Antioxidants for female subfertility

Cochrane Database of Systematic Reviews

Volumn 2020, Issue 8, 2020, Pages

  Showell, Marian G ^a   Mackenzie Proctor, Rebecca ^b   Jordan, Vanessa ^a   Hart, Roger J ^c  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b AUCKLAND CITY HOSPITAL   (New Zealand)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANTIOXIDANT; ARGININE; ASCORBIC ACID; CALCIUM; CARNITINE; INOSITOL; MELATONIN; OMEGA 3 FATTY ACID; PENTOXIFYLLINE; SELENIUM; UBIDECARENONE; VITAMIN B COMPLEX; VITAMIN D; MINERAL; PLACEBO; VITAMIN;

ARTICLE; BIRTH RATE; ECTOPIC PREGNANCY; FEMALE SUBFERTILITY; GASTROINTESTINAL SYMPTOM; HUMAN; IN VITRO FERTILIZATION; INTERVENTION STUDY; INTRACYTOPLASMIC SPERM INJECTION; INTRAUTERINE INSEMINATION; LIVE BIRTH; MALE FERTILITY; OVARY HYPERSTIMULATION; OVARY POLYCYSTIC DISEASE; POPULATION RESEARCH; PRACTICE GUIDELINE; PREGNANCY OUTCOME; PREGNANCY RATE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SPONTANEOUS ABORTION; SYSTEMATIC REVIEW; FEMALE; FEMALE INFERTILITY; META ANALYSIS; MULTIPLE PREGNANCY; ORAL DRUG ADMINISTRATION; OXIDATIVE STRESS; PREGNANCY; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ABORTION, SPONTANEOUS; ADMINISTRATION, ORAL; ANTIOXIDANTS; FEMALE; HUMANS; INFERTILITY, FEMALE; LIVE BIRTH; MINERALS; OXIDATIVE STRESS; PENTOXIFYLLINE; PLACEBOS; PREGNANCY; PREGNANCY RATE; PREGNANCY, MULTIPLE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; VITAMINS;

EID: 85089951033     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD007807.pub4     Document Type: Article

References (239)

1. Agrawal R, Burt E, Gallagher AM, Butler L, Venkatakrishnan R, Peitsidis P. Prospective randomized trial of multiple micronutrients in subfertile women undergoing ovulation induction: a pilot study. Reproductive Biomedicine Online 2012;24(1):54-60. x-wiley/crsRef/2782523
2. Al-Alousi TA, Al-Allak MM, Aziz AA, Al Ghazali BS. The effect of omega-3 on the number of retrieved ova, fertilization rate, and embryo grading in subfertile women undergoing intracytoplasmic sperm injection. Biomedical and Pharmacology Journal 2018;11(4):2221-32. x-wiley/crsRef/14403019
3. Badawy A, El Nashar AB, El Totongy M. Clomiphene citrate plus N-acetyl cysteine versus clomiphene citrate for augmenting ovulation in the management of unexplained infertility: a randomized double-blind controlled trial. Fertility and Sterility 2006;86(3):647-50. x-wiley/crsRef/2782529
4. Batioglu AS, Sahin U, Gurlek B, Ozturk N, Unsal E. The efficacy of melatonin administration on oocyte quality. Gynecological Endocrinology 2012;28(2):91-3. x-wiley/crsRef/2782533
5. Battaglia C, Salvatori M, Maxia N, Petraglia F, Facchinetti F, Volpe A. Adjuvant L-arginine treatment for in-vitro fertilization in poor responder patients. Human Reproduction 1999;14(7):1690-7. x-wiley/crsRef/6375127
6. Battaglia C, Regani G, Marsella T, Facchinetti F, Volpe A, Venturoli S. Adjuvant L-arginine treatment in controlled ovarian hyperstimulation: a double-blind randomized study. Human Reproduction 2002;17(3):659-65. x-wiley/crsRef/2782535
7. Behrouzi Lak T, Haj Shafia M, Talebi E, Bahrami Bukani M, Mehrshad A, Zarei L. Evaluation of n-acetyl cysteine effect in ovulation induction: Response of patients who are candidates for intra uterine insemination. International Journal of Fertility and Sterility 2016;10(Supplement 1):85. x-wiley/crsRef/14403021
8. Behrouzi Lak T, Hajshafiha M, Nanbakhsh F, Oshnouei S. N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: an RCT. International Journal of Reproductive Biomedicine (Yazd, Iran) 2017;15(4):203-8. x-wiley/crsRef/14403022
9. Bentov Y, Hannam T, Jurisicova A, Esfandiari N, Casper RF. Coenzyme Q10 supplementation and oocyte aneuploidy in women undergoing IVF-ICSI treatment. Clinical Medicine Insights. Reproductive Health 2014;8:31-6. x-wiley/crsRef/2782537
10. Caballero T, Fiameni F, Valcarcel A, Buzzi J. Dietary supplementation with coenzyme Q10 in poor responder patients undergoing IVF-ICSI treatment. Fertilty and Sterility 2016;106(Supplement 3):e58. x-wiley/crsRef/14403024
11. Carlomagno G, Montanino Oliva M, Roseff SJ, Unfer V. Myo-inositol: Ovarian stimulation and IVF outcomes. Fertility and Sterility 2012;98 Suppl 1(3):S74-S75 Abstract no:O-251. x-wiley/crsRef/2782541
12. Cheraghi E, Mehranjani MS, Shariatzadeh MA, Esfahani MH, Ebrahimi Z. N-Acetylcysteine improves oocyte and embryo quality in polycystic ovary syndrome patients undergoing intracytoplasmic sperm injection: An alternative to metformin. Reproduction, Fertility, and Development 2016;28(6):723-31. x-wiley/crsRef/14403025
13. Cheraghi E, Mehranjani MS, Shariatzadeh MA, Nasr E, Alani B. N-Acetylcysteine compared to metformin, improves the expression profile of growth differentiation factor-9 and receptor tyrosine kinase c-kit in the oocytes of patients with polycystic ovarian syndrome. International Journal of Fertility & Sterility 2018;11(4):270-8. x-wiley/crsRef/14403026
14. Cheraghi E, Shariatzadeh MA, Soleimani M, Nasr Esfahani MH, Ebrahimi Z. Association of follicular fluid endocrine changes with oocyte morphology and quality in PCOS patients undergoing metformin and N-acetylcysteine treatment. International Journal of Fertility & Sterility 2013;7 Suppl 1:44. x-wiley/crsRef/6375130
15. Cheraghi E, Soleimani Mehranjani M, Ali Shariatzadeh M, Nasr Esfahani M, Ebrahimi Z. Co-administration of metformin and N-Acetyl Cysteine fails to improve clinical manifestations in PCOS individual undergoing ICSI. International Journal of Fertility & Sterility 2014;8(2):119-28. x-wiley/crsRef/6375131
16. Cheraghi E, Soleimani Mehranjani M, Shariatzadeh SM, Nasr Esfahani MH, Ebrahimi Z. Expression changes of GDF-9 and BMP-15 in the oocytes of PCOS patients undergoing treatment with N-acetylcysteine. International Journal of Fertility & Sterility 2014;8 Suppl 1:201. x-wiley/crsRef/6375132
17. Choi S-Y, Kim CH, Ahn J-W, Kwon S-K, Lee K-H, Kang B-M. Effect of calcium and vitamin D supplementation on follicular fluid tumor necrosis-alpha and interleukin-6 and IVF/ICSI outcomes in infertile patients with polycystic ovary syndrome. Fertility and Sterility 2012;98 Suppl 1(3):S208-S209 Abstract no:P-326. x-wiley/crsRef/2782547
18. Cicek N, Eryilmaz OG, Sarikaya E, Gulerman C, Genc Y. Vitamin E: Effect on controlled ovarian stimulation of unexplained infertile women. Journal of Assisted Reproduction and Genetics 2012;29(4):325-8. x-wiley/crsRef/2782549
19. Daneshbodi H, Vaziri N, Nadjarzadeh A, Lotfi MH, Mozaffari-Khosravi H. Effect of omega-3 supplementation on gonadotropins and prolactin levels in women with polycystic ovary syndrome: A double blinded randomized controlled trial. Iranian Journal of Reproductive Medicine 2013;11:58-9. x-wiley/crsRef/14403027
20. Nadjarzadeh A, Dehghani-Firouzabadi R, Daneshbodi H, Lotfi MH, Vaziri N, Mozaffari-Khosravi H. Effect of omega-3 supplementation on visfatin, adiponectin, and anthropometric indices in women with polycystic ovarian syndrome. Journal of Reproduction and Infertility 2015;16(4):212-220. x-wiley/crsRef/14403028
21. Deeba F, Fatima P. Multiple micronutrients (MMN) in infertile women undergoing ovulation induction: a randomized control trial. Journal of Obstetrics and Gynaecology Research 2015;41:170. x-wiley/crsRef/6375138
22. El Refaeey A, Selem A, Badawy A. Combined coenzyme Q10 and clomiphene citrate for ovulation induction in clomiphene-citrate-resistant polycystic ovary syndrome. Reproductive Biomedicine Online 2014;29(1):119-24. x-wiley/crsRef/2782555
