The protein C pathway

Critical Care Medicine

Volumn 28, Issue 9 SUPPL., 2000, Pages

  Esmon, C ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

Endothelium; Microvasculature; Protein C; Sepsis; Thrombosis

Indexed keywords

ACTIVATED PROTEIN C; PROTEIN C; PROTEIN S;

DISEASE COURSE; DOWN REGULATION; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; REVIEW; SEPSIS; THROMBIN TIME; THROMBOSIS; TREATMENT OUTCOME;

EID: 0033815369     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200009001-00010     Document Type: Review

References (37)

1. Cell mediated events that control blood coagulation and vascular injury
2. The roles of protein C and thrombomodulin in the regulation of blood coagulation
3. Identification, cloning and regulation of a novel endothelial cell protein C/activated protein C receptor
4. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex
5. Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor
6. Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates
7. Protein C inhibitor is a potent inhibitor of the thrombin-thrombomodulin complex
8. Inhibition and complexation of activated protein C by two major inhibitors in plasma
9. In vivo and in vitro complexes of activated protein C with two inhibitors in baboons
10. 2-antiplasmin in blood and comparisons to inhibition of factor Xa, thrombin, and plasmin
11. Activation of protein C and its distribution between its inhibitors, protein C inhibitor, α1-antitrypsin and α2-macroglobulin, in patients with disseminated intravascular coagulation
12. Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C concentrate
13. Homozygous protein S deficiency: 7-Year follow-up
14. An update on clinical and basic aspects of the protein C anti-coagulant pathway
15. Human protein C receptor is present primarily on endothelium of large blood vessels: Implications for the control of the protein C pathway
16. Reconstitution of the human endothelial cell protein C receptor with thrombomodulin in phosphatidylcholine vesicles enhances protein C activation
17. A 23bp insertion in the endothelial protein C receptor (EPCR) gene in patients with myocardial infarction and deep vein thrombosis
18. Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells
19. Familial protein S deficiency is associated with recurrent thrombosis
20. Inhibition of protein C, a cofactor function of human and bovine protein S by C4b-binding protein
21. Inflammation and thrombosis: Mutual regulation linked through the protein C anticoagulant pathway
22. Inflammatory roles of P-Selectin
23. Protein C prevents the coagulopathic and lethal effects of E. coli infusion in the baboon
24. Use of protein-C concentrate, heparin, and haemodiafiltration in meningococcus-induced purpura fulminans
25. Recombinant human activated protein C (rhAPC) produces a trend toward improvement in morbidity and 28 day survival in patients with severe sepsis
26. Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats
27. Activated protein C prevents LPS-induced pulmonary vascular injury by inhibiting cytokine production
28. Activated protein C reduces the severity or compression-induced spinal cord injury in rats by inhibiting activation of leukocytes
29. Quantification of circulating activated protein C in human plasma by immunoassays - Enzyme levels are proportional to total protein C levels
30. Protein C, an antithrombotic protein, is reduced in hospitalized patients with intravascular coagulation
31. Epidemic meningococcemia and purpura fulminans with induced protein C deficiency
32. Human protein C inhibits selectin-mediated cell adhesion: Role of unique fucosylated oligosaccharide
33. Selective effects of protein C on activation of human monocytes by lipopolysaccharide, interferon-gamma, or PMA: Modulation of effects on CD11b and CD14 but not CD25 or CD54 induction
34. Endothelial cell protein C receptor (EPCR) constitutively translocates into the nucleus and also mediates activated protein C, but not protein C, nuclear translocation
35. The endothelial protein C receptor, neutrophil, proteinase-3 and Wegener's granulomatosis
36. The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis
37. TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex