Effects of Zinc Supplementation on Endocrine Outcomes in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial

Biological Trace Element Research

Volumn 170, Issue 2, 2016, Pages 271-278

  Jamilian, Mehri ^a   Foroozanfard, Fatemeh ^b   Bahmani, Fereshteh ^b   Talaee, Rezvan ^b   Monavari, Mahshid ^b   Asemi, Zatollah ^b  

^a ARAK UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b KASHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Inflammation; Oxidative stress; Polycystic ovary syndrome; Reproductive outcomes; Supplementation; Zinc

Indexed keywords

C REACTIVE PROTEIN; HYDROXYPROGESTERONE; MALONALDEHYDE; METFORMIN; PLACEBO; ZINC SULFATE; BIOLOGICAL MARKER; CYTOKINE; ZINC;

ABSENCE OF SIDE EFFECTS; ADULT; ALOPECIA; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HIRSUTISM; HUMAN; INFLAMMATION; MINERAL SUPPLEMENTATION; OVARY POLYCYSTIC DISEASE; OXIDATIVE STRESS; PATIENT COMPLIANCE; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; ADOLESCENT; BLOOD; DIETARY SUPPLEMENT; DRUG EFFECTS; METABOLISM; POLYCYSTIC OVARY SYNDROME;

ADOLESCENT; ADULT; BIOMARKERS; C-REACTIVE PROTEIN; CYTOKINES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFLAMMATION; MALONDIALDEHYDE; OXIDATIVE STRESS; POLYCYSTIC OVARY SYNDROME; ZINC;

EID: 84961057165     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-015-0480-7     Document Type: Article

References (47)