23. El Sharkwy IA, Abd El Aziz WM. Randomized controlled trial of N-acetylcysteine versus l-carnitine among women with clomiphene-citrate-resistant polycystic ovary syndrome. International Journal of Gynaecology and Obstetrics 2019;147(1):59-64. x-wiley/crsRef/14403030
24. El Sharkwy I, Sharaf El-Din M. l-Carnitine plus metformin in clomiphene-resistant obese PCOS women, reproductive and metabolic effects: a randomized clinical trial. Gynecological Endocrinology 2019;35(8):701-5. x-wiley/crsRef/14403032
25. Eryilmaz OG, Devran A, Sarikaya E, Aksakal FN, Mollamahmutoglu L, Cicek N. Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems. Journal of Assisted Reproduction & Genetics 2011;28(9):815-20. x-wiley/crsRef/2782557
26. Espino J, Macedo M, Lozano G, Ortiz A, Rodriguez C, Rodriguez AB, et al. Impact of melatonin supplementation in women with unexplained infertility undergoing fertility treatment. Antioxidants (Basel, Switzerland) 2019;8(9):1-11. x-wiley/crsRef/14403034
27. Fernando S, Biggs SN, Horne RS, Vollenhoven B, Lolatgis N, Hope N, et al. The impact of melatonin on the sleep patterns of women undergoing IVF: a double blind RCT. Human Reproduction Open 2017;2017(4):1-10. x-wiley/crsRef/14403036
28. Fernando S, Wallace E, Biggs S, Horne R, Rombauts L. Melatonin in assisted reproductive technology (MIART)-oral melatonin treatment during ovarian stimulation does not affect sleep-a double-blind randomized placebo controlled trial. Reproductive Sciences 2017;24(1 Supplement 1):297A. x-wiley/crsRef/14403037
29. Fernando S, Wallace E, Rombauts L. Melatonin in assisted reproductive technology: the MIART trial - a pilot double-blind randomised placebo-controlled clinical trial. Human Reproduction (Oxford, England) 2017;32(Suppl 1):i54. x-wiley/crsRef/14403038
30. Fernando S, Wallace EM, Vollenhoven B, Lolatgis N, Hope N, Wong M, et al. Melatonin in assisted reproductive technology: a pilot double-blind randomized placebo-controlled clinical trial. Frontiers in Endocrinology 2018;9(101555782):545. x-wiley/crsRef/14403039
31. Gerli S, Mignosa M, Di Renzo GC. Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial. European Review for Medical & Pharmacological Sciences 2003;7(6):151-9. x-wiley/crsRef/2782561
32. Gerli S, Papaleo E, Ferrari A, Di Renzo G. Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS. European Review for Medical and Pharmacolgical Sciences 2007;11(5):347-54. x-wiley/crsRef/2782562
33. Ghomian N, Khadem N, Moeindarbari S, Abdolrazagh A. Comparison of pregnancy rate in patients with polycystic ovary syndrome treated with clomiphene alone and in combination with n-acetyl cysteine: a randomized clinical trial. International Journal of Women's Health and Reproduction Sciences 2019;7(2):185-9. x-wiley/crsRef/14403041
34. Griesinger G, Franke K, Kinast C, Kutzelnigg A, Riedinger S, Kulin S, et al. Ascorbic acid supplement during luteal phase in IVF. Journal of Assisted Reproduction and Genetics 2002;19(4):164-8. x-wiley/crsRef/2782564
35. Hashemi Z, Sharifi N, Khani B, Aghadavod E, Asemi Z. The effects of vitamin E supplementation on endometrial thickness, and gene expression of vascular endothelial growth factor and inflammatory cytokines among women with implantation failure. Journal of Maternal-Fetal and Neonatal Medicine 2017;32(1):95-102. x-wiley/crsRef/14403043
36. Hefny M, Mohammad M, Wafa Y. Effect of N-acetylcysteine as an adjuvant to clomiphene citrate for induction of ovulation in patients with polycystic ovary syndrome. BJOG 2018;125:38-9. x-wiley/crsRef/14403045
37. Heidar Z, Hamzepour N, Zadeh Modarres S, Mirzamoradi M, Aghadavod E, Pourhanifeh MH, et al. The effects of selenium supplementation on clinical symptoms and gene expression related to inflammation and vascular endothelial growth factor in infertile women candidate for In Vitro Fertilization. Biological Trace Element Research 2019;193(2):319-25. x-wiley/crsRef/14403047
38. Ismail AM, Hamed AH, Saso S, Thabet HH. Adding L-carnitine to clomiphene resistant PCOS women improves the quality of ovulation and the pregnancy rate. A randomized clinical trial. European Journal of Obstetrics, Gynecology and Reproductive Biology 2014;180:148-52. x-wiley/crsRef/14403048
39. Salem HT, Ismail A. L-carnitin as a treatment in clomiphene resistant PCO for improving quality of ovulation and pregnancy outcome; a novel treatment. Human Reproduction 2012;27:Abstract number: P-529. x-wiley/crsRef/14403049
40. Jahromi BN, Sadeghi S, Alipour S, Parsanezhad ME, Alamdarloo SM. Effect of melatonin on the outcome of assisted reproductive technique cycles in women with diminished ovarian reserve: a double-blinded randomized clinical trial. Iranian Journal of Medical Sciences 2017;42(1):73-8. x-wiley/crsRef/14403051
41. Jamilian M, Zadeh Modarres S, Amiri SM, Karimi M, Mafi A, Ostadmohammadi V, et al. The influences of chromium supplementation on glycemic control, markers of cardio-metabolic risk, and oxidative stress in infertile polycystic ovary syndrome women candidate for in vitro fertilization: a randomized, double-blind, placebo-controlled trial. Biological Trace Element Research 2018;185(1):48-55. x-wiley/crsRef/14403053
42. Keikha F. Combination N-acetyl cysteine and clomiphene citrate in clomiphene citrate-resistant polycystic ovary syndrome. Iranian Journal of Reproductive Medicine 2010;8:12-3. x-wiley/crsRef/6375140
43. Kim C, Lee S, Koo Y, Lee H, Lee Y, Jeon I, et al. N-acetyl-cysteine treatment improves insulin sensitivity, ovarian response to gonadotrophin and IVF outcome in patients with polycystic ovary syndrome. In: ESHRE Conference Proceedings. Vol. I. 18 - 21 June 2006:178. x-wiley/crsRef/2782568
44. Kim CH, Yoon JW, Ahn JW, Kang HJ, Lee JW, Kang BM. The effect of supplementation with omega-3-polyunsaturated fatty acids in intracytoplasmic sperm injection cycles for infertile patients with a history of unexplained total fertilization failure. Fertility and Sterility 2010;94(4):S242. Abstract no P-518. x-wiley/crsRef/2782570
45. Lisi F, Carfagna P, Oliva MM, Rago R, Lisi R, Poverini R, et al. Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study. Reproductive Biology and Endocrinology 2012;10:52. x-wiley/crsRef/2782572 [DOI: 10.1186/1477-7827-10-52]
46. Lu X, Wu Z, Wang M, Cheng W. Effects of vitamin C on the outcome of in vitro fertilization-embryo transfer in endometriosis: a randomized controlled study. Journal of International Medical Research 2018;46(11):4624-33. x-wiley/crsRef/14403055
47. Maged AM, Elsawah H, Abdelhafez A, Bakry A, Mostafa WA. The adjuvant effect of metformin and N-acetylcysteine to clomiphene citrate in induction of ovulation in patients with polycystic ovary syndrome. Gynecological Endocrinology 2015;31(8):635-8. x-wiley/crsRef/6375144
48. Mier-Cabrera J, Geenera-Garcia M, De la Jara-Diaz, Perichart-Perera Otilla, Vadillo-Ortega F, Hernandez-Guerrero C. Effect of vitamins C and E supplementation on peripheral oxidative stress markers and pregnancy rate in women with endometriosis. International Journal of Gynecology and Obstetrics 2008;100:252-6. x-wiley/crsRef/2782574
49. Mohammadbeigi R, Afkhamzadeh A, Daneshpour NS. The effect of calcium-vitamin D in efficacy of induction ovulation in infertile women with polycystic ovary syndrome. Iranian Journal of Obstetrics, Gynecology and Infertility 2012;15:7-13. x-wiley/crsRef/2782576
