Vitamin D status relates to reproductive outcome in women with polycystic ovary syndrome: Secondary analysis of a multicenter randomized controlled trial

Journal of Clinical Endocrinology and Metabolism

Volumn 101, Issue 8, 2016, Pages 3027-3035

  Pal, Lubna ^a   Zhang, Heping ^a   Williams, Joanne ^a   Santoro, Nanette F ^b   Diamond, Michael P ^c   Schlaff, William D ^b   Coutifaris, Christos ^d   Carson, Sandra A ^e   Steinkampf, Michael P ^f   Carr, Bruce R ^g   McGovern, Peter G ^h   Cataldo, Nicholas A ⁱ   Gosman, Gabriella G ^j   Nestler, John E ^k   Myers, Evan ^l   Legro, Richard S ^m  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

^f UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^g UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^h UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

ⁱ STANFORD UNIVERSITY   (United States)

^j UNIVERSITY OF PITTSBURGH   (United States)

^k VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^l DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^m PENN STATE COLLEGE OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; CLOMIFENE CITRATE; GLUCOSE; INSULIN; METFORMIN; SEX HORMONE BINDING GLOBULIN; VITAMIN D; FERTILITY PROMOTING AGENT;

ADULT; ARTICLE; BODY MASS; COHORT ANALYSIS; FEMALE; FEMALE INFERTILITY; FETUS WASTAGE; HUMAN; INSULIN RESISTANCE; LIVE BIRTH; MAJOR CLINICAL STUDY; MULTICENTER STUDY (TOPIC); MULTIPLE CYCLE TREATMENT; OVARY POLYCYSTIC DISEASE; OVULATION INDUCTION; PREDICTIVE VALUE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REPRODUCTIVE SUCCESS; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; ADOLESCENT; BLOOD; CLINICAL TRIAL; COMPLICATION; CONTROLLED STUDY; INFERTILITY, FEMALE; MULTICENTER STUDY; POLYCYSTIC OVARY SYNDROME; PREGNANCY; PREGNANCY RATE; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; FEMALE; FERTILITY AGENTS, FEMALE; HUMANS; INFERTILITY, FEMALE; OVULATION INDUCTION; POLYCYSTIC OVARY SYNDROME; PREGNANCY; PREGNANCY RATE; PROGNOSIS; TREATMENT OUTCOME; VITAMIN D; YOUNG ADULT;

EID: 84984679633     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2015-4352     Document Type: Article

References (43)

1. Chandra A, Martinez GM, Mosher WD, Abma JC, Jones J; Centers for Disease Control and Prevention, National Center for Health Statistics. Fertility. family planning, and reproductive health of US women: data from the 2002 National Survey of Family Growth. Vital Health Stat. 2005;23(25). http://www.cdc.gov/nchs/data/series/sr-23/sr23-025.pdf. Published December 2005. Accessed December 6, 2015.
2. U.S. Department of Health andHumanServices, Office on Women's Health. Infertility fact sheet. http://www.womenshealth.gov/publications/our-publications/fact-sheet/infertility.html. Updated July 16, 2012. Accessed December 6, 2015.
3. Azziz R, Carmina E, Dewailly D, et al. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil Steril. 2009;91(2):456-488.
4. Holick MF. VitaminDdeficiency.NEngl J Med. 2007;357(3):266-281.
5. Hickie JP, Lavigne DM, Woodward WD. Reduced fecundity of Vitamin D deficient rats. Comp Biochem Physiol A Comp Physiol. 1983;74(4):923-925.
6. Kinuta K, Tanaka H, Moriwake T, Aya K, Kato S, Seino Y. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology,. 2000;141(4):1317-1324.
7. Ozkan S, Jindal S, Greenseid K, et al. Replete Vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril. 2010;94:1314-1319.
8. Ott J, Wattar L, Kurz C, et al. Parameters for calcium metabolism in women with polycystic ovary syndrome who undergo clomiphene citrate stimulation: a prospective cohort study. Eur J Endocrinol. 2012;166(5):897-902.
9. Rudick B, Ingles S, Chung K, Stanczyk F, Paulson R, Bendikson K. Characterizing the influence of Vitamin D levels on IVF outcomes. Hum Reprod. 2012;27(11):3321-3327.
10. Rudick BJ, Ingles SA,ChungK, Stanczyk FZ, Paulson RJ, Bendikson KA. Influence of Vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles. Fertil Steril. 2014;101(2):447-452.
11. Polyzos NP, Anckaert E, Guzman L, et al. Vitamin D deficiency and pregnancy rates in women undergoing single embryo, blastocyst stage, transfer (SET) for IVF/ICSI. Hum Reprod. 2014;29(9):2032-2040.
12. Garbedian K, Boggild M, Moody J, Liu KE. Effect of Vitamin D status on clinical pregnancy rates following in vitro fertilization. CMAJ Open. 2013;1(2):E77-E82.
13. Fabris A, Pacheco A, Cruz M, Puente JM, Fatemi H, Garcia-Velasco JA. Impact of circulating levels of total and bioavailable serum Vitamin D on pregnancy rate in egg donation recipients. Fertil Steril. 2014;102(6):1608-1612.
14. Franasiak JM, Molinaro TA, Dubell EK, et al. Vitamin D levels do not affect IVF outcomes following the transfer of euploid blastocysts. Am J Obstet Gynecol. 2015;212(3):315.e1-e6.
15. Firouzabadi RD, Rahmani E, Rahsepar M, FirouzabadiMM.Value of follicular fluid Vitamin D in predicting the pregnancy rate in an IVF program. Arch Gynecol Obstet. 2014;289(1):201-206.
16. Li HW, Brereton RE, Anderson RA, Wallace AM, Ho CK. Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome. Metabolism. 2011;60: 1475-1481.
17. Krul-Poel YH, Snackey C, Louwers Y, et al. The role of Vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review. Eur J Endocrinol. 2013;169(6):853-865.
18. Pal L, Berry A, Coraluzzi L, et al. Therapeutic implications of Vitamin D and calcium in overweight women with polycystic ovary syndrome. Gynecol Endocrinol. 2012;28(12):965-968.
19. Rashidi B, Haghollahi F, Shariat M, Zayerii F. The effects of calcium-vitaminDand metformin on polycystic ovary syndrome: a pilot study. Taiwan J Obstet Gynecol. 2009;48(2):142-147.
20. Tehrani HG, Mostajeran F, Shahsavari S. The effect of calcium and Vitamin D supplementation on menstrual cycle, body mass index and hyperandrogenism state of women with poly cystic ovarian syndrome. J Res Med Sci. 2014;19(9):875-880.
21. Asemi Z, Foroozanfard F, Hashemi T, Bahmani F, Jamilian M, Esmaillzadeh A. Calcium plus Vitamin D supplementation affects glucose metabolism and lipid concentrations in overweight and obese Vitamin D deficient women with polycystic ovary syndrome. Clin Nutr. 2015;34(4):586-592.
22. Raja-Khan N, Shah J, Stetter CM, et al. High-dose Vitamin D supplementation and measures of insulin sensitivity in polycystic ovary syndrome: a randomized, controlled pilot trial. Fertil Steril. 2014; 101(6):1740-1746.
23. Vause TD, Cheung AP, Sierra S, et al. Ovulation induction in polycystic ovary syndrome. J Obstet Gynaecol Can. 2010;32(5):495-502.
24. Legro RS, Barnhart HX, Schlaff WD, et al. Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. N Engl J Med. 2007;356(6):551-566.
25. Ockè MC, Schrijver J, Obermann-de Boer GL, Bloemberg BP, Haenen GR, Kromhout D. Stability of blood (pro)vitamins during four years of storage at-20 degrees C: consequences for epidemiologic research. J Clin Epidemiol. 1995;48:1077-1085.
26. Antoniucci DM, Black DM, Sellmeyer DE. Serum 25-hydroxyvitamin D is unaffected by multiple freeze-thaw cycles. Clin Chem. 2005;51(1):258-261.
27. Hatch R, Rosenfield RL, Kim MH, Tredway D. Hirsutism: implications, etiology, and management. Am J Obstet Gynecol. 1981; 140:815-830.
28. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of Vitamin D deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011; 96(7):1911-1930.
29. Lemeshow S, Hosmer DW Jr. A review of goodness of fit statistics for use in the development of logistic regression models. Am J Epidemiol. 1982;115(1):92-106.
30. Lalkhen AG, McCloskey A. Clinical tests: sensitivity and specificity. Continuing education in anaesthesia, Crit Care&Pain. 2008;8(6): 221-223.
31. Ota K, Dambaeva S, Han AR, et al. Vitamin D deficiency may be a risk factor for recurrent pregnancy losses by increasing cellular immunity and autoimmunity. Hum Reprod. 2014;29(2):208-219.
32. Ross AC, Manson JE, Abrams SA, et al. The 2011 report on dietary reference intakes for calcium and Vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96(1):53-58.
33. Seifer DB, Zackula R, Grainger DA. Trends of racial disparities in assisted reproductive technology outcomes in black women compared with white women: Society for Assisted Reproductive Technology 1999 and 2000 vs. 2004-2006. Fertil Steril. 2010;93(2): 626-635.
34. Tal R, Seifer DB. Potential mechanisms for racial and ethnic differences in antimüllerian hormone and ovarian reserve. Int J Endocrinol. 2013;2013:818912.
35. Wehr E, Pilz S, Boehm BO, März W, Obermayer-Pietsch B. Association of Vitamin D status with serum androgen levels in men. Clin Endocrinol (Oxf). 2010;73:243-248.
36. Irani M, Seifer DB, Grazi RV, et al. Vitamin D supplementation decreases TGF-1 bioavailability in PCOS: a randomized placebocontrolled trial. J Clin Endocrinol Metab. 2015;100(11):4307-4314.
37. Ding C, Gao D, Wilding J, Trayhurn P, Bing C. VitaminDsignalling in adipose tissue. Br J Nutr. 2012;108(11):1915-1923.
38. PoweCE, EvansMK,Wenger J, et al. Vitamin D-binding protein and Vitamin D status of black Americans and white Americans. N Engl J Med. 2013;369(21):1991-2000.
39. Thongthai P, Chailurkit LO, Chanprasertyothin S, et al. Vitamin D binding protein gene polymorphism as a risk factor for Vitamin D deficiency in Thais. Endocr Pract. 2015;21(3):221-225.
40. McGrath JJ, Saha S, Burne TH, Eyles DW. A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations. J Steroid Biochem Mol Biol. 2010;121:471-477.
41. Vigan? P, Lattuada D, Mangioni S, et al. Cycling and early pregnant endometrium as a site of regulated expression of the Vitamin D system. J Mol Endocrinol. 2006;36(3):415-424.
42. Asadi M, Matin N, Frootan M, Mohamadpour J, Qorbani M, Tanha FD. Vitamin D improves endometrial thickness in PCOS women who need intrauterine insemination: a randomized doubleblind placebo-controlled trial. Arch Gynecol Obstet. 2014;289(4): 865-870.
43. Usadi RS, Legro RS. Reproductive impact of polycystic ovary syndrome. Curr Opin Endocrinol Diabetes Obes. 2012;19(6):505-511.