The effect of micronutrient supplements on female fertility: A systematic review

Archives of Gynecology and Obstetrics

Volumn 285, Issue 5, 2012, Pages 1463-1471

  Grajecki, Donata ^a   Zyriax, Birgit Christine ^a   Buhling, Kai J ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Fertility; Infertility; Micronutrients; Systematic review; Treatment; Vitamins

Indexed keywords

ASCORBIC ACID; CYANOCOBALAMIN; ELEVIT PRONATAL; FOLIC ACID; IODINE; MAGNESIUM; METFORMIN; MULTIVITAMIN; PLACEBO; PYRIDOXINE; SELENIUM; THIAMINE; THYROXINE; TRACE ELEMENT; UNCLASSIFIED DRUG; VITAMIN;

COHORT ANALYSIS; CONCEPTION; DIETARY INTAKE; DRUG MEGADOSE; FEMALE FERTILITY; HUMAN; LUTEAL INSUFFICIENCY; OVARY POLYCYSTIC DISEASE; PREGNANCY OUTCOME; PREGNANCY RATE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW; VITAMIN SUPPLEMENTATION; ARTIFICIAL INSEMINATION; DIET SUPPLEMENTATION; FEMALE INFERTILITY; FERTILIZATION IN VITRO; INTRACYTOPLASMIC SPERM INJECTION; NUTRITIONAL ASSESSMENT;

DIETARY SUPPLEMENTS; FEMALE; FERTILITY; HUMANS; MICRONUTRIENTS;

EID: 84862769160     PISSN: 09320067     EISSN: 14320711     Source Type: Journal    
DOI: 10.1007/s00404-012-2237-2     Document Type: Review

References (63)

