-
1
-
-
0034112615
-
Immunologic response to infection and its role in septic shock
-
Casey LC. Immunologic response to infection and its role in septic shock. Crit Care Clin 2000; 16: 193-213.
-
(2000)
Crit. Care Clin.
, vol.16
, pp. 193-213
-
-
Casey, L.C.1
-
2
-
-
0034927826
-
Sepsis and evolution of the innate immune response
-
Beutler B, Poltorak A. Sepsis and evolution of the innate immune response. Crit Care Med 2001; 29 (suppl): S2-S6.
-
(2001)
Crit. Care Med.
, vol.29
, Issue.SUPPL.
-
-
Beutler, B.1
Poltorak, A.2
-
3
-
-
0033020625
-
Human endothelium as a source of multifunctional cytokines: Molecular regulation and possible role in human disease
-
Krishnaswamy G, Kelley J, Yerra L, Smith JK, Chi DS. Human endothelium as a source of multifunctional cytokines: Molecular regulation and possible role in human disease. J Interferon Cytokine Res 1999; 19: 91-104.
-
(1999)
J. Interferon Cytokine Res.
, vol.19
, pp. 91-104
-
-
Krishnaswamy, G.1
Kelley, J.2
Yerra, L.3
Smith, J.K.4
Chi, D.S.5
-
4
-
-
0037588986
-
The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
-
Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 2003; 101: 3765-77.
-
(2003)
Blood
, vol.101
, pp. 3765-3777
-
-
Aird, W.C.1
-
5
-
-
0027312882
-
Pathogenesis of disseminated intravascular coagulation in sepsis
-
Levi M, ten Cate H, van der Poll T, van Deventer SJ. Pathogenesis of disseminated intravascular coagulation in sepsis. JAMA 1993; 270: 975-9.
-
(1993)
JAMA
, vol.270
, pp. 975-979
-
-
Levi, M.1
ten Cate, H.2
van der Poll, T.3
van Deventer, S.J.4
-
6
-
-
0037352616
-
Cardiovascular management of septic shock
-
Dellinger RP. Cardiovascular management of septic shock. Crit Care Med 2003; 31: 946-55.
-
(2003)
Crit. Care Med.
, vol.31
, pp. 946-955
-
-
Dellinger, R.P.1
-
7
-
-
0026710191
-
Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine
-
Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101: 1644-55.
-
(1992)
Chest
, vol.101
, pp. 1644-1655
-
-
Bone, R.C.1
Balk, R.A.2
Cerra, F.B.3
Dellinger, R.P.4
Fein, A.M.5
Knaus, W.A.6
Schein, R.M.7
Sibbald, W.J.8
-
8
-
-
0037389094
-
SCCM/ESICM/ACCP/ATS/SIS. 2001 SCCM/ESICM/ACCP/ATS/SIS. International Sepsis Definitions Conference
-
Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G, SCCM/ESICM/ACCP/ATS/SIS. 2001 SCCM/ESICM/ACCP/ATS/SIS. International Sepsis Definitions Conference. Crit Care Med 2003; 31: 1250-6.
-
(2003)
Crit. Care Med.
, vol.31
, pp. 1250-1256
-
-
Levy, M.M.1
Fink, M.P.2
Marshall, J.C.3
Abraham, E.4
Angus, D.5
Cook, D.6
Cohen, J.7
Opal, S.M.8
Vincent, J.L.9
Ramsay, G.10
-
9
-
-
0034958947
-
Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
-
Angus D, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29: 1303-10.
-
(2001)
Crit. Care Med.
, vol.29
, pp. 1303-1310
-
-
Angus, D.1
Linde-Zwirble, W.T.2
Lidicker, J.3
Clermont, G.4
Carcillo, J.5
Pinsky, M.R.6
-
10
-
-
0026591793
-
The protein C anticoagulant pathway
-
Esmon CT. The protein C anticoagulant pathway. Arterioscler Thromb 1992; 12: 135-45.
-
(1992)
Arterioscler. Thromb.
, vol.12
, pp. 135-145
-
-
Esmon, C.T.1
-
11
-
-
0019729432
-
Human protein C: Inactivation of factors V and VIII in plasma by the activated molecule
-
Marlar RA, Kleiss AJ, Griffin JH. Human protein C: Inactivation of factors V and VIII in plasma by the activated molecule. Ann N Y Acad Sci 1981; 370: 303-10.
-
(1981)
Ann. N. Y. Acad. Sci.
, vol.370
, pp. 303-310
-
-
Marlar, R.A.1
Kleiss, A.J.2
Griffin, J.H.3
-
12
-
-
0025030398
-
Inhibition of thrombus formation by activated recombinant protein C in a primate model of arterial thrombosis
-
Gruber A, Hanson SR, Kelly AB, Yan BS, Bang N, Griffin JH, Harker LA. Inhibition of thrombus formation by activated recombinant protein C in a primate model of arterial thrombosis. Circulation 1990; 82: 578-5.
