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Volumn 28, Issue 7, 2000, Pages 2209-2216

Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications

Author keywords

Activated protein C; D dimer; DIC; Leukemia; Protein C; Sepsis; Septic shock; Severe sepsis

Indexed keywords

ACTIVATED PROTEIN C; CYTOSTATIC AGENT; D DIMER; PROTEIN C;

EID: 0033860427     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200007000-00005     Document Type: Article
Times cited : (206)

References (73)
  • 1
    • 0026874127 scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
    • 1. American College of Chest Physicians/ Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20:864-874
    • (1992) Crit Care Med , vol.20 , pp. 864-874
  • 3
    • 0026766175 scopus 로고
    • Modulators of coagulation: A critical appraisal of their role in sepsis
    • 3. Bone RC: Modulators of coagulation: A critical appraisal of their role in sepsis. Arch Intern Med 1992; 152:1381-1389
    • (1992) Arch Intern Med , vol.152 , pp. 1381-1389
    • Bone, R.C.1
  • 4
    • 0031057343 scopus 로고    scopus 로고
    • The cytokine-mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia
    • 4. Levi M, van der Poll T, ten Cate H, et al: The cytokine-mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia. Eur J Clin Invest 1997; 27:3-9
    • (1997) Eur J Clin Invest , vol.27 , pp. 3-9
    • Levi, M.1    Van Der Poll, T.2    Ten Cate, H.3
  • 6
    • 0026534242 scopus 로고
    • Septic shock, multiple organ failure, and disseminated intravascular coagulation: Compared patterns of antithrombin III, protein C, and protein S deficiencies
    • 6. Fourrier F, Chopin C, Goudemand J, et al: Septic shock, multiple organ failure, and disseminated intravascular coagulation: Compared patterns of antithrombin III, protein C, and protein S deficiencies. Chest 1992; 101: 816-823
    • (1992) Chest , vol.101 , pp. 816-823
    • Fourrier, F.1    Chopin, C.2    Goudemand, J.3
  • 7
    • 0028127109 scopus 로고
    • Study of the balance between coagulation and fibrinolysis in disseminated intravascular coagulation using molecular markers
    • 7. Asakura H, Jokaji H, Saito M, et al: Study of the balance between coagulation and fibrinolysis in disseminated intravascular coagulation using molecular markers. Blood Coagul Fibrinolysis 1994; 5:829-832
    • (1994) Blood Coagul Fibrinolysis , vol.5 , pp. 829-832
    • Asakura, H.1    Jokaji, H.2    Saito, M.3
  • 8
    • 0020063793 scopus 로고
    • Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C
    • 8. Esmon NL, Owen WG, Esmon CT: Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C. J Biol Chem 1982; 257:859-864
    • (1982) J Biol Chem , vol.257 , pp. 859-864
    • Esmon, N.L.1    Owen, W.G.2    Esmon, C.T.3
  • 9
    • 0020072618 scopus 로고
    • Mechanism of action of human activated protein C, a thrombin-dependent anticoagulant enzyme
    • 9. Marlar RA, Kleiss AJ, Griffin JH: Mechanism of action of human activated protein C, a thrombin-dependent anticoagulant enzyme. Blood 1982; 59:1067-1072
    • (1982) Blood , vol.59 , pp. 1067-1072
    • Marlar, R.A.1    Kleiss, A.J.2    Griffin, J.H.3
  • 10
    • 0029790055 scopus 로고    scopus 로고
    • The endothelial protein C receptor augments protein C activation by the thrombin-thrombomodulin complex
    • 10. Stearns-Kurosawa DJ, Kurosawa S, Mollica JS, et al: The endothelial protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Proc Natl Acad Sci U S A 1996; 93:10212-10216
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 10212-10216
    • Stearns-Kurosawa, D.J.1    Kurosawa, S.2    Mollica, J.S.3
