Pentoxifylline versus placebo in the treatment of infertility associated with minimal or mild endometriosis: A pilot randomized clinical trial

Human Reproduction

Volumn 12, Issue 9, 1997, Pages 2046-2050

  Balasch, Juan ^a   Creus, Montserrat ^a   Fábregues, Francisco ^a   Carmona, Francisco ^a   Martínez Román, Sergio ^a   Manau, Dolors ^a   A vanrell, Juan ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Endometriosis; Immunomodulation; Infertility; Pentoxifylline

Indexed keywords

PENTOXIFYLLINE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; ENDOMETRIOSIS; FEMALE; FEMALE INFERTILITY; HUMAN; ORAL DRUG ADMINISTRATION; PREGNANCY RATE; RANDOMIZED CONTROLLED TRIAL;

EID: 0030828629     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/12.9.2046     Document Type: Article

References (30)

1. Adams on, G.D, and Pasta, D.J. (1994) Surgical treatment 01 enaomeinosisassociated infertility: meta-analysis compared with survival analysis. Am. J. Obstet. Gynecol, 171, 1488-1504.
2. American Fertility Society (1985) Revised American Fertility Society classification of endometriosis 1985. Fertil. Steril., 43, 351-352.
3. Balasch, J., Creus, M., Fábregues, F. et al. (1996a) Antiphospholipid antibodies and human reproductive failure. Hum. Reprod., 11, 2310-2315.
4. Balasch, J., Creus, M, Fábregues, F. et al. (1996b) Visible and non-visible endometriosis at laparoscopy in fertile and infertile women and in patients with chronic pelvic pain: a prospective study. Hum. Reprod, 11, 387-391.
5. Bayer, S.R., Seibel, M.M., Saffan, D.S. et al. (1988) Efficacy of danazol treatment for minimal endometriosis in infertile women, A prospective, randomized study. J. Reprod, Med., 33, 179-183.
6. Brosens, I., Donnez, J, and Benagiano, G. (1993) Improving the classification of endometriosis. Hum. Reprod., 8, 1792-1795.
7. Christman, G.M. and Halme, J.K. (1992) Pathophysiology of endometriosisassociated symptoms. Infertil. Reprod. Clin. N. Am., 3, 551-564.
8. D'Hooghe, T.M. and Hill, J.A. (1995) Autoantibodies in endometriosis. In Kurpisz, M. and Fernandez, N. (eds), Immunology of Human Reproduction. Bios Scientific Publishers, Oxford, pp. 133-162.
9. Evers, J.L.H. (1989) The pregnancy rate of the no-treatment group in randomized clinical trials of endometriosis therapy. Fertil. Steril, 52, 906-907.
10. Evers, J.L.H. (1993) How to treat endometriosis-associated subfertility. Or . should we? Focus on Reprod., III, 9-15,
11. Fedele, L,t Parazzini, F., Radici, E. et al. (1992) Buserelin acetate versus expectant management in the treatment of infertility associated with minimal or mild endometriosis: A randomized clinical trial. Am. J. Obstet, Gynecol., 166, 1345-1350.
12. Gleicher, N. (1992) Endometriosis: a new approach is needed. Hum. Reprod., 7, 821-824.
13. Gleicher, N. (1995) Immune dysfunction - a potential target for treatment in endometriosis. Br. J, Obstet. Gynecol., 102 (Suppl. 12), 4-7.
14. Hill, J.A. (1992) Immunologie factors in endometriosis and endometriosisassociated reproductive failure. Infertil Reprod. Med. Clin. N. Am., 3, 583-596.
15. Hughes, E.G., Fedorkow, D.M. and Collins, J.A. (1993) A quantitative overview of controlled trials in endometriosis-associated infertility. Fertil Steril, 59, 963-970.
16. Mahmood, T.A. and Templeton, A. (1990) Pathophysiology of mild endometriosis: review of literature. Hum. Reprod., 5, 765-784.
17. Martmez-Roman, S.. Balasch, J., Creus, M. et al. (1997) Immunological factors in endometriosis-associated reproductive failure: studies in fertile and infertile women with and without endometriosis. Hum. Reprod., 12, 1794-1799.
18. Matson, P.L., Yovich, J.M., Edirisinghe, W.R. et al. (1995) An argument for the past and continued use of pentoxifylline in assisted reproductive technology. Ham. Reprod., 10 (Suppl. 1), 67-71.
19. Nothnick, W.B., Currry, T.E. and Vernon, M.W. (1994) Immunomodulation of rat endometriotic implant growth and protein production. Am. J. Reprod. Inimitnol., 31, 151-162.
20. Oral, E., Olive. D.L. and Ariel, A. (1996) The peritoneal environment in endometriosis. Hum. Reprod. Update, 2, 385-398.
21. Prentice, A. and Ingamells. S, (1996) Endometriosis and infertility. J. Br. Fertil. Soc., 1, 51-55.
22. Ramey, J.W. and Archer, D.F. (1993) Peritoneal fluid: its relevance to the development of endometriosis. Fertil. Steril., 60, 1-14.
23. Seibel, M.M., Berger, M.J., Weinstein, F.G. and Taymor, M.L. (1982) The effectiveness of danazol on subsequent fertility in minimal endometriosis. Fertil. Steril, 38, 534-537.
24. Steinleitner, A., Lambert, H. and Roy, S. (1991a) Immunomodulation with pentoxifylline abrogates macrophage-mediated infertility in an in vivo model: a paradigm for a novel approach to the treatment of endometriosisassociated subfertility. Fertil. Steril., 55, 26-31.
25. Steinleitner, A., Lambert, H., Suarez, M. et al. (1991b) Immunomodulation in the treatment of endometriosis-associated subfertility: use of pentoxifylline to reverse the inhibition of fertilization by surgically induced endometriosis in a rodent model. Fertil. Steril., 56, 975-979.
26. Steinleitner, A., Lambert, H., Suarez, M. et al. (1991c) Periovulatory calcium channel blockade enhances reproductive performance in an animal model for endometriosis-associated subfertility. Am. J. Obstet. Gynecol., 164, 949-952.
27. Telimua. S. (1988) Danazol and medroxiprogesterone acetate inefficacious in the treatment of infertility in endometriosis. Fertil. Steril., 50, 872-875.
28. Thomas, E.J. and Cooke, I.D. (1987) Successful treatment of asymptomatic endometriosis: Does it benefit infertile women? Br. Med. J., 294, 1117-1119.
29. Tournaye, H., Van Steirteghem, A.C. and Devroey, P. (1994) Pentoxifylline in idiopathic male-factor infertility: a review of its therapeutic efficacy after oral administration. Hum. Reprod., 9, 996-1000.
30. Vinatier, D., Dufour, P. and Oosterlynck, D. (1996) Immunological aspects of endometriosis. Hum. Reprod. Update, 2, 371-384.