메뉴 건너뛰기




Volumn 28, Issue 6, 2016, Pages 723-731

N-Acetylcysteine improves oocyte and embryo quality in polycystic ovary syndrome patients undergoing intracytoplasmic sperm injection: An alternative to metformin

Author keywords

fertilisation rate; follicular fluid; ovulation induction.

Indexed keywords

ACETYLCYSTEINE; CHORIONIC GONADOTROPIN; INSULIN; LEPTIN; LUTEINIZING HORMONE; MALONALDEHYDE; METFORMIN; PLACEBO; ANTIDIABETIC AGENT; ANTIOXIDANT; NONSTEROID ANTIINFLAMMATORY AGENT;

EID: 84964989266     PISSN: 10313613     EISSN: 14485990     Source Type: Journal    
DOI: 10.1071/RD14182     Document Type: Article
Times cited : (38)

References (41)
  • 3
    • 0034892698 scopus 로고    scopus 로고
    • Metformin directly inhibits androgen production in human thecal cells
    • Attia, G. R., Rainey, W. E., and Carr, B. R. (2001). Metformin directly inhibits androgen production in human thecal cells. Fertil. Steril. 76, 517-524. doi:10.1016/S0015-0282(01)01975-6
    • (2001) Fertil. Steril , vol.76 , pp. 517-524
    • Attia, G.R.1    Rainey, W.E.2    Carr, B.R.3
  • 4
    • 33846961466 scopus 로고    scopus 로고
    • N-Acetyl cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: A crossover trial
    • Badawy, A., and Abdelgawad, S. (2007). N-Acetyl cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: a crossover trial. Acta Obstet. Gynecol. Scand. 86, 218-222. doi:10.1080/ 00016340601090337
    • (2007) Acta Obstet. Gynecol. Scand , vol.86 , pp. 218-222
    • Badawy, A.1    Abdelgawad, S.2
  • 5
    • 33646423057 scopus 로고    scopus 로고
    • Effect of oocyte morphology on embryo development and implantation
    • Balaban, B., and Urman, B. (2006). Effect of oocyte morphology on embryo development and implantation. Reprod. Biomed. Online 12, 608-615. doi:10.1016/S1472-6483(10)61187-X
    • (2006) Reprod. Biomed. Online , vol.12 , pp. 608-615
    • Balaban, B.1    Urman, B.2
  • 6
    • 0038410183 scopus 로고    scopus 로고
    • An intracellular modulation of free radical production could contribute to the beneficial effects of metformin towards oxidative stress
    • Bonnefont-Rousselot, D., Raji, B., Walrand, S., Jore, D., Legrand, A., Peynet, J., and Vasson, M. (2003). An intracellular modulation of free radical production could contribute to the beneficial effects of metformin towards oxidative stress. Metabolism 52, 586-589. doi:10.1053/META. 2003.50093
    • (2003) Metabolism , vol.52 , pp. 586-589
    • Bonnefont-Rousselot, D.1    Raji, B.2    Walrand, S.3    Jore, D.4    Legrand, A.5    Peynet, J.6    Vasson, M.7
  • 7
    • 62149142389 scopus 로고    scopus 로고
    • Evaluation of day one embryo quality and IVF outcome: A comparison of two scoring systems
    • Brezinova, J., Oborna, I., Svobodova, M., and Fingerova, H. (2009). Evaluation of day one embryo quality and IVF outcome: a comparison of two scoring systems. Reprod. Biol. Endocrinol. 7, 9. doi:10.1186/ 1477-7827-7-9
    • (2009) Reprod. Biol. Endocrinol , vol.7 , pp. 9
    • Brezinova, J.1    Oborna, I.2    Svobodova, M.3    Fingerova, H.4
  • 9
    • 0034929864 scopus 로고    scopus 로고
    • Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points
    • De Flora, S., Izzotti, A., D'Agostini, F., and Balansky, R. M. (2001). Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points. Carcinogenesis 22, 999-1013. doi:10.1093/CARCIN/22.7.999
    • (2001) Carcinogenesis , vol.22 , pp. 999-1013
