Effect of vitamin D supplementation on polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials

Complementary Therapies in Clinical Practice

Volumn 26, Issue , 2017, Pages 53-60

  Fang, Fang ^a   Ni, Ke ^a   Cai, Yiting ^a   Shang, Jin ^a   Zhang, Xiaoke ^a   Xiong, Chengliang ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Wuhan Tongji Reproductive Medicine Hospital   (China)

Author keywords

Meta analysis; PCOS; RCTs; Vitamin D

Indexed keywords

VITAMIN D;

FEMALE; HUMAN; META ANALYSIS; POLYCYSTIC OVARY SYNDROME; RANDOMIZED CONTROLLED TRIAL (TOPIC);

FEMALE; HUMANS; POLYCYSTIC OVARY SYNDROME; RANDOMIZED CONTROLLED TRIALS AS TOPIC; VITAMIN D;

EID: 84999176891     PISSN: 17443881     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ctcp.2016.11.008     Document Type: Review

References (45)

1. [1] March, W.A., Moore, V.M., Willson, K.J., Phillips, D.I., Norman, R.J., Davies, M.J., The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Hum. Reprod. 25 (2010), 544–551.
2. [2] Wehr, E., Pilz, S., Schweighofer, N., Giuliani, A., Kopera, D., Pieber, T.R., Obermayer, P.B., Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome. Eur. J. Endocrinol. 161 (2009), 575–582.
3. [3] Ahmad, S., Prevalence of vitamin D deficiency in women with infertility due to polycystic ovary syndrome. BJOG-Int J. Obstet. Gy 120 (2013), 208–209.
4. [4] Li, H.W.R., Brereton, R.E., Anderson, R.A., Wallace, A.M., Ho, C.K.M., Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome. Metabolism 60 (2011), 1475–1481.
5. [5] Bhattacharya, S.M., Jha, A., Association of vitamin D3 deficiency with clinical and biochemical parameters in Indian women with polycystic ovary syndrome. Int. J. Gynaecol. Obstet. 123 (2013), 74–75.
6. [6] Muscogiuri, G., Mitri, J., Mathieu, C., Badenhoop, K., Tamer, G., Orio, F., Mezza, T., Vieth, R., Colao, A., Pittas, A., Mechanisms in endocrinology: vitamin D as a potential contributor in endocrine health and disease. Eur. J. Endocrinol. 171 (2014), R101–R110.
7. [7] Thomson, R.L., Spedding, S., Buckley, J.D., Vitamin D in the aetiology and management of polycystic ovary syndrome. Clin. Endocrinol. (Oxf) 77 (2012), 343–350.
8. [8] Agic, A., Xu, H., Altgassen, C., Noack, F., Wolfler, M.M., Diedrich, K., Friedrich, M., Taylor, R.N., Hornung, D., Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers. Reprod. Sci. 14 (2007), 486–497.
9. [9] Panidis, D., Balaris, C., Farmakiotis, D., Rousso, D., Kourtis, A., Balaris, V., Katsikis, I., Zournatzi, V., Diamanti-Kandarakis, E., Serum parathyroid hormone concentrations are increased in women with polycystic ovary syndrome. Clin. Chem. 51 (2005), 1691–1697.
10. [10] Kotsa, K., Yavropoulou, M.P., Anastasiou, O., Yovos, J.G., Role of vitamin D treatment in glucose metabolism in polycystic ovary syndrome. Fertil. Steril. 92 (2009), 1053–1058.
11. [11] Selimoglu, H., Duran, C., Kiyici, S., Ersoy, C., Guclu, M., Ozkaya, G., Tuncel, E., Erturk, E., Imamoglu, S., The effect of vitamin D replacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndrome. J. Endocrinol. Invest. 33 (2010), 234–238.
12. [12] Wehr, E., Pieber, T.R., Obermayer, P.B., Effect of vitamin D3 treatment on glucose metabolism and menstrual frequency in polycystic ovary syndrome women: a pilot study. J. Endocrinol. Invest. 34 (2011), 757–763.
13. [13] Zawadzki, J.K., Dunaif, A., Diagnostic Criteria for Polycystic Ovary Syndrome: towards a Rational Approach. Dunaif, A., Givens, J.R., Haseltine, F.P., Merriam, G.R., (eds.) Polycystic Ovary Syndrome, 1992, Blackwell Scientific Publications, Boston, 377–384.
