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Volumn 17, Issue 11, 2020, Pages 687-701

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

(11)  Swanson, Kelly S a   Gibson, Glenn R b   Hutkins, Robert c   Reimer, Raylene A d   Reid, Gregor e   Verbeke, Kristin f,g   Scott, Karen P h   Holscher, Hannah D a   Azad, Meghan B i   Delzenne, Nathalie M j   Sanders, Mary Ellen k  


Author keywords

[No Author keywords available]

Indexed keywords

BETA GLUCAN; FRUCTOSE OLIGOSACCHARIDE; GALACTOSE OLIGOSACCHARIDE; INULIN; LITESSE ULTRA POLYDEXTROSE; PECTIN; PREBIOTIC AGENT; PROBIOTIC AGENT; SYNBIOTIC AGENT; UNCLASSIFIED DRUG;

EID: 85089743727     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/s41575-020-0344-2     Document Type: Review
Times cited : (779)

References (129)
  • 1
    • 84947216877 scopus 로고    scopus 로고
    • The ecology of the microbiome: networks, competition, and stability
    • COI: 1:CAS:528:DC%2BC2MXhslGmsr3P, PID: 26542567
    • Coyte, K. Z., Schluter, J. & Foster, K. R. The ecology of the microbiome: networks, competition, and stability. Science 350, 663–666 (2015).
    • (2015) Science , vol.350 , pp. 663-666
    • Coyte, K.Z.1    Schluter, J.2    Foster, K.R.3
  • 2
    • 84873718952 scopus 로고    scopus 로고
    • Therapeutic modulation of intestinal dysbiosis
    • COI: 1:CAS:528:DC%2BC3sXit1Kksb8%3D, PID: 23017673
    • Walker, A. W. & Lawley, T. D. Therapeutic modulation of intestinal dysbiosis. Pharmacol. Res. 69, 75–86 (2013).
    • (2013) Pharmacol. Res. , vol.69 , pp. 75-86
    • Walker, A.W.1    Lawley, T.D.2
  • 3
    • 85030834925 scopus 로고    scopus 로고
    • Modulation of the gastrointestinal microbiome with nondigestible fermentable carbohydrates to improve human health
    • Deehan, E. C. et al. Modulation of the gastrointestinal microbiome with nondigestible fermentable carbohydrates to improve human health. Microbiol. Spectr. 10.1128/microbiolspec.BAD-0019-2017 (2017). DOI: 10.1128/microbiolspec.BAD-0019-2017
    • (2017) Microbiol. Spectr.
    • Deehan, E.C.1
  • 4
    • 85049137140 scopus 로고    scopus 로고
    • Human gut microbiome: hopes, threats and promises
    • COI: 1:CAS:528:DC%2BC1MXisVehtLc%3D, PID: 29934437
    • Cani, P. D. Human gut microbiome: hopes, threats and promises. Gut 67, 1716–1725 (2018).
    • (2018) Gut , vol.67 , pp. 1716-1725
    • Cani, P.D.1
  • 5
    • 0029013322 scopus 로고
    • Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics
    • COI: 1:CAS:528:DyaK2MXmt1ajsrY%3D, PID: 7782892
    • Gibson, G. R. & Roberfroid, M. B. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J. Nutr. 125, 1401–1412 (1995).
    • (1995) J. Nutr. , vol.125 , pp. 1401-1412
    • Gibson, G.R.1    Roberfroid, M.B.2
  • 6
    • 58149137305 scopus 로고    scopus 로고
    • Clinical trial on the efficacy of a new symbiotic formulation, Flortec, in patients with irritable bowel syndrome: a multicenter, randomized study
    • PID: 18685503
    • Andriulli, A. et al. Clinical trial on the efficacy of a new symbiotic formulation, Flortec, in patients with irritable bowel syndrome: a multicenter, randomized study. J. Clin. Gastroenterol. 42, S218–S223 (2008).
    • (2008) J. Clin. Gastroenterol. , vol.42 , pp. S218-S223
    • Andriulli, A.1
  • 7
    • 84879460966 scopus 로고    scopus 로고
    • A randomised clinical trial (RCT) of a symbiotic mixture in patients with irritable bowel syndrome (IBS): effects on symptoms, colonic transit and quality of life
    • PID: 22885882
    • Cappello, C., Tremolaterra, F., Pascariello, A., Ciacci, C. & Iovino, P. A randomised clinical trial (RCT) of a symbiotic mixture in patients with irritable bowel syndrome (IBS): effects on symptoms, colonic transit and quality of life. Int. J. Colorectal Dis. 28, 349–358 (2013).
    • (2013) Int. J. Colorectal Dis. , vol.28 , pp. 349-358
    • Cappello, C.1    Tremolaterra, F.2    Pascariello, A.3    Ciacci, C.4    Iovino, P.5
  • 8
    • 85068525197 scopus 로고    scopus 로고
    • Emerging health concepts in the probiotics field: streamlining the definitions
    • PID: 31164874
    • Martin, R. & Langella, P. Emerging health concepts in the probiotics field: streamlining the definitions. Front. Microbiol. 10, 1047 (2019).
    • (2019) Front. Microbiol. , vol.10 , pp. 1047
    • Martin, R.1    Langella, P.2
  • 9
    • 57349191494 scopus 로고    scopus 로고
    • Effect of different prebiotics on the fermentation kinetics, probiotic survival and fatty acids profiles in nonfat symbiotic fermented milk
    • COI: 1:CAS:528:DC%2BD1cXhsV2ltrvE, PID: 19000641
    • Oliveira, R. P. et al. Effect of different prebiotics on the fermentation kinetics, probiotic survival and fatty acids profiles in nonfat symbiotic fermented milk. Int. J. Food Microbiol. 128, 467–472 (2009).
    • (2009) Int. J. Food Microbiol. , vol.128 , pp. 467-472
    • Oliveira, R.P.1
  • 10
    • 85074788795 scopus 로고    scopus 로고
    • Postbiotics: facts and open questions. A position paper on the need for a consensus definition
    • COI: 1:CAS:528:DC%2BB3cXosFejsLs%3D, PID: 31965850
    • Collado, M. C., Vinderola, G. & Salminen, S. Postbiotics: facts and open questions. A position paper on the need for a consensus definition. Benef. Microbes 10, 711–719 (2019).
    • (2019) Benef. Microbes , vol.10 , pp. 711-719
    • Collado, M.C.1    Vinderola, G.2    Salminen, S.3
  • 11
    • 77957911673 scopus 로고    scopus 로고
    • Pharmabiotic manipulation of the microbiota in gastrointestinal disorders, from rationale to reality
    • PID: 20951927
    • Shanahan, F. & Collins, S. M. Pharmabiotic manipulation of the microbiota in gastrointestinal disorders, from rationale to reality. Gastroenterol. Clin. North. Am. 39, 721–726 (2010).
    • (2010) Gastroenterol. Clin. North. Am. , vol.39 , pp. 721-726
    • Shanahan, F.1    Collins, S.M.2
  • 12
    • 84905675648 scopus 로고    scopus 로고
    • Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic
    • PID: 24912386, Important paper updating the probiotic concept
    • Hill, C. et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat. Rev. Gastroenterol. Hepatol. 11, 506–514 (2014). Important paper updating the probiotic concept.
    • (2014) Nat. Rev. Gastroenterol. Hepatol. , vol.11 , pp. 506-514
    • Hill, C.1
  • 13
    • 85027283029 scopus 로고    scopus 로고
    • Expert consensus document: the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics
    • PID: 28611480, Important paper updating the prebiotic concept. Paper includes the author who first introduced the concept of ‘prebiotics’
    • Gibson, G. R. et al. Expert consensus document: the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat. Rev. Gastroenterol. Hepatol. 14, 491–502 (2017). Important paper updating the prebiotic concept. Paper includes the author who first introduced the concept of ‘prebiotics’.