    • De Flora, S.1    Izzotti, A.2    D'Agostini, F.3    Balansky, R.M.4
  • 11
    • 77951578326 scopus 로고    scopus 로고
    • Increased anti-Mullerian hormone and decreased FSH levels in follicular fluid obtained in women with polycystic ovaries at the time of follicle puncture for in vitro fertilization
    • Desforges-Bullet, V., Gallo, C., Lefebvre, C., Pigny, P., Dewailly, D., and Catteau-Jonard, S. (2010). Increased anti-Mullerian hormone and decreased FSH levels in follicular fluid obtained in women with polycystic ovaries at the time of follicle puncture for in vitro fertilization. Fertil. Steril. 94, 198-204. doi:10.1016/J.FERTNSTERT.2009.03.004
    • (2010) Fertil. Steril , vol.94 , pp. 198-204
    • Desforges-Bullet, V.1    Gallo, C.2    Lefebvre, C.3    Pigny, P.4    Dewailly, D.5    Catteau-Jonard, S.6
  • 12
    • 39549088961 scopus 로고    scopus 로고
    • Polycystic ovary syndrome and oocyte developmental competence
    • Dumesic, D. A., Padmanabhan, V., and Abbott, D. H. (2008). Polycystic ovary syndrome and oocyte developmental competence. Obstet. Gynecol. Surv. 63, 39-48. doi:10.1097/OGX.0B013E31815E85FC
    • (2008) Obstet. Gynecol. Surv , vol.63 , pp. 39-48
    • Dumesic, D.A.1    Padmanabhan, V.2    Abbott, D.H.3
  • 13
    • 33645792829 scopus 로고    scopus 로고
    • Is oocyte morphology prognostic of embryo developmental potential after ICSI?
    • Ebner, T., Moser, M., and Tews, G. (2006). Is oocyte morphology prognostic of embryo developmental potential after ICSI? Reprod. Biomed. Online 12, 507-512. doi:10.1016/S1472-6483(10)62006-8
    • (2006) Reprod. Biomed. Online , vol.12 , pp. 507-512
    • Ebner, T.1    Moser, M.2    Tews, G.3
  • 16
    • 0037530654 scopus 로고    scopus 로고
    • The effect of metformin on ovarian stimulation and in vitro fertilization in insulin-resistant women with polycystic ovary syndrome: An open-label randomized cross-over trial
    • Fedorcsak, P., Dale, P., Storeng, R.,Abyholm, T., and Tanbo, T. (2003). The effect of metformin on ovarian stimulation and in vitro fertilization in insulin-resistant women with polycystic ovary syndrome: an open-label randomized cross-over trial. Gynecol. Endocrinol. 17, 207-214. doi:10.1080/713603249
    • (2003) Gynecol. Endocrinol , vol.17 , pp. 207-214
    • Fedorcsak, P.1    Dale, P.2    Storeng, R.3    Abyholm, T.4    Tanbo, T.5
  • 17
    • 0029095150 scopus 로고
    • Polycystic ovary syndrome
    • Franks, S. (1995). Polycystic ovary syndrome. N. Engl. J. Med. 333, 853-861. doi:10.1056/NEJM199509283331307
    • (1995) N. Engl. J. Med , vol.333 , pp. 853-861
    • Franks, S.1
  • 18
    • 0036283549 scopus 로고    scopus 로고
    • N-Acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome
    • Fulghesu, A. M., Ciampelli, M., Muzj, G., Belosi, C., Selvaggi, L., Ayala, G. F., and Lanzone, A. (2002). N-Acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome. Fertil. Steril. 77, 1128-1135. doi:10.1016/S0015-0282(02)03133-3
    • (2002) Fertil. Steril , vol.77 , pp. 1128-1135
    • Fulghesu, A.M.1    Ciampelli, M.2    Muzj, G.3    Belosi, C.4    Selvaggi, L.5    Ayala, G.F.6    Lanzone, A.7
  • 20
    • 3042634808 scopus 로고    scopus 로고
    • Metformin treatment before IVF/ICSI in women with polycystic ovary syndrome; A prospective, randomized, double blind study