1. Teede HJ, Misso ML, Deeks AA, Moran LJ, Stuckey BG, Wong JL, Norman RJ, Costello MF (2011) Assessment and management of polycystic ovary syndrome: summary of an evidence-based guideline. Med J Aust 195(6):S65–112
2. Scicchitano P, Dentamaro I, Carbonara R, Bulzis G, Dachille A, Caputo P, Riccardi R, Locorotondo M, Mandurino C, Matteo Ciccone M (2012) Cardiovascular risk in women with PCOS. Int J Endocrinol Metab 10(4):611–618
3. Caglar GS, Oztas E, Karadag D, Pabuccu R, Demirtas S (2011) Ischemia-modified albumin and cardiovascular risk markers in polycystic ovary syndrome with or without insulin resistance. Fertil Steril 95(1):310–313
4. Goodarzi MO, Dumesic DA, Chazenbalk G, Azziz R (2011) Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nat Rev Endocrinol 7(4):219–231
5. Alpanes M, Luque-Ramirez M, Martinez-Garcia MA, Fernandez-Duran E, Alvarez-Blasco F, Escobar-Morreale HF (2015) Influence of adrenal hyperandrogenism on the clinical and metabolic phenotype of women with polycystic ovary syndrome. Fertil Steril 103(3):795–801 e792
6. Su C, Chen M, Huang H, Lin J (2015) Testosterone enhances lipopolysaccharide-induced interleukin-6 and macrophage chemotactic protein-1 expression by activating the extracellular signal-regulated kinase 1/2/nuclear factor-kappaB signalling pathways in 3T3-L1 adipocytes. Mol Med Rep 12(1):696–704
7. Nasiri N, Moini A, Eftekhari-Yazdi P, Karimian L, Salman-Yazdi R, Zolfaghari Z, Arabipoor A (2015) Abdominal obesity can induce both systemic and follicular fluid oxidative stress independent from polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol 184:112–116
8. Foresta C, Garolla A, Cosci I, Menegazzo M, Ferigo M, Gandin V, De Toni L (2014) Role of zinc trafficking in male fertility: from germ to sperm. Hum Reprod 29(6):1134–1145
9. Prasad AS (2014) Zinc: an antioxidant and anti-inflammatory agent: role of zinc in degenerative disorders of aging. J Trace Elem Med Biol 28(4):364–371
10. Amini L, Tehranian N, Movahedin M, Ramezani Tehrani F, Ziaee S (2015) Antioxidants and management of polycystic ovary syndrome in Iran: a systematic review of clinical trials. Iran J Reprod Med 13(1):1–8
11. Zheng G, Wang L, Guo Z, Sun L, Wang C, Zuo Z, Qiu H (2015) Association of serum heavy metals and trace element concentrations with reproductive hormone levels and polycystic ovary syndrome in a Chinese population. Biol Trace Elem Res. [Epub ahead of print]
12. Guler I, Himmetoglu O, Turp A, Erdem A, Erdem M, Onan MA, Taskiran C, Taslipinar MY, Guner H (2014) Zinc and homocysteine levels in polycystic ovarian syndrome patients with insulin resistance. Biol Trace Elem Res 158(3):297–304
13. Michaelsson G, Vahlquist A, Juhlin L (1977) Serum zinc and retinol-binding protein in acne. Br J Dermatol 96(3):283–286
14. Rostami Mogaddam M, Safavi Ardabili N, Maleki N, Soflaee M (2014) Correlation between the severity and type of acne lesions with serum zinc levels in patients with acne vulgaris. Biomed Res Int 2014:474108. doi:10.1155/2014/474108 Epub 2014 Jul 24
15. Kim J, Ahn J (2014) Effect of zinc supplementation on inflammatory markers and adipokines in young obese women. Biol Trace Elem Res 157(2):101–106
16. Kirkil G, Hamdi Muz M, Seckin D, Sahin K, Kucuk O (2008) Antioxidant effect of zinc picolinate in patients with chronic obstructive pulmonary disease. Respir Med 102(6):840–844
17. Chimienti F, Aouffen M, Favier A, Seve M (2003) Zinc homeostasis-regulating proteins: new drug targets for triggering cell fate. Curr Drug Targets 4(4):323–338
18. de Oliveira KJ, Donangelo CM, de Oliveira AV, da Silveira Jr CL, Koury JC (2009) Effect of zinc supplementation on the antioxidant, copper, and iron status of physically active adolescents. Cell Biochem Funct 27(3):162–166
19. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 81(1):19–25
20. Ramezani Tehrani F, Minooee S, Azizi F (2014) Validation of a simplified method to assess hirsutism in the iranian population. Eur J Obstet Gynecol Reprod Biol 174:91–95
21. Hatch R, Rosenfield RL, Kim MH, Tredway D (1981) Hirsutism: implications, etiology, and management. Am J Obstet Gynecol 140(7):815–830
22. Kolodziejczyk B, Duleba AJ, Spaczynski RZ, Pawelczyk L (2000) Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome. Fertil Steril 73(6):1149–1154
23. Olsen EA, Hordinsky MK, Price VH, Roberts JL, Shapiro J, Canfield D, Duvic M, King Jr LE, McMichael AJ (2004) Alopecia areata investigational assessment guidelines—part II. National Alopecia Areata Foundation. J Am Acad Dermatol 51(3):440–447