    • (2017) Nat. Rev. Gastroenterol. Hepatol. , vol.14 , pp. 491-502
    • Gibson, G.R.1
  • 14
    • 84855363386 scopus 로고    scopus 로고
    • Synbiotics in health and disease
    • PID: 22129388, This article acknowledges the importance of differentiating between two distinct types of synbiotic: the complementary synbiotic (microbial and substrate components act independently) and the synergistic synbiotic (the substrate component is chosen to support the growth of the microbial component). Differentiating synbiotics this way ensures that the development of synbiotics is not constrained any way and indeed encourages innovation
    • Kolida, S. & Gibson, G. R. Synbiotics in health and disease. Annu. Rev. Food Sci. Technol. 2, 373–393 (2011). This article acknowledges the importance of differentiating between two distinct types of synbiotic: the complementary synbiotic (microbial and substrate components act independently) and the synergistic synbiotic (the substrate component is chosen to support the growth of the microbial component). Differentiating synbiotics in this way ensures that the development of synbiotics is not constrained in any way and indeed encourages innovation.
    • (2011) Annu. Rev. Food Sci. Technol. , vol.2 , pp. 373-393
    • Kolida, S.1    Gibson, G.R.2
  • 15
    • 85044629324 scopus 로고    scopus 로고
    • Synbiotics for improved human health: Recent developments, challenges, and opportunities
    • PID: 29350558
    • Krumbeck, J. A., Walter, J. & Hutkins, R. W. Synbiotics for improved human health: Recent developments, challenges, and opportunities. Annu. Rev. Food Sci. Technol. 9, 451–479 (2018).
    • (2018) Annu. Rev. Food Sci. Technol. , vol.9 , pp. 451-479
    • Krumbeck, J.A.1    Walter, J.2    Hutkins, R.W.3
  • 16
    • 85039868261 scopus 로고    scopus 로고
    • Q&A: friends (but sometimes foes) within: the complex evolutionary ecology of symbioses between host and microbes
    • PID: 29282064
    • Gerardo, N. & Hurst, G. Q&A: friends (but sometimes foes) within: the complex evolutionary ecology of symbioses between host and microbes. BMC Biol. 15, 126 (2017).
    • (2017) BMC Biol. , vol.15
    • Gerardo, N.1    Hurst, G.2
  • 17
    • 85060049834 scopus 로고    scopus 로고
    • Enrichment and evaluation of galacto-oligosaccharides produced by whole cell treatment of sugar reaction mixture
    • COI: 1:CAS:528:DC%2BC1MXlvFSgsLc%3D, PID: 30644031
    • Srivastava, A. & Mishra, S. Enrichment and evaluation of galacto-oligosaccharides produced by whole cell treatment of sugar reaction mixture. Mol. Biol. Rep. 46, 1181–1188 (2019).
    • (2019) Mol. Biol. Rep. , vol.46 , pp. 1181-1188
    • Srivastava, A.1    Mishra, S.2
  • 18
    • 85061100374 scopus 로고    scopus 로고
    • Frucooligosaccharides purification: complexing simple sugars with phenylboronic acid
    • COI: 1:CAS:528:DC%2BC1MXislCru70%3D, PID: 30797336
    • Porras-Dominguez, J. R. et al. Frucooligosaccharides purification: complexing simple sugars with phenylboronic acid. Food Chem. 285, 204–212 (2019).
    • (2019) Food Chem. , vol.285 , pp. 204-212
    • Porras-Dominguez, J.R.1
  • 19
    • 0030295006 scopus 로고    scopus 로고
    • Production, properties and applications of food-grade oligosaccharides
    • COI: 1:CAS:528:DyaK28XnsF2ksbw%3D
    • Crittenden, R. G. & Playne, M. J. Production, properties and applications of food-grade oligosaccharides. Trends Food Sci. Technol. 7, 353–361 (1996).
    • (1996) Trends Food Sci. Technol. , vol.7 , pp. 353-361
    • Crittenden, R.G.1    Playne, M.J.2
  • 20
    • 85066503120 scopus 로고    scopus 로고
    • Improving end-user trust in the quality of commercial probiotic products
    • PID: 31105649
    • Jackson, S. A. et al. Improving end-user trust in the quality of commercial probiotic products. Front. Microbiol. 10, 739 (2019).
    • (2019) Front. Microbiol. , vol.10 , pp. 739
    • Jackson, S.A.1
  • 21
    • 85049211175 scopus 로고    scopus 로고
    • Probiotic Bifidobacterium strains and galactooligosaccharides improve intestinal barrier function in obese adults but show no synergism when used together as synbiotics
    • PID: 29954454, this paper, a synbiotic consisting of Bifidobacterium strains and galactooligosaccharides did not demonstrate functional synergism but showed that the microorganism and fermentative substrate components by themselves improved the markers of colonic permeability
    • Krumbeck, J. A. et al. Probiotic Bifidobacterium strains and galactooligosaccharides improve intestinal barrier function in obese adults but show no synergism when used together as synbiotics. Microbiome 6, 121 (2018). In this paper, a synbiotic consisting of Bifidobacterium strains and galactooligosaccharides did not demonstrate functional synergism but showed that the microorganism and fermentative substrate components by themselves improved the markers of colonic permeability.
    • (2018) Microbiome , vol.6 , pp. 121
    • Krumbeck, J.A.1
  • 22
    • 85077902157 scopus 로고    scopus 로고
    • Efficacy of synbiotic supplementation in obesity treatment: a systematic review and meta-analysis of clinical trials
    • COI: 1:CAS:528:DC%2BC1MXltlei, PID: 30595036
    • Hadi, A., Alizadeh, K., Hajianfar, H., Mohammadi, H. & Miraghajani, M. Efficacy of synbiotic supplementation in obesity treatment: a systematic review and meta-analysis of clinical trials. Crit. Rev. Food Sci. Nutr. 60, 584–596 (2020).
    • (2020) Crit. Rev. Food Sci. Nutr. , vol.60 , pp. 584-596
    • Hadi, A.1    Alizadeh, K.2    Hajianfar, H.3    Mohammadi, H.4    Miraghajani, M.5
  • 23
    • 85057729392 scopus 로고    scopus 로고
    • Effects of prebiotic and synbiotic supplementation on glycaemia and lipid profile in type 2 diabetes: a meta-analysis of randomized controlled trials
    • COI: 1:CAS:528:DC%2BC1MXitFGmt7rL, PID: 30607329
    • Mahboobi, S., Rahimi, F. & Jafarnejad, S. Effects of prebiotic and synbiotic supplementation on glycaemia and lipid profile in type 2 diabetes: a meta-analysis of randomized controlled trials. Adv. Pharm. Bull. 8, 565–574 (2018).
    • (2018) Adv. Pharm. Bull. , vol.8 , pp. 565-574
    • Mahboobi, S.1    Rahimi, F.2    Jafarnejad, S.3
  • 24
    • 84984917580 scopus 로고    scopus 로고
    • Effect of probiotics and synbiotics on blood glucose: a systematic review and meta-analysis of controlled trials
    • PID: 27590729
    • Nikbakht, E. et al. Effect of probiotics and synbiotics on blood glucose: a systematic review and meta-analysis of controlled trials. Eur. J. Nutr. 57, 95–106 (2018).
    • (2018) Eur. J. Nutr. , vol.57 , pp. 95-106
    • Nikbakht, E.1
  • 25
    • 85068617998 scopus 로고    scopus 로고
    • Gut microbiome-targeted therapies in nonalcoholic fatty liver disease: a systematic review, meta-analysis, and meta-regression
    • PID: 31124558
    • Sharpton, S. R., Maraj, B., Harding-Theobald, E., Vittinghoff, E. & Terrault, N. A. Gut microbiome-targeted therapies in nonalcoholic fatty liver disease: a systematic review, meta-analysis, and meta-regression. Am. J. Clin. Nutr. 110, 139–149 (2019).
    • (2019) Am. J. Clin. Nutr. , vol.110 , pp. 139-149
    • Sharpton, S.R.1    Maraj, B.2    Harding-Theobald, E.3    Vittinghoff, E.4    Terrault, N.A.5
  • 26
    • 85070876796 scopus 로고    scopus 로고
    • Efficacy of synbiotic supplementation in patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis of clinical trials: Synbiotic supplementation and NAFLD
    • COI: 1:CAS:528:DC%2BC1cXosVequro%3D, PID: 29584449
    • Hadi, A., Mohammadi, H., Miraghajani, M. & Ghaedi, E. Efficacy of synbiotic supplementation in patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis of clinical trials: Synbiotic supplementation and NAFLD. Crit. Rev. Food Sci. Nutr. 59, 2494–2505 (2019).
    • (2019) Crit. Rev. Food Sci. Nutr. , vol.59 , pp. 2494-2505
    • Hadi, A.1    Mohammadi, H.2    Miraghajani, M.3    Ghaedi, E.4
  • 27
    • 85054477412 scopus 로고    scopus 로고
    • Systematic review with meta-analysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in irritable bowel syndrome
    • PID: 30294792
    • Ford, A. C., Harris, L. A., Lacy, B. E., Quigley, E. M. M. & Moayyedi, P. Systematic review with meta-analysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in irritable bowel syndrome. Aliment. Pharmacol. Ther. 48, 1044–1060 (2018).
    • (2018) Aliment. Pharmacol. Ther. , vol.48 , pp. 1044-1060
    • Ford, A.C.1    Harris, L.A.2    Lacy, B.E.3    Quigley, E.M.M.4    Moayyedi, P.5
  • 28
    • 85068796332 scopus 로고    scopus 로고
    • A systematic review, meta-analysis, and meta-regression evaluating the efficacy and mechanisms of action of probiotics and synbiotics in the prevention of surgical site infections and surgery-related complications
    • Skonieczna-Zydecka, K. et al. A systematic review, meta-analysis, and meta-regression evaluating the efficacy and mechanisms of action of probiotics and synbiotics in the prevention of surgical site infections and surgery-related complications. J. Clin. Med. 7, 556 (2018).
    • (2018) J. Clin. Med. , vol.7 , pp. 556
    • Skonieczna-Zydecka, K.1
  • 29
    • 85033494941 scopus 로고    scopus 로고
    • Effectiveness of probiotic, prebiotic, and synbiotic therapies in reducing postoperative complications: a systematic review and network meta-analysis
    • Kasatpibal, N. et al. Effectiveness of probiotic, prebiotic, and synbiotic therapies in reducing postoperative complications: a systematic review and network meta-analysis. Clin. Infect. Dis. 64 (Suppl. 2), S153–S160 (2017).
    • (2017) Clin. Infect. Dis. , vol.64Suppl. 2 , pp. S153-S160
    • Kasatpibal, N.1
  • 30
    • 85055153018 scopus 로고    scopus 로고
    • Prebiotic, probiotic, and synbiotic supplementation in chronic kidney disease: a systematic review and meta-analysis
    • COI: 1:CAS:528:DC%2BC1cXhvFyntLnF, PID: 30366767
    • McFarlane, C., Ramos, C. I., Johnson, D. W. & Campbell, K. L. Prebiotic, probiotic, and synbiotic supplementation in chronic kidney disease: a systematic review and meta-analysis. J. Ren. Nutr. 29, 209–220 (2019).
    • (2019) J. Ren. Nutr. , vol.29 , pp. 209-220
    • McFarlane, C.1    Ramos, C.I.2    Johnson, D.W.3    Campbell, K.L.4
  • 31
    • 85053079270 scopus 로고    scopus 로고
    • Biotic supplements for renal patients: a systematic review and meta-analysis
    • Pisano, A., D’Arrigo, G., Coppolino, G. & Bolignano, D. Biotic supplements for renal patients: a systematic review and meta-analysis. Nutrients 10, 1224 (2018).
    • (2018) Nutrients , vol.10 , pp. 1224
    • Pisano, A.1    D’Arrigo, G.2    Coppolino, G.3    Bolignano, D.4
  • 32
    • 84962359291 scopus 로고    scopus 로고
    • Synbiotics for prevention and treatment of a dermatitis: a meta-analysis of randomized clinical trials
    • PID: 26810481, This meta-analysis provides evidence that supports the use of synbiotics for the treatment of atopic dermatitis, which is thought to be associated with altered gut microbiota that promote an environment that is more susceptible to allergic disease
    • Chang, Y. S. et al. Synbiotics for prevention and treatment of a dermatitis: a meta-analysis of randomized clinical trials. JAMA Pediatr. 170, 236–242 (2016). This meta-analysis provides evidence that supports the use of synbiotics for the treatment of atopic dermatitis, which is thought to be associated with altered gut microbiota that promote an environment that is more susceptible to allergic disease.
    • (2016) JAMA Pediatr. , vol.170 , pp. 236-242
    • Chang, Y.S.1
  • 33
    • 85042861435 scopus 로고    scopus 로고
    • Effects of perioperative supplementation with pro-/synbiotics on clinical outcomes in surgical patients: a meta-analysis with trial sequential analysis of randomized controlled trials
    • COI: 1:CAS:528:DC%2BC28XhslKmsr%2FN, PID: 27836310
    • Wu, X. D., Liu, M. M., Liang, X., Hu, N. & Huang, W. Effects of perioperative supplementation with pro-/synbiotics on clinical outcomes in surgical patients: a meta-analysis with trial sequential analysis of randomized controlled trials. Clin. Nutr. 37, 505–515 (2018).
    • (2018) Clin. Nutr. , vol.37 , pp. 505-515
    • Wu, X.D.1    Liu, M.M.2    Liang, X.3    Hu, N.4    Huang, W.5
  • 34
    • 85067638756 scopus 로고    scopus 로고
    • Efficacy of probiotics and synbiotics in patients with nonalcoholic fatty liver disease: a meta-analysis
    • PID: 31203554, This meta-analysis highlights the benefits of synbiotics for the hallmarks of non-alcoholic fatty liver disease, liver steatosis, liver enzymes, lipid profiles and liver stiffness
    • Liu, L., Li, P., Liu, Y. & Zhang, Y. Efficacy of probiotics and synbiotics in patients with nonalcoholic fatty liver disease: a meta-analysis. Dig. Dis. Sci. 64, 3402–3412 (2019). This meta-analysis highlights the benefits of synbiotics for the hallmarks of non-alcoholic fatty liver disease, liver steatosis, liver enzymes, lipid profiles and liver stiffness.
    • (2019) Dig. Dis. Sci. , vol.64 , pp. 3402-3412
    • Liu, L.1    Li, P.2    Liu, Y.3    Zhang, Y.4
  • 35
    • 85085194241 scopus 로고    scopus 로고
    • Preventing respiratory tract infections by synbiotic interventions: A systematic review and meta-analysis of randomized controlled trials
    • Chan, C. K. Y., Tao, J., Chan, O. S., Li, H. B. & Pang, H. Preventing respiratory tract infections by synbiotic interventions: A systematic review and meta-analysis of randomized controlled trials. Adv. Nutr. 10.1093/advances/nmaa003 (2020). DOI: 10.1093/advances/nmaa003
    • (2020) Adv. Nutr.
    • Chan, C.K.Y.1    Tao, J.2    Chan, O.S.3    Li, H.B.4    Pang, H.5
  • 36
    • 85054331814 scopus 로고    scopus 로고
    • Reflections on the history of systematic reviews
    • PID: 29921711
    • Clarke, M. & Chalmers, I. Reflections on the history of systematic reviews. BMJ Evid. Based Med. 23, 121–122 (2018).
    • (2018) BMJ Evid. Based Med. , vol.23 , pp. 121-122
    • Clarke, M.1    Chalmers, I.2
  • 39
    • 84959122961 scopus 로고    scopus 로고
    • Efficacy of perioperative synbiotics treatment for the prevention of surgical site infection after laparoscopic colorectal surgery: a randomized controlled trial
    • COI: 1:CAS:528:DC%2BC2MXotVCjsrg%3D, PID: 25933911
    • Komatsu, S. et al. Efficacy of perioperative synbiotics treatment for the prevention of surgical site infection after laparoscopic colorectal surgery: a randomized controlled trial. Surg. Today 46, 479–490 (2016).
    • (2016) Surg. Today , vol.46 , pp. 479-490
    • Komatsu, S.1
  • 40
    • 1642451908 scopus 로고    scopus 로고
    • Randomised clinical trial of synbiotic therapy in elective surgical patients
    • COI: 1:STN:280:DC%2BD2c%2FisFWiug%3D%3D, PID: 14724157
    • Anderson, A. D., McNaught, C. E., Jain, P. K. & MacFie, J. Randomised clinical trial of synbiotic therapy in elective surgical patients. Gut 53, 241–245 (2004).
    • (2004) Gut , vol.53 , pp. 241-245
    • Anderson, A.D.1    McNaught, C.E.2    Jain, P.K.3    MacFie, J.4
  • 41
    • 85078030701 scopus 로고    scopus 로고
    • Effects of synbiotic supplement on human gut microbiota, body composition and weight loss in obesity
    • Sergeev, I. N., Aljutaily, T., Walton, G. & Huarte, E. Effects of synbiotic supplement on human gut microbiota, body composition and weight loss in obesity. Nutrients 12, 222 (2020).
    • (2020) Nutrients , vol.12 , pp. 222
    • Sergeev, I.N.1    Aljutaily, T.2    Walton, G.3    Huarte, E.4
  • 42
    • 85042375719 scopus 로고    scopus 로고
    • The effects of synbiotic supplementation on insulin resistance/sensitivity, lipid profile and total antioxidant capacity in women with gestational diabetes mellitus: a randomized double blind placebo controlled clinical trial
    • COI: 1:CAS:528:DC%2BC1cXislOqsb8%3D, PID: 29432772
    • Nabhani, Z., Hezaveh, S. J. G., Razmpoosh, E., Asghari-Jafarabadi, M. & Gargari, B. P. The effects of synbiotic supplementation on insulin resistance/sensitivity, lipid profile and total antioxidant capacity in women with gestational diabetes mellitus: a randomized double blind placebo controlled clinical trial. Diabetes Res. Clin. Pract. 138, 149–157 (2018).
    • (2018) Diabetes Res. Clin. Pract. , vol.138 , pp. 149-157
    • Nabhani, Z.1    Hezaveh, S.J.G.2    Razmpoosh, E.3    Asghari-Jafarabadi, M.4    Gargari, B.P.5
  • 43
    • 85021687419 scopus 로고    scopus 로고
    • The effects of synbiotic “Bifidobacterium lactis B94 plus inulin” addition on standard triple therapy of Helicobacter pylori eradication in children
    • PID: 28656129
    • Ustundag, G. H., Altuntas, H., Soysal, Y. D. & Kokturk, F. The effects of synbiotic “Bifidobacterium lactis B94 plus inulin” addition on standard triple therapy of Helicobacter pylori eradication in children. Can. J. Gastroenterol. Hepatol. 2017, 8130596 (2017).
    • (2017) Can. J. Gastroenterol. Hepatol. , vol.2017 , pp. 8130596
    • Ustundag, G.H.1    Altuntas, H.2    Soysal, Y.D.3    Kokturk, F.4
  • 44
    • 84944715210 scopus 로고    scopus 로고
    • Bifidobacterium lactis B94 plus inulin for Treatment of Helicobacter pylori infection in children: does it increase eradication rate and patient compliance?
    • COI: 1:STN:280:DC%2BC28zgt1yntA%3D%3D, PID: 26448408
    • Islek, A., Sayar, E., Yilmaz, A. & Artan, R. Bifidobacterium lactis B94 plus inulin for Treatment of Helicobacter pylori infection in children: does it increase eradication rate and patient compliance? Acta Gastroenterol. Belg. 78, 282–286 (2015).
    • (2015) Acta Gastroenterol. Belg. , vol.78 , pp. 282-286
    • Islek, A.1    Sayar, E.2    Yilmaz, A.3    Artan, R.4
  • 45
    • 84926525061 scopus 로고    scopus 로고
    • Perioperative synbiotics decrease postoperative complications in periampullary neoplasms: a randomized, double-blind clinical trial
    • COI: 1:CAS:528:DC%2BC2MXlsleitb4%3D, PID: 25803626
    • Sommacal, H. M., Bersch, V. P., Vitola, S. P. & Osvaldt, A. B. Perioperative synbiotics decrease postoperative complications in periampullary neoplasms: a randomized, double-blind clinical trial. Nutr. Cancer 67, 457–462 (2015).
    • (2015) Nutr. Cancer , vol.67 , pp. 457-462
    • Sommacal, H.M.1    Bersch, V.P.2    Vitola, S.P.3    Osvaldt, A.B.4
  • 46
    • 85005790360 scopus 로고    scopus 로고
    • Probiotic with or without fiber controls body fat mass, associated with serum zonulin, in overweight and obese adults-randomized controlled trial
    • PID: 27810310
    • Stenman, L. K. et al. Probiotic with or without fiber controls body fat mass, associated with serum zonulin, in overweight and obese adults-randomized controlled trial. EBioMedicine 13, 190–200 (2016).
    • (2016) EBioMedicine , vol.13 , pp. 190-200
    • Stenman, L.K.1
  • 47
    • 84992363298 scopus 로고    scopus 로고
    • Stable engraftment of Bifidobacterium longum AH1206 in the human gut depends on individualized features of the resident microbiome
    • COI: 1:CAS:528:DC%2BC28XhsF2qtbzN, PID: 27693307
    • Maldonado-Gomez, M. X. et al. Stable engraftment of Bifidobacterium longum AH1206 in the human gut depends on individualized features of the resident microbiome. Cell Host Microbe 20, 515–526 (2016).
    • (2016) Cell Host Microbe , vol.20 , pp. 515-526
    • Maldonado-Gomez, M.X.1
  • 48
    • 84856235433 scopus 로고    scopus 로고
    • CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials
    • PID: 22036893
    • Moher, D. et al. CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. Int. J. Surg. 10, 28–55 (2012).
    • (2012) Int. J. Surg. , vol.10 , pp. 28-55
    • Moher, D.1
  • 49
    • 85057964419 scopus 로고    scopus 로고
    • Considerations for best practices in studies of fiber or other dietary components and the intestinal microbiome
    • COI: 1:CAS:528:DC%2BC1MXnt1GltLs%3D, PID: 30130151
    • Klurfeld, D. M. et al. Considerations for best practices in studies of fiber or other dietary components and the intestinal microbiome. Am. J. Physiol. Endocrinol. Metab. 315, E1087–E1097 (2018).
    • (2018) Am. J. Physiol. Endocrinol. Metab. , vol.315 , pp. E1087-E1097
    • Klurfeld, D.M.1
  • 50
    • 84898604796 scopus 로고    scopus 로고
    • An in vitro study of the effect of probiotics, prebiotics and synbiotics on the elderly faecal microbiota
    • COI: 1:CAS:528:DC%2BC2cXnvFSkurc%3D, PID: 24685554
    • Likotrafiti, E., Tuohy, K. M., Gibson, G. R. & Rastall, R. A. An in vitro study of the effect of probiotics, prebiotics and synbiotics on the elderly faecal microbiota. Anaerobe 27, 50–55 (2014).
    • (2014) Anaerobe , vol.27 , pp. 50-55
    • Likotrafiti, E.1    Tuohy, K.M.2    Gibson, G.R.3    Rastall, R.A.4
  • 51
    • 85054549063 scopus 로고    scopus 로고
    • The application of in vitro human intestinal models on the screening and development of pre- and probiotics
    • COI: 1:CAS:528:DC%2BC1MXhslWqsbfO, PID: 29695182
    • Pham, V. T. & Mohajeri, M. H. The application of in vitro human intestinal models on the screening and development of pre- and probiotics. Benef. Microbes 9, 725–742 (2018).