50. Mokhtari V, Afsharian P, Shahhoseini M, Kalantar SM, Moini A. Efficacy of n-acetyl cysteine on implantation by effect on HOXA9 gene expression: a double blinded randomized placebo controlled trial. International Journal of Fertility and Sterility 2016;10(Supplement 1):102. x-wiley/crsRef/14403057
51. Mokhtari F, Akbari AF, Azmoodeh O, Bakhtiyari M, Almasi-Hashiani A. Effects of melatonin administration on chemical pregnancy rates of polycystic ovary syndrome patients undergoing intrauterine insemination: a randomized clinical trial. International Journal of Fertility and Sterility 2019;13(3):225-9. x-wiley/crsRef/14403059
52. Mostajeran F, Tehrani HG, Rahbary B. N-Acetylcysteine as an adjuvant to letrozole for induction of ovulation in infertile patients with polycystic ovary syndrome. Advanced Biomedical Research 2018;7(101586897):100. x-wiley/crsRef/14403061
53. Nasr A. Effect of N-acetyl-cysteine after ovarian drilling in clomiphene citrate-resistant PCOS women: a pilot study. Reproductive BioMedicine Online 2010;20(3):403-9. x-wiley/crsRef/2782578
54. Ozkaya MO, NazIroglu M, Barak C, Berkkanoglu M. Effects of multivitamin/mineral supplementation on trace element levels in serum and follicular fluid of women undergoing in vitro fertilization (IVF). Biological Trace Element Research 2011;139(1):1-9. x-wiley/crsRef/2782580
55. Ozkaya MO, Nazrolu M. Multivitamin and mineral supplementation modulates oxidative stress and antioxidant vitamin levels in serum and follicular fluid of women undergoing in vitro fertilization. Fertility and Sterility 2010;94(6):2465-6. x-wiley/crsRef/2782581
56. Panti Abubakar A, Egondu Shehu C, Saidu Y, Nwobodo EI, Tunau Abubakar K, Jimoh A, et al. Oxidative stress and antioxidant supplementation in patients with polycystic ovarian syndrome (PCOS). International Journal of Gynecology and Obstetrics 2015;131 Suppl 5:E505. x-wiley/crsRef/6375148
57. Polak de Fried E, Bossi NM, Notrica JA, Vazquez Levin MH. Vitamin-d treatment does not improve pregnancy rates in patients undergoing art: a prospective, randomized, double-blind placebo-controlled trial. Fertility and Sterility 2013;100(Suppl):S493. x-wiley/crsRef/2782585
58. Rasekhjahromi A, Babaarabi ZZ, Ebrahimi M, Jahromi MN. Comparison of sufficient and insufficient vitamin e in treatment of infertile PCOS patients. International Journal of Gynecology and Obstetrics 2018;143(Supplement 3):343. x-wiley/crsRef/14403063
59. Rashidi B, Haghollahia F, Shariata M, Zayeriia F. The effects of calcium-vitamin D and metformin on polycystic ovary syndrome: a pilot study. Taiwanese Journal of Obstetrics and Gynecology 2009;48(2):142-7. x-wiley/crsRef/2782587
60. Razavi M, Jamilian M, Kashan ZF, Heidar Z, Mohseni M, Ghandi Y, et al. Selenium supplementation and the effects on reproductive outcomes, biomarkers of inflammation, and oxidative stress in women with polycystic ovary syndrome. Hormone and Metabolic Research 2015;48(3):185-90. x-wiley/crsRef/6375150
61. Rizk A, Bedaiwy M, Al-Inany H. N-acetyl-cysteine is a novel adjuvant to clomiphene citrate in clomiphene citrate–resistant patients with polycystic ovary syndrome. Fertility and Sterility 2005;83(2):367-70. x-wiley/crsRef/2782589
62. Rizk A, Bedaiwy M, El Enany H. N-acetyl-cysteine is a novel adjuvant to clomiphene citrate in clomiphene citrate–resistant patients with polycystic ovary syndrome. Human Reproduction; Abstracts of the 20th Annual Meeting of the ESHRE, June 27-30. 2004 2004;19:i53. x-wiley/crsRef/6375151
63. Rizzo P, Raffone E, Benedetto V. Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles: a prospective, clinical trial. European Review for Medical and Pharmacological Sciences 2010;14(6):555-61. x-wiley/crsRef/2782591
64. Salehpour S, Tohidi M, Akhound M, Amirzargar N. N acetyl cysteine, a novel remedy for polycystic ovary syndrome. International Journal of Fertility and Sterility 2009;3(2):66-73. x-wiley/crsRef/2782595
65. Salehpour S, Akbari Sene A, Saharkhiz N, Sohrabi M, Moghimian F. N-acetyl-cysteine as an adjuvant to clomiphene citrate for successful induction of ovulation in infertile patients with polycystic ovary syndrome. Iranian Journal of Reproductive Medicine 2012;10 Suppl 1:18 Abstract no: O-30. x-wiley/crsRef/6375152
66. Salehpour S, Akbari Sene A, Saharkhiz N, Sohrabi M, Moghimian F. N-acetyl-cysteine as an adjuvant to clomiphene citrate for successful induction of ovulation in infertile patients with polycystic ovary syndrome. Iranian Journal of Reproductive Medicine 2012;10:9. x-wiley/crsRef/6375153
67. Salehpour S, Akbari Sene A, Saharkhiz N, Sohrabi MR, Moghimian F. N-acetylcysteine as an adjuvant to clomiphene citrate for successful induction of ovulation in infertile patients with polycystic ovary syndrome. Journal of Obstetrics & Gynaecology Research 2012;38:1182-6. x-wiley/crsRef/2782597
68. Schachter M, Raziel A, Strassburger D, Rotem C, Ron-El R, Friedler S. Prospective, randomized trial of metformin and vitamins for the reduction of plasma homocysteine in insulin-resistant polycystic ovary syndrome. Fertility and Sterility. 2007;88(1):227-30. x-wiley/crsRef/2782601
69. Schillaci R, Mangione D, Lo Monte G, Vassiliadis A. Inositol supplementation and IVF outcome: Preliminary data. Italian Journal of Gynaecology and Obstetrics 2012;24(1):38-44. x-wiley/crsRef/14403065
70. Sen Sharma D. Co-enzyme Q10-A mitochondrial antioxidant - a new hope for success in infertility in clomiphene-citrate-resistant polycystic ovary syndrome. BJOG 2017;124(Supplement 1):9. x-wiley/crsRef/14403067
71. Siavashani AM, Zadeh Modarres S, Mirhosseini N, Aghadavod E, Salehpour S, Asemi Z. The effects of chromium supplementation on gene expression of insulin, lipid, and inflammatory markers in infertile women with polycystic ovary syndrome candidate for in vitro fertilization: a randomized, double-blinded, placebo-controlled trial. Frontiers in Endocrinology 2018;9(101555782):726. x-wiley/crsRef/14403069
72. Taylor TH, Das D, Patrick JL, Katz S, Johnson LN, Crain J. Embryo euploidy rates from advanced maternal age (AMA) patients with and without coenzyme Q10 (COQ10) supplementation: a pilot study and randomized control trial. Fertility and Sterility. Conference: 74th Annual Congress of the American Society for Reproductive Medicine, ASRM 2018. Denver Colorado, USA 2018;110(4):e406. x-wiley/crsRef/14403071
73. Tunon JM, Trilles PP, Molina MG, Duvison MH, Pastor BM, Martin PS, et al. A double-blind, randomized prospective study to evaluate the efficacy of previous therapy with melatonin, myo-inositol, folic acid, and selenium in improving the results of an assisted reproductive treatment. Clinical Medicine Insights: Therapeutics 2017;9:no pagination. x-wiley/crsRef/14403073
74. Valeri C, Sbracia G, Selman H, Antonini G, Pacchiarotti A. Beneficial effects of melatonin on oocytes and embryo quality in aged IVF patients. Human Reproduction 2015;30:i48-9. x-wiley/crsRef/6375155
75. Westphal LM, Polan ML, Trant AS. Double-blind, placebo-controlled study of Fertilityblend: a nutritional supplement for improving fertility in women. Clinical and Experimental Obstetrics & Gynecology 2006;33(4):205-8. x-wiley/crsRef/2782606
76. Xu Y, Nisenblat V, Lu C, Li R, Qiao J, Zhen X, et al. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reproductive Biology and Endocrinology 2018;16(1):Article Number: 29. x-wiley/crsRef/14403075
77. Xu Y, Zhen X. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled prospective study. Human Reproduction. Conference: 34th Annual Meeting of the European Society of Human Reproduction and Embryology. ESHRE. Barcelona, Spain 2018;33 Suppl 1(2018):i299-i300. x-wiley/crsRef/14403076