  • 11
    • 0023089665 scopus 로고
    • Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro
    • 11. Moore KL, Andreoli SP, Esmon NL, et al: Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro. J Clin Invest 1987; 79:124-130
    • (1987) J Clin Invest , vol.79 , pp. 124-130
    • Moore, K.L.1    Andreoli, S.P.2    Esmon, N.L.3
  • 12
    • 0022601049 scopus 로고
    • Modulation of endothelial cell hemostatic properties by tumor necrosis factor
    • 12. Nawroth PP, Stern DM: Modulation of endothelial cell hemostatic properties by tumor necrosis factor. J Exp Med 1986; 163: 740-745
    • (1986) J Exp Med , vol.163 , pp. 740-745
    • Nawroth, P.P.1    Stern, D.M.2
  • 13
    • 0023755932 scopus 로고
    • Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells
    • 13. Conway EM, Rosenberg RD: Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells. Mol Cell Biol 1988; 8:5588-5592
    • (1988) Mol Cell Biol , vol.8 , pp. 5588-5592
    • Conway, E.M.1    Rosenberg, R.D.2
  • 14
    • 2442724586 scopus 로고
    • Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anti-coagulant activity
    • 14. Nawroth PP, Handley DA, Esmon CT, et al: Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anti-coagulant activity. Proc Natl Acad Sci U S A 1986; 83:3460-3464
    • (1986) Proc Natl Acad Sci U S A , vol.83 , pp. 3460-3464
    • Nawroth, P.P.1    Handley, D.A.2    Esmon, C.T.3
  • 15
    • 0023122016 scopus 로고
    • Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboons
    • 15. Taylor FB Jr, Chang A, Esmon CT, et al: Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboons. J Clin Invest 1987; 79:918-925
    • (1987) J Clin Invest , vol.79 , pp. 918-925
    • Taylor F.B., Jr.1    Chang, A.2    Esmon, C.T.3
  • 16
    • 0024419991 scopus 로고
    • Quantitative relation between plasma endotoxin, antithrombin, protein C, extrinsic coagulation pathway inhibitor and fibrinopeptide A in systemic meningococcal disease
    • 16. Brandtzaeg P, Sandset PM, Joe GB, et al: Quantitative relation between plasma endotoxin, antithrombin, protein C, extrinsic coagulation pathway inhibitor and fibrinopeptide A in systemic meningococcal disease. Thromb Res 1989; 55:459-470
    • (1989) Thromb Res , vol.55 , pp. 459-470
    • Brandtzaeg, P.1    Sandset, P.M.2    Joe, G.B.3
  • 17
    • 0027214771 scopus 로고
    • Time course of hemostatic abnormalities in sepsis and its relation to outcome
    • 17. Lorente JA, Garcia-Frade LJ, Landin L, et al: Time course of hemostatic abnormalities in sepsis and its relation to outcome. Chest 1993; 103:1536-1542
    • (1993) Chest , vol.103 , pp. 1536-1542
    • Lorente, J.A.1    Garcia-Frade, L.J.2    Landin, L.3
  • 18
    • 0027289342 scopus 로고
    • Management of fever in patients with cancer and treatment-induced neutropenia
    • 18. Pizzo PA: Management of fever in patients with cancer and treatment-induced neutropenia. N Engl J Med 1993; 328:1323-1332
    • (1993) N Engl J Med , vol.328 , pp. 1323-1332
    • Pizzo, P.A.1
  • 19
    • 0029743427 scopus 로고    scopus 로고
    • Factor VIIa and antithrombin III activity during severe sepsis and septic shock in neutropenic patients
    • 19. Mesters RM, Mannucci PM, Coppola R, et al: Factor VIIa and antithrombin III activity during severe sepsis and septic shock in neutropenic patients. Blood 1996; 88:881-886
    • (1996) Blood , vol.88 , pp. 881-886
    • Mesters, R.M.1    Mannucci, P.M.2    Coppola, R.3
  • 20
    • 0026630953 scopus 로고
    • Direct detection of activated protein C in blood from human subjects