-
(1990)
Circulation
, vol.82
, pp. 578-585
-
-
Gruber, A.1
Hanson, S.R.2
Kelly, A.B.3
Yan, B.S.4
Bang, N.5
Griffin, J.H.6
Harker, L.A.7
-
13
-
-
0021958273
-
Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases antiactivator activity
-
Sakata Y, Curriden S, Lawrence D, Griffin JH, Loskutoff DJ. Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases antiactivator activity. Proc Natl Acad Sci USA 1985; 82: 1121-5.
-
(1985)
Proc. Natl. Acad. Sci. USA
, vol.82
, pp. 1121-1125
-
-
Sakata, Y.1
Curriden, S.2
Lawrence, D.3
Griffin, J.H.4
Loskutoff, D.J.5
-
14
-
-
0021928672
-
Activated protein C decreases plasminogen activator-inhibitor activity in endothelial cell-conditioned medium
-
van Hinsbergh VW, Bertina RM, van Wijngaardern A, van Tilburg NH, Emeis JJ, Haverkate F. Activated protein C decreases plasminogen activator-inhibitor activity in endothelial cell-conditioned medium. Blood 1985; 65: 444-51.
-
(1985)
Blood
, vol.65
, pp. 444-451
-
-
van Hinsbergh, V.W.1
Bertina, R.M.2
van Wijngaardern, A.3
van Tilburg, N.H.4
Emeis, J.J.5
Haverkate, F.6
-
15
-
-
0033830963
-
The anticoagulant and anti-inflammatory roles of the protein C anticoagulant pathway
-
Esmon CT. The anticoagulant and anti-inflammatory roles of the protein C anticoagulant pathway. J Autoimmun 2000; 15: 113-6.
-
(2000)
J. Autoimmun.
, vol.15
, pp. 113-136
-
-
Esmon, C.T.1
-
16
-
-
0038682435
-
Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease activated receptor-1 and endothelial cell protein C receptor
-
Mosnier LO, Griffin JH. Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease activated receptor-1 and endothelial cell protein C receptor. Biochem J 2003; 373: 65-70.
-
(2003)
Biochem. J.
, vol.373
, pp. 65-70
-
-
Mosnier, L.O.1
Griffin, J.H.2
-
17
-
-
0030776168
-
Human protein C receptor is present primarily on endothelium of large blood vessels: Implications for the control of the protein C pathway
-
Laszik Z, Mitro, A, Taylor FB Jr, Ferrell G, Esmon CT. Human protein C receptor is present primarily on endothelium of large blood vessels: Implications for the control of the protein C pathway. Circulation 1997; 96: 3633-40.
-
(1997)
Circulation
, vol.96
, pp. 3633-3640
-
-
Laszik, Z.1
Mitro, A.2
Taylor Jr., F.B.3
Ferrell, G.4
Esmon, C.T.5
-
18
-
-
0043240071
-
Expression and function of the endothelial protein C receptor in human neutrophils
-
Sturn DH, Kaneider NC, Feistritzer C, Djanani A, Fukudome K, Wiedermann CJ. Expression and function of the endothelial protein C receptor in human neutrophils. Blood 2003; 102: 1499-505.
-
(2003)
Blood
, vol.102
, pp. 1499-1505
-
-
Sturn, D.H.1
Kaneider, N.C.2
Feistritzer, C.3
Djanani, A.4
Fukudome, K.5
Wiedermann, C.J.6
-
19
-
-
0029626658
-
Binding of activated protein C to a specific receptor on human mononuclear phagocytes inhibits intracellular calcium signaling and monocyte-dependent proliferative responses
-
Hancock WW, Grey ST, Hau L, Akalin E, Orthner C, Sayegh MH, Salem HH. Binding of activated protein C to a specific receptor on human mononuclear phagocytes inhibits intracellular calcium signaling and monocyte-dependent proliferative responses. Transplantation 1995; 60: 1525-32.
-
(1995)
Transplantation
, vol.60
, pp. 1525-1532
-
-
Hancock, W.W.1
Grey, S.T.2
Hau, L.3
Akalin, E.4
Orthner, C.5
Sayegh, M.H.6
Salem, H.H.7
-
20
-
-
0042530424
-
Endothelial protein C receptor-dependent inhibition of human eosinophil chemotaxis by protein C
-
Feistritzer C, Sturn DH, Kaneider NC, Djanani A, Wiedermann CJ. Endothelial protein C receptor-dependent inhibition of human eosinophil chemotaxis by protein C. J Allergy Clin Immunol 2003; 112: 375-81.
-
(2003)
J. Allergy Clin. Immunol.
, vol.112
, pp. 375-381
-
-
Feistritzer, C.1
Sturn, D.H.2
Kaneider, N.C.3
Djanani, A.4
Wiedermann, C.J.5
-
21
-
-
0038290189
-
Activated protein C inhibits the expression of platelet-derived growth factor in the lung
-
Shimizu S, Gabazza EC, Taguchi O, Yasui H, Taguchi Y, Hayashi T, Ido M, Shimizu T, Nakagaki T, Kobayashi H, Fukudome K, Tsuneyoshi N, D'Alessandro-Gabazza CN, Izumizaki M, Iwase M, Homma I, Adachi Y, Suzuki K. Activated protein C inhibits the expression of platelet-derived growth factor in the lung. Am J Respir Crit Care Med 2003; 167: 1416-26.