    • Kjøtrød, S. B., von During, V., and Carlsen, S. M. (2004). Metformin treatment before IVF/ICSI in women with polycystic ovary syndrome; a prospective, randomized, double blind study. Hum. Reprod. 19, 1315-1322. doi:10.1093/HUMREP/DEH248
    • (2004) Hum. Reprod , vol.19 , pp. 1315-1322
    • Kjøtrød, S.B.1    Von During, V.2    Carlsen, S.M.3
  • 22
    • 77952955539 scopus 로고    scopus 로고
    • Comparison of embryological and clinical outcome in GnRH antagonist vs GnRH agonist protocols for in vitro fertilization in PCOS non-obese patients. A prospective randomized study
    • Kurzawa, R., Ciepiela, P., Baczkowski, T., Safranow, K., and Brelik, P. (2008). Comparison of embryological and clinical outcome in GnRH antagonist vs. GnRH agonist protocols for in vitro fertilization in PCOS non-obese patients. A prospective randomized study. J. Assist. Reprod. Genet. 25, 365-374. doi:10.1007/S10815-008-9249-7
    • (2008) J. Assist. Reprod. Genet , vol.25 , pp. 365-374
    • Kurzawa, R.1    Ciepiela, P.2    Baczkowski, T.3    Safranow, K.4    Brelik, P.5
  • 23
    • 84860210494 scopus 로고    scopus 로고
    • Delay in oocyte aging in mice by the antioxidant N-acetyl-L-cysteine (NAC)
    • Liu, J., Liu, M., Ye, X., Liu, K., Huang, J., Wang, L., Ji, G., Liu, N., Tang, X., and Baltz, J. M. (2012). Delay in oocyte aging in mice by the antioxidant N-acetyl-L-cysteine (NAC). Hum. Reprod. 27, 1411-1420. doi:10.1093/ HUMREP/DES019
    • (2012) Hum. Reprod , vol.27 , pp. 1411-1420
    • Liu, J.1    Liu, M.2    Ye, X.3    Liu, K.4    Huang, J.5    Wang, L.6    Ji, G.7    Liu, N.8    Tang, X.9    Baltz, J.M.10
  • 24
    • 0142247208 scopus 로고    scopus 로고
    • Metformin in polycystic ovary syndrome: Systematic review and meta-analysis
    • Lord, J. M., Flight, I. H., and Norman, R. J. (2003). Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ 327, 951. doi:10.1136/BMJ.327.7421.951
    • (2003) BMJ , vol.327 , pp. 951
    • Lord, J.M.1    Flight, I.H.2    Norman, R.J.3
  • 25
    • 78649327038 scopus 로고    scopus 로고
    • Effect of N-acetyl-cysteine after ovarian drilling in clomiphene citrate-resistant PCOS women: A pilot study
    • Nasr, A. (2010). Effect of N-acetyl-cysteine after ovarian drilling in clomiphene citrate-resistant PCOS women: a pilot study. Reprod. Biomed. Online 20, 403-409. doi:10.1016/J.RBMO.2009.12.012
    • (2010) Reprod. Biomed. Online , vol.20 , pp. 403-409
    • Nasr, A.1
  • 26
    • 24044476642 scopus 로고    scopus 로고
    • Metformin treatment in patients with polycystic ovary syndrome undergoing in vitro fertilization: A prospective randomized trial
    • O nalan, G., Pabuccu, R., Goktolga, U., Ceyhan, T., Bagis, T., and Cincik, M. (2005). Metformin treatment in patients with polycystic ovary syndrome undergoing in vitro fertilization: a prospective randomized trial. Fertil. Steril. 84, 798-801. doi:10.1016/J.FERTNSTERT.2005.03.043
    • (2005) Fertil. Steril , vol.84 , pp. 798-801
    • Nalan, G.O.1    Pabuccu, R.2    Goktolga, U.3    Ceyhan, T.4    Bagis, T.5    Cincik, M.6
  • 27
    • 81855204970 scopus 로고    scopus 로고
    • Clinical, endocrine and metabolic effects of metformin vs N-acetyl-cysteine in women with polycystic ovary syndrome
    • Oner, G., and Muderris, I. I. (2011). Clinical, endocrine and metabolic effects of metformin vs N-acetyl-cysteine in women with polycystic ovary syndrome. Eur. J. Obstet. Gynecol. Reprod. Biol. 159, 127-131. doi:10.1016/J.EJOGRB.2011.07.005
    • (2011) Eur. J. Obstet. Gynecol. Reprod. Biol , vol.159 , pp. 127-131
    • Oner, G.1    Muderris, I.I.2
  • 28
    • 60549105378 scopus 로고    scopus 로고
    • Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: A comprehensive review
    • Palomba, S., Falbo, A., Zullo, F., and Orio, F. (2009). Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review. Endocr. Rev. 30, 1-50. doi:10.1210/ER.2008-0030
    • (2009) Endocr. Rev , vol.30 , pp. 1-50
    • Palomba, S.1    Falbo, A.2    Zullo, F.3    Orio, F.4
  • 29
    • 0034527379 scopus 로고    scopus 로고
    • Effect of four-week metformin treatment on plasma and erythrocyte antioxidative defense enzymes in newly diagnosed obese patients with type 2 diabetes
    • Pavlovic, D., Kocic, R., Kocic, G., Jevtovic, T., Radenkovic, S., Mikic, D., Stojanovic, M., and Djordjevic, P. (2000). Effect of four-week metformin treatment on plasma and erythrocyte antioxidative defense enzymes in newly diagnosed obese patients with type 2 diabetes. Diabetes Obes. Metab. 2, 251-256. doi:10.1046/J.1463-1326.2000.00089.X
    • (2000) Diabetes Obes. Metab , vol.2 , pp. 251-256
    • Pavlovic, D.1    Kocic, R.2    Kocic, G.3    Jevtovic, T.4    Radenkovic, S.5    Mikic, D.6    Stojanovic, M.7    Djordjevic, P.8
  • 30
    • 84866672635 scopus 로고    scopus 로고
    • Assessment of oocyte quality in polycystic ovarian syndrome and endometriosis by spindle imaging and reactive oxygen species levels in follicular fluid and its relationship with IVF-ET outcome
    • Rajani, S., Chattopadhyay, R., Goswami, S. K., Ghosh, S., Sharma, S., and Chakravarty, B. (2012).Assessment of oocyte quality in polycystic ovarian syndrome and endometriosis by spindle imaging and reactive oxygen species levels in follicular fluid and its relationship with IVF-ET outcome. J. Hum. Reprod. Sci 5, 187-193. doi:10.4103/0974-1208.101020
    • (2012) J. Hum. Reprod. Sci , vol.5 , pp. 187-193
    • Rajani, S.1    Chattopadhyay, R.2    Goswami, S.K.3    Ghosh, S.4    Sharma, S.5    Chakravarty, B.6
  • 32
    • 13544250688 scopus 로고    scopus 로고
    • N-Acetyl-cysteine is a novel adjuvant to clomiphene citrate in clomiphene citrate-resistant patients with polycystic ovary syndrome
    • Rizk, A. Y., Bedaiwy, M. A., and Al-Inany, H. G. (2005). N-Acetyl-cysteine is a novel adjuvant to clomiphene citrate in clomiphene citrate-resistant patients with polycystic ovary syndrome. Fertil. Steril. 83, 367-370. doi:10.1016/J.FERTNSTERT.2004.07.960
    • (2005) Fertil. Steril , vol.83 , pp. 367-370
    • Rizk, A.Y.1    Bedaiwy, M.A.2    Al-Inany, H.G.3
  • 33
    • 84975849722 scopus 로고    scopus 로고
    • N-Acetylcysteine as an adjuvant to clomiphene citrate for successful induction of ovulation in infertile patients with polycystic ovary syndrome
    • Salehpour, S., Akbari Sene, A., Saharkhiz, N., Sohrabi, M. R., and Moghimian, F. (2012). N-Acetylcysteine as an adjuvant to clomiphene citrate for successful induction of ovulation in infertile patients with polycystic ovary syndrome. J. Obstet. Gynaecol. Res. 38, 1182-1186. doi:10.1111/J.1447-0756.2012.01844.X
    • (2012) J. Obstet. Gynaecol. Res , vol.38 , pp. 1182-1186
    • Salehpour, S.1    Akbari Sene, A.2    Saharkhiz, N.3    Sohrabi, M.R.4    Moghimian, F.5
  • 34
    • 0035112663 scopus 로고    scopus 로고
    • Metformin treatment of patients with polycystic ovary syndrome undergoing in vitro fertilization improves outcomes and is associated with modulation of the insulin-like growth factors