    • (2018) Benef. Microbes , vol.9 , pp. 725-742
    • Pham, V.T.1    Mohajeri, M.H.2
  • 52
    • 85061871049 scopus 로고    scopus 로고
    • Ameliorative effect of probiotics (Lactobacillus paracaseii and Protexin(R)) and prebiotics (propolis and bee pollen) on clindamycin and propionic acid-induced oxidative stress and altered gut microbiota in a rodent model of autism
    • PID: 30782287
    • Aabed, K. et al. Ameliorative effect of probiotics (Lactobacillus paracaseii and Protexin(R)) and prebiotics (propolis and bee pollen) on clindamycin and propionic acid-induced oxidative stress and altered gut microbiota in a rodent model of autism. Cell Mol. Biol. 65, 1–7 (2019).
    • (2019) Cell Mol. Biol. , vol.65 , pp. 1-7
    • Aabed, K.1
  • 53
    • 85056694480 scopus 로고    scopus 로고
    • Probiotics, prebiotics and synbiotics for weight loss and metabolic syndrome in the microbiome era
    • COI: 1:STN:280:DC%2BB3crktVSrtA%3D%3D, PID: 30468509
    • Ferrarese, R., Ceresola, E. R., Preti, A. & Canducci, F. Probiotics, prebiotics and synbiotics for weight loss and metabolic syndrome in the microbiome era. Eur. Rev. Med. Pharmacol. Sci. 22, 7588–7605 (2018).
    • (2018) Eur. Rev. Med. Pharmacol. Sci. , vol.22 , pp. 7588-7605
    • Ferrarese, R.1    Ceresola, E.R.2    Preti, A.3    Canducci, F.4
  • 54
    • 1542359547 scopus 로고    scopus 로고
    • Modulation of anti-pathogenic activity in canine-derived Lactobacillus species by carbohydrate growth substrate
    • COI: 1:CAS:528:DC%2BD2cXislakt7s%3D, PID: 14962135
    • Tzortzis, G., Baillon, M. L., Gibson, G. R. & Rastall, R. A. Modulation of anti-pathogenic activity in canine-derived Lactobacillus species by carbohydrate growth substrate. J. Appl. Microbiol. 96, 552–559 (2004).
    • (2004) J. Appl. Microbiol. , vol.96 , pp. 552-559
    • Tzortzis, G.1    Baillon, M.L.2    Gibson, G.R.3    Rastall, R.A.4
  • 55
    • 84894437195 scopus 로고    scopus 로고
    • Effects of genetic, processing, or product formulation changes on efficacy and safety of probiotics
    • COI: 1:CAS:528:DC%2BC2cXnsFWhsrg%3D, PID: 24571253
    • Sanders, M. E. et al. Effects of genetic, processing, or product formulation changes on efficacy and safety of probiotics. Ann. NY Acad. Sci. 1309, 1–18 (2014).
    • (2014) Ann. NY Acad. Sci. , vol.1309 , pp. 1-18
    • Sanders, M.E.1
  • 56
    • 0043197149 scopus 로고    scopus 로고
    • Recent advances in the use of functional foods: effects of the commercial fermented milk with Bifidobacterium animalis strain DN-173 010 and yoghurt strains on gut transit time in the elderly
    • Meance, S. et al. Recent advances in the use of functional foods: effects of the commercial fermented milk with Bifidobacterium animalis strain DN-173 010 and yoghurt strains on gut transit time in the elderly. Microb. Ecol. Health Dis. 15, 15–22 (2003).
    • (2003) Microb. Ecol. Health Dis. , vol.15 , pp. 15-22
    • Meance, S.1
  • 57
    • 79952756960 scopus 로고    scopus 로고
    • Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation
    • COI: 1:CAS:528:DC%2BC3MXjvVCktbo%3D, PID: 20847294
    • Dethlefsen, L. & Relman, D. A. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proc. Natl Acad. Sci. USA 108, 4554–4561 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 4554-4561
    • Dethlefsen, L.1    Relman, D.A.2
  • 58
    • 84907486974 scopus 로고    scopus 로고
    • Antibiotics and the gut microbiota
    • COI: 1:CAS:528:DC%2BC2cXhslGgtrzM, PID: 25271726
    • Modi, S. R., Collins, J. J. & Relman, D. A. Antibiotics and the gut microbiota. J. Clin. Invest. 124, 4212–4218 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 4212-4218
    • Modi, S.R.1    Collins, J.J.2    Relman, D.A.3
  • 59
    • 85037666947 scopus 로고    scopus 로고
    • Systematic review: human gut dysbiosis induced by non-antibiotic prescription medications
    • PID: 29205415
    • Le Bastard, Q. et al. Systematic review: human gut dysbiosis induced by non-antibiotic prescription medications. Aliment. Pharmacol. Ther. 47, 332–345 (2018).
    • (2018) Aliment. Pharmacol. Ther. , vol.47 , pp. 332-345
    • Le Bastard, Q.1
  • 60
    • 84892828465 scopus 로고    scopus 로고
    • Diet rapidly and reproducibly alters the human gut microbiome
    • COI: 1:CAS:528:DC%2BC2cXhtFOls78%3D, PID: 24336217
    • David, L. A. et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 505, 559–563 (2014).
    • (2014) Nature , vol.505 , pp. 559-563
    • David, L.A.1
  • 62
    • 78649520016 scopus 로고    scopus 로고
    • A dose dependent impact of prebiotic galactooligosaccharides on the intestinal microbiota of healthy adults
    • COI: 1:CAS:528:DC%2BC3cXhsV2nsrjJ, PID: 21059476
    • Davis, L. M., Martinez, I., Walter, J. & Hutkins, R. A dose dependent impact of prebiotic galactooligosaccharides on the intestinal microbiota of healthy adults. Int. J. Food Microbiol. 144, 285–292 (2010).
    • (2010) Int. J. Food Microbiol. , vol.144 , pp. 285-292
    • Davis, L.M.1    Martinez, I.2    Walter, J.3    Hutkins, R.4
  • 63
    • 85046534759 scopus 로고    scopus 로고
    • Gut microbiota utilize immunoglobulin A for mucosal colonization
    • COI: 1:CAS:528:DC%2BC1cXpsVCgsL8%3D, PID: 29724905
    • Donaldson, G. P. et al. Gut microbiota utilize immunoglobulin A for mucosal colonization. Science 360, 795–800 (2018).
    • (2018) Science , vol.360 , pp. 795-800
    • Donaldson, G.P.1
  • 64
    • 84958182323 scopus 로고    scopus 로고
    • In vitro fermentation of prebiotic carbohydrates by intestinal microbiota in the presence of Lactobacillus amylovorus DSM 16998
    • COI: 1:STN:280:DC%2BC28vmtVChug%3D%3D, PID: 26615853
    • Cardarelli, H. R. et al. In vitro fermentation of prebiotic carbohydrates by intestinal microbiota in the presence of Lactobacillus amylovorus DSM 16998. Benef. Microbes 7, 119–133 (2016).
    • (2016) Benef. Microbes , vol.7 , pp. 119-133
    • Cardarelli, H.R.1
  • 65
    • 84866146940 scopus 로고    scopus 로고
    • Diversity, stability and resilience of the human gut microbiota
    • COI: 1:CAS:528:DC%2BC38Xhtleru7jO, PID: 22972295
    • Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K. & Knight, R. Diversity, stability and resilience of the human gut microbiota. Nature 489, 220–230 (2012).
    • (2012) Nature , vol.489 , pp. 220-230
    • Lozupone, C.A.1    Stombaugh, J.I.2    Gordon, J.I.3    Jansson, J.K.4    Knight, R.5
  • 66
    • 84871454511 scopus 로고    scopus 로고
    • Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk
    • COI: 1:CAS:528:DC%2BC38Xhs1CjsL3K, PID: 23140640
    • Holmes, E., Li, J. V., Marchesi, J. R. & Nicholson, J. K. Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk. Cell Metab. 16, 559–564 (2012).