-
(2003)
Am. J. Respir. Crit. Care Med.
, vol.167
, pp. 1416-1426
-
-
Shimizu, S.1
Gabazza, E.C.2
Taguchi, O.3
Yasui, H.4
Taguchi, Y.5
Hayashi, T.6
Ido, M.7
Shimizu, T.8
Nakagaki, T.9
Kobayashi, H.10
Fukudome, K.11
Tsuneyoshi, N.12
D'Alessandro-Gabazza, C.N.13
Izumizaki, M.14
Iwase, M.15
Homma, I.16
Adachi, Y.17
Suzuki, K.18
-
22
-
-
0033810792
-
Protein C levels as a prognostic indicator of outcome in sepsis and related diseases
-
Fisher CJ Jr, Yan SB. Protein C levels as a prognostic indicator of outcome in sepsis and related diseases. Crit Care Med 2000; 28 (suppl): S49-56.
-
(2000)
Crit. Care Med.
, vol.28
, Issue.SUPPL.
-
-
Fisher Jr., C.J.1
Yan, S.B.2
-
23
-
-
0035826096
-
Efficacy and safety of recombinant human activated protein C for severe sepsis
-
Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group
-
Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ Jr. Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344: 699-709.
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 699-709
-
-
Bernard, G.R.1
Vincent, J.L.2
Laterre, P.F.3
LaRosa, S.P.4
Dhainaut, J.F.5
Lopez-Rodriguez, A.6
Steingrub, J.S.7
Garber, G.E.8
Helterbrand, J.D.9
Ely, E.W.10
Fisher Jr., C.J.11
-
24
-
-
0034917322
-
Activated protein C versus protein C in severe sepsis
-
Yan SB, Dhainaut JF. Activated protein C versus protein C in severe sepsis. Crit Care Med 2001; 29 (suppl): S69-74.
-
(2001)
Crit. Care Med.
, vol.29
, Issue.SUPPL.
-
-
Yan, S.B.1
Dhainaut, J.F.2
-
25
-
-
1542495556
-
Mediator modulation therapy of severe sepsis and septic shock: Does it work?
-
Dellinger RP, Parrillo JE. Mediator modulation therapy of severe sepsis and septic shock: Does it work? Crit Care Med 2004; 32: 282-6.
-
(2004)
Crit. Care Med.
, vol.32
, pp. 282-286
-
-
Dellinger, R.P.1
Parrillo, J.E.2
-
26
-
-
0013930355
-
Coagulation changes in clinical shock. II. Effect of septic shock on clotting times and fibrinogen in humans
-
Attar S, Mansberger AR Jr, Irani B, Kirby W Jr, Masaitis C, Cowley RA. Coagulation changes in clinical shock. II. Effect of septic shock on clotting times and fibrinogen in humans. Ann Surg 1966; 164: 41-50.
-
(1966)
Ann. Surg.
, vol.164
, pp. 41-50
-
-
Attar, S.1
Mansberger Jr., A.R.2
Irani, B.3
Kirby Jr., W.4
Masaitis, C.5
Cowley, R.A.6
-
27
-
-
0013901126
-
Blood coagulation factor activity in experimental endotoxemia
-
West RL, Elovitz MJ, Hardaway RM. Blood coagulation factor activity in experimental endotoxemia. Ann Surg 1966; 163: 567-72.
-
(1966)
Ann. Surg.
, vol.163
, pp. 567-572
-
-
West, R.L.1
Elovitz, M.J.2
Hardaway, R.M.3
-
28
-
-
0014421611
-
Changes in the blood coagulation system associated with septicemia
-
Corrigan JJ Jr, Ray WL, May N. Changes in the blood coagulation system associated with septicemia. N Engl J Med 1968; 279: 851-6.
-
(1968)
N. Engl. J. Med.
, vol.279
, pp. 851-856
-
-
Corrigan Jr., J.J.1
Ray, W.L.2
May, N.3
-
29
-
-
0035904368
-
Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: A randomized controlled trial
-
for the KyberSept Trial Study Group
-
Warren BL, Eid A, Singer P, Pillay SS, Carl P, Novak I, Chalupa P, Atherstone A, Penzes I, Kubler A, Knaub S, Keinecke HO, Heinrichs H, Schindel F, Juers M, Bone RC, Opal SM, for the KyberSept Trial Study Group. Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial. JAMA 2001; 286: 1869-78.
-
(2001)
JAMA
, vol.286
, pp. 1869-1878
-
-
Warren, B.L.1
Eid, A.2
Singer, P.3
Pillay, S.S.4
Carl, P.5
Novak, I.6
Chalupa, P.7
Atherstone, A.8
Penzes, I.9
Kubler, A.10
Knaub, S.11
Keinecke, H.O.12
Heinrichs, H.13
Schindel, F.14
Juers, M.15
Bone, R.C.16
Opal, S.M.17
-
30
-
-
0038690407
-
Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: A randomized controlled trial
-
the OPTIMIST Trial Study Group
-
Abraham E, Reinhart K, Opal S, Doig C, Rodriguez AL, Beale R, Svoboda P, Laterre PF, Simon S, Light B, Spapen H, Stone J, Seibert A, Peckelsen C, De Deyne C, Postier R, Pettila V, Artigas A, Percell SR, Shu V, Zwingelstein C, Tobias J, Poole L, Stolzenbach JC, Creasey AA, the OPTIMIST Trial Study Group. Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: A randomized controlled trial. JAMA 2003; 290: 238-47.