14. [14] Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum. Reprod. 19 (2004), 41–47.
15. [15] Higgins, J.P.T., Green, S., Cochrane handbook for Systematic Reviews of Interventions Version 5.1.0. 2011 The Cochrane Collaboration.
16. [16] Asadi, M., Matin, N., Frootan, M., Mohamadpour, J., Qorbani, M., Tanha, F.D., Vitamin D improves endometrial thickness in PCOS women who need intrauterine insemination: a randomized double-blind placebo-controlled trial. Arch. Gynecol. Obstet. 289 (2014), 865–870.
17. [17] Foroozanfard, F., Jamilian, M., Bahmani, F., Talaee, R., Talaee, N., Hashemi, T., Nasri, K., Asemi, Z., Esmaillzadeh, A., Calcium plus vitamin D supplementation influences biomarkers of inflammation and oxidative stress in overweight and vitamin D-deficient women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial. Clin. Endocrinol. (Oxf) 83 (2015), 888–894.
18. [18] Bonakdaran, S., Khorasani, Z.M., Davachi, B., Khorasani, J.M., The effects of calcitriol on improvement of insulin resistance, ovulation and comparison with metformin therapy in PCOS patients: a randomized placebo-controlled clinical trial. Iran. J. Reprod. Med. 10 (2012), 465–472.
19. [19] Ardabili, H.R., Gargari, B.P., Farzadi, L., Effects of vitamin D on cardiovascular disease risk factors in polycystic ovary syndrome women with vitamin D deficiency. J. Endocrinol. Invest. 36 (2013), 28–32.
20. [20] Raja-Khan, N., Shah, J., Stetter, C.M., Lott, M.E.J., Kunselman, A.R., Dodson, W.C., Legro, R.S., High-dose vitamin D supplementation and measures of insulin sensitivity in polycystic ovary syndrome: a randomized, controlled pilot trial. Fertil. Steril. 101 (2014), 1740–1746.
21. [21] Tehrani, H.G., Mostajeran, F., Shahsavari, S., The effect of calcium and vitamin D supplementation on menstrual cycle, body mass index and hyperandrogenism state of women with poly cystic ovarian syndrome. J. Res. Med. Sci. 19 (2014), 875–880.
22. [22] Asemi, Z., Foroozanfard, F., Hashemi, T., Bahmani, F., Jamilian, M., Esmaillzadeh, A., Calcium plus vitamin D supplementation affects glucose metabolism and lipid concentrations in overweight and obese vitamin D deficient women with polycystic ovary syndrome. Clin. Nutr. 34 (2015), 586–592.
23. [23] Garg, G., Kachhawa, G., Ramot, R., Khadgawat, R., Tandon, N., Sreenivas, V., Kriplani, A., Gupta, N., Effect of vitamin D supplementation on insulin kinetics and cardiovascular risk factors in polycystic ovarian syndrome: a pilot study. Endocr. Connect. 4 (2015), 108–116.
24. [24] Rashidi, B., Haghollahi, F., Shariat, M., Zayerii, F., The effects of calcium-vitamin D and metformin on polycystic ovary syndrome: a pilot study. Taiwan J. Obstet. Gynecol. 48 (2009), 142–147.
25. [25] Firouzabadi, R., Aflatoonian, A., Modarresi, S., Sekhavat, L., MohammadTaheri, S., Therapeutic effects of calcium & vitamin D supplementation in women with PCOS. Complement. Ther. Clin. Pract. 18 (2012), 85–88.
26. [26] Ardabili, H.R., Gargari, B.P., Farzadi, L., Vitamin D supplementation has no effect on insulin resistance assessment in women with polycystic ovary syndrome and vitamin D deficiency. Nutr. Res. 32 (2012), 195–201.
27. [27] Prentice, A., Vitamin D deficiency: a global perspective. Nutr. Rev. 66 (2008), S153–S164.
28. [28] Lips, P., Worldwide status of vitamin D nutrition. J. Steroid Biochem. 121 (2010), 297–300.