    • 20. Gruber A, Griffin JH: Direct detection of activated protein C in blood from human subjects. Blood 1992; 79:2340-2348
    • (1992) Blood , vol.79 , pp. 2340-2348
    • Gruber, A.1    Griffin, J.H.2
  • 22
    • 0028840297 scopus 로고
    • Multiple organ dysfunction syndrome in bone marrow transplantation
    • 22. Haire WD, Ruby EI, Gordon BG, et al: Multiple organ dysfunction syndrome in bone marrow transplantation. JAMA 1995; 274: 1289-1295
    • (1995) JAMA , vol.274 , pp. 1289-1295
    • Haire, W.D.1    Ruby, E.I.2    Gordon, B.G.3
  • 23
    • 0027225620 scopus 로고
    • Naturally occurring anticoagulants and bone marrow transplantation: Plasma protein C predicts the development of venocclusive disease of the liver
    • 23. Faioni EM, Krachmalnicoff A, Bearman SI, et al: Naturally occurring anticoagulants and bone marrow transplantation: Plasma protein C predicts the development of venocclusive disease of the liver. Blood 1993; 81: 3458-3462
    • (1993) Blood , vol.81 , pp. 3458-3462
    • Faioni, E.M.1    Krachmalnicoff, A.2    Bearman, S.I.3
  • 24
    • 0029030147 scopus 로고
    • Trauma, sepsis and disseminated intravascular coagulation
    • 24. Hardaway RM: Trauma, sepsis and disseminated intravascular coagulation. J Intensive Care Med 1995; 10:145-152
    • (1995) J Intensive Care Med , vol.10 , pp. 145-152
    • Hardaway, R.M.1
  • 25
    • 0029119879 scopus 로고
    • An update on clinical and basic aspects of the protein C anti-coagulant pathway
    • 25. Esmon CT, Schwarz HP: An update on clinical and basic aspects of the protein C anti-coagulant pathway. Trends Cardiovasc Med 1995; 5:141-148
    • (1995) Trends Cardiovasc Med , vol.5 , pp. 141-148
    • Esmon, C.T.1    Schwarz, H.P.2
  • 26
    • 0001748803 scopus 로고
    • Antithrombotic and anti-inflammatory agents of the protein C anticoagulant pathway
    • 26. Yan SB, Grinnell BW: Antithrombotic and anti-inflammatory agents of the protein C anticoagulant pathway. Ann Rep Med Chem 1994; 11:103-112
    • (1994) Ann Rep Med Chem , vol.11 , pp. 103-112
    • Yan, S.B.1    Grinnell, B.W.2
  • 27
    • 0030756899 scopus 로고    scopus 로고
    • The protein C pathway: New insights
    • 27. Esmon CT, Ding W, Yasuhiro K, et al: The protein C pathway: New insights. Thromb Haemost 1997; 78:70-74
    • (1997) Thromb Haemost , vol.78 , pp. 70-74
    • Esmon, C.T.1    Ding, W.2    Yasuhiro, K.3
  • 28
    • 0026409651 scopus 로고
    • Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C concentrate
    • 28. Dreyfus M, Magny JF, Bridey F, et al: Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C concentrate. N Engl J Med 1991; 325:1565-1568
    • (1991) N Engl J Med , vol.325 , pp. 1565-1568
    • Dreyfus, M.1    Magny, J.F.2    Bridey, F.3
  • 29
    • 0027965649 scopus 로고
    • Physiological anticoagulation. Resistance to activated protein C and venous thromboembolism
    • 29. Dahlbäck B: Physiological anticoagulation. Resistance to activated protein C and venous thromboembolism. J Clin Invest 1994; 94: 923-927
    • (1994) J Clin Invest , vol.94 , pp. 923-927
    • Dahlbäck, B.1
  • 30
    • 0027973305 scopus 로고
    • Cytokine response to infection in patients with acute myelogenous leukaemia following intensive chemotherapy
    • 30. Ostermann H, Rothenburger M, Mesters RM, et al: Cytokine response to infection in patients with acute myelogenous leukaemia following intensive chemotherapy. Br J Haematol 1994; 88:332-337
    • (1994) Br J Haematol , vol.88 , pp. 332-337
    • Ostermann, H.1    Rothenburger, M.2    Mesters, R.M.3
  • 31
    • 0021863658 scopus 로고
    • Serial studies of protein C and its plasma inhibitor in patients with disseminated intravascular coagulation
