Protein C in the treatment of coagulopathy in meningococcal disease

Critical Care Medicine

Volumn 26, Issue 5, 1998, Pages 965-968

  Rintala, Esa ^a   Seppälä, Olli Pekka ^a   Kotilainen, Pirkko ^a   Pettilä, Ville ^b   Rasi, Vesa ^c  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c FINNISH RED CROSS BLOOD SERVICE   (Finland)

Author keywords

Antithrombin III; Coagulopathy; Disseminated intravascular coagulation; Intensive care; Meningitis; Multiple organ failure; Neisseria meningitidis; Protein C; Purpura fulminans; Sepals

Indexed keywords

ANTITHROMBIN III; PROTEIN C; PROTEIN C CONCENTRATE [HUMAN] VAPOR HEATED; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CASE REPORT; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG SAFETY; FEMALE; FULMINATING PURPURA; GANGRENE; HUMAN; HUMAN CELL; HUMAN TISSUE; INTENSIVE CARE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MENINGOCOCCOSIS; MULTIPLE ORGAN FAILURE; NEISSERIA MENINGITIDIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ADULT; CRITICAL CARE; DISSEMINATED INTRAVASCULAR COAGULATION; FEMALE; HUMANS; MALE; MENINGITIS, MENINGOCOCCAL; MIDDLE AGED; MULTIPLE ORGAN FAILURE; PROTEIN C; PURPURA, SCHOENLEIN-HENOCH;

EID: 0031919338     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199805000-00038     Document Type: Article

References (19)

1. Giraud T, Dhainaut JF, Scremmer B, et al: Adult overwhelming meningococcal purpura. A study of 35 cases, 1977-1989. Arch Intern Med 1991; 151:310-316
2. Leclerc F, Hazelzet J, Jude R, et al: Protein C and S deficiency in severe infectious purpura of children: A collaborative study of 40 cases. Intensive Care Med 1992; 18:1-4
3. Gedde-Dahl TW, Bjark P, Hoiby EA, et al: Severity of meningococcal disease: Assessment by factors and scores and implications for patient management. Rev Infect Dis 1990; 12:973-992
4. McManus ML, Churchwell KB: Coagulopathy as a predictor of outcome in meningococcal sepsis and the systemic inflammatory response syndrome with purpura. Crit Care Med 1993; 21: 706-711
5. Humphries JE: Thrombophilia and complex acquired deficiencies of anti-thrombin, protein C, and protein S. Semin Hematol 1995; 32(Suppl 2):8-16
6. Esmon CT, Schwarz HP: An update on clinical and basic aspects of the protein C anticoagulant pathway. Trends Cardiovasc Med 1995; 5:141-148
7. Gerson WT, Dickerman JD, Bovill EG, et al: Severe acquired protein C deficiency in purpura fulminans associated with disseminated intravascular coagulation: Treatment with protein C concentrate. Pediatrics 1993; 91:418-422
8. Rivard GE, David M, Farrell C, et al: Treatment of purpura fulminans in meningococcemia with protein C concentrate. J Pediatr 1995; 126:646-652
9. Taylor FB Jr, Chang A, Esmon CT, et al: Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon. J Clin Invest 1987; 79:918-925
10. Murakami K, Okajima K, Uchiba M, et al: Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats. Blood 1996; 87:642-647
11. Baglin T: Disseminated intravascular coagulation: Diagnosis and treatment. BMJ 1996; 312:683-687
12. Blauhut B, Necek S, Vinazzer H, et al: Substitution therapy with an anti-thrombin III concentrate in shock and DIC. Thromb Res 1982; 27:271-278
13. Fourrier F, Chopin C, Huart JJ, et al: Double blind placebo-controlled study of antithrombin III concentrates in septic shock with disseminated intravascular coagulation. Chest 1993; 104: 882-888
14. Vinazzer H: Therapeutic use of anti-thrombin III in shock and disseminated intravascular coagulation. Semin Thromb Haemost 1989; 15:347-352
15. Frieling JTM, van Deuren M, Wijdenes J, et al: Interleukin-6 and its soluble receptor during acute meningococcal infections: Effect of plasma or whole blood exchange. Crit Care Med 1996; 24:1801-1805
16. van Deuren M, van der Meer JW: Extracorporal techniques to accelerate clearance of TNF-α and IL-1β in septic patients. In: Yearbook of Intensive Care and Emergency Medicine. Vincent J-L (Ed). Berlin, Springer Verlag, 1997, pp 140-148
17. Rogiers P, Zhang H, Voncent J-L: Hemofiltration in sepsis and septic shock. In: Yearbook of Intensive Care and Emergency Medicine. Vincent J-L (Ed). Berlin, Springer Verlag, 1997, pp 133-139
18. Bjorvatn B, Bjertnaes L, Fadnes HO, et al: Meningococcal septicaemia treated with combined plasmapheresis and leucapheresis or with blood exhange. BMJ 1984; 288:439-441
19. van Deuren M, Santman FW, van Dalen R, et al: Plasma and whole blood exchange in meningococcal sepsis. Clin Infect Dis 1992; 15:424-430