Effect of vitamin D supplementation on assisted reproduction technology (ART) outcomes and underlying biological mechanisms: Protocol of a randomized clinical controlled trial. The "supplementation of vitamin D and reproductive outcome" (SUNDRO) study

BMC Pregnancy and Childbirth

Volumn 19, Issue 1, 2019, Pages

  Paffoni, Alessio ^a   Somigliana, Edgardo ^a,b   Sarais, Veronica ^c   Ferrari, Stefania ^a   Reschini, Marco ^a   Makieva, Sofia ^c   Papaleo, Enrico ^c   Viganò, Paola ^c  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

25(OH)D; Cumulus cells; Endometrium; Follicular fluid; Infertility; IVF; Oocyte quality; Pregnancy rate; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; PLACEBO; 25-HYDROXYVITAMIN D; VITAMIN D;

ADULT; ARTICLE; BIOLOGICAL ACTIVITY; CLINICAL OUTCOME; CLINICAL PROTOCOL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EMBRYO; FEMALE; FEMALE INFERTILITY; HUMAN; HUMAN CELL; IN VITRO FERTILIZATION; INFERTILITY THERAPY; MAJOR CLINICAL STUDY; MULTICENTER STUDY; OOCYTE RETRIEVAL; PARALLEL DESIGN; PREGNANCY RATE; RANDOMIZED CONTROLLED TRIAL; SAMPLE SIZE; SINGLE DRUG DOSE; TREATMENT RESPONSE; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; BLOOD; DIETARY SUPPLEMENT; INFERTILITY; PREGNANCY; PROCEDURES; RANDOMIZED CONTROLLED TRIAL (TOPIC); TREATMENT OUTCOME;

ADULT; DIETARY SUPPLEMENTS; FEMALE; FERTILIZATION IN VITRO; HUMANS; INFERTILITY; OOCYTE RETRIEVAL; PREGNANCY; PREGNANCY RATE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REPRODUCTIVE TECHNIQUES, ASSISTED; TREATMENT OUTCOME; VITAMIN D;

EID: 85074532281     PISSN: None     EISSN: 14712393     Source Type: Journal    
DOI: 10.1186/s12884-019-2538-6     Document Type: Article

References (25)

1. Rosen CJ. Clinical practice vitamin D insufficiency. N Engl J Med. 2011;364:248-54.
2. Holick MF. The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action. Mol Asp Med. 2008;29:361-8.
3. Luk J, Torrealday S, Neal Perry G, et al. Relevance of vitamin D in reproduction. Hum Reprod. 2012;27:3015-27.
4. Kinuta K, Tanaka H, Moriwake T, et al. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology. 2000;141:1317-24.
5. Lerchbaum E, Rabe T. Vitamin D and female fertility. Curr Opin Obstet Gynecol. 2014;26:145-50.
6. Zhao J, Huang X, Xu B, Yan Y, Zhang Q, et al. Whether vitamin D was associated with clinical outcome after IVF/ICSI: a systematic review and meta-analysis. Reprod Biol Endocrinol. 2018;16:13.
7. Paffoni A, Ferrari S, Viganò P, et al. Vitamin D deficiency and infertility: insights from in vitro fertilization cycles. J Clin Endocrinol Metab. 2014;99:E2372-6.
8. Aflatoonian A, Arabjahvani F, Eftekhar M, Sayadi M. Effect of vitamin D insufficiency treatment on fertility outcomes in frozen-thawed embryo transfer cycles: a randomized clinical trial. Iran J Reprod Med. 2014;12:595-600.
9. Chang HM, Qiao J, Leung PC. Oocyte-somatic cell interactions in the human ovary-novel role of bone morphogenetic proteins and growth differentiation factors. Hum Reprod Update. 2016;23:1-18.
10. Uyar A, Torrealday S, Seli E. Cumulus and granulosa cell markers of oocyte and embryo quality. Fertil Steril. 2013;99:979-97.
11. Viganò P, Lattuada D, Mangioni S, et al. Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. J Mol Endocrinol. 2006;36:415-24.
12. Faulisi S, Reschini M, Borroni R, et al. Clinical value of basal serum progesterone prior to initiate ovarian hyper-stimulation with GnRH antagonists: a retrospective cohort study. Gynecol Obstet Investig. 2017;82:175-80.
13. Papaleo E, Pagliardini L, Vanni VS, et al. A direct healthcare cost analysis of the cryopreserved versus fresh transfer policy at the blastocyst stage. Reprod BioMed Online. 2017;34:19-26.
14. Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod. 2011;26:1270-83.
15. Ferrero H, Delgado-Rosas F, Garcia-Pascual CM, et al. Efficiency and purity provided by the existing methods for the isolation of luteinized granulosa cells: a comparative study. Hum Reprod. 2012;27:1781-9.
16. Bray NL, Pimentel H, Melsted P, et al. Near-optimal probabilistic RNA-seq quantification. Nat Biotechnol. 2016;34:525-7.
17. Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15:550.
18. Pocock SJ. When (not) to stop a clinical trial for benefit. JAMA. 2005;294:2228-30.
19. Kane SP. Sample size calculator. 2019. ClinCalc: https://clincalc.com/stats/samplesize.aspx. Accessed 16 Sept 2019.
20. Pagliardini L, Vigano' P, Molgora M, et al. High prevalence of vitamin D deficiency in infertile women referring for assisted reproduction. Nutrients. 2015;7:9972-84.
21. Cipriani C, Romagnoli E, Scillitani A, et al. Effect of a single oral dose of 600,000 IU of cholecalciferol on serum calciotropic hormones in young subjects with vitamin D deficiency: a prospective intervention study. J Clin Endocrinol Metab. 2010;95:4771-7.
22. Vieth R. Vitamin D and cancer mini-symposium: the risk of additional vitamin D. Ann Epidemiol. 2009;19:441-5.
23. Teh WT, McBain J, Rogers P. What is the contribution of embryo-endometrial asynchrony to implantation failure? J Assist Reprod Genet. 2016;33:1419-30.
24. Roth DE, Leung M, Mesfin E, et al. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237.
25. De-Regil LM, Palacios C, Lombardo LK, et al. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev. 2016;1:CD008873.