    • 31. Marlar RA, Endres-Brooks J, Miller C: Serial studies of protein C and its plasma inhibitor in patients with disseminated intravascular coagulation. Blood 1985; 66:59-63
    • (1985) Blood , vol.66 , pp. 59-63
    • Marlar, R.A.1    Endres-Brooks, J.2    Miller, C.3
  • 32
    • 0023184343 scopus 로고
    • Purpura fulminans in meningococcemia: Association with acquired deficiencies of protein C and S
    • 32. Powars DR, Rogers ZR, Patch MJ, et al: Purpura fulminans in meningococcemia: Association with acquired deficiencies of protein C and S. N Engl J Med 1987; 317:571-572
    • (1987) N Engl J Med , vol.317 , pp. 571-572
    • Powars, D.R.1    Rogers, Z.R.2    Patch, M.J.3
  • 33
    • 0026061609 scopus 로고
    • Protein C, protein S and C4b-binding protein in severe infection and septic shock
    • 33. Hesselvik JF, Malm J, Dahlbäck B, et al: Protein C, protein S and C4b-binding protein in severe infection and septic shock. Thromb Haemost 1991; 65:126-129
    • (1991) Thromb Haemost , vol.65 , pp. 126-129
    • Hesselvik, J.F.1    Malm, J.2    Dahlbäck, B.3
  • 34
    • 0026788072 scopus 로고
    • Protein C and S deficiency in severe infectious purpura of children: A collaborative study of 40 cases
    • 34. Leclerc F, Hazelzet J, Jude B, et al: Protein C and S deficiency in severe infectious purpura of children: A collaborative study of 40 cases. Intensive Care Med 1992; 18:202-205
    • (1992) Intensive Care Med , vol.18 , pp. 202-205
    • Leclerc, F.1    Hazelzet, J.2    Jude, B.3
  • 35
    • 0026625080 scopus 로고
    • Protein C, protein S and C4b-binding protein in neonatal severe infection and septic shock
    • 35. Roman J, Velasco F, Fernandez F, et al: Protein C, protein S and C4b-binding protein in neonatal severe infection and septic shock. J Perinat Med 1992; 20:111-116
    • (1992) J Perinat Med , vol.20 , pp. 111-116
    • Roman, J.1    Velasco, F.2    Fernandez, F.3
  • 36
    • 0027248914 scopus 로고
    • Epidemic meningococcemia and purpura fulminans with induced protein C deficiency
    • 36. Powars D, Larsen R, Johnson J, et al: Epidemic meningococcemia and purpura fulminans with induced protein C deficiency. Clin Infect Dis 1993; 17:254-261
    • (1993) Clin Infect Dis , vol.17 , pp. 254-261
    • Powars, D.1    Larsen, R.2    Johnson, J.3
  • 37
    • 0028359396 scopus 로고
    • Relation between cytokines and routine laboratory data in children with septic shock and purpura
    • 37. Hazelzet JA, van der Voort E, Lindemans J, et al: Relation between cytokines and routine laboratory data in children with septic shock and purpura. Intensive Care Med 1994; 20: 371-374
    • (1994) Intensive Care Med , vol.20 , pp. 371-374
    • Hazelzet, J.A.1    Van Der Voort, E.2    Lindemans, J.3
  • 38
    • 0028855106 scopus 로고
    • Coagulation activation and tissue necrosis in meningococcal septic shock: Severely reduced protein C levels predict a high mortality
    • 38. Fijnvandraat K, Derkx B, Peters M, et al: Coagulation activation and tissue necrosis in meningococcal septic shock: Severely reduced protein C levels predict a high mortality. Thromb Haemost 1995; 73:15-20
    • (1995) Thromb Haemost , vol.73 , pp. 15-20
    • Fijnvandraat, K.1    Derkx, B.2    Peters, M.3
  • 39
    • 0029011240 scopus 로고
    • Activation of the protein C pathway in acute sepsis
    • 39. Alcaraz A, Espana F, Sanchez-Cuenaca J, et al: Activation of the protein C pathway in acute sepsis. Thromb Res 1995; 79:83-93
    • (1995) Thromb Res , vol.79 , pp. 83-93
    • Alcaraz, A.1    Espana, F.2    Sanchez-Cuenaca, J.3
