Prospective, randomized trial of metformin and vitamins for the reduction of plasma homocysteine in insulin-resistant polycystic ovary syndrome

Fertility and Sterility

Volumn 88, Issue 1, 2007, Pages 227-230

  Schachter, Morey ^a   Raziel, Arieh ^a   Strassburger, Devorah ^a   Rotem, Carmela ^b,c   Ron El, Raphael ^a   Friedler, Shevach ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b RABIN MEDICAL CENTER   (Israel)

^c Research and Development   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BETAINE; CHORIONIC GONADOTROPIN; CYANOCOBALAMIN; FOLIC ACID; GLUCOMIN; GONADOTROPIN; HOMOCYSTEINE; HUMAN MENOPAUSAL GONADOTROPIN; METFORMIN; PYRIDOXAL 5 PHOSPHATE; PYRIDOXINE; RECOMBINANT FOLLITROPIN; TRIPTORELIN; UNCLASSIFIED DRUG; VITAMIN B COMPLEX;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FERTILIZATION IN VITRO; HUMAN; INFERTILITY THERAPY; INSULIN RESISTANCE; INTRACYTOPLASMIC SPERM INJECTION; LOADING DRUG DOSE; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MONOTHERAPY; OUTCOME ASSESSMENT; OVARY POLYCYSTIC DISEASE; OVULATION INDUCTION; PREGNANCY RATE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; VITAMIN SUPPLEMENTATION;

ADULT; FEMALE; HOMOCYSTEINE; HUMANS; INSULIN RESISTANCE; METFORMIN; POLYCYSTIC OVARY SYNDROME; PROSPECTIVE STUDIES; VITAMINS;

EID: 34347233845     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2006.11.071     Document Type: Article

References (24)

1. McCarty M.F. Insulin secretion as a potential determinant of homocysteine levels. Med Hypotheses 55 (2000) 454-455
2. House J.D., Jacobs R.L., Stead L.M., Brosnan M.E., and Brosnan J.T. Regulation of homocysteine metabolism. Adv Enzyme Regul 39 (1999) 69-91
3. Meigs J.B., Jacques P.F., Selhub J., Singer D.E., Nathan D.M., Rifai N., et al. Fasting plasma homocysteine levels in the insulin resistance syndrome. Diabetes Care 24 (2001) 1403-1410
4. Setola E., Monti L.D., Galluccio E., Palloshi A., Fragasso G., Paroni R., et al. Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: relationship between homocysteine levels and hyperinsulinemia. Eur J Endocrinol 151 (2004) 483-489
5. Craig L.B., Ke R.W., and Kutteh W.H. Increased prevalence of insulin resistance in women with a history of recurrent pregnancy loss. Fertil Steril 78 (2002) 487-490
6. Kilicdag E.B., Bagis T., Zeyneloglu H.B., Tarim E., Aslan E., Haydardedeoglu B., et al. Homocysteine levels in women with polycystic ovary syndrome treated with metfrormin versus rosiglitazone: a randomized study. Hum Reprod 20 (2005) 894-899
7. Kilicdag E.B., Bagis T., Tarim E., Aslan E., Erkanli S., Simsek E., et al. Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial. Hum Reprod 20 (2005) 1521-1528
8. Vrbikova J., Bicikova M., Tallova J., Hill M., and Starka L. Homocysteine and steroids levels in metformin treated women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes 110 (2002) 74-76
9. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 81 (2004) 19-25
10. Brun J.F., Raynaud E., and Mercier J. Homeostasis model assessment and related simplified evaluations of insulin sensitivity from fasting insulin and glucose. Diabetes Care 23 (2000) 1037-1038
11. Mather K.J., Hunt A.E., Steinberg H.O., Paeadisi G., Hok G., Katz A., et al. Repeatability characteristics of simple indices of insulin resistance: implications for research applications. J Clin Endocrinol Metab 86 (2001) 5457-5464
12. Bonora E., Targher G., Alberiche M., Bonadonna R.C., Saggiani F., Zenere M., et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diabetes Care 23 (2000) 57-63
13. Strassburger D., Friedler S., Raziel A., Schachter M., Kasterstein E., and Ron-El R. Very low sperm count affects the result of intracytoplasmic sperm injection. J Assist Reprod Genet 17 (2000) 431-436
14. Coppola A., Davi G., De-Stefano V., Mancini F.P., Cerbone A.M., and Di-Minno G. Homocysteine, coagulation, platelet function and thrombosis. Semin Thromb Hemost 26 (2000) 243-254
15. Chambers J.C., Ueland P.M., Wright M., Dore C.J., Refsum H., and Kooner J.S. Investigation of relationship between reduced, oxidized, and protein-bound homocysteine and vascular endothelial function in healthy human subjects. Circ Res 89 (2001) 187-192
16. Van Guldener C., and Stehouwer C.D. Hyperhomocysteinemia, vascular pathology and endothelial dysfunction. Semin Thromb Hemost 26 (2000) 281-289
17. Quere I., Mercier E., Bellet H., Janbon C., Mares P., and Gris J.C. Vitamin supplementation and pregnancy outcome in women with recurrent early pregnancy loss and hyperhomocysteinemia. Fertil Steril 75 (2001) 823-825
18. Schachter M., Raziel A., Friedler S., Strassburger D., Bern O., and Ron-El R. Insulin resistance in patients with polycystic ovary syndrome is associated with elevated homocysteine. Hum Reprod 18 (2003) 721-727
19. Rouzi A.A., and Ardawi M.S. Plasma homocysteine and insulin resistance in women with polycystic ovary syndrome. Fertil Steril 84 Suppl (2005) S432
20. Wulffele M.G., Kooy A., Lehert P., Bets D., Ogterop J.C., Borger van der Burg B., et al. Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized placebo controlled trial. J Intern Med 254 (2003) 455-463
21. Lox C.D., and Prien S.D. The homocysteine pathway during the first two weeks of pregnancy following IVF-ET. Fertil Steril 74 Suppl (2000) S205
22. Jakubowicz D.J., Iuorno M.J., Jakubowicz S., Roberts K.A., and Nestler J.E. Effects of metformin on early pregnancy loss in the polycystic ovary syndrome. J Clin Endocrinol Metab 87 (2002) 524-529
23. Yarali H., Yildirir A., Aybar F., Kabakci G., Bukulmez O., Akgul E., and Ota A. Diastolic dysfunction and increased serum homocysteine concentrations may contribute to increased cardiovascular risk in patients with polycystic ovary syndrome. Fertil Steril 76 (2001) 511-516
24. Yilmaz M., Bukan N., Ayvaz G., Karakoc A., Toruner F., Cakir N., et al. The effects of rosiglitazone and metformin on oxidative stress and homocysteine levels in lean patients with polycystic ovary syndrome. Hum Reprod 20 (2005) 3333-3340