    • Stadtmauer, L. A., Toma, S. K., Riehl, R. M., and Talbert, L. M. (2001). Metformin treatment of patients with polycystic ovary syndrome undergoing in vitro fertilization improves outcomes and is associated with modulation of the insulin-like growth factors. Fertil. Steril. 75, 505-509. doi:10.1016/S0015-0282(00)01766-0
    • (2001) Fertil. Steril , vol.75 , pp. 505-509
    • Stadtmauer, L.A.1    Toma, S.K.2    Riehl, R.M.3    Talbert, L.M.4
  • 35
    • 33745670469 scopus 로고    scopus 로고
    • The use of metformin for women with PCOS undergoing IVF treatment
    • Tang, T., Glanville, J., Orsi, N., Barth, J. H., and Balen, A. H. (2006). The use of metformin for women with PCOS undergoing IVF treatment. Hum. Reprod. 21, 1416-1425. doi:10.1093/HUMREP/DEL025
    • (2006) Hum. Reprod , vol.21 , pp. 1416-1425
    • Tang, T.1    Glanville, J.2    Orsi, N.3    Barth, J.H.4    Balen, A.H.5
  • 36
    • 0346725827 scopus 로고    scopus 로고
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
    • The Rotterdam ESHRE/ASRM-Sponsored PCOS Work Group (2004). Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil. Steril. 81, 19-25. doi:10.1016/J.FERTNSTERT.2003.10.004
    • (2004) Fertil. Steril , vol.81 , pp. 19-25
  • 37
    • 0842330821 scopus 로고    scopus 로고
    • The pathophysiology of polycystic ovary syndrome
    • Tsilchorozidou, T., Overton, C., and Conway, G. S. (2004). The pathophysiology of polycystic ovary syndrome. Clin. Endocrinol. (Oxf.) 60, 1-17. doi:10.1046/J.1365-2265.2003.01842.X
    • (2004) Clin. Endocrinol. (Oxf.) , vol.60 , pp. 1-17
    • Tsilchorozidou, T.1    Overton, C.2    Conway, G.S.3
  • 39
    • 1842779002 scopus 로고    scopus 로고
    • Assisted reproduction in the treatment of polycystic ovarian syndrome
    • Urman, B., Tiras, B., and Yakin, K. (2004). Assisted reproduction in the treatment of polycystic ovarian syndrome. Reprod. Biol. Endocrinol. 8, 419-430
    • (2004) Reprod. Biol. Endocrinol , vol.8 , pp. 419-430
    • Urman, B.1    Tiras, B.2    Yakin, K.3
  • 40
    • 28544441286 scopus 로고    scopus 로고
    • The effects of rosiglitazone and metformin on oxidative stress and homocysteine levels in lean patients with polycystic ovary syndrome
    • Yilmaz, M., Bukan, N., Ayvaz, G., Karakoc, A., Toruner, F., C akir, N., and Arslan, M. (2005). The effects of rosiglitazone and metformin on oxidative stress and homocysteine levels in lean patients with polycystic ovary syndrome. Hum. Reprod. 20, 3333-3340. doi:10.1093/HUMREP/ DEI258
    • (2005) Hum. Reprod , vol.20 , pp. 3333-3340
    • Yilmaz, M.1    Bukan, N.2    Ayvaz, G.3    Karakoc, A.4    Toruner, F.5    Akir, N.C.6    Arslan, M.7
  • 41
    • 0036177496 scopus 로고    scopus 로고
    • Co-administration of metformin during rFSH treatment in patients with clomiphene citrate-resistant polycystic ovarian syndrome: A prospective randomized trial
    • Yarali, H., Yildiz, B. O., Demirol, A., Zeyneloǧlu, H. B., Yiǧit, N., Bukulmez, O., and Koray, Z. (2002). Co-administration of metformin during rFSH treatment in patients with clomiphene citrate-resistant polycystic ovarian syndrome: a prospective randomized trial. Hum. Reprod. 17(2), 289-294. doi:10.1093/HUMREP/17.2.289
    • (2002) Hum. Reprod , vol.17 , Issue.2 , pp. 289-294
    • Yarali, H.1    Yildiz, B.O.2    Demirol, A.3    Zeyneloǧlu, H.B.4    Yiǧit, N.5    Bukulmez, O.6    Koray, Z.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.