  • 40
    • 0021707112 scopus 로고
    • Radioimmunoassays for protein C and factor X: Plasma antigen levels in abnormal hemostatic states
    • 40. Epstein DJ, Bergum PW, Bajaj SP, et al: Radioimmunoassays for protein C and factor X: Plasma antigen levels in abnormal hemostatic states. Am J Clin Pathol 1984; 82: 573-581
    • (1984) Am J Clin Pathol , vol.82 , pp. 573-581
    • Epstein, D.J.1    Bergum, P.W.2    Bajaj, S.P.3
  • 41
    • 0025244937 scopus 로고
    • Neonatal purpura fulminans due to homozygous protein C-or protein S deficiencies
    • 41. Marlar RA, Neumann A: Neonatal purpura fulminans due to homozygous protein C-or protein S deficiencies. Semin Thromb Haemost 1990; 16:299-309
    • (1990) Semin Thromb Haemost , vol.16 , pp. 299-309
    • Marlar, R.A.1    Neumann, A.2
  • 42
    • 0009465879 scopus 로고    scopus 로고
    • Upregulation of the message for rodent endothelial cell protein C receptor (EPCR) by endotoxin and thrombin
    • 42. Ding W, Gu J-M, Fukudome K, et al: Upregulation of the message for rodent endothelial cell protein C receptor (EPCR) by endotoxin and thrombin. Abstr. Circulation 1996; 94:1-694
    • (1996) Abstr. Circulation , vol.94 , pp. 1-694
    • Ding, W.1    Gu, J.-M.2    Fukudome, K.3
  • 43
    • 0031973176 scopus 로고    scopus 로고
    • Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: Lack of correlation with thrombomodulin suggests involvement of different pathological processes
    • 43. Kurosawa S, Stearns-Kurosawa DJ, Carson CW, et al: Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: Lack of correlation with thrombomodulin suggests involvement of different pathological processes. Blood 1998; 91:725-727
    • (1998) Blood , vol.91 , pp. 725-727
    • Kurosawa, S.1    Stearns-Kurosawa, D.J.2    Carson, C.W.3
  • 44
    • 0024502137 scopus 로고
    • Activation and complexation of protein C and cleavage and decrease of protein s in plasma of patients with intravascular coagulation
    • 44. Heeb MJ, Mosher D, Griffin JH: Activation and complexation of protein C and cleavage and decrease of protein S in plasma of patients with intravascular coagulation. Blood 1989; 73:455-461
    • (1989) Blood , vol.73 , pp. 455-461
    • Heeb, M.J.1    Mosher, D.2    Griffin, J.H.3
  • 45
    • 0025119274 scopus 로고
    • Determination of plasma protein C inhibitor and of two activated protein C-inhibitor complexes in normals and in patients with intra-vascular coagulation and thrombotic disease
    • 45. Espana F, Vicente V, Tabernero D, et al: Determination of plasma protein C inhibitor and of two activated protein C-inhibitor complexes in normals and in patients with intra-vascular coagulation and thrombotic disease. Thromb Res 1990; 59:593-608
    • (1990) Thromb Res , vol.59 , pp. 593-608
    • Espana, F.1    Vicente, V.2    Tabernero, D.3
  • 46
    • 0025301848 scopus 로고
    • A qualitative and quantitative analysis of the activation and inactivation of protein C in vivo in a primate model
    • 46. Hoogendoorn H, Nesheim ME, Giles AR: A qualitative and quantitative analysis of the activation and inactivation of protein C in vivo in a primate model. Blood 1990; 75: 2164-2171
    • (1990) Blood , vol.75 , pp. 2164-2171
    • Hoogendoorn, H.1    Nesheim, M.E.2    Giles, A.R.3
  • 47
    • 0027273931 scopus 로고
    • 2-macroglobulin, in patients with disseminated intravascular coagulation
    • 2-macroglobulin, in patients with disseminated intravascular coagulation. Thromb Haemost 1993; 69:448-453
    • (1993) Thromb Haemost , vol.69 , pp. 448-453
    • Scully, M.F.1    Toh, C.H.2    Hoogendoorn, H.3
  • 48
