Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation

Blood

Volumn 95, Issue 12, 2000, Pages 3781-3787

  Mizutani, Akio ^b   Okajima, Kenji ^a   Uchiba, Mitsuhiro ^b   Noguchi, Takayuki ^b  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 10A; DYFLOS; FIBRIN DEGRADATION PRODUCT; HEPARIN; INTERLEUKIN 8; MYELOPEROXIDASE; SERINE PROTEINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVITY; KIDNEY BLOOD FLOW; KIDNEY BLOOD VESSEL; KIDNEY DISEASE; KIDNEY INJURY; KIDNEY ISCHEMIA; LEUKOCYTE ACTIVATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

EID: 0034660464     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.12.3781     Document Type: Article

References (35)

1. Walker FJ, Sexton PW, Esmon CT. The inhibition of blood coagulation by activated protein C through the selective inactivation of activated factor V. Biochim Biophys Acta. 1979;571:333.
2. Esmon CT. The protein C anticoagulant pathway. Arterioscler Thromb. 1992;12:135.
3. Taylor FB Jr, Chang A, Esmon CT, et al. Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon. J Clin Invest. 1987;79:918.
4. Taylor FB Jr, Chang AC, Peer GT, et al. DEGR-factor Xa blocks disseminated intravascular coagulation initiated by Escherichia coli without preventing shock or organ damage. Blood. 1991;78: 364.
5. St John RC, Dorinsky PM. Immunologic therapy for ARDS, septic shock and multiple organ failure. Chest. 1993;103:932.
6. Grey S, Hau H, Salem HH, Hancock WW. Selective effects of protein C on activation of human monocytes by lipopolysaccharide, Interferon-γ, or PMA: modulation of effects on CD11b and CD14 but not CD25 or CD54 induction. Transplant Proc. 1993;25:2913.
7. Grey ST, Tsuchida A, Hau H, Orthner CL, Salem HH, Hancock WW. Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-γ, or phorbol ester. J Immunol. 1994; 153:3664.
8. Murakami K, Okajima K, Uchiba M, et al. Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats. Blood. 1996;87:642.
9. Murakami K, Okajima K, Uchiba M, et al. Activated protein C prevents LPS-induced pulmonary vascular injury by inhibiting cytokine production. Am J Physiol. 1997;272:L197.
10. Thadhani R, Pascual M, Bonventre JV. Acute renal failure. N Engl J Med. 1996;334:1448.
11. Kelly KJ, Williams WW Jr, Colvin RB, et al. Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury. J Clin Invest. 1996;97:1056.
12. Bonventre JV. Mechanisms of acute renal failure. Kidney Int. 1993;43:1160.
13. Chiao H, Kohda Y, McLeroy P, Craig L, Housini I, Star RA. α-Melanocyte-stimulating hormone protects against renal injury after ischemia in mice and rats. J Clin Invest. 1997;99:1165.
14. Losonczy G Jr. Early postischaemic renal fibrin deposition and reduction of glomerular filtration rate in the rat: effect of the defibrinating agent Arwin. Acta Physiol Hung. 1985;66:183.
15. Druid H, Eneström S, Rammer L. Effect of anticoagulation upon nephron obstruction in experimental acute ischaemic renal failure: a morphological study. Int J Exp Pathol. 1998;79:55.
16. Okajima K, Koga S, Kaji M, et al. Effect of protein C and activated protein C on coagulation and fibrinolysis in normal human subjects. Thromb Haemost. 1990;63:48.
17. Nesheim ME, Kettner C, Shaw E, Mann KG. Co-factor dependence of factor Xa incorporation into the prothrombinase complex. J Biol Chem. 1981; 256:6537.
18. Bajaj SP, Rapaport SI, Prodanos CA. A simplified procedure for purification of human prothrombin, factor IX and factor X. Prep Biochem. 1981;11: 397.
19. Morita T, Jackson CM. Localization of the structural difference between bovine blood coagulation factors X1 and X2 to tyrosine 18 in the activation peptide. J Biol Chem. 1986;261:4008.
20. Mann KG. Membrane-bound enzyme complexes in blood coagulation. In Spaet TH. ed. Progress in Hemostasis and Thrombosis. Vol 7. New York, NY: Grune & Stratton; 1984:1-24.
21. Taoka Y, Okajima K, Uchiba M, et al. Activated protein C reduces the severity of compression-induced spinal cord injury in rats by inhibiting activation of leukocytes. J Neurosci. 1998;18:1393.
22. Rabb H, Mendiola CC, Saba SR, et al. Antibodies to ICAM-1 protect kidneys in severe ischemic reperfusion injury. Biochem Biophys Res Commun. 1995;211:67.
23. Okajima K, Ueyama H, Hashimoto Y, et al. Homozygous variant of antithrombin III that lacks affinity for heparin, AT III Kumamoto. Thromb Haemost. 1989;61:20.
24. Plante GE, Bissonnette M, Sirois MG, Regoli D, Sirois P. Renal permeability alteration precedes hypertension and involves bradykinin in the spontaneously hypertensive rat. J Clin Invest. 1992; 89:2030.
25. Hansell P, Nygren A, Ueda J. Influence of verapamil on regional blood flow: a study using multi-channel laser-Doppler flowmetry. Acta Physiol Scand. 1990;139:15.
26. Gurbanov K, Rubinstein I, Hoffman A, Abassi Z, Better OS, Winaver J. Differential regulation of renal regional blood flow by endothelin-1. Am J Physiol. 1996;271:F1166.
27. Kelly KJ, Williams WW Jr, Colvin RB, Bonventre JV. Antibody to intercellular adhesion molecule 1 protects the kidney against ischemic injury. Proc Natl Acad Sci U S A. 1994;91:812.
28. Inauen W, Granger DN, Meininger CJ, Schelling ME, Granger HJ, Kvietys PR. An in vitro model of ischemia/reperfusion-induced microvascular injury. Am J Physiol. 1990;259:G134.
29. Bonventre JV, Colvin RB. Adhesion molecules in renal disease. Curr Opin Nephrol Hypertens. 1996;5:254.
30. Liu W, Okajima K, Murakami K, Harada N, Isobe H, Irie T. Role of neutrophil elastase in stress-induced gastric mucosal injury in rals. J Lab Clin Med. 1998;132:432.
31. Kawabata M, Suzuki M, Sugitani M, Imaki K, Toda M, Miyamoto T. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun. 1991;177:814.
32. Pober JS, Cotran RS. Cytokines and endothelial cell biology. Physiol Rev. 1990;70:427.
33. Daemen MA, van de Ven MW, Heineman E, Buurman WA. Involvement of endogenous interleukin-10 and tumor necrosis factor-alpha in renal ischemia-reperfusion injury. Transplantation. 1999;27:792.
34. Remick DG, Villarete L. Regulation of cytokine gene expression by reactive oxygen and reactive nitrogen intermediates. J Leukoc Biol. 1996;59: 471.
35. Okajima K, Imamura H, Koga S, Inoue M, Takatsuki K, Aoki N. Treatment of patients with disseminated intravascular coagulation by protein C. Am J Hematol 1990;33:277.