78. Aboulfoutouh I, Youssef M, Khattab S. Can antioxidants supplementation improve ICSI/IVF outcomes in women undergoing IVF/ICSI treatment cycles? Randomised controlled study. Fertility and Sterility 2011;96 Suppl 3:S242-9. x-wiley/crsRef/6375156
79. Youssef MA, Abdelmoty HI, Elashmwi HA, Abduljawad EM, Elghamary N, Magdy A, et al. Oral antioxidants supplementation for women with unexplained infertility undergoing ICSI/IVF: randomized controlled trial. Human Fertility 2015;18(1):38-42. x-wiley/crsRef/2782608
80. Zadeh Modarres S, Heidar Z, Foroozanfard F, Rahmati Z, Aghadavod E, Asemi Z. The Effects of selenium sSupplementation on gene expression related to insulin and lipid in infertile polycystic ovary syndrome women candidate for in vitro fertilization: a randomized, double-blind, placebo-controlled trial. Biological Trace Element Research 2018;183(2):218-25. x-wiley/crsRef/14403078
81. Aflatoonian A, Arabjahvani F, Eftekhar M, Sayadi M. Effect of vitamin D insufficiency treatment on fertility outcomes in frozen-thawed embryo transfer cycles: a randomized clinical trial. Iranian Journal of Reproductive Medicine 2014;12(9):595-600. x-wiley/crsRef/2782610
82. Aksoy AN, Kadanali S. Evaluating the effects of vitamin E addition to clomiphene citrate on endometrial receptivity: a prospective controlled study. Turkiye Klinikleri Jinekoloji Obstetrik 2010;20(2):71-6. x-wiley/crsRef/2782612
83. Alborzi S, Ghotbi S, Parsanezhad ME, Dehbashi S, Alborzi S, Alborzi M. Pentoxifylline therapy after laparoscopic surgery for different stages of endometriosis: a prospective, double-blind, randomized, placebo-controlled study. Journal of Minimally Invasive Gynecology 2007;14(1):54-8. x-wiley/crsRef/2782525
84. Ghotbi S, Parsanezhad ME, Dehbashi S, Alborzi S, Alborzi M. Pentoxifylline therapy after laparoscopic surgery for different stages of endometriosis: A prospective, double-blind, randomized, placebo-controlled study. Journal of Minimally Invasive Gynecology 2007;14(1):54-8. x-wiley/crsRef/6375125
85. Aleyasin A, Aghahosseini M, Mohseni M, Mahavi A. Effects of pentoxifylline and vitamin E on pregnancy rate in infertile women by ZIFT: a randomized clinical trial. Iranian Journal of Reproductive Medicine 2009;7:175-9. x-wiley/crsRef/2782527
86. Al-Omari W, Abdul-Qadder A, Sulaiman W, Taher M. Antioxidants improve metabolic and ovarian response in polycsytic ovary syndrome. In: ESHRE. Vol. xviii. 2003:84. x-wiley/crsRef/2782614
87. Ardabili HR, Gargari BP, Farzadi L. Vitamin D supplementation has no effect on insulin resistance assessment in women with polycystic ovary syndrome and vitamin D deficiency. Nutrition Research 2012;32(3):195-201. x-wiley/crsRef/2782616
88. Asadi M, Matin N, Frootan M, Mohamadpour J, Qorbani M, Tanha FD. Vitamin D improves endometrial thickness in PCOS women who need intrauterine insemination: A randomized double-blind placebo-controlled trial. Archives of Gynecology and Obstetrics 2014;289(4):865-870. x-wiley/crsRef/2782618
89. Baillargeon JP, Iuorno MJ, Jakubowicz DJ, Apridonidze T, He N, Nestler JE. Metformin therapy increases insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator in women with polycystic ovary syndrome. Journal of Clinical Endocrinology & Metabolism 2004;89(1):242-9. x-wiley/crsRef/2782620
90. Balasch J, Creus M, Fabregues F, Carmona F, Martinez-Roman S, Manau D, et al. Pentoxifylline versus placebo in the treatment of infertility associated with minimal or mild endometriosis. Human Reproduction 1997;12(9):2046-50. x-wiley/crsRef/2782531
91. Benelli E, Del Ghianda S, Di Cosmo C, Tonacchera M. A combined therapy with myo-inositol and d-chiro-inositol improves endocrine parameters and insulin resistance in PCOS young overweight women. International Journal of Endocrinology 2016;2016:3204083. x-wiley/crsRef/6375158
92. Bonakdaran S, Khorasani ZM, Davachi B, Shakeri MT. Comparison of calcitriol and metformin effects on clinical and metabolic consequences of polycystic ovary syndrome. Iranian Journal of Obstetrics, Gynecology and Infertility 2012;14(8):16-24. x-wiley/crsRef/2782622
93. Cheang KI, Baillargeon J-P, Essah PA, Ostlund RE Jr, Apridonize T, Islam L, et al. Insulin-stimulated release of d-chiro-inositol-containing inositol phosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovary syndrome. Metabolism: Clinical and Experimental 2008;57(10):1390-7. x-wiley/crsRef/2782624
94. Ciotta L, Stracquadanio M, Pagano I, Formuso C, Di Leo S, Cianci A. D-chiro-inositol treatment in patients with polycystic ovary syndrome. Giornale Italiano di Ostetricia e Ginecologia 2012;34(1):145-8. x-wiley/crsRef/2782626
95. Costantino D, Minozzi G, Minozzi F, Guaraldi C. Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial. European Review for Medical and Pharmacological Sciences 2009;13(2):105-10. x-wiley/crsRef/2782628
96. Creus M, Fabregues F, Carmona F, Del Pino M, Manau D, Balasch J. Combined laparoscopic surgery and pentoxifylline therapy for treatment of endometriosis-associated infertility: a preliminary trial. Human Reproduction 2008;23:1910-6. x-wiley/crsRef/2782553
97. Crha I, Hruba D, Ventruba P, Fiala J, Totusek J, Visnova H. Ascorbic acid and infertility treatment. Central European Journal of Public Health 2003;11(2):63-7. x-wiley/crsRef/2782630
98. Dastorani M, Aghadavod E, Mirhosseini N, Foroozanfard F, Zadeh Modarres S, Amiri Siavashani M, et al. The effects of vitamin D supplementation on metabolic profiles and gene expression of insulin and lipid metabolism in infertile polycystic ovary syndrome candidates for in vitro fertilization. Reproductive Biology and Endocrinology 2018;16(1):Article number: 94. x-wiley/crsRef/14403080
99. Elgindy EA, El-Huseiny AM, Mostafa MI, Gaballah AM, Ahmed TA. N-acetyl cysteine: could be an effective adjuvant therapy in ICSI cycles. In: ASRM. Vol. 90. September 2008:suppl 1. x-wiley/crsRef/6375159
100. Elgindy EA, El-Huseiny AM, Mostafa MI, Gaballah AM, Ahmed TA. N-acetyl cysteine: could it be an effective adjuvant therapy in ICSI cycles? A preliminary study. Reproductive Biomedicine Online 2010;20(6):789-96. x-wiley/crsRef/2782634
101. Elnashar A, Fahmy M, Mansour A, Ibrahim K. N-acetyl cysteine versus metformin in treatment of clomiphene citrate–resistant polycystic ovarysyndrome: a randomized study. In: 12th Annual Meeting of the Middle East Fertility Society. Vol. 10 Suppl 1. 2005. x-wiley/crsRef/6375160
102. Elnashar A, Fahmy M, Mansour A, Ibrahim K. N-acetyl cysteine vs. metformin in treatment of clomiphene citrate–resistant polycystic ovary syndrome: a prospective randomized controlled study. Fertility and Sterility 2007;88(2):407-11. x-wiley/crsRef/6375161
103. Elnashar A Fahmy M Mansour A Ibrahim K. N-acetyl cysteine vs. metformin in treatment of clomiphene citrate-resistant polycystic ovary syndrome: a prospective randomized controlled study. Fertility and Sterility 2007;88(2):406-9. x-wiley/crsRef/2782639
104. Farzadi L, Salman Zadeh S. Metformin-therapy effects in 50 clomiphene citrate resistant PCOS patients. Journal of Medical Sciences 2006;6(5):765-71. x-wiley/crsRef/2782641
105. Fatemi F, Mohammadzadeh A, Sadeghi MR, Akhondi MM, Kamali K, Jouhari S, et al. Do dietary supplements improve ICSI outcomes in polycystic ovarian syndrome in infertile women? Journal of Reproduction and Infertility. 2nd International Congress of the Iranian Society of Embryology and Reproductive Biology, ISERB 2016. Islamic Republic of Iran 2016;17 Suppl 2(2):31-2. x-wiley/crsRef/14403082