-
(2003)
JAMA
, vol.290
, pp. 238-247
-
-
Abraham, E.1
Reinhart, K.2
Opal, S.3
Doig, C.4
Rodriguez, A.L.5
Beale, R.6
Svoboda, P.7
Laterre, P.F.8
Simon, S.9
Light, B.10
Spapen, H.11
Stone, J.12
Seibert, A.13
Peckelsen, C.14
De Deyne, C.15
Postier, R.16
Pettila, V.17
Artigas, A.18
Percell, S.R.19
Shu, V.20
Zwingelstein, C.21
Tobias, J.22
Poole, L.23
Stolzenbach, J.C.24
Creasey, A.A.25
more..
-
31
-
-
0019457996
-
Regulation of bovine activated protein C by protein S: The role of the cofactor protein in species specificity
-
Walker FJ. Regulation of bovine activated protein C by protein S: The role of the cofactor protein in species specificity. Thromb Res 1981; 22: 321-7.
-
(1981)
Thromb. Res.
, vol.22
, pp. 321-327
-
-
Walker, F.J.1
-
32
-
-
0025823014
-
Species specificity of the fibrinolytic effects of activated protein C
-
Weinstein RE, Walker FJ. Species specificity of the fibrinolytic effects of activated protein C. Thromb Res 1991; 63: 123-31.
-
(1991)
Thromb. Res.
, vol.63
, pp. 123-131
-
-
Weinstein, R.E.1
Walker, F.J.2
-
33
-
-
0027749378
-
Effect of rabbit activated protein C on thrombin generation and fibrinolysis in a species-specific in vivo model: Effect of modulation of protein S activity
-
Weinstein RE, Walker FJ. Effect of rabbit activated protein C on thrombin generation and fibrinolysis in a species-specific in vivo model: effect of modulation of protein S activity. Semin Thromb Haemost 1993; 19: 368-77.
-
(1993)
Semin. Thromb. Haemost.
, vol.19
, pp. 368-377
-
-
Weinstein, R.E.1
Walker, F.J.2
-
34
-
-
0028255956
-
Rabbit plasma, unlike its human counterpart, contains no complex between protein S and C4b-binding protein
-
He X, Dahlback B. Rabbit plasma, unlike its human counterpart, contains no complex between protein S and C4b-binding protein. Thromb Haemost 1994; 71: 446-51.
-
(1994)
Thromb. Haemost.
, vol.71
, pp. 446-451
-
-
He, X.1
Dahlback, B.2
-
35
-
-
0028174359
-
Resistance to inhibition by alpha-1-antitrypsin and species specificity of a chimeric human/bovine protein C
-
Holly RD, Foster DC. Resistance to inhibition by alpha-1-antitrypsin and species specificity of a chimeric human/bovine protein C. Biochemistry 1994; 33: 1876-80.
-
(1994)
Biochemistry
, vol.33
, pp. 1876-1880
-
-
Holly, R.D.1
Foster, D.C.2
-
36
-
-
0023122016
-
Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon
-
Taylor FB Jr, Chang A, Esmon CT, D'Angelo A, Vigano-D'Angelo S, Blick KE. Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon. J Clin Invest 1987; 79: 918-25.
-
(1987)
J. Clin. Invest.
, vol.79
, pp. 918-925
-
-
Taylor Jr., F.B.1
Chang, A.2
Esmon, C.T.3
D'Angelo, A.4
Vigano-D'Angelo, S.5
Blick, K.E.6
-
37
-
-
0017148819
-
Intravascular coagulation associated with the adult respiratory distress syndrome
-
Bone RC, Francis PB, Pierce AK. Intravascular coagulation associated with the adult respiratory distress syndrome. Am J Med 1976; 61: 585-9.
-
(1976)
Am. J. Med.
, vol.61
, pp. 585-589
-
-
Bone, R.C.1
Francis, P.B.2
Pierce, A.K.3
-
39
-
-
0026534242
-
Septic shock, multiple organ failure and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C and protein S deficiencies
-
Fourrier F, Chopin C, Goudemand J, Hendrycx S, Caron C, Rime A, Marey A, Lestavel P. Septic shock, multiple organ failure and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C and protein S deficiencies. Chest 1992; 101: 816-23.
-
(1992)
Chest
, vol.101
, pp. 816-823
-
-
Fourrier, F.1
Chopin, C.2
Goudemand, J.3
Hendrycx, S.4
Caron, C.5
Rime, A.6
Marey, A.7
Lestavel, P.8
-
40
-
-
0027214771
-
Time course of hemostatic abnormalities in sepsis and its relation to outcome
-
Lorente JA, Garcia-Frade LJ, Landin L, de Pablo R, Torrado C, Renes E, Garcia-Avello A. Time course of hemostatic abnormalities in sepsis and its relation to outcome. Chest 1993; 103: 1536-42.