    • 0024589205 scopus 로고
    • Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture
    • 48. Moore KL, Esmon CT, Esmon NL: Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture. Blood 1989; 73:159-165
    • (1989) Blood , vol.73 , pp. 159-165
    • Moore, K.L.1    Esmon, C.T.2    Esmon, N.L.3
  • 49
    • 0027725139 scopus 로고
    • Expression of tissue factor, thrombomodulin, and E-selectin in baboons with lethal Escherichia coli sepsis
    • 49. Drake TA, Cheng J, Chang A, et al: Expression of tissue factor, thrombomodulin, and E-selectin in baboons with lethal Escherichia coli sepsis. Am J Pathol 1993; 142: 1458-1470
    • (1993) Am J Pathol , vol.142 , pp. 1458-1470
    • Drake, T.A.1    Cheng, J.2    Chang, A.3
  • 50
    • 0024333745 scopus 로고
    • Sepsis syndrome: A valid clinical entity
    • 50. Bone RC, Fisher CJ, Clemmer TP, et al: Sepsis syndrome: A valid clinical entity. Crit Care Med 1989; 17:389-393
    • (1989) Crit Care Med , vol.17 , pp. 389-393
    • Bone, R.C.1    Fisher, C.J.2    Clemmer, T.P.3
  • 51
    • 0025710312 scopus 로고
    • Increase in national hospital discharge survey rates for septicemia - United States. 1979-1987
    • 51. Increase in national hospital discharge survey rates for septicemia - United States. 1979-1987. MMWR Morb Mortal Wkly Rep 1990; 39:31-34
    • (1990) MMWR Morb Mortal Wkly Rep , vol.39 , pp. 31-34
  • 52
    • 0029401567 scopus 로고
    • The Italian sepsis study: Preliminary results on the incidence and evolution of SIRS, sepsis, severe sepsis and septic shock
    • 52. Salvo I, de Cian W, Musicco M, et al: The Italian sepsis study: Preliminary results on the incidence and evolution of SIRS, sepsis, severe sepsis and septic shock. Intensive Care Med 1995; 21:S244-S249
    • (1995) Intensive Care Med , vol.21
    • Salvo, I.1    De Cian, W.2    Musicco, M.3
  • 53
    • 0028557981 scopus 로고
    • Treatment of septic shock with human monoclonal antibody HA-1A. A randomized, double-blind, placebo-controlled trial. CHESS trial study group
    • 53. McCloskey RV, Straube RC, Sanders C, et al: Treatment of septic shock with human monoclonal antibody HA-1A. A randomized, double-blind, placebo-controlled trial. CHESS trial study group. Ann Intern Med 1994; 121:1-5
    • (1994) Ann Intern Med , vol.121 , pp. 1-5
    • McCloskey, R.V.1    Straube, R.C.2    Sanders, C.3
  • 54
    • 0029043636 scopus 로고    scopus 로고
    • A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: Results of a prospective, multicenter, randomized, controlled trial. The E5 sepsis study group
    • 54. Bone RC, Balk RA, Fein AM, et al: A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: Results of a prospective, multicenter, randomized, controlled trial. The E5 sepsis study group. Crit Care Med 1996; 23:994-1006
    • (1996) Crit Care Med , vol.23 , pp. 994-1006
    • Bone, R.C.1    Balk, R.A.2    Fein, A.M.3
  • 55
    • 0028239555 scopus 로고
    • Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome
    • 55. Fisher CJ, Dhainaut JA, Opal SM, et al: Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. JAMA 1994; 271:1836-1843
    • (1994) JAMA , vol.271 , pp. 1836-1843
    • Fisher, C.J.1    Dhainaut, J.A.2    Opal, S.M.3
  • 56
    • 23444446083 scopus 로고
    • Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis
    • 56. Natanson C, Hoffman WD, Suffredini AF, et al: Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis. Ann Intern Med 1994; 120: 771-783
    • (1994) Ann Intern Med , vol.120 , pp. 771-783
    • Natanson, C.1    Hoffman, W.D.2    Suffredini, A.F.3
  • 57
    • 0029900294 scopus 로고    scopus 로고
    • Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein
    • 57. Fisher CJ, Agosti JM, Opal SM, et al: Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. N Engl J Med 1996; 334:1697-1702
    • (1996) N Engl J Med , vol.334 , pp. 1697-1702
    • Fisher, C.J.1    Agosti, J.M.2    Opal, S.M.3
  • 58
    • 9344246862 scopus 로고    scopus 로고
    • Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: A multicenter, randomized, placebo-controlled, dose-ranging study
    • 58. Reinhart K, Wiegand-Lohnert C, Grimminger F, et al: Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: A multicenter, randomized, placebo-controlled, dose-ranging study. Crit Care Med 1996; 24: 733-742
    • (1996) Crit Care Med , vol.24 , pp. 733-742
    • Reinhart, K.1    Wiegand-Lohnert, C.2    Grimminger, F.3
  • 59
    • 0030746482 scopus 로고    scopus 로고
    • Anti-inflammatory therapies to treat sepsis and septic shock: A reassessment
    • 59. Zeni F, Freeman B, Natanson C: Anti-inflammatory therapies to treat sepsis and septic shock: A reassessment. Crit Care Med 1997; 25:1095-1100
    • (1997) Crit Care Med , vol.25 , pp. 1095-1100
    • Zeni, F.1    Freeman, B.2    Natanson, C.3
  • 60
    • 17044458176 scopus 로고    scopus 로고
    • Effect of a recombinant dimeric tumor necrosis factor receptor on inflammatory responses to intravenous endotoxin in normal humans
    • 60. Van der Poll T, Coyle SM, Levi M, et al: Effect of a recombinant dimeric tumor necrosis factor receptor on inflammatory responses to intravenous endotoxin in normal humans. Blood 1997; 89:3727-3734
    • (1997) Blood , vol.89 , pp. 3727-3734
    • Van Der Poll, T.1    Coyle, S.M.2    Levi, M.3
  • 61
    • 0024451060 scopus 로고
    • Efficacy of antithrombin III supplementation in animal models of fulminant Escherichia coli endotoxemia or bacteremia
    • 61. Emerson TE, Fournel MA, Redens TB, et al: Efficacy of antithrombin III supplementation in animal models of fulminant Escherichia coli endotoxemia or bacteremia. Am J Med 1989; 87(Suppl 3b):27-35
    • (1989) Am J Med , vol.87 , Issue.SUPPL. 3B , pp. 27-35
    • Emerson, T.E.1    Fournel, M.A.2    Redens, T.B.3
  • 62
    • 0027319678 scopus 로고
    • Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock
    • 62. Creasey AA, Chang ACK, Feigen L, et al: Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock. J Clin Invest 1993; 91:2850-2860
    • (1993) J Clin Invest , vol.91 , pp. 2850-2860
    • Creasey, A.A.1    Chang, A.C.K.2    Feigen, L.3
  • 63
    • 0029855166 scopus 로고    scopus 로고
    • Increase of plasminogen activator inhibitor levels predicts outcome of leukocytopenic patients with sepsis
    • 63. Mesters RM, Flörke, Ostermann H, et al: Increase of plasminogen activator inhibitor levels predicts outcome of leukocytopenic patients with sepsis. Thromb Haemost 75: 902-907
    • Thromb Haemost , vol.75 , pp. 902-907
    • Mesters, R.M.1    Flörke2    Ostermann, H.3
  • 64
    • 0027367126 scopus 로고
    • Selective effects of protein C on activation of human monocytes by lipopolysaccharide, interferon-gamma, or PMA: Modulation of effects on CD11b and CD14 but not CD25 or CD54 induction
    • 64. Grey T, Hau H, Salem HH, et al: Selective effects of protein C on activation of human monocytes by lipopolysaccharide, interferon-gamma, or PMA: Modulation of effects on CD11b and CD14 but not CD25 or CD54 induction. Transplant Proc 1993; 25: 2913-2914
    • (1993) Transplant Proc , vol.25 , pp. 2913-2914
    • Grey, T.1    Hau, H.2    Salem, H.H.3
  • 65
    • 0029873131 scopus 로고    scopus 로고