    • (2012) Cell Metab. , vol.16 , pp. 559-564
    • Holmes, E.1    Li, J.V.2    Marchesi, J.R.3    Nicholson, J.K.4
  • 67
    • 84944234155 scopus 로고    scopus 로고
    • Quantitative imaging of gut microbiota spatial organization
    • COI: 1:CAS:528:DC%2BC2MXhs1SqsL3J, PID: 26439864
    • Earle, K. A. et al. Quantitative imaging of gut microbiota spatial organization. Cell Host Microbe 18, 478–488 (2015).
    • (2015) Cell Host Microbe , vol.18 , pp. 478-488
    • Earle, K.A.1
  • 69
    • 84887621475 scopus 로고    scopus 로고
    • Safety and efficacy of inulin and oligofructose supplementation in infant formula: results from a randomized clinical trial
    • COI: 1:CAS:528:DC%2BC3sXktlKktr0%3D, PID: 23498848
    • Closa-Monasterolo, R. et al. Safety and efficacy of inulin and oligofructose supplementation in infant formula: results from a randomized clinical trial. Clin. Nutr. 32, 918–927 (2013).
    • (2013) Clin. Nutr. , vol.32 , pp. 918-927
    • Closa-Monasterolo, R.1
  • 70
    • 0033661618 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of fructooligosaccharides in the treatment of irritable bowel syndrome
    • COI: 1:CAS:528:DC%2BD3cXosl2mt7Y%3D, PID: 11101487
    • Olesen, M. & Gudmand-Hoyer, E. Efficacy, safety, and tolerability of fructooligosaccharides in the treatment of irritable bowel syndrome. Am. J. Clin. Nutr. 72, 1570–1575 (2000).
    • (2000) Am. J. Clin. Nutr. , vol.72 , pp. 1570-1575
    • Olesen, M.1    Gudmand-Hoyer, E.2
  • 71
    • 84929298373 scopus 로고    scopus 로고
    • Soy protein-based infant formulas with supplemental fructooligosaccharides: gastrointestinal tolerance and hydration status in newborn infants
    • COI: 1:CAS:528:DC%2BC2MXhtVCqsr%2FI, PID: 25912040
    • Lasekan, J., Baggs, G., Acosta, S. & Mackey, A. Soy protein-based infant formulas with supplemental fructooligosaccharides: gastrointestinal tolerance and hydration status in newborn infants. Nutrients 7, 3022–3037 (2015).
    • (2015) Nutrients , vol.7 , pp. 3022-3037
    • Lasekan, J.1    Baggs, G.2    Acosta, S.3    Mackey, A.4
  • 72
    • 85069466252 scopus 로고    scopus 로고
    • Dealing with the remaining controversies of probiotic safety
    • PID: 31131618
    • van den Nieuwboer, M. & Claassen, E. Dealing with the remaining controversies of probiotic safety. Benef. Microbes 10, 605–616 (2019).
    • (2019) Benef. Microbes , vol.10 , pp. 605-616
    • van den Nieuwboer, M.1    Claassen, E.2
  • 73
    • 84994462053 scopus 로고    scopus 로고
    • Probiotic use in at-risk populations
    • Sanders, M. E. et al. Probiotic use in at-risk populations. J. Am. Pharm. Assoc. 56, 680–686 (2016).
    • (2016) J. Am. Pharm. Assoc. , vol.56 , pp. 680-686
    • Sanders, M.E.1
  • 74
    • 77954820449 scopus 로고    scopus 로고
    • Safety assessment of probiotics for human use
    • PID: 21327023
    • Sanders, M. E. et al. Safety assessment of probiotics for human use. Gut Microbes 1, 164–185 (2010).
    • (2010) Gut Microbes , vol.1 , pp. 164-185
    • Sanders, M.E.1
  • 75
    • 8744229000 scopus 로고    scopus 로고
    • Better reporting of harms in randomized trials: an extension of the CONSORT statement
    • PID: 15545678
    • Ioannidis, J. P. et al. Better reporting of harms in randomized trials: an extension of the CONSORT statement. Ann. Intern. Med. 141, 781–788 (2004).
    • (2004) Ann. Intern. Med. , vol.141 , pp. 781-788
    • Ioannidis, J.P.1
  • 76
    • 85051960349 scopus 로고    scopus 로고
    • Harms reporting in randomized controlled trials of interventions aimed at modifying microbiota: a systematic review
    • PID: 30014150
    • Bafeta, A., Koh, M., Riveros, C. & Ravaud, P. Harms reporting in randomized controlled trials of interventions aimed at modifying microbiota: a systematic review. Ann. Intern. Med. 169, 240–247 (2018).
    • (2018) Ann. Intern. Med. , vol.169 , pp. 240-247
    • Bafeta, A.1    Koh, M.2    Riveros, C.3    Ravaud, P.4
  • 77
    • 84920969881 scopus 로고    scopus 로고
    • The administration of probiotics and synbiotics in immune compromised adults: is it safe?
    • PID: 25304690
    • van den Nieuwboer, M. et al. The administration of probiotics and synbiotics in immune compromised adults: is it safe? Benef. Microbes 6, 3–17 (2015).
    • (2015) Benef. Microbes , vol.6 , pp. 3-17
    • van den Nieuwboer, M.1
  • 78
    • 84944404934 scopus 로고    scopus 로고
    • Safety of probiotics and synbiotics in children under 18 years of age
    • PID: 25809217
    • van den Nieuwboer, M. et al. Safety of probiotics and synbiotics in children under 18 years of age. Benef. Microbes 6, 615–630 (2015).
    • (2015) Benef. Microbes , vol.6 , pp. 615-630
    • van den Nieuwboer, M.1
  • 80
    • 85089744359 scopus 로고    scopus 로고
    • NIH National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE) https://ctep.cancer.gov/protocoldevelopment/electronic_applications/ctc.htm (2018).
  • 81
    • 84905680479 scopus 로고    scopus 로고
    • Government of Canada. Accepted Claims about the Nature of Probiotic Microorganisms in Food https://www.canada.ca/en/health-canada/services/food-nutrition/food-labelling/health-claims/accepted-claims-about-nature-probiotic-microorganisms-food.html (2009).
    • (2009) Accepted Claims about the Nature of Probiotic Microorganisms in Food
  • 82
    • 85089728158 scopus 로고    scopus 로고
    • Governement of Canada. Questions and Answers on Probiotics https://www.canada.ca/en/health-canada/services/food-nutrition/food-labelling/health-claims/questions-answers-probiotics.html (2009).
    • (2009) Questions and Answers on Probiotics
  • 83
    • 85089728792 scopus 로고    scopus 로고
    • Ministero della Salute y Secretaría de Agricultura, Ganadería y Pesca
    • Ministero della Salute y Secretaría de Agricultura, Ganadería y Pesca. Guidelines on Probiotics and Prebiotics [Italian] http://www.salute.gov.it/imgs/C_17_pubblicazioni_1016_ulterioriallegati_ulterioreallegato_0_alleg.pdf (2018).
    • (2018) Guidelines on Probiotics and Prebiotics [Italian]
  • 84
    • 85089735973 scopus 로고    scopus 로고
    • Secretaria de Politicas, Regulacion e Institutos, Ministerio de Salud, Argentina
    • Secretaria de Politicas, Regulacion e Institutos, Ministerio de Salud, Argentina. Codigo Alimentario Argentino [Spanish] http://www.anmat.gov.ar/webanmat/Legislacion/Alimentos/Resolucion_Conjunta_261-2011_y_22-2011.pdf (2011).
    • (2011) Codigo Alimentario Argentino [Spanish]
  • 85
    • 85089725938 scopus 로고    scopus 로고
    • Define regimen de control sanitario para productors en formas farmaceutias orales, elaborados con Lactobacillus spp
    • Departamento Agencia Nacional de Medicamentos, Salud Publica, Gobierno de Chile. Define regimen de control sanitario para productors en formas farmaceutias orales, elaborados con Lactobacillus spp., Bifidobacterium spp. y otros bacilos especificos [Spanish] https://www.carey.cl/download/filebase/newsalert/res-n-3435-probioticos.pdf (2018).