106. Fatemi F, Mohammadzadeh A, Sadeghi MR, Akhondi MM, Mohammadmoradi S, Kamali K, et al. Role of vitamin E and D3 supplementation in Intra-Cytoplasmic Sperm Injection outcomes of women with polycystic ovarian syndrome: a double blinded randomized placebo-controlled trial. Clinical Nutrition ESPEN 2017;18:23-30. x-wiley/crsRef/14403083
107. Firouzabadi RD, Aflatoonian A, Modarresi S, Sekhavat L, Mohammad Taheri S. Therapeutic effects of calcium & vitamin D supplementation in women with PCOS. Complementary Therapies in Clinical Practice 2012;18(2):85-8. x-wiley/crsRef/2782559
108. Genazzani AD, Lanzoni C, Ricchieri F, Jasonni VM. Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome. Gynecological Endocrinology 2008;24(3):139-44. x-wiley/crsRef/2782643
109. Hashim HA, Anwar K, El-Fatah RA. N-acetyl cysteine plus clomiphene citrate versus metformin and clomiphene citrate in treatment of clomiphene-resistant polycystic ovary syndrome: a randomized controlled trial. Journal of Women's Health 2010;19(11):2043-8. x-wiley/crsRef/2782645
110. Hebisha SA, Abdelhaleem BA, Salaam HN. Follicular fluid homocysteine with acetyl cysteine supplemented ovarian stimulation: orrelation with oocyte yield and ICSI cycle outcome. Reproductive BioMedicine Online 2016;32:S5. x-wiley/crsRef/6375163
111. Hebisha SA, Mahmoud HM. Follicular fluid homocysteine levels with acetyl cysteine supplemented ovarian stimulation: correlation with oocyte yield and ICSI outcome. International Journal of Advanced Research 2016;4(9):1906-9. x-wiley/crsRef/6375164
112. Hebisha SA, Omran MS, Sallam HN, Ahmed AI. Follicular fluid homocysteine levels with N-acetyl cysteine supplemented controlled ovarian hyperstimulation, correlation with oocyte yield and ICSI cycle outcome. Fertility and Sterility 2015;104 Suppl(3):e324. x-wiley/crsRef/6375165
113. Henmi H, Endo T, Kitajima Y, Manase K, Hata H, Kudo R. Effects of ascorbic acid supplementation on serum progesterone levels in patients with a luteal phase defect. Fertility and Sterility 2003;80(2):459-61. x-wiley/crsRef/2782647
114. Hernández-Yero A, Santana Pérez F, Ovies Carballo G, Cabrera-Rode E. Diamel therapy in polycystic ovary syndrome reduces hyperinsulinaemia, insulin resistance, and hyperandrogenaemia. International Journal of Endocrinology 2012:382719. x-wiley/crsRef/2782649
115. Immediata V, Romualdi D, De Cicco S, Tagliaferri V, Di Florio C, Cirella E, et al. Metformin versus myoinositol: which one is better in obese PCOS patients - a crossover study on clinical, endocrine and metabolic effects. Human Reproduction 2014;29 Suppl 1:i334 Abstract no: P-522. x-wiley/crsRef/6375167
116. Iuorno MJ, Jakubowicz DJ, Baillargeon JP, Dillon P, Gunn RD, Allan G, et al. Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome. Endocrine Practice 2002;8(6):417-23. x-wiley/crsRef/2782651
117. Jamilian M, Bahmani F, Siavashani MA, Mazloomi M, Asemi Z, Esmaillzadeh A. The effects of chromium supplementation on endocrine profiles, biomarkers of inflammation, and oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Biological Trace Element Research: 2016;172(1):72-8. x-wiley/crsRef/14403085
118. Siavashani MA, Jamilian M, Karamali M, Khassaf A, Hosseini A, Sharif R, et al. The effects of chromium supplementation on endocrine profiles, biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Journal of Reproduction and Infertility. 2nd International Congress of the Iranian Society of Embryology and Reproductive Biology, ISERB 2016. Islamic Republic of Iran 2016;17 Suppl 2(2):189-90. x-wiley/crsRef/14403086
119. Jamilian M, Foroozanfard F, Bahmani F, Talaee R, Monavari M, Asemi Z. Effects of zinc supplementation on endocrine outcomes in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Biological Trace Element Research 2016;170(2):271-8. x-wiley/crsRef/14403088
120. Kamencic H, Thiel JA. Pentoxifylline after conservative surgery for endometriosis: a randomized, controlled trial. Journal of Minimally Invasive Gynecology 2008;15(1):62-6. x-wiley/crsRef/2782653
121. Thiel JA, Kamencic H. Pentoxifylline (trental) after conservative surgery for endometriosis: a randomized control trial [abstract]. Journal of Minimally Invasive Gynecology 2006;(13 Suppl 5):S10. x-wiley/crsRef/6375172
122. Kermack AJ, Lowen PK, Wellstead SJ, Fisk HL, Montag M, Houghton FD, et al. PREPARE trial: a randomised double blinded controlled trial of a preconception Omega 3 and vitamin D rich dietary supplement in couples undergoing assisted reproduction treatment. Human Reproduction 2017;32(Supplement 1):i290. x-wiley/crsRef/14403090
123. Kilicdag EB, Bagis T, Tarim E, Aslan E, Erkanli S, Simsek E, et al. Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial. Human Reproduction 2005;20(6):1521-8. x-wiley/crsRef/2782655
124. Le Donne M, Alibrandi A, Giarrusso R, Lo Monaco I, Muraca U. Diet, metformin and inositol in overweight and obese women with polycystic ovary syndrome: effects on body composition. Minerva Ginecologica 2012;64(1):23-9. x-wiley/crsRef/2782657
125. Li Y, Ma H, Zhang Y, Kuang H, Ng EHY, Hou L, et al. Effect of berberine on insulin resistance in women with polycystic ovary syndrome: Study protocol for a randomized multicenter controlled trial. Trials 2013;14(1):226. x-wiley/crsRef/6375174
126. Mokhtari V, Afsharian P, Shahhoseini M, Kalantar SM, Moini A. Efficacy of n-acetyl cysteine on implantation by effect on HOXA9 gene expression: a double blinded randomized placebo controlled trial. International Journal of Fertility and Sterility 2016;10(Supplement 1):102. x-wiley/crsRef/14403092
127. Salmani B, Teimoorbakhsh E, Shahhoseini M, Akhlaghi AA, Moeini A, Afsharian P. Effect of N-acetyl cysteine on expression of oxidation-reduction genes during implantation window in Recurrent Implantation Failure: a double blinded randomized placebo controlled trial, phase II. Human Reproduction 2018;33(Supplement 1):i358-i359. x-wiley/crsRef/14403093
128. Moosavifar N, Mohammadpour AH, Jallali M, Karimiz G, Saberi H. Evaluation of effect of silymarin on granulosa cell apoptosis and follicular development in patients undergoing in vitro fertilization. Eastern Mediterranean Health Journal 2010;16(6):642-5. x-wiley/crsRef/2782659
129. Nazzaro A, Salerno A, Marino S, Granato C, Pastore E. The addition of melatonin to myo-inositol plus folic acid improves oocyte quality and pregnancy outcome in IVF cycle: a prospective clinical trial. Human Reproduction 2011;26:i227-8. x-wiley/crsRef/2782661
130. Nestler JE, Jakubowicz DJ, Reamer P, Gunn RD, Allan G. Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. New England Journal of Medicine 1999;340(17):1314-20. x-wiley/crsRef/2782663
131. Nestler J, Gunn R, Bates S, Gregory J, Jacobson W, Rogol A. D-chiro-inositol (INS-1) enhances ovulatory rate in hyperandrogenemic, oligomenorrheic women with the polycystic ovary syndrome. Fertility and Sterility 2001;76(3 Suppl 1):S110-1. x-wiley/crsRef/2782665
132. Nichols J. A randomised controlled trial to compare conception rates for preconceptional folic acid 400 mg daily versus Pregnacare Plus in assisted conception. World Health Organization International Clinical Trials Registry Platform 2010. x-wiley/crsRef/2782667 [ISRCTN23488518]
133. Nordio M, Proietti E. The combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation alone. European Review for Medical and Pharmacological Sciences 2012;16(5):575-81. x-wiley/crsRef/2782669
