxylated isoforms of recombinant human protein S with different biologic properties. Blood 76, 2546-2554.
23. Hashimoto, N., Morita, T. and Iwanaga, S. (1985). A method for systematic purification from bovine plasma of six vitamin K-dependent coagulation factors: prothrombin, factor X, factor IX, protein S, protein C and protein Z. J. Biochem. 97, 1347-1355.
24. Hurrell, J. G. R., Smith, J. A. and Leach, S. J. (1977). Immunological measurements of conformational motility in regions of the myoglobin molecule. Biochem. 16, 175-185.
25. Jenny, R. J., Messier, T. L., Quellette, L. A. and Church, W. R. (1993). Immunochemical techniques for studying coagulation proteins. Meth. Enzymol. 222, 400-417.
26. 2+ binding to a high affinity site that does not contain γ-carboxyglutamic acid. J. Biol. Chem. 258, 5554-5560.
27. Josic, D., Bal, F. and Schwinn, H. (1993). Isolation of plasma proteins from the clotting cascade by heparin affinity chromatography. J. Chromatogr. 632, 1-10.
28. Keyt, B., Furie, B. C. and Furie, B. (1982). Structural transitions in bovine factor IX associated with metal binding and zymogen activation. J. Biol. Chem. 257, 8687-8695.
29. Kim, H. C., McMillian, C. W., White, G. C., Bergman, G. E., Horton, M. W. and Saidi, P. (1992). Purified factor IX using monoclonal immunoaffinity technique: clinical trials in hemophilia B and comparision to prothrombin complex concentrates. Blood 79, 568-575.
30. Lau, H. K. F. and Rosenberg, R. D. (1989). Conformational changes in human prothrombin as detected by antibody populations. Biochim. Biophys. Acta 996, 95-102.
31. Liebman, H. A., Limentani, S. A., Furie, B. C. and Furie, B. (1985). Immunoaffinity purification of factor IX (Christmas factor) by using conformation-specific antibodies directed against the factor IX-metal complex. Proc. Natl. Acad. Sci. USA 82, 3879-3883.
32. Limentani, S. A., Furie, B. C., Poiesz, B. J., Montagna, R., Wells, K. and Furie, B. (1987). Separation of human factor IX from HTLV-1 or HIV by immunoaffinity chromatography using conformation-specific antibodies. Blood 70, 1312-1315.
33. Malhotra, O. P. (1990). Dicoumarol-induced 9-γ-carboxyglutamic acid prothrombin : isolation and comparison with the 6-, 7-, 8-, and 10-γ-carboxyglutamic acid isomers. Biochem. Cell Biol. 68, 705-715.
34. Marcovina, S., Coppola, R., Valsecchi, C., Zoppo, A., Gelfi, C. and Mannucci, P. M. (1989). Monoclonal antibodies directed to the calcium-free conformation of human Protein S. Thromb. Haemost. 62, 708-714.
35. 2+-binding protein of rat spermatogenic cells: its purification and characterization. Biochem. Biophys. Res. Commun. 176, 1358-1364.
36. Nakamura, S. and Sakata, Y. (1987). Immunoaffinity purification of protein C by using conformation-specific monoclonal antibodies to Protein C-calcium ion complex. Biochim. Biophys. Acta 925, 85-93.
37. Nelsestuen, G. L., Broderius, M. and Martin, G. (1976). Role of γ-carboxyglutamic acid: cation specificity of prothrombin and factor X-phospholipid binding. J. Biol. Chem. 251, 6886-6893.
38. Nelsestuen, G. L., Zytkovicz, T. H. and Howard, J. B. (1974). The mode of action of vitamin K : identification of γ-carboxyglutamic acid as a component of prothrombin. J. Biol. Chem. 249, 6347-6350.
39. Ohsawa, K., Kimura, M., Kurosawa-Ohsawa, K., Takahashi, M., Koyama, M., Abiko, Y., Hirahara, K., Matsuishi, T. and Tanaka, S. (1992). Purification of sufficiently γ-carboxylated recombinant protein C and its derivatives. J. Chromatogy. 597, 285-291.
40. Olivera, B. M., Rivier, J., Clark, C., Ramilo, C. A., Corpuz, G. P., Abogadie, F. C., Mena, E. E., Woodward, S. R., Hillyard, D. R. and Cruz, L. J. (1990). Diversity of Conus neuropeptides. Science 249, 257-263.
41. Pedrocchi, M., Schafer, B. W., Durussel, I., Cox, J. A. and Heizmann, C. W. (1994). Purification and characterization of the recombinant human calcium-binding S100 proteins CAPL and CACY. Biochemistry 33, 6732-6738.
42. Price, P. A., Fraser, J. D. and Metz-Virca, G. (1987). Molecular cloning of matrix Gla protein: implications for substrate recognition by the vitamin K-dependent γ-carboxylase. Proc. Natl. Acad. Sci. USA 84, 8335-8339.
43. 2+-dependent proteins. Thromb. Haemost. 65, 1199, A1819.
44. Simionescu, L., Zamfir-Grigorescu, D., Dimitriu, V., Dumitriu, E., Campean, G., lonescu, T. and Pusca, S. (1988). Methods of isolation and purification of bovine and rat osteocalcin. Endocrinology 26, 187-203.
45. Smith, K. J. (1988). Immunoaffinity purification of factor IX from commercial concentrates and infusion studies in animals. Blood 72, 1269-1277.
46. 2+-dependent monoclonal antibody with the Protein C activation peptide region. J. Biol. Chem. 263, 826-832.
47. Stenflo, J. (1976). A new vitamin K-dependent protein. J. Biol. Chem. 251, 355-363.
48. Stenflo, J., Fernlund, P., Egan, W. and Roepstorff, P. (1974). Vitamin K dependent modifications of glutamic acid residues in prothrombin. Proc. Natl. Acad. Sci. USA 71, 2730-2733.
49. 2+-free GLA domain sheds light on membrane binding of blood coagulation proteins. Nature Structural Biol. 2, 504-509.
50. Tai, M. M., Furie, B. C. and Furie, B. (1980). Conformation-specific antibodies directed against the bovine prothrombin-calcium complex. J. Biol. Chem. 255, 2790-2795.
51. Tanaka, T., Umekawa, H., Ohmura, T. and Hidaka, H. (1984). Calcium-dependent hydrophobic chromatography of calmodulin, S-100 protein and troponin-C. Biochim. Biophys. Acta 787, 158-164.
52. Tharakan, J., Highsmith, F., Clark, D. and Drohan, W. (1992). Physical and biochemical characterization of five commercial resins for immunoaffinity purification of factor IX. J. Chromatogr 595, 103-111.
53. Tharakan, J. P., Clark, D. B. and Drohan, W. N. (1990). Effect of feed flow-rate, antigen concentration and antibody density on immunoaffinity purification of coagulation factor IX. J. Chromat. 522, 153-162.
54. Velander, W. H., Morcol, T., Clark, D. B., Gee, D. and Drohan, W. N. (1990). Technological challenges for large scale purification of protein C. Protein C and Related Anticoagulants, ed. by D. F. Bruley and W. N. Drohan, vol. 11, pp. 11-27. Portfolio Publishing Company, Houston.
55. Vician, L. and Tishkoff, G. H. (1976). Purification of human blood clotting factor X by blue dextran agarose affinity chromatography. Biochim. Biophys. Acta 434, 199-208.
56. Vincenot, A., Gaussem, P., Pittet, J. L., Debost, S. and Aiach, M. (1995). Amino acids 225-235 of the protein C serineprotease domain are important for the interaction with thrombin-thrombomodulin complex. FEBS Lett. 367, 153-157.
57. Wakabayashi, K., Sakata, Y. and Aoki, N. (1986). Conformation-specific monoclonal antibodies to the calcium-induced structure of protein C. J. Biol. Chem. 261, 11097-11105.
58. Ware, J., Diuguid, D. L., Liebman, H. A., Rabiet, M., Kasper, C. K., Furie, B. C., Furie, B. and Stafford, D. (1989). Factor IX San Dimas. J. Biol. Chem. 264, 11401-11406.
59. Van, S. B. (1991). Method for the purification of vitamin K-dependent proteins. U.S. Patent #4981952.
60. Van, S. C. B., Grinnell, B. W. and Wold, F. (1989). Posttranslational modifications of proteins: some problems left to solve. Trends Biol. Sci. 14, 264-268.
61. Yan, S. C. B., Razzano, R, Chao, Y. B., Walls, J. D., Berg, D. T., McClure, D. B. and Grinnell, B. W. (1990). Characterization and novel purification of recombinant human protein C from three mammalian cell lines. Bio/Technology 8, 655-661.
62. 7D) of human activated protein C displays greatly reduced activity as an anticoagulant. Biochemistry 29, 10828-10834.