-
(1993)
Chest
, vol.103
, pp. 1536-1542
-
-
Lorente, J.A.1
Garcia-Frade, L.J.2
Landin, L.3
de Pablo, R.4
Torrado, C.5
Renes, E.6
Garcia-Avello, A.7
-
41
-
-
0027248914
-
Epidemic meningococcemia and purpura fulminans with induced protein C deficiency
-
Powars D, Larsen R, Johnson J, Hulbert T, Sun T, Patch MJ, Francis R, Chan L. Epidemic meningococcemia and purpura fulminans with induced protein C deficiency. Clin Infect Dis 1993; 17: 254-61.
-
(1993)
Clin. Infect. Dis.
, vol.17
, pp. 254-261
-
-
Powars, D.1
Larsen, R.2
Johnson, J.3
Hulbert, T.4
Sun, T.5
Patch, M.J.6
Francis, R.7
Chan, L.8
-
42
-
-
0021086761
-
Inherited protein C deficiency and coumarin-responsive chronic relapsing purpura fulminans in a newborn infant
-
Branson HE, Katz J, Marble R, Griffin JH. Inherited protein C deficiency and coumarin-responsive chronic relapsing purpura fulminans in a newborn infant. Lancet 1983; 2: 1165-8.
-
(1983)
Lancet
, vol.2
, pp. 1165-1168
-
-
Branson, H.E.1
Katz, J.2
Marble, R.3
Griffin, J.H.4
-
43
-
-
0024785583
-
Homozygous protein C deficiency: Early treatment with warfarin
-
Hartman KR, Manco-Johnson M, Rawlings JS, Bower DJ, Marlar RA. Homozygous protein C deficiency: early treatment with warfarin. Am J Pediatr Hem Oncol 1989; 11: 395-401.
-
(1989)
Am. J. Pediatr. Hem. Oncol.
, vol.11
, pp. 395-401
-
-
Hartman, K.R.1
Manco-Johnson, M.2
Rawlings, J.S.3
Bower, D.J.4
Marlar, R.A.5
-
44
-
-
0026409651
-
Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C concentrate
-
Dreyfus M, Magny JF, Bridey F, Schwarz HP, Planche C, Dehan M, Tchernia G. Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C concentrate. N Engl J Med 1991; 325: 1565-8.
-
(1991)
N. Engl. J. Med.
, vol.325
, pp. 1565-1568
-
-
Dreyfus, M.1
Magny, J.F.2
Bridey, F.3
Schwarz, H.P.4
Planche, C.5
Dehan, M.6
Tchernia, G.7
-
45
-
-
0027397621
-
Severe acquired protein C deficiency in purpura fulminans associated with disseminated intravascular coagulation: Treatment with protein C concentrate
-
Gerson WT, Dickerman JD, Bovill EG, Golden E. Severe acquired protein C deficiency in purpura fulminans associated with disseminated intravascular coagulation: treatment with protein C concentrate. Pediatrics 1993; 91: 418-22.
-
(1993)
Pediatrics
, vol.91
, pp. 418-422
-
-
Gerson, W.T.1
Dickerman, J.D.2
Bovill, E.G.3
Golden, E.4
-
46
-
-
0029112841
-
Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface
-
Esmon CT. Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface. FASEB J 1995; 9: 946-55.
-
(1995)
FASEB J.
, vol.9
, pp. 946-955
-
-
Esmon, C.T.1
-
47
-
-
0027161205
-
Molecular events that control the protein C anticoagulant pathway
-
Esmon CT. Molecular events that control the protein C anticoagulant pathway. Thromb Haemost 1993; 70: 29-35.
-
(1993)
Thromb. Haemost.
, vol.70
, pp. 29-35
-
-
Esmon, C.T.1
-
48
-
-
0027435111
-
Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates
-
Hanson SR, Griffin JH, Harker LA, Kelly AB, Esmon CT, Gruber A. Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates. J Clin Invest 1993; 92: 2003-12.
-
(1993)
J. Clin. Invest.
, vol.92
, pp. 2003-2012
-
-
Hanson, S.R.1
Griffin, J.H.2
Harker, L.A.3
Kelly, A.B.4
Esmon, C.T.5
Gruber, A.6
-
49
-
-
0027444776
-
Generation of activated protein C during thrombolysis
-
Gruber A, Pal A, Kiss RG, Sas G, Griffin JH. Generation of activated protein C during thrombolysis. Lancet 1993; 342: 1275-6.
-
(1993)
Lancet
, vol.342
, pp. 1275-1276
-
-
Gruber, A.1
Pal, A.2
Kiss, R.G.3
Sas, G.4
Griffin, J.H.5
-
50
-
-
0033062738
-
Neutrophil and endothelial cell interactions in sepsis. The role of adhesion molecules
-
Parent C, Eichacker PQ. Neutrophil and endothelial cell interactions in sepsis. The role of adhesion molecules. Infect Dis Clin N Am 1999; 13: 427-47.
-
(1999)
Infect. Dis. Clin. N. Am.
, vol.13
, pp. 427-447
-
-
Parent, C.1
Eichacker, P.Q.2
-
51
-
-
0023089665
-
Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro
-
Moore KL, Andreoli SP, Esmon NL, Esmon CT, Bang NU. Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro. J Clin Invest 1987; 79: 124-30.
-
(1987)
J. Clin. Invest.
, vol.79
, pp. 124-130
-
-
Moore, K.L.1
Andreoli, S.P.2
Esmon, N.L.3
Esmon, C.T.4
Bang, N.U.5
-
52
-
-
0024589205
-
Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture
-
Moore KL, Esmon CT, Esmon NL. Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture. Blood 1989; 73: 159-65.
-
(1989)
Blood
, vol.73
, pp. 159-165
-
-
Moore, K.L.1
Esmon, C.T.2
Esmon, N.L.3
-
54
-
-
0035833529
-
Dysfunction of endothelial protein C activation in severe meningococcal sepsis
-
Faust SN, Levin M, Harrison OB, Goldin RD, Lockhart MS, Kondaveeti S, Laszik Z, Esmon CT, Heyderman RS. Dysfunction of endothelial protein C activation in severe meningococcal sepsis. N Engl J Med 2001; 345: 408-16.
-
(2001)
N. Engl. J. Med.
, vol.345
, pp. 408-416
-
-
Faust, S.N.1
Levin, M.2
Harrison, O.B.3
Goldin, R.D.4
Lockhart, M.S.5
Kondaveeti, S.6
Laszik, Z.7
Esmon, C.T.8
Heyderman, R.S.9
-
55
-
-
0035164538
-
Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis
-
Bernard GR, Ely EW, Wright TJ, Fraiz J, Stasek JE Jr, Russell JA, Mayers I, Rosenfeld BA, Morris PE, Yan SB, Helterbrand JD. Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis. Crit Care Med 2001; 29: 2051-9.
-
(2001)
Crit. Care Med.
, vol.29
, pp. 2051-2059
-
-
Bernard, G.R.1
Ely, E.W.2
Wright, T.J.3
Fraiz, J.4
Stasek Jr., J.E.5
Russell, J.A.6
Mayers, I.7
Rosenfeld, B.A.8
Morris, P.E.9
Yan, S.B.10
Helterbrand, J.D.11
-
56
-
-
0036795261
-
Pharmacokinetic-pharmacodynamic analysis of drotrecogin alfa (activated) in patients with severe sepsis
-
Macias WL, Dhainaut JF, Yan SC, Helterbrand JD, Seger M, Johnson G 3rd, Small DS. Pharmacokinetic-pharmacodynamic analysis of drotrecogin alfa (activated) in patients with severe sepsis. Clin Pharmacol Ther 2002; 72: 391-402.
-
(2002)
Clin. Pharmacol. Ther.
, vol.72
, pp. 391-402
-
-
Macias, W.L.1
Dhainaut, J.F.2
Yan, S.C.3
Helterbrand, J.D.4
Seger, M.5
Johnson III, G.6
Small, D.S.7
-
57
-
-
0001474003
-
The effect of leukocyte elastase on protein C and activated protein C
-
(Abstract 664)
-
Philapitsch A, Schwarz HP. The effect of leukocyte elastase on protein C and activated protein C (Abstract 664). Thromb Haemost 1993; 69: 726.
-
(1993)
Thromb. Haemost.
, vol.69
, pp. 726
-
-
Philapitsch, A.1
Schwarz, H.P.2
-
58
-
-
0034927828
-
Hepatic response to sepsis: Interaction between coagulation and inflammatory processes
-
Dhainaut JF, Marin N, Mignon A, Vinsonneau C. Hepatic response to sepsis: interaction between coagulation and inflammatory processes. Crit Care Med 2001; 29 (suppl): S42-7.
-
(2001)
Crit. Care Med.
, vol.29
, Issue.SUPPL.
-
-
Dhainaut, J.F.1
Marin, N.2
Mignon, A.3
Vinsonneau, C.4
-
59
-
-
0038128677
-
Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: A randomized, double-blind, placebo-controlled, dose-finding study
-
de Kleijn ED, de Groot R, Hack CE, Mulder PG, Engl W, Moritz B, Joosten KF, Hazelzet JA. Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: A randomized, double-blind, placebo-controlled, dose-finding study. Crit Care Med 2003; 31: 1839-47.
-
(2003)
Crit. Care Med.
, vol.31
, pp. 1839-1847
-
-
de Kleijn, E.D.1
de Groot, R.2
Hack, C.E.3
Mulder, P.G.4
Engl, W.5
Moritz, B.6
Joosten, K.F.7
Hazelzet, J.A.8
-
60
-
-
0037251585
-
Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis
-
PROWESS Investigators
-
Ely EW, Laterre PF, Angus DC, Helterbrand JD, Levy H, Dhainaut JF, Vincent JL, Macias WL, Bernard GR; PROWESS Investigators. Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med 2003; 31: 12-9.
-
(2003)
Crit. Care Med.