134. Oner G, Muderris II. Clinical, endocrine and metabolic effects of metformin vs N-acetyl-cysteine in women with polycystic ovary syndrome. European Journal of Obstetrics, Gynecology, and Reproductive Biology 2011;159(1):127-31. x-wiley/crsRef/2782671
135. Pal L, Zhang H, Williams J, Santoro NF, Diamond MP, Schlaff WD, et al. Vitamin D status relates to reproductive outcome in women with polycystic ovary syndrome: Secondary analysis of a multicenter randomized controlled trial. Journal of Clinical Endocrinology and Metabolism 2016;101(8):3027-35. x-wiley/crsRef/6375176
136. Papaleo E, Unfer V, Baillargeon JP, De Santis L, Fusi F, Brigante C et al. Myo-inositol in patients with polycystic ovary syndrome: a novel method for ovulation induction. Gynecological Endocrinology 2007;23(12):700-3. x-wiley/crsRef/2782673
137. Papaleo E, De Santis, Baillargeon JP, Zacchè M, Fusi FM, Brigante C, et al. Comparison of myo-inositol plus folic acid vs clomiphene citrate for first-line treatment in women with polycystic ovary syndrome. Human Reproduction: ESHRE 24th Annual Meeting, Barcelona, 6-9 July 2008 2008;23 Suppl 1:Abstract No: O-251 Oral. x-wiley/crsRef/2782675
138. Pasha NG. Assessment of the effect of Ca-vitamin D and metformin on PCOS. WHO International Clinical Trials Registry Platform Search Portal. x-wiley/crsRef/2782708 [IRCT: IRCT201009131760N9]
139. Pizzo A, Lagana AS, Barbaro L. Comparison between effects of myo-inositol and D-chiro-inositol on ovarian function and metabolic factors in women with PCOS. Gynecological Endocrinology 2014;30(3):205-8. x-wiley/crsRef/6375178
140. Raffone E, Rizzo P, Benedetto V. Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women. Gynecological Endocrinology 2010;26(4):275-80. x-wiley/crsRef/2782677
141. Ruder EH, Hartman TJ, Reindollar RH, Goldman MB. Female dietary antioxidant intake and time to pregnancy among couples treated for unexplained infertility. Fertility and Sterility 2014;101(3):759-66. x-wiley/crsRef/6375180
142. Salem HT, Ismail A. L-carnitin as a treatment in clomiphene resistant PCO for improving quality of ovulation and pregnancy outcome; a novel treatment. Human Reproduction. 28th Annual Meeting of the European Society of Human Reproduction and Embryology, ESHRE 2012. Istanbul Turkey 2012;27 Suppl 2(ii302-ii337):Abstract number: P-529. x-wiley/crsRef/2782599
143. Santanam N, Kavtaradze N, Dominguez C, Rock J, Partasarathy S, Murphy A. Antioxidant supplementation reduces total chemokines and inflammatory cytokines in women with endometriosis. Fertility and Sterility 2003;80(Suppl 3):S32-3. Abstract no: O-85. x-wiley/crsRef/2782681
144. Taheri M, Modarres M, Abdollahi A. The effect of vitamin d supplementation on anti-mullerian hormone levels in reproductive-age women. Reproduction, Fertility and Development 2015;27:185-6. x-wiley/crsRef/2782683
145. Tamura H, Takasaki A, Miwa I, Taniguchi K, Maekawa R, Asada H, et al. Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate. Journal of Pineal Research 2008;44(3):280-7. x-wiley/crsRef/2782685
146. Twigt JM, Hammiche F, Sinclair KD, Beckers NG, Visser JA, Lindemans J, et al. Preconception folic acid use modulates estradiol and follicular responses to ovarian stimulation. Journal of Clinical Endocrinology and Metabolism 2011;96(2):E322-9. x-wiley/crsRef/2782689
147. Vargas ML, Almario RU, Buchan W, Kim K, Karakas SE. Metabolic and endocrine effects of long-chain versus essential omega-3 polyunsaturated fatty acids in polycystic ovary syndrome. Metabolism 2011;60(12):1711-8. x-wiley/crsRef/2782691
148. Yoon JW, Kim CH, Ahn JW, Kang HJ, Song BM. Effect of omega-3-polyunsaturated fatty acids and metformin on ovarian morphology and intraovarian blood flow in patients with polycystic ovary syndrome. Fertility and Sterility 2010;94/4(Abstract no. P-346):S194. x-wiley/crsRef/2782693 [ISSN: 0015-0282]
149. ChiCTR1800019772. Effect of omega-3 fatty acids on oocyte quality and early embryo development in elderly infertile women. www.chictr.org.cn/showproj.aspx?proj=33415 (first received 28 November 2018). x-wiley/crsRef/14403095
150. ChiCTR-IPR-15006369. The improvement of endometrial receptivity in PCOS patients by Vitamin D3: a prospective randomized controlled clinical trial. www.chictr.org.cn/showproj.aspx?proj=10938 (first received 8 August 2015). x-wiley/crsRef/14403097
151. CTRI/2012/08/002943. Nutritional supplement for women with polycystic ovary syndrome or subfertility. www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=5002 (first received 31 August 2012). x-wiley/crsRef/2782702
152. EUCTR2015-004233-27. Vitamin D Supplementation on Assisted Reproduction Technology (ART) outcomes: a randomized clinical controlled trial and an investigation of the involved biological mechanisms. https://www.clinicaltrialsregister.eu/ctr-search/search?query=eudract_number:2015-004233-27 (first received 22 September 2015). x-wiley/crsRef/14403099
153. Paffoni A, Somigliana E, Sarais V, Ferrari S, Reschini M, Makieva S, et al. Effect of vitamin D supplementation on assisted reproduction technology (ART) outcomes and underlying biological mechanisms: protocol of a randomized clinical controlled trial. The "supplementation of vitamin D and reproductive outcome" (SUNDRO) study. BMC Pregnancy and Childbirth 2019;Nov 1; 19(1):395. x-wiley/crsRef/14403100 [DOI: 10.1186/s12884-019-2538-6]
154. IRCT201009131760N9. Assessment the effect of calcium-vitamin D and metformin on polycystic ovarian syndrome. en.irct.ir/trial/1273 (first received 3 April 2011). x-wiley/crsRef/14403102
155. IRCT201112148408N1. Evaluation of the effects of calcium-vitamine D supplementary on ovulation and fertility outcomes of patients with poly cystic ovary syndrome referring to Infertility Clinic of Imam Khomeini Hospital in 2011 and 2012 for in vitro fertilization. en.irct.ir/trial/8878 (first received 17 August 2012). x-wiley/crsRef/2782700
156. IRCT201207156420N11. Effect of vitamin D deficiency treatment on fertility outcomes in frozen-thawed embryo transfer cycles. www.who.int/trialsearch/Trial2.aspx?TrialID=IRCT201207156420N11 2013 (first received 24 December 2013). x-wiley/crsRef/14403104
157. IRCT2012120311430N2. The efficacy of vitamin D3 in patients with repeated ART(Assisted Reproductive Teqchnique) failure. en.irct.ir/trial/11701 (first received 20 April 2013). x-wiley/crsRef/14403106
158. IRCT201306115942N2. Effects of antioxidative treatments on pregnancy results. apps.who.int/trialsearch/Trial2.aspx?TrialID=IRCT201306115942N2%20 (first received 26 August 2013). x-wiley/crsRef/14403108
159. IRCT20150831023831N2. Effect of N-acetyl cysteine on expression of oxidation-reduction genes (FKBP4, PRDX6, NRF1,NRF2, GPX3 and MTHFR) during implantation window in women with recurrent implantation failure. en.irct.ir/trial/30417 (first received 14 April 2018). x-wiley/crsRef/14403110
160. IRCT201510266917N3. Effect of thiamine tablet (B1) on general health and treatment success in infertile women with polycystic ovary syndrom. en.irct.ir/trial/7348 (first received 1 May 2016). x-wiley/crsRef/14403112
161. IRCT2016022821653N5. The influence of vitamin D and vitamin E in the treatment of infertile women with polycystic ovary syndrome. en.irct.ir/trial/18910 (first received 25 October 2016). x-wiley/crsRef/14403114