    • (2018) Bifidobacterium Spp. Y Otros Bacilos Especificos [Spanish]
  • 86
    • 85089735926 scopus 로고    scopus 로고
    • Invima. Resolucion 288 de 2008 [Spanish]. http://normograma.invima.gov.co/docs/resolucion_minproteccion_0288_2008.htm (2008).
    • (2008) Resolucion 288 De 2008 [Spanish].
  • 88
    • 85089737584 scopus 로고    scopus 로고
    • http://www.fao.org/fao-who-codexalimentarius/sh-proxy/en/?lnk=1&url=https%253A%252F%252Fworkspace.fao.org%252Fsites%252Fcodex%252FMeetings%252FCX-720-41%252FWD%252Fnf41_11e.pdf (2019)
    • Codex Alimentarius Commission. Joint FAO/WHO Food Standards Programme Codex Committee on Nutrition and Foods for Special Dietary Uses: Forty-first Session http://www.fao.org/fao-who-codexalimentarius/sh-proxy/en/?lnk=1&url=https%253A%252F%252Fworkspace.fao.org%252Fsites%252Fcodex%252FMeetings%252FCX-720-41%252FWD%252Fnf41_11e.pdf (2019).
    • Joint FAO/WHO Food Standards Programme Codex Committee on Nutrition and Foods for Special Dietary Uses: Forty-First Session
  • 89
    • 85089730101 scopus 로고    scopus 로고
    • Harmonized Probiotic Guidelines to be Discussed at Codex Alimentarius Meeting November 24-29
    • Mary Ellen Sanders. Harmonized Probiotic Guidelines to be Discussed at Codex Alimentarius Meeting November 24-29, ISAPP https://isappscience.org/harmonized-probiotic-guidelines-to-be-discussed-at-codex-alimentarius-meeting-november-24-29/ (2019).
    • (2019) ISAPP
  • 90
    • 85089740817 scopus 로고    scopus 로고
    • Food Safety Authority of Ireland. Probiotic Health Claims https://www.fsai.ie/faq/probiotic_health_claims.html (2020).
    • (2020) Probiotic Health Claims
  • 91
    • 85041297498 scopus 로고    scopus 로고
    • Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention study
    • COI: 1:CAS:528:DC%2BC1cXhsVarsrg%3D, PID: 29307330, This study demonstrated that people with a high dietary fibre intake had a greater gut microbiota response and are therefore more likely to benefit from an inulin-type fructan prebiotic than those with a low dietary fibre intake
    • Healey, G. et al. Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention study. Br. J. Nutr. 119, 176–189 (2018). This study demonstrated that people with a high dietary fibre intake had a greater gut microbiota response and are therefore more likely to benefit from an inulin-type fructan prebiotic than those with a low dietary fibre intake.
    • (2018) Br. J. Nutr. , vol.119 , pp. 176-189
    • Healey, G.1
  • 92
    • 85011715907 scopus 로고    scopus 로고
    • Toward a personalized approach in prebiotics research
    • Dey, M. Toward a personalized approach in prebiotics research. Nutrients 9, 92 (2017).
    • (2017) Nutrients , vol.9 , pp. 92
    • Dey, M.1
  • 93
    • 85078055281 scopus 로고    scopus 로고
    • Establishing or exaggerating causality for the gut microbiome: lessons from human microbiota-associated rodents
    • COI: 1:CAS:528:DC%2BB3cXnvFelt7g%3D, PID: 31978342
    • Walter, J., Armet, A. M., Finlay, B. B. & Shanahan, F. Establishing or exaggerating causality for the gut microbiome: lessons from human microbiota-associated rodents. Cell 180, 221–232 (2020).
    • (2020) Cell , vol.180 , pp. 221-232
    • Walter, J.1    Armet, A.M.2    Finlay, B.B.3    Shanahan, F.4
  • 94
    • 66749093542 scopus 로고    scopus 로고
    • Funding food science and nutrition research: financial conflicts and scientific integrity
    • COI: 1:CAS:528:DC%2BD1MXhtlWrtrbL, PID: 19403704
    • Rowe, S. et al. Funding food science and nutrition research: financial conflicts and scientific integrity. J. Nutr. 139, 1051–1053 (2009).
    • (2009) J. Nutr. , vol.139 , pp. 1051-1053
    • Rowe, S.1
  • 95
    • 84930428242 scopus 로고    scopus 로고
    • Achieving a transparent, actionable framework for public-private partnerships for food and nutrition research
    • COI: 1:CAS:528:DC%2BC2MXhtVOgtrfJ, PID: 26034107
    • Alexander, N. et al. Achieving a transparent, actionable framework for public-private partnerships for food and nutrition research. Am. J. Clin. Nutr. 101, 1359–1363 (2015).
    • (2015) Am. J. Clin. Nutr. , vol.101 , pp. 1359-1363
    • Alexander, N.1
  • 96
    • 20144387523 scopus 로고    scopus 로고
    • Synbiotics reduce postoperative infectious complications: a randomized controlled trial in biliary cancer patients undergoing hepatectomy
    • PID: 15711820
    • Kanazawa, H. et al. Synbiotics reduce postoperative infectious complications: a randomized controlled trial in biliary cancer patients undergoing hepatectomy. Langenbecks Arch. Surg. 390, 104–113 (2005).
    • (2005) Langenbecks Arch. Surg. , vol.390 , pp. 104-113
    • Kanazawa, H.1
  • 97
    • 84939441787 scopus 로고    scopus 로고
    • Synbiotics in surgery for chronic pancreatitis: are they truly effective? A single-blind prospective control trial
    • PID: 25575262
    • Rammohan, A. et al. Synbiotics in surgery for chronic pancreatitis: are they truly effective? A single-blind prospective control trial. Ann. Surg. 262, 31–37 (2015).
    • (2015) Ann. Surg. , vol.262 , pp. 31-37
    • Rammohan, A.1
  • 98
    • 34347330287 scopus 로고    scopus 로고
    • Effect of enteral nutrition and synbiotics on bacterial infection rates after pylorus-preserving pancreatoduodenectomy: a randomized, double-blind trial
    • PID: 17592288
    • Rayes, N. et al. Effect of enteral nutrition and synbiotics on bacterial infection rates after pylorus-preserving pancreatoduodenectomy: a randomized, double-blind trial. Ann. Surg. 246, 36–41 (2007).
    • (2007) Ann. Surg. , vol.246 , pp. 36-41
    • Rayes, N.1
  • 99
    • 34248361622 scopus 로고    scopus 로고
    • Randomized clinical trial of effect of synbiotics, neomycin and mechanical bowel preparation on intestinal barrier function in patients undergoing colectomy
    • COI: 1:CAS:528:DC%2BD2sXmtl2it74%3D, PID: 17443852
    • Reddy, B. S. et al. Randomized clinical trial of effect of synbiotics, neomycin and mechanical bowel preparation on intestinal barrier function in patients undergoing colectomy. Br. J. Surg. 94, 546–554 (2007).
    • (2007) Br. J. Surg. , vol.94 , pp. 546-554
    • Reddy, B.S.1
  • 100
    • 79955670167 scopus 로고    scopus 로고
    • Effects of perioperative synbiotic treatment on infectious complications, intestinal integrity, and fecal flora and organic acids in hepatic surgery with or without cirrhosis
    • Usami, M. et al. Effects of perioperative synbiotic treatment on infectious complications, intestinal integrity, and fecal flora and organic acids in hepatic surgery with or without cirrhosis. J. Parenter. Enter. Nutr. 35, 317–328 (2011).
    • (2011) J. Parenter. Enter. Nutr. , vol.35 , pp. 317-328
    • Usami, M.1
  • 101
    • 84896818656 scopus 로고    scopus 로고
    • Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study
    • COI: 1:CAS:528:DC%2BC2cXjs1Klsr4%3D, PID: 24401715
    • Eslamparast, T. et al. Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study. Am. J. Clin. Nutr. 99, 535–542 (2014).