29. [29] Lee, C.T., Wang, J.Y., Chou, K.Y., Hsu, M.I., 1,25-Dihydroxyvitamin D3 increases testosterone-induced 17beta-estradiol secretion and reverses testosterone-reduced connexin 43 in rat granulosa cells. Reprod. Biol. Endocrinol., 12, 2014, 90.
30. [30] El-Shal, A.S., Shalaby, S.M., Aly, N.M., Rashad, N.M., Abdelaziz, A.M., Genetic variation in the vitamin D receptor gene and vitamin D serum levels in Egyptian women with polycystic ovary syndrome. Mol. Biol. Rep. 40 (2013), 6063–6073.
31. [31] Guducu, N., Gormus, U., Kutay, S.S., Kavak, Z.N., Dunder, I., 25-Hydroxyvitamin D levels are related to hyperinsulinemia in polycystic ovary syndrome. Gynecol. Endocrinol. 30 (2014), 557–560.
32. [32] Krul-Poel, Y.H., Snackey, C., Louwers, Y., Lips, P., Lambalk, C.B., Laven, J.S., Simsek, S., The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review. Eur. J. Endocrinol. 169 (2013), 853–865.
33. [33] Muscogiuri, G., Policola, C., Prioletta, A., Sorice, G., Mezza, T., Lassandro, A., Della Casa, S., Pontecorvi, A., Giaccari, A., Low levels of 25(OH)D and insulin-resistance: 2 unrelated features or a cause-effect in PCOS?. Clin. Nutr. 31 (2012), 476–480.
34. [34] Pal, L., Berry, A., Coraluzzi, L., Kustan, E., Danton, C., Shaw, J., Taylor, H., Therapeutic implications of vitamin D and calcium in overweight women with polycystic ovary syndrome. Gynecol. Endocrinol. 28 (2012), 965–968.
35. [35] He, C., Lin, Z., Robb, S.W., Ezeamama, A.E., Serum vitamin D levels and polycystic ovary syndrome: a systematic review and meta-analysis. Nutrients 7 (2015), 4555–4577.
36. [36] Alvarez, J.A., Ashraf, A.P., Hunter, G.R., Gower, B.A., Serum 25-hydroxyvitamin D and parathyroid hormone are independent determinants of whole-body insulin sensitivity in women and may contribute to lower insulin sensitivity in African Americans. Am. J. Clin. Nutr. 92 (2010), 1344–1349.
37. [37] D'Aurizio, F., Villalta, D., Metus, P., Doretto, P., Tozzoli, R., Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases?. Autoimmun. Rev. 14 (2015), 363–369.
38. [38] Sahmay, S., Atakul, N., Aydogan, B., Aydin, Y., Imamoglu, M., Seyisoglu, H., Elevated serum levels of anti-Mullerian hormone can be introduced as a new diagnostic marker for polycystic ovary syndrome. Acta Obstet. Gyn Scan 92 (2013), 1369–1374.
39. [39] Piouka, A., Farmakiotis, D., Katsikis, I., Macut, D., Gerou, S., Panidis, D., Anti-Mullerian hormone levels reflect severity of PCOS but are negatively influenced by obesity: relationship with increased luteinizing hormone levels. Am. J. Physiol-Endoc M. 296 (2009), E238–E243.
40. [40] Irani, M., Minkoff, H., Seifer, D.B., Merhi, Z., Vitamin D increases serum levels of the soluble receptor for advanced glycation end products in women with PCOS. J. Clin. Endocrinol. Metab. 99 (2014), E886–E890.
41. [41] Dabrowski, F.A., Grzechocinska, B., Wielgos, M., The role of vitamin D in reproductive health–a trojan horse or the golden fleece?. Nutrients 7 (2015), 4139–4153.
42. [42] Lerchbaum, E., Obermayer-Pietsch, B., Vitamin D and fertility: a systematic review. Eur. J. Endocrinol. 166 (2012), 765–778.
43. [43] Grzechocinska, B., Dabrowski, F.A., Cyganek, A., Wielgos, M., The role of vitamin D in impaired fertility treatment. Neuroendocrinol. Lett. 34 (2013), 756–762.
44. [44] Lerchbaum, E., Rabe, T., Vitamin D and female fertility. Curr. Opin. Obstet. Gyn 26 (2014), 145–150.
45. [45] Anagnostis, P., Karras, S., Goulis, D.G., Vitamin D in human reproduction: a narrative review. Int. J. Clin. Pract. 67 (2013), 225–235.