162. IRCT20160410027311N6. The effect of selenium and vit E supplementation on oogenesis improvement in infertile women with occult premature ovarian insufficiency: A randomized contorolled clinical trial. en.irct.ir/trial/22404 (first received 30 April 2018). x-wiley/crsRef/14403116
163. ISRCTN23488518. A randomised controlled trial to compare conception rates for preconceptional folic acid 400 mg daily versus Pregnacare Plus in assisted conception. http://www.who.int/trialsearch/Trial2.aspx?TrialID=ISRCTN23488518 (first received 10 July 2007). x-wiley/crsRef/14403118
164. JPR-UMIN000016992. Double-blinded randomized controlled trial to evaluate the effect of dietary supplements, propolis, royal jelly and resveratrol for infertility treatment of aging women. upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000019631 (first received 31 March 2015). x-wiley/crsRef/14403120
165. NCT01019785. Vitamin D during in vitro fertilisation (IVF) - a prospective randomised trial (delivery). clinicaltrials.gov/show/NCT01019785 (first received 25 November 2009)2. [CLINICALTRIALS.GOV: NCT01019785] x-wiley/crsRef/2782698
166. NCT01267604. Ovarian stimulation: inositol and melatonin [Improving oocyte retrieval using a combined therapy of recombinant follicle stimulating hormone (rFSH) and inositol and melatonin]. clinicaltrials.gov/ct2/show/NCT01267604 (first received 28 December 2010). x-wiley/crsRef/2782712 [NCT01267604]
167. NCT01659788. Co Enzyme Q10 improves IVF outcome in with advanced reproductive age. clinicaltrials.gov/ct2/show/NCT01659788 (first received 8 August 2012). x-wiley/crsRef/14403122
168. NCT01665547. Adding L-carnitine in clomiphene resistant polycystic ovary improves the quality of ovulation and the pregnancy outcome. clinicaltrials.gov/ct2/show/NCT01665547 (first received 15 August 2012). x-wiley/crsRef/14403124
169. NCT01782911. Effect of resveratol on metabolic parameters and oocyte quality in PCOS patients (RES-IVF). clinicaltrials.gov/ct2/show/NCT01782911 (first received 4 February 2013). x-wiley/crsRef/2782706
170. NCT01896492. Clomiphene plus N-acetyl cysteine for induction of ovulation in newly diagnosed PCOS. clinicaltrials.gov/ct2/show/NCT01896492 (first received 11 July 2013). x-wiley/crsRef/14403126
171. NCT02058212. Use of antioxidant in endometriotic women to improve intracytoplasmic sperm injection (ICSI). clinicaltrials.gov/ct2/show/NCT02058212 (first received 10 February 2014). x-wiley/crsRef/6375184
172. NCT02239107. N-acetyl Cysteine for Ovulation Induction in Clomiphene Citrate Resistant Polycystic Ovary Syndrome. clinicaltrials.gov/ct2/show/NCT02239107 (first received 12 September 2014). x-wiley/crsRef/14403128
173. NCT02993588. Impact of melatonin on IVF/ICSI outcomes in prospective poor responders. clinicaltrials.gov/ct2/show/NCT02993588 (first received 15 December 2016). x-wiley/crsRef/14403130
174. NCT03023514. Lipoic acid supplementation in IVF. clinicaltrials.gov/ct2/show/NCT03023514 (first received 18 January 2017). x-wiley/crsRef/6375186
175. NCT03085030. Can antioxidants affect pregnancy rate in patients with expected low number of egg retrieval in IVF cycles. clinicaltrials.gov/ct2/show/NCT03085030 (first received 21 March 2017). x-wiley/crsRef/14403132
176. NCT03117725. Melatonin study Between diminished and normal responder in IVF. clinicaltrials.gov/ct2/show/NCT03117725 (first received 18 April 2017). x-wiley/crsRef/14403134
177. NCT03306745. Micronutrient supplementation in PCO-syndrome. clinicaltrials.gov/ct2/show/NCT03306745 (first received 11 October 2017). x-wiley/crsRef/14403136
178. NCT03396380. Effect of vitamin D supplement in induction of ovulation in overweight women with polycystic ovary syndrome. clinicaltrials.gov/ct2/show/NCT03396380 (first received 11 January 2018). x-wiley/crsRef/14403138
179. NCT03476564. Effects of pentoxifylline and vitamin E on pregnancy rate in infertile women treated by ICSI:. clinicaltrials.gov/ct2/show/NCT03476564 (first received 26 March 2018). x-wiley/crsRef/14403140
180. NCT04019899. Myo-inositol and vitamin D3 during IVF. clinicaltrials.gov/show/NCT04019899 (first received 15 July 2019). x-wiley/crsRef/14403142
181. PACTR201902584533870. Could L-carnitine help poor responders to ovarian stimulation? pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=5916 (first received 12 February 2019). x-wiley/crsRef/14403144
182. TCTR20171109001. Effect of 1,000 mg supplement of ascorbic acid during ovarian stimulation on the rate of fertilization: double blind randomized controlled trial. www.clinicaltrials.in.th/index.php?tp=regtrials&menu=trialsearch&smenu=fulltext&task=search&task2=view1&id=2965 (first received 5 November 2017). x-wiley/crsRef/14403146
183. Agarwal A, Aponte-Mellado A, Premkumar BJ, Shaman A, Gupta S. The effects of oxidative stress on female reproduction: a review. Reproductive Biology and Endocrinology 2012;10:49.
184. Arhin SK, Zhao Y, Lu X, Chetry M, Lu J. Effect of micronutrient supplementation on IVF outcomes: a systematic review of the literature. Reproductive BioMedicine Online 2017;35(6):715-22.
185. Badawy A, State O, Abdelgawad S. N-acetyl cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: a cross-over trial. Acta Obstetricia et Gynecologica Scandinavica 2007;86(2):218-22.
186. Bjelakovic G, Nikolova D, Simonetti RG, Gluud C. Antioxidant supplements for preventing gastrointestinal cancers. Cochrane Database of Systematic Reviews 2008, Issue 3. Art. No: CD004183. [DOI: 10.1002/14651858.CD004183.pub3]
187. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database of Systematic Reviews 2012, Issue 3. Art. No: CD007176. [DOI: 10.1002/14651858.CD007176.pub2]
188. Boivin J, Bunting L, Collins JA, Nygren KG. International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care. Human Reproduction (Oxford, England) 2007;22(6):1506-12.
189. Chandra A, Copen CE, Stephen EH. Infertility and impaired fecundity in the United States, 1982-2010: data from the National Survey of Family Growth. National Health Statistics Reports 2013;67:1-18.
190. Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC. Use of multivitamins, intake of B vitamins, and risk of ovulatory infertility. Fertility and Sterility 2008;89:668-76.
191. Clarke J, Van Rumste M, Farquhar C, Johnson N, Mol B, Herbison P. Measuring outcomes in fertility trials - can we rely on clinical pregnancy rates? Fertility and Sterility 2010;94(5):1647-51.
192. Deeks JJ, Higgins JP, Altman DG (editors). Chapter 10: Analysing data and undertaking meta-analyses. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.0 (updated July 2019). The Cochrane Collaboration, 2019. Available from www.training.cochrane.org/handbook.
193. Dias S, McNamee R, Vail A. Evidence for improving quality of reporting randomized controlled trials in subfertility. Human Reproduction 2006;21(10):2617-27.
194. Ebisch I, Thomas C, Peters W, Braat D, Steegers-Theunissen R. The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Human Reproduction Update 2007;13(2):163-74.
195. Elnashar A. Antioxidants for female infertility: Review of systematic reviews. European Journal of Obstetrics Gynecology and Reproductive Biology 2019;234:e84.
196. Fang F, Ni K, Cai Y, Shang J, Zhang X, Xiong C. Effect of vitamin D supplementation on polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Clinical Practice 2017;26:53-60.
197. 2016 Global Supplement report. www.marketresearch.com/Nutrition-Business-Journal-v2520/Global-Supplement-10063772/ 2016.
198. 2019 Global Supplement Report. https://store.newhope.com/products/2019-global-supplement-report 2019.