    • (2014) Am. J. Clin. Nutr. , vol.99 , pp. 535-542
    • Eslamparast, T.1
  • 102
    • 84856763599 scopus 로고    scopus 로고
    • Bifidobacterium longum with fructo-oligosaccharides in patients with non alcoholic steatohepatitis
    • PID: 21901256
    • Malaguarnera, M. et al. Bifidobacterium longum with fructo-oligosaccharides in patients with non alcoholic steatohepatitis. Dig. Dis. Sci. 57, 545–553 (2012).
    • (2012) Dig. Dis. Sci. , vol.57 , pp. 545-553
    • Malaguarnera, M.1
  • 103
    • 85016232480 scopus 로고    scopus 로고
    • Synbiotic supplementation in lean patients with non-alcoholic fatty liver disease: a pilot, randomised, double-blind, placebo-controlled, clinical trial
    • COI: 1:CAS:528:DC%2BC2sXlvFeqtL4%3D, PID: 28345499
    • Mofidi, F. et al. Synbiotic supplementation in lean patients with non-alcoholic fatty liver disease: a pilot, randomised, double-blind, placebo-controlled, clinical trial. Br. J. Nutr. 117, 662–668 (2017).
    • (2017) Br. J. Nutr. , vol.117 , pp. 662-668
    • Mofidi, F.1
  • 104
    • 85054608740 scopus 로고    scopus 로고
    • Pro- and prebiotic effects on oxidative stress and inflammatory markers in non-alcoholic fatty liver disease
    • COI: 1:CAS:528:DC%2BC1MXhsVSgtr3I, PID: 30272851
    • Javadi, L. et al. Pro- and prebiotic effects on oxidative stress and inflammatory markers in non-alcoholic fatty liver disease. Asia Pac. J. Clin. Nutr. 27, 1031–1039 (2018).
    • (2018) Asia Pac. J. Clin. Nutr. , vol.27 , pp. 1031-1039
    • Javadi, L.1
  • 105
    • 85028348393 scopus 로고    scopus 로고
    • A randomized synbiotic trial to prevent sepsis among infants in rural India
    • COI: 1:CAS:528:DC%2BC2sXhtlGktrrE, PID: 28813414, This paper discussed the use of a synbiotic consisting ofLactobacillus plantarumand fructo-oligosaccharides a large (4,500 participants) intervention study to protect infants against sepsis
    • Panigrahi, P. et al. A randomized synbiotic trial to prevent sepsis among infants in rural India. Nature 548, 407–412 (2017). This paper discussed the use of a synbiotic consisting of Lactobacillus plantarum and fructo-oligosaccharides in a large (4,500 participants) intervention study to protect infants against sepsis.
    • (2017) Nature , vol.548 , pp. 407-412
    • Panigrahi, P.1
  • 106
    • 85062864585 scopus 로고    scopus 로고
    • Probiotic or synbiotic alters the gut microbiota and metabolism in a randomised controlled trial of weight management in overweight adults
    • COI: 1:CAS:528:DC%2BC1MXitl2qurfI, PID: 30525950
    • Hibberd, A. A. et al. Probiotic or synbiotic alters the gut microbiota and metabolism in a randomised controlled trial of weight management in overweight adults. Benef. Microbes 10, 121–135 (2019).
    • (2019) Benef. Microbes , vol.10 , pp. 121-135
    • Hibberd, A.A.1
  • 107
    • 84903774453 scopus 로고    scopus 로고
    • Effects of synbiotic supplementation on insulin resistance in subjects with the metabolic syndrome: a randomised, double-blind, placebo-controlled pilot study
    • COI: 1:CAS:528:DC%2BC2cXhtVOgt7fO, PID: 24848793
    • Eslamparast, T. et al. Effects of synbiotic supplementation on insulin resistance in subjects with the metabolic syndrome: a randomised, double-blind, placebo-controlled pilot study. Br. J. Nutr. 112, 438–445 (2014).
    • (2014) Br. J. Nutr. , vol.112 , pp. 438-445
    • Eslamparast, T.1
  • 108
    • 84895438032 scopus 로고    scopus 로고
    • Effects of synbiotic food consumption on metabolic status of diabetic patients: a double-blind randomized cross-over controlled clinical trial
    • PID: 23786900
    • Asemi, Z., Khorrami-Rad, A., Alizadeh, S. A., Shakeri, H. & Esmaillzadeh, A. Effects of synbiotic food consumption on metabolic status of diabetic patients: a double-blind randomized cross-over controlled clinical trial. Clin. Nutr. 33, 198–203 (2014).
    • (2014) Clin. Nutr. , vol.33 , pp. 198-203
    • Asemi, Z.1    Khorrami-Rad, A.2    Alizadeh, S.A.3    Shakeri, H.4    Esmaillzadeh, A.5
  • 109
    • 84903821583 scopus 로고    scopus 로고
    • Consumption of synbiotic bread decreases triacylglycerol and VLDL levels while increasing HDL levels in serum from patients with type-2 diabetes
    • COI: 1:CAS:528:DC%2BC2cXls1Oltrs%3D, PID: 24706266
    • Shakeri, H. et al. Consumption of synbiotic bread decreases triacylglycerol and VLDL levels while increasing HDL levels in serum from patients with type-2 diabetes. Lipids 49, 695–701 (2014).
    • (2014) Lipids , vol.49 , pp. 695-701
    • Shakeri, H.1
  • 110
    • 84989216814 scopus 로고    scopus 로고
    • The effects of synbiotic supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes: a randomised, double-blind, placebo-controlled trial
    • COI: 1:CAS:528:DC%2BC28XhslSrt7fM, PID: 27681077
    • Ahmadi, S., Jamilian, M., Tajabadi-Ebrahimi, M., Jafari, P. & Asemi, Z. The effects of synbiotic supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes: a randomised, double-blind, placebo-controlled trial. Br. J. Nutr. 116, 1394–1401 (2016).
    • (2016) Br. J. Nutr. , vol.116 , pp. 1394-1401
    • Ahmadi, S.1    Jamilian, M.2    Tajabadi-Ebrahimi, M.3    Jafari, P.4    Asemi, Z.5
  • 111
    • 84969981067 scopus 로고    scopus 로고
    • A randomized controlled clinical trial investigating the effect of synbiotic administration on markers of insulin metabolism and lipid profiles in overweight type 2 diabetic patients with coronary heart disease
    • COI: 1:CAS:528:DC%2BC28XosFWnur8%3D, PID: 27219886
    • Tajabadi-Ebrahimi, M. et al. A randomized controlled clinical trial investigating the effect of synbiotic administration on markers of insulin metabolism and lipid profiles in overweight type 2 diabetic patients with coronary heart disease. Exp. Clin. Endocrinol. Diabetes 125, 21–27 (2017).
    • (2017) Exp. Clin. Endocrinol. Diabetes , vol.125 , pp. 21-27
    • Tajabadi-Ebrahimi, M.1
  • 112
    • 84922277304 scopus 로고    scopus 로고
    • Consumption of Bifidobacterium lactis Bi-07 by healthy elderly adults enhances phagocytic activity of monocytes and granulocytes
    • PID: 25191600
    • Maneerat, S. et al. Consumption of Bifidobacterium lactis Bi-07 by healthy elderly adults enhances phagocytic activity of monocytes and granulocytes. J. Nutr. Sci. 2, e44 (2013).
    • (2013) J. Nutr. Sci. , vol.2
    • Maneerat, S.1
  • 113
    • 79952083516 scopus 로고    scopus 로고
    • Beneficial effects of a synbiotic supplement on self-perceived gastrointestinal well-being and immunoinflammatory status of healthy adults
    • PID: 21244240
    • Nova, E., Viadel, B., Warnberg, J., Carreres, J. E. & Marcos, A. Beneficial effects of a synbiotic supplement on self-perceived gastrointestinal well-being and immunoinflammatory status of healthy adults. J. Med. Food 14, 79–85 (2011).
    • (2011) J. Med. Food , vol.14 , pp. 79-85
    • Nova, E.1    Viadel, B.2    Warnberg, J.3    Carreres, J.E.4    Marcos, A.5
  • 114
    • 85058791463 scopus 로고    scopus 로고
    • The effects of synbiotic supplementation on metabolic status in