Inflammation, sepsis, and coagulation

Haematologica

Volumn 84, Issue 3, 1999, Pages 254-259

  Esmon, Charles T ^a,b,c   Fukudome, Kenji ^a   Mather, Tim ^d   Bode, Wolfram ^d   Regan, Lisa M ^c   Stearns Kurosawa, Deborah J ^a   Kurosawa, Shinichiro ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

Coagulation; Inflammation; Sepsis

Indexed keywords

ACTIVATED PROTEIN C; FIBRINOGEN; THROMBIN; THROMBOMODULIN;

ARTICLE; BLOOD CLOTTING; BLOOD VESSEL INJURY; HUMAN; INFLAMMATION; PATHOPHYSIOLOGY; PROTEIN BINDING; REGULATORY MECHANISM; SEPTIC SHOCK; SIGNAL TRANSDUCTION; THROMBOSIS;

EID: 0032879431     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Hanson SR, Griffin JH, Harker LA, et al. Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates. J Clin Invest 1993; 92: 2003-12.
2. Esmon CT, Schwarz HP. An update on clinical and basic aspects of the protein C anticoagulant pathway. Trends Cardiovasc Med 1995; 5:141-8.
3. Conard J, Bauer KA, Gruber A, et al. Normalization of markers of coagulation activation with a purified protein C concentrate in adults with homozygous protein C deficiency. Blood 1993; 82:1159-64.
4. Dreyfus M, Magny JF, Bridey F, et al. Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C concentrate. N Engl J Med 1991; 325:1565-8.
5. Taylor FB, Jr., Chang A, Hinshaw LB, et al. A model for thrombin protection against endotoxin. Thromb Res 1984; 36:177-85.
6. Comp PC, Jacocks RM, Ferrell GL, et al. Activation of protein C in vivo. J Clin Invest 1982; 70:127-34.
7. Taylor F, Chang A, Ferrell G, et al. C4b-binding protein exacerbates the host response to Escherichia coli. Blood 1991; 78:357-63.
8. Taylor FB, Jr., Chang A, Esmon CT, et al. Protein C prevents the coagulopathic and lethal effects of E. coli infusion in the baboon. J Clin Invest 1987; 79:918-25.
9. Grey ST, Tsuchida A, Hau H, et al. Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-γ, or phorbol ester. J Immunol 1994; 153: 3664-72.
10. Grinnell BW, Hermann RB, Van SB. Human protein C inhibits selectin-mediated cell adhesion: role of unique fucosylated oligosaccharide. Glycobiology 1994; 4: 221-6.
11. Esmon CT. Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface. FASEB J 1995; 9:946-55.
12. Fukudome K, Esmon CT. Identification, cloning and regulation of a novel endothelial cell protein C/activated protein C receptor. J Biol Chem 1994; 269: 26486-91.
13. Fukudome K, Esmon CT. Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor(EPCR). The structural and functional conservation in human, bovine, and murine EPCR. J Biol Chem 1995; 270:5571-7.
14. Beckman EM, Porcelli SA, Morita CT, et al. Recognition of a lipid antigen by CD1-restricted αβ+ T cells. Nature 1994;372:691-4.
15. Germain RN. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 1994;76:287-99.
16. Calabi F, Yu CY, Bilsland CAG, et al.CD1: from structure to function. In: Srivastava R, Ram BP, Tyle P, eds. Immunogenetics of the major histocompatibility complex. New York: VCH Publ.; 1991. pp 215-43.
17. 2/M phase-prevalent protein. J Cell Sci 1993; 104:19-30.
18. Fukudome K, Kurosawa S, Stearns-Kurosawa DJ, et al. The endothelial cell protein C receptor: cell surface expression and direct ligand binding by the soluble receptor. J Biol Chem 1996; 271:17491-8.
19. Stearns-Kurosawa DJ, Kurosawa S, Mollica JS, et al. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Proc Natl Acad Sci USA 1996; 93:10212-6.
20. Mathews II, Padmanabhan KP, Tulinsky A. Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin. Biochemistry 1994; 33:13547-52.
21. Stubbs MT, Oschkinat H, Mayr I, et al.The interaction of thrombin with fibrinogen. A structural basis for its specificity. Eur J Biochem 1992; 206:187-95.
22. 2+ for rapid activation by the thrombin-thrombomodulin complex. J Biol Chem 1994; 269:3151-4.
23. Mather T, Oganessyan V, Hof P, et al. The 2.8 Å crystal structure of Gla-domainless activated protein C. EMBO J 1996; 15:6822-31.
24. Esmon CT. Inflammation and thrombosis: mutual regulation linked through the protein C anticoagulant pathway. The Immunologist 1998; 6:84-9.