24. Atsch E, Bochi GV, Pereira Rda S, Kober H, Agertt VA, de Campos MM, Gomes P, Duarte MM, Moresco RN (2011) A simple and inexpensive automated technique for measurement of serum nitrite/nitrate. Clin Biochem 44(4):348–350
25. Benzie IF, Strain JJ (1996) The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem 239(1):70–76
26. Beutler E, Gelbart T (1985) Plasma glutathione in health and in patients with malignant disease. J Lab Clin Med 105(5):581–584
27. Janero DR (1990) Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med 9(6):515–540
28. Bargiota A, Diamanti-Kandarakis E (2012) The effects of old, new and emerging medicines on metabolic aberrations in PCOS. Ther Adv Endocrinol Metab 3(1):27–47
29. Park H, Kim CW, Kim SS, Park CW (2009) The therapeutic effect and the changed serum zinc level after zinc supplementation in alopecia areata patients who had a low serum zinc level. Ann Dermatol 21(2):142–146
30. Bhat YJ, Manzoor S, Khan AR, Qayoom S (2009) Trace element levels in alopecia areata. Indian J Dermatol Venereol Leprol 75(1):29–31
31. Lux-Battistelli C (2015) Combination therapy with zinc gluconate and PUVA for alopecia areata totalis: an adjunctive but crucial role of zinc supplementation. Dermatol Ther. doi:10.1111/dth.12215
32. Sonnichsen N, Reinicke C, Herrmann C, Glatzel E (1984) Zinc therapy of alopecia areata. Dermatol Monatsschr 170(7):437–442
33. Ead RD (1981) Oral zinc sulphate in alopacia areata-a double blind trial. Br J Dermatol 104(4):483–484
34. Vivoli G, Fantuzzi G, Bergomi M, Tonelli E, Gatto MR, Zanetti F, Del Dot M (1990) Relationship between zinc in serum and hair and some hormones during sexual maturation in humans. Sci Total Environ 95:29–40
35. Plonka PM, Handjiski B, Popik M, Michalczyk D, Paus R (2005) Zinc as an ambivalent but potent modulator of murine hair growth in vivo- preliminary observations. Exp Dermatol 14(11):844–853
36. Dias PC, Sena-Evangelista KC, Paiva MS, Ferreira DQ, Ururahy MA, Rezende AA, Abdalla DS, Pedrosa LF (2014) The beneficial effects of rosuvastatin are independent of zinc supplementation in patients with atherosclerosis. J Trace Elem Med Biol 28(2):194–199
37. Kelishadi R, Hashemipour M, Adeli K, Tavakoli N, Movahedian-Attar A, Shapouri J, Poursafa P, Rouzbahani A (2010) Effect of zinc supplementation on markers of insulin resistance, oxidative stress, and inflammation among prepubescent children with metabolic syndrome. Metab Syndr Relat Disord 8(6):505–510
38. da Costa CM, Brazao V, Collins Kuehn C, Rodrigues Oliveira LG, do Prado Junior JC, Sala MA, Carraro Abrahao AA (2013) Zinc and pregnancy: marked changes on the immune response following zinc therapy for pregnant females challenged with Trypanosoma cruzi. Clin Nutr 32(4):592–598
39. Roussel AM, Kerkeni A, Zouari N, Mahjoub S, Matheau JM, Anderson RA (2003) Antioxidant effects of zinc supplementation in tunisians with type 2 diabetes mellitus. J Am Coll Nutr 22(4):316–321
40. Shaheen AA, el Fattah AA (1995) Effect of dietary zinc on lipid peroxidation, glutathione, protein thiols levels and superoxide dismutase activity in rat tissues. Int J Biochem Cell Biol 27(1):89–95
41. Tang QQ, Su SY, Fang MY (2014) Zinc supplement modulates oxidative stress and antioxidant values in rats with severe acute pancreatitis. Biol Trace Elem Res 159(1–3):320–324
42. Venneria E, Intorre F, Foddai MS, Azzini E, Palomba L, Raguzzini A, Polito A, Ciarapica D, Zaccaria M (2014) Antioxidant effect of zinc supplementation on both plasma and cellular red-ox status markers in a group of elderly italian population. J Nutr Health Aging 18(4):345–350
43. Gupta S, Ghulmiyyah J, Sharma R, Halabi J, Agarwal A (2014) Power of proteomics in linking oxidative stress and female infertility. Biomed Res Int 2014:916212
44. Mier-Cabrera J, Genera-Garcia M, De la Jara-Diaz J, Perichart-Perera O, Vadillo-Ortega F, Hernandez-Guerrero C (2008) Effect of vitamins C and E supplementation on peripheral oxidative stress markers and pregnancy rate in women with endometriosis. Int J Gynaecol Obstet 100(3):252–256
45. Nielsen F, Mikkelsen BB, Nielsen JB, Andersen HR, Grandjean P (1997) Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors. Clin Chem 43(7):1209–1214
46. Powell SR (2000) The antioxidant properties of zinc. J Nutr 130:1447S–1454S
47. McCormick CC, Menard MP, Cousins RJ (1981) Induction of hepatic metallothionein by feeding zinc to rats of depleted zinc status. Am J Physiol 240(4):E414–E421