199. GRADE Working Group, McMaster University GRADEpro GDT. Version accessed 28 February 2017. Hamilton (ON): GRADE Working Group, McMaster University, 2015.
200. Grajecki D, Zyriax B-C, Buhling KJ. The effect of micronutrient supplements on female fertility: a systematic review. Archives of Gynecology and Obstetrics 2012;285(5):1463-71.
201. Gupta S, Agarwal A, Banerjee J, Alvarez JG. The role of oxidative stress in spontaneous abortion and recurrent pregnancy loss: a systematic review. Obstetrical and Gynecological Survey 2007;62(5):335-47.
202. Haggarty P, McCallum H, McBain H, Andrews K, Duthie S, McNeill G, et al. Effect of B vitamins and genetics on success of in-vitro fertilisation: prospective cohort study. Lancet 2006;367(9521):1513-9.
203. Hart R. Unexplained infertility, endometriosis, and fibroids. BMJ 2003;327(7417):721-4.
204. Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.0 (updated August 2019). The Cochrane Collaboration, 2019. Available from www.training.cochrane.org/handbook.
205. Irani M, Merhi Z. Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertility and Sterility 2014;102(2):460-8.e3.
206. Ko EY, Sabanegh ES Jr. The role of over-the-counter supplements for the treatment of male infertility--fact or fiction? Journal of Andrology 2012;33(3):292-308.
207. Lagana AS, Vitagliano A, Noventa M, Ambrosini G, D'Anna R. Myo-inositol supplementation reduces the amount of gonadotropins and length of ovarian stimulation in women undergoing IVF: a systematic review and meta-analysis of randomized controlled trials. Archives of Gynecology and Obstetrics 2018;298(4):675-84.
208. Ledee-Bataille N, Olivennes F, Lefaix JL, Chaouat G, Frydman R, Delanian S. Combined treatment by pentoxifylline and tocopherol for recipient women with a thin endometrium enrolled in an oocyte donation programme. Human Reproduction 2002;17:1249-53.
209. Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JP, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from handbook.cochrane.org.
210. Levin I, Almog B, Shwartz T, Gold V, Ben-Yosef D, Shaubi M, et al. Effects of laser polar-body biopsy on embryo quality. Fertility and Sterility 2012;97(5):1085-8.
211. Lu D, Song H, Li Y, Clarke J, Shi G. Pentoxifylline for endometriosis. Cochrane Database of Systematic Reviews 2012, Issue 1. Art. No: CD007677. [DOI: 10.1002/14651858.CD007677.pub3]
212. Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S, Stevens GA. National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys. PLOS Medicine 2012;9(12):e1001356.
213. Nestler JE. Myo-inositolphosphoglycans (IPGs) as mediators of insulin’s steroidogenic actions. Journal of BasicClinical Physiological Pharmacology 1998;9(2-4):197-204.
214. NHS. Supplements: who needs them? NHS choices. www.nhs.uk/news/2011/05May/Documents/BtH_supplements.pdf (Accessed 25th June 2017).
215. O'Reilly E, Sevigny M, Sabarre K-A, Phillips KP. Perspectives of complementary and alternative medicine (CAM) practitioners in the support and treatment of infertility. BMC Complementary and Alternative Medicine 2014;14:394.
216. Pacis MM, Fortin CN, Zarek SM, Mumford SL, Segars JH. Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review. Journal of Assisted Reproduction and Genetics 2015;32(3):323-35.
217. Page MJ, Higgins JP, Sterne JA. Chapter 13: Assessing risk of bias due to missing results in a synthesis. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.0 (updated July 2019). The Cochrane Collaboration, 2019. Available from www.training.cochrane.org/handbook.
218. Practice Committee of the American Society for Reproductive Medicine. Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertility and Sterility 2020;114(3):533-5.
219. Pundir J, Charles D, Sabatini L, Hiam D, Jitpiriyaroj S, Teede H, et al. Overview of systematic reviews of non-pharmacological interventions in women with polycystic ovary syndrome. Human Reproduction Update 2019;25(2):243-56.
220. Reportlinkercom. Vitamin and supplement industry: market research reports, statistics and analysis, 2010. www.reportlinker.com/ci02037/Vitamin-and-Supplement.html (Accessed 26 June 20.10).
221. Nordic Cochrane Centre, The Cochrane Collaboration Review Manager 5 (RevMan 5). Version 5.3. Copenhagen: Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
222. Ruder EH, Hartman TJ, Blumberg J, Goldman MB. Oxidative stress and antioxidants: exposure and impact on female fertility. Human Reproduction Update 2008;14(4):345-57.
223. Schünemann HJ, Higgins JP, Vist GE, Glasziou P, Akl EA, Skoetz N, et al. Chapter 14: Completing ‘Summary of findings’ tables and grading the certainty of the evidence. In: Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.0 (updated July 2019). The Cochrane Collaboration, 2019. Available from www.training.cochrane.org/handbook.
224. Sekhon L, Gupta S, Kim Y, Agarwal A. Female infertility and antioxidants. Current Women’s Health Reviews 2010;6:84-95.
225. Showell MG, Brown J, Yazdani A, Stankiewicz MT, Hart RJ. Antioxidants for male subfertility. Cochrane Database of Systematic Reviews 2011, Issue 1. Art. No: CD007411. [DOI: 10.1002/14651858.CD007411.pub2]
226. Showell MG, Mackenzie-Proctor R, Jordan V, Hodgson R, Farquhar C. Inositol for subfertile women with polycystic ovary syndrome. Cochrane Database of Systematic Reviews 2018;(12). [DOI: 10.1002/14651858.CD012378.pub2] [CD012378]
227. Smits RM, Mackenzie-Proctor R, Yazdani A, Stankiewicz MT, Jordan V, Showell MG. Antioxidants for male subfertility. Cochrane Database of Systematic Reviews 2019;(3). [DOI: 10.1002/14651858.CD007411.pub4] [CD007411]
228. Stankiewicz M, Smith C, Alino H, Norman R. The use of complementary medicine and therapies by patients attending a reproductive medicine unit in South Australia: a prospective survey. Australian and New Zealand Journal of Obstetrics and Gynaecology 2007;47(2):145-9. [DOI: 10.1111/j.1479-828X.2007.00702.x]
229. Takasaki A, Tamura H, Taniguchi K, Asada H, Taketani T, Matsuoka A, et al. Luteal blood flow and luteal function. Journal of Ovarian Research 2009;2:1.
230. Thakker D, Raval A, Patel I, Walia R. N-acetylcysteine for polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled clinical trials. Obstetrics and Gynecology International 2015;2015:817849.
231. Thomson RL, Spedding S, Buckley JD. Vitamin D in the aetiology and management of polycystic ovary syndrome. Clinical Endocrinology 2012;77(3):343-50.
232. Tremellen K. Oxidative stress and male infertility - a clinical perspective. Human Reproduction Update 2008;14(3):243-58.
233. Wathes DC, Abayasekara DR, Aitken RJ. Polyunsaturated fatty acids in male and female reproduction. Biology of Reproduction 2007;77(2):190-201.
234. Zegers-Hochschild F, Adamson GD, De Mouzon J, Ishihara O, Mansour R, Nygren K, et al. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertility and Sterility 2009;92(5):1520-4.
235. Zhang Y, Zhang C, Shu J, Guo J, Chang HM, Leung PC, et al. Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis. Human Reproduction Update 2020;26(2):247-63.
236. Zhao W, Mosley BS, Cleves MA, Melnyk S, James SJ, Hobbs CA. Neural tube defects and maternal bio markers of folate, homocysteine, and glutathione metabolism. Birth Defects Research Part A: Clinical and Molecular Teratology 2006;76(4):230-6. [DOI: 10.1002/bdra.20240]
237. Clarke J, Showell MG, Hart RJ, Agarwal A, Gupta S. Antioxidants for female subfertility. Cochrane Database of Systematic Reviews 2009, Issue 2. Art. No: CD007807. [DOI: 10.1002/14651858.CD007807]
238. Showell MG, Brown J, Clarke J, Hart RJ. Antioxidants for female subfertility. Cochrane Database of Systematic Reviews 2013, Issue 8. Art. No: CD007807. [DOI: 10.1002/14651858.CD007807.pub2]
239. Showell MG, Mackenzie-Proctor R, Jordan V, Hart RJ. Antioxidants for female subfertility. Cochrane Database of Systematic Reviews 2017, Issue 7. Art. No: CD007807. [DOI: 10.1002/14651858.CD007807.pub3]