    • A physiologic anti-inflammatory pathway based on thrombomodulin expression and generation of activated protein C by human mononuclear phagocytes
    • 65. Grey ST, Hancock WW: A physiologic anti-inflammatory pathway based on thrombomodulin expression and generation of activated protein C by human mononuclear phagocytes. J Immunol 1996; 156: 2256-2263
    • (1996) J Immunol , vol.156 , pp. 2256-2263
    • Grey, S.T.1    Hancock, W.W.2
  • 66
    • 0025835094 scopus 로고
    • C4b-binding protein exacerbates the host response to Escherichia coli
    • 66. Taylor FB Jr, Chang A, Ferrell G, et al: C4b-binding protein exacerbates the host response to Escherichia coli. Blood 1991; 78: 357-363
    • (1991) Blood , vol.78 , pp. 357-363
    • Taylor F.B., Jr.1    Chang, A.2    Ferrell, G.3
  • 67
    • 0030034186 scopus 로고    scopus 로고
    • Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats
    • 67. Murakami K, Okajima K, Uchiba M, et al: Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats. Thromb Haemost 1996; 87:642-647
    • (1996) Thromb Haemost , vol.87 , pp. 642-647
    • Murakami, K.1    Okajima, K.2    Uchiba, M.3
  • 68
    • 0031989122 scopus 로고    scopus 로고
    • Activated protein C concentrate for the treatment of meningococcal endotoxin shock in rabbits
    • 68. Roback MG, Stack AM, Thompson C, et al: Activated protein C concentrate for the treatment of meningococcal endotoxin shock in rabbits. Shock 1998; 9:138-142
    • (1998) Shock , vol.9 , pp. 138-142
    • Roback, M.G.1    Stack, A.M.2    Thompson, C.3
  • 69
    • 0027397621 scopus 로고
    • Severe acquired protein C deficiency in purpura fulminans associated with disseminated intravascular coagulation: Treatment with protein C concentrate
    • 69. Gerson WT, Dickerman JD, Bovill EG, et al: Severe acquired protein C deficiency in purpura fulminans associated with disseminated intravascular coagulation: Treatment with protein C concentrate. Pediatrics 1993; 91: 418-422
    • (1993) Pediatrics , vol.91 , pp. 418-422
    • Gerson, W.T.1    Dickerman, J.D.2    Bovill, E.G.3
  • 70
    • 0028958909 scopus 로고
    • Treatment of purpura fulminans in meningococcemia with protein C concentrate
    • 70. Rivard GE, David M, Farrell C, et al: Treatment of purpura fulminans in meningococcemia with protein C concentrate. J Pediatr 1995; 126:646-652
    • (1995) J Pediatr , vol.126 , pp. 646-652
    • Rivard, G.E.1    David, M.2    Farrell, C.3
  • 71
    • 15844395458 scopus 로고    scopus 로고
    • Protein C in the treatment of coagulopathy in meningococcal disease
    • 71. Rintala E, Seppala O, Kotilainen P, et al: Protein C in the treatment of coagulopathy in meningococcal disease. Lancet 1996; 347: 1767
    • (1996) Lancet , vol.347 , pp. 1767
    • Rintala, E.1    Seppala, O.2    Kotilainen, P.3
  • 72
    • 0031590612 scopus 로고    scopus 로고
    • Use of protein C concentrate, heparin, and haemodiafiltration in meningococcus-induced purpura fulminans
    • 72. Smith OP, White B, Vaughan D, et al: Use of protein C concentrate, heparin, and haemodiafiltration in meningococcus-induced purpura fulminans. Lancet 1997; 350: 1590-1593
    • (1997) Lancet , vol.350 , pp. 1590-1593
    • Smith, O.P.1    White, B.2    Vaughan, D.3
  • 73
    • 0000586696 scopus 로고    scopus 로고
    • Treatment of DIC in septic shock with protein C concentrate
    • 73. Veldman A, Escuriola-Ettingshausen C, Beeg T, et al: Treatment of DIC in septic shock with protein C concentrate. Blood 1997; 90: 3271
    • (1997) Blood , vol.90 , pp. 3271
    • Veldman, A.1    Escuriola-Ettingshausen, C.2    Beeg, T.3


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