1. American College of Obstetrics and Gynecology (2002) Disorders of ovulation and menstruation. Reproductive endocrinology: an update in obstetrics and gynecology. American College of Obstetrics and Gynecology, Washington, DC, pp 67-79
2. WHO (1997) Reproductive Health Indicators for Global Monitoring: report of an interagency technical meeting. Document WHO/RHT/HRP/97.27
3. Gnoth C (2005) Definition and prevalence of subfertility and infertility. Hum Reprod 20:1144-1147 (Pubitemid 40790235)
4. Kaufmann M, Costa SD, Scharl A (ed) (2006) Die Gynäkologie Fertilitätsstörungen und Sterilität:164
5. Belsey MA (ed) (1988) Epidemiology of perinatal disorders. Infertility: prevalence, etiology and natural history. Yale University Press, UK
6. Wagner GW, Stephenson PA (1992) Infertility in industrialized countries: prevalence and prevention. Sozial- und Präventivmedizin (37):213-217 (Pubitemid 23002251)
7. Rutstein SO, Shah IH (2004) Infecundity, infertility, and childlessness in developing countries (DHS Comparative Reports No. 9)
8. WHO (2007) Preventing and controlling micronutrient deficiencies in populations affected by an emergency. http://www.who. int/nutrition/ publications/WHO-WFP-UNICEFstatement.pdf
9. Max Rubner Institut (2008) Nationale Verzehrs Studie II: Ergebnisbericht, Teil 2
10. Ramakrishnan R, Manjrekar R, Rivera J, Gonzales-Cossio T, Martorell R (1998) Micronutritions and pregnancy outcomes: a review of the literature. Nutr Res 19:103-159
11. Rumbold A, Middleton P, Crowther CA (2005) Vitamin supplementation for preventing miscarriage. Cochrane Collaboration, UK
12. Haider BA, Bhutta ZA (2006) Mutiple-micronutrient supplementation for women during pregnancy. Cochrane Collaboration, UK
13. Hofmeyr GJ, Atallah AN, Duley L (2006) Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Collaboration, UK
14. Muggli EE, Halliday JL (2007) Folic acid and risk of twinning: a systematic review of the recent literature, July 1994 to July 2006. Med J Aust 5:243-248 (Pubitemid 46421443)
15. Lumley J, Watson L, Watson M, Bower C (2008) Periconceptional supplementation with folate and/or multivitamins for preventing neural tube defects. Cochrane Collaboration, UK
16. Mahomed K, Bhutta Z, Middleton P (2007) Zinc supplementation for improving pregnancy and infant outcome: systematic review. Cochrane Collaboration, UK
17. Greenhalgh T (2003) Einführung in die evidence-based medicine. Kritische Beurteilung klinischer Studien als Basis einer rationalen Medizin: Verlag Hans Huber
18. Khan KS, Kleijen J Phase 6 data extraction and monitoring progress. http://www.york.ac.uk/inst/crd/CRD-Reports/crdreport 4-ph6.pdf
19. Cochrane Collaboration (2006) Cochrane handbook for systematic reviews of intervention
20. Khan KS, ter Riet G, Popay J, Nixon J, Kleijen J Study quality assessment. www.medicine.mcgill.ca/.../Readings%5CUK%20 Guide%20%20Study%20Quality%20Assessment.pdf
21. Verhagen AP, Vet HCW, Bie RA, Kessels AGH, Boers M, Bouter LM (1998) The Delphi list: a criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus. J Clin Epidemiol 12:1235-1241 (Pubitemid 29009523)
22. Jüni P, Altman DG, Egger M (2001) Systematic reviews in healthcare: assessing the quality of controlled clinical trials. BMJ 323:42-46 (Pubitemid 32682008)
23. Czeizel AE, Dudas I, Metneki J (1994) Pregnancy outcomes in a randomised controlled trial of periconceptional multivitamin supplementation. Arch Gynecol Obstet 255:131-139 (Pubitemid 24232337)
24. Czeizel AE, Dudas I, Metneki J (1996) The effect of preconceptional multivitamin supplementation on fertility. Int J Vitam Nutr Res 66:55-58 (Pubitemid 126527159)
25. Westphal LM, Polan ML, Trant AS, Mooney SB (2004) A nutritional supplement for improving fertility in women. J Reprod Med 49:289-293 (Pubitemid 38525190)
26. Cavarro JE, Rich-Edwards JW, Rosner BA, Willet WC (2007) A prospective study of dairy foods intake and ovulatory infertility. Hum Reprod 22:1340-1347 (Pubitemid 47062804)
27. Cavarro JE, Rich-Edwards JW, Rosner BA, Willet WC (2007) Diet and lifestyle and the risk of ovulatory infertility. Obstet Gynecol 110:1050-1058 (Pubitemid 350059410)
28. Cavarro JE, Rich-Edwards JW, Rosner BA, Willet WC (2008) Use of multivitamins, intake of B- vitamins and risk of ovulatory infertility. Fertil Steril 89:668-676 (Pubitemid 351335052)
29. Cavarro JE, Rich-Edwards JW, Rosner BA, Willet WC (2006) Iron intake and the risk of ovulatory infertility. Obstet Gynecol 108:1145-1152 (Pubitemid 44665409)
30. Rich-Edwards JW, Goldmann MB, Willett WC, Hunter DJ, Stampfer MJ (1994) Adolescent body mass index and ovulatory infertility. Am J Obstet Gynecol 171:171-177 (Pubitemid 24254437)
31. Ronnenberg AG, Venners SA, Xu X, Chen C, Wang L, Guang W, Huang A, Wang X (2007) Preconceptional B-vitamin and hoocystein status, conception and early pregnancy loss. Am J Epidemiol 166:304-312 (Pubitemid 47216812)
32. Kilicdag EB, Bagis T, Tarim E, Aslan E, Erkanli S, Simsek E, Haydardedeoglu B, Kuscu E (2005) Administration of B-group vitamins reduces circulating homocysteine in polycystic ovary syndrome patients treated with metformin: a randomised trial. Hum Reprod 20:1521-1528 (Pubitemid 40852242)