, vol.31
, pp. 12-19
-
-
Ely, E.W.1
Laterre, P.F.2
Angus, D.C.3
Helterbrand, J.D.4
Levy, H.5
Dhainaut, J.F.6
Vincent, J.L.7
Macias, W.L.8
Bernard, G.R.9
-
61
-
-
0037352375
-
Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial
-
for the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) Study Group
-
Vincent JL, Angus DC, Artigas A, Kalil A, Basson BR, Jamal HH, Johnson G 3rd, Bernard GR, for the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) Study Group. Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med 2003; 31: 834-40.
-
(2003)
Crit. Care Med.
, vol.31
, pp. 834-840
-
-
Vincent, J.L.1
Angus, D.C.2
Artigas, A.3
Kalil, A.4
Basson, B.R.5
Jamal, H.H.6
Johnson III, G.7
Bernard, G.R.8
-
62
-
-
0037389471
-
Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis
-
Bernard GR, Macias WL, Joyce DE, Williams MD, Bailey J, Vincent JL. Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis. Crit Care 2003; 7: 155-63.
-
(2003)
Crit. Care
, vol.7
, pp. 155-163
-
-
Bernard, G.R.1
Macias, W.L.2
Joyce, D.E.3
Williams, M.D.4
Bailey, J.5
Vincent, J.L.6
-
63
-
-
0037408190
-
Pneumococcal meningitis in adults: Spectrum of complications and prognostic factors in a series of 87 cases
-
Kastenbauer S, Pfister HW. Pneumococcal meningitis in adults: spectrum of complications and prognostic factors in a series of 87 cases. Brain 2003; 126: 1015-25.
-
(2003)
Brain
, vol.126
, pp. 1015-1025
-
-
Kastenbauer, S.1
Pfister, H.W.2
-
64
-
-
0020370172
-
Use of endothelium cultured on microcarriers as a model for the microcirculation
-
Busch C, Cancilla PA, DeBault LE, Goldsmith JC, Owen WG. Use of endothelium cultured on microcarriers as a model for the microcirculation. Lab Invest 1982; 47: 498-504.
-
(1982)
Lab. Invest.
, vol.47
, pp. 498-504
-
-
Busch, C.1
Cancilla, P.A.2
DeBault, L.E.3
Goldsmith, J.C.4
Owen, W.G.5
-
65
-
-
0034059213
-
The endothelial protein C receptor
-
Esmon CT. The endothelial protein C receptor. Thromb Haemost 2000; 83: 639-43.
-
(2000)
Thromb. Haemost.
, vol.83
, pp. 639-643
-
-
Esmon, C.T.1
-
66
-
-
0037036069
-
Activation of endothelial cell protease activated receptor 1 by the protein C pathway
-
Riewald M, Petrovan RJ, Donner A Hulbert T, Sun T, Patch MJ, Francis R, Chan L. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 2002; 296: 1880-2.
-
(2002)
Science
, vol.296
, pp. 1880-1882
-
-
Riewald, M.1
Petrovan, R.J.2
Donner, A.3
Hulbert, T.4
Sun, T.5
Patch, M.J.6
Francis, R.7
Chan, L.8
-
67
-
-
0027998013
-
Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LIPS, IFN-gamma, or phorbol ester
-
Grey ST, Tsuchida A, Hau H, Orthner CL, Salem HH, Hancock WW. Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LIPS, IFN-gamma, or phorbol ester. J Immunol 1994; 153: 3664-72.
-
(1994)
J. Immunol.
, vol.153
, pp. 3664-3672
-
-
Grey, S.T.1
Tsuchida, A.2
Hau, H.3
Orthner, C.L.4
Salem, H.H.5
Hancock, W.W.6
-
68
-
-
0035815747
-
Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis
-
Joyce DE, Gelbert L, Ciaccia A, DeHoff B, Grinnell BW. Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis. J Biol Chem 2001; 276: 11199-203.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 11199-11203
-
-
Joyce, D.E.1
Gelbert, L.2
Ciaccia, A.3
DeHoff, B.4
Grinnell, B.W.5
-
69
-
-
0037296305
-
Inhibition of endothelial cell-mediated generation of activated protein C by direct and antithrombin-dependent thrombin inhibitors
-
Linder R, Frebelius S, Jansson K, Swedenborg J. Inhibition of endothelial cell-mediated generation of activated protein C by direct and antithrombin-dependent thrombin inhibitors. Blood Coagul Fibrinolysis 2003; 14: 139-46.
-
(2003)
Blood Coagul. Fibrinolysis
, vol.14
, pp. 139-146
-
-
Linder, R.1
Frebelius, S.2
Jansson, K.3
Swedenborg, J.4
-
70
-
-
12444249948
-
Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulopathy response in patients with severe sepsis
-
for the PROWESS Sepsis Study Group
-
Dhainaut JF, Yan SB, Margolis BD, Lorente JA, Russell JA, Freebairn RC, Spapen HD, Riess H, Basson B, Johnson G 3rd, Kinasewitz GT, for the PROWESS Sepsis Study Group. Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulopathy response in patients with severe sepsis. Thromb Haemost 2003; 90: 642-53.
-
(2003)
Thromb. Haemost.
, vol.90
, pp. 642-653
-
-
Dhainaut, J.F.1
Yan, S.B.2
Margolis, B.D.3
Lorente, J.A.4
Russell, J.A.5
Freebairn, R.C.6
Spapen, H.D.7
Riess, H.8
Basson, B.9
Johnson III, G.10
Kinasewitz, G.T.11
-
71
-
-
0141567620
-
Recombinant human activated protein C (rhAPC; drotrecogin alfa (activated)) has minimal effect on markers of coagulation, fibrinolysis, and inflammation in acute human endotoxemia
-
Derhaschnig U, Reiter R, Knobl P, Baumgartner M, Keen P, Jilma B. Recombinant human activated protein C (rhAPC; drotrecogin alfa (activated)) has minimal effect on markers of coagulation, fibrinolysis, and inflammation in acute human endotoxemia. Blood 2003; 102: 2093-8.
-
(2003)
Blood
, vol.102
, pp. 2093-2098
-
-
Derhaschnig, U.1
Reiter, R.2
Knobl, P.3
Baumgartner, M.4
Keen, P.5
Jilma, B.6
-
72
-
-
3042571475
-
Effects of drotrecogin alfa (activated) in human endotoxemia
-
Kalil AC, Coyle SM, Um JY, LaRosa SP, Turlo MA, Calvano SE, Sundin DP, Nelson DR, Lowry SF. Effects of drotrecogin alfa (activated) in human endotoxemia. Shock 2004; 21: 222-9.
-
(2004)
Shock
, vol.21
, pp. 222-229
-
-
Kalil, A.C.1
Coyle, S.M.2
Um, J.Y.3
LaRosa, S.P.4
Turlo, M.A.5
Calvano, S.E.6
Sundin, D.P.7
Nelson, D.R.8
Lowry, S.F.9
-
73
-
-
0347634503
-
Activated protein C concentrate reverses purpura fulminans in severe genetic protein C deficiency
-
Manco-Johson MJ, Knapp-Clevenger R. Activated protein C concentrate reverses purpura fulminans in severe genetic protein C deficiency. J Pediatr Hematol Oncol 2004; 26: 25-7.
-
(2004)
J. Pediatr. Hematol. Oncol.
, vol.26
, pp. 25-27
-
-
Manco-Johson, M.J.1
Knapp-Clevenger, R.2
-
74
-
-
0035829842
-
Early goal-directed therapy in the treatment of severe sepsis and septic shock
-
Early Goal-Directed Therapy Collaborative Group
-
Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M, Early Goal-Directed Therapy Collaborative Group. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345: 1368-77.
-
(2001)
N. Engl. J. Med.
, vol.345
, pp. 1368-1377
-
-
Rivers, E.1
Nguyen, B.2
Havstad, S.3
Ressler, J.4
Muzzin, A.5
Knoblich, B.6
Peterson, E.7
Tomlanovich, M.8
-
75
-
-
0347122086
-
Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis
-
Garnacho-Montero J, Garcia-Garmendia L, Barrero-Almodovar A, Jimenez-Jimenez FJ, Perez-Paredes C, Ortiz-Leyba C. Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis. Crit Care Med 2003; 31: 2742-51.
-
(2003)
Crit. Care Med.
, vol.31
, pp. 2742-2751
-
-
Garnacho-Montero, J.1
Garcia-Garmendia, L.2
Barrero-Almodovar, A.3
Jimenez-Jimenez, F.J.4
Perez-Paredes, C.5
Ortiz-Leyba, C.6
-
76
-
-
0037151571
-
Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
-
Annane D, Sebille V, Charpentier C, Bollaert PE, Francois B, Korach JM, Capellier G, Cohen Y, Azoulay E, Troche G, Chaumet-Riffaut P, Bellissant E. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002; 288: 862-71.
-
(2002)
JAMA
, vol.288
, pp. 862-871
-
-
Annane, D.1
Sebille, V.2
Charpentier, C.3
Bollaert, P.E.4
Francois, B.5
Korach, J.M.6
Capellier, G.7
Cohen, Y.8
Azoulay, E.9
Troche, G.10
Chaumet-Riffaut, P.11
Bellissant, E.12
-
77
-
-
0041942666
-
Clinical equipoise remains for issues of adrenocorticotropic hormone administration, cortisol testing, and therapeutic use of hydrocortisone
-
Corticus Study Coordinators
-
Annane D, Briegel J, Keh D, Moreno R, Singer M, Sprung CL; Corticus Study Coordinators. Clinical equipoise remains for issues of adrenocorticotropic hormone administration, cortisol testing, and therapeutic use of hydrocortisone. Crit Care Med 2003; 31: 2250-1.
-
(2003)
Crit. Care Med.
, vol.31
, pp. 2250-2251
-
-
Annane, D.1
Briegel, J.2
Keh, D.3
Moreno, R.4
Singer, M.5
Sprung, C.L.6
-
78
-
-
0035829852
-
Intensive insulin therapy in the critically ill patients
-
van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001; 345: 1359-67.
-
(2001)
N. Engl. J. Med.
, vol.345
, pp. 1359-1367
-
-
van den Berghe, G.1
Wouters, P.2
Weekers, F.3
Verwaest, C.4
Bruyninckx, F.5
Schetz, M.6
Vlasselaers, D.7
Ferdinande, P.8
Lauwers, P.9
Bouillon, R.10
|