33. Leeda M, Riyazi N, de Vries JIP, Jakobs C, van Geijn HP, Dekker GA (1997) Effects of folic acid and vitamin B6 supplementation on women with hyperhomocysteinemia and a history of preeclampsia or fetal growth restriction. Am J Obstet Gynecol 179:135-139 (Pubitemid 28394486)
34. Hemni H, Endo T, Kitajima Y, Manase K, Hata H, Kudo R (2003) Ascorbic acid supplementation and serum progesteron levels in patients with a luteal phase defect. Fertil Steril 80:459-461 (Pubitemid 36959812)
35. Mc Laren Howard J, Davis S, Hunnisett A (1994) Red cell magnesium and gluthadione peroxidase in infertile women- effects of oral supplementation with magnesium and selenium. Magnes Res 7:49-57
36. Bals-Pratsch M, Schober O, Hanker JP, de Geyter C, Schneider HPG (1990) Disorders of thyroid function and sterility in women. Zentralblatt Gynäkologie 115:18-23
37. Quere I, Mercier E, Bellet H, Janbon C, Mares C, Gris JC (2001) Vitamin supplementation and pregnancy outcome in women with recurrent early pregnancy loss and hyperhomocysteinemia. Fertil Steril 75:823-825 (Pubitemid 32273524)
38. Eskes TK (2000) Homocysteine and human reproduction. Clin Exp Obstet Gynecol 27:157-167 (Pubitemid 32141606)
39. Steegers-Theunissen RPM (2004) Hyperhomocysteinemia, pregnancy complications, and the timing of investigation. Obstet Gynecol 104:336-343
40. Soltan MH, Jenkins DM (1983) Plasma copper and zinc concentrations and infertility. Br J Obstet Gynecol 90:457-459 (Pubitemid 13096217)
41. Dillon JC, Milliez J (2000) Reproductive failure in women living in iodine deficient areas of West Africa. Br J Obstet Gynecol 107:631-636 (Pubitemid 30242857)
42. Ellimann A (1998) Survey of subfertility patients attending a community clinic over a two years span, before and after national folate campaign. Br J Fam Plan 24:80-81
43. Glander HJ, Liebsch F (1973) Are vitamin capsules containing 0.1 g tocopherol sufficient for fertility therapy? Dermatologische Monatszeitschrift 159:1048-1050
44. Bayer R (1956) Zur Behandlung der primären und sekundären essentiellen Infertilität mit hohen Vitamin-E-Dosen. Gynäkologie und Geburtshilfe 16(5):396-405
45. Chan A, Keane RJ, Hanna M, Abbot M (1995) Terminations of pregnancy to oral retinoids in South Australia. Aust NZ J Obstet Gynecol 35:422-426
46. El-Sayed H (1969) Vitamin B6 nutriture in subjects taking oral contraceptives for fertility control. Diss Abstr 30:4674
47. Bennet M (2001) Vitamin B12 deficiency, fertility and recurrent fetal loss. J Reprod Med 46:209-212
48. Ebisch IMW, Thomas CMG, Peters WHM, Braat DDM, Steegers- Theunissen RPM (2007) The importance of folate, zinc and antioxidants in the pathogenesis and the prevention of subfertility. Hum Reprod Update 13:163-174 (Pubitemid 46323193)
49. Junien C (2006) Impact of diets and nutrients/drugs on early epigenetic programming. J Inherit Metabol Dis 29:356-359
50. Carmichel SL, Shaw GM, Yang W, Laurent C, Herring A, Marjorie HR, Canfield M (2005) Correlates of intake of folic acid-containing supplements among pregnant women. Am J Obstet Gynecol 194:203-210
51. Stang J, Brown J, Jacobs D (2002) Effects of iron and folic acid supplements on serum zinc levels among a cohort of pregnant women. Clin Nutr 17:15-26
52. Nilsen I, Vollset SE, Gjessing H, Magnus P, Meltzer HM, Haugen M, Ueland PM (2006) Patterns of predictors of folic acid supplements use among pregant women: the Norwegian mother and child study. Am J Clin Nutr 84:1134-1141 (Pubitemid 44730385)
53. Jackson I, Doig WB, Mc Donald G (1967) Pernicious anaemia as a cause of infertility. Lancet 7527:1159-1160
54. Rotondi M, Amato G, Biondi B, Maziotti G, Del Buono A, Nicchio MR, Balzano S, Bellastella A, Glinoer D, Carella C (2000) Parity as a thyroid-size determining factor in areas with moderate iodine deficiency. J Clin Endocrinol Metab 85:4534-4537 (Pubitemid 32157629)
55. Rushton DH, Ramsay ID, Gilkes JJH, Norris MJ (1991) Ferritin and fertility. Lancet 8756:1554
56. Schachter M, Raziel A, Strassburger D, Rotem C, Ron-El R, Fiedler S (2007) Prospective, randomised trial of metformin and vitamins for the reduction of plasma homocysteine in insulinresistant polycystic ovary syndrome. Fertil Steril 88:227-230 (Pubitemid 47001388)
57. Sanfilippo JS, Blotcky AJ, Rau CV (1993) Selenium in peritoneal fluid. J Reprod Med 38:422-424 (Pubitemid 23178810)
58. Freni SC (1994) Exposure of high fluoride concentrations in drinking water is associated with decreased birth rates. J Toxicol 42:109-121 (Pubitemid 24162562)
59. Helwig JP (2007) Iron for infertility. Nursing for women's health (11):16-23
60. Ahmed F (1975) Effect of oral contraceptives agents on vitamin nutrition status. J Reprod Med 28:606-615
61. Longombe AO, Geelhoed GW (1997) Iodine deficiency disorders in Northeast Zaire. Nutr Res 13:342-343 (Pubitemid 27242173)
62. Hall M, Davidson RJL (1968) Prophylactic folic acid in women with pernicious anaemia pregnant after periods of infertility. J Clin Pathol 21:599-602
63. Czeizel AE (1998) Periconceptional folic acid containing multivitamin supplementation: final results. Eur J Obstet Gynecol 78:151-161 (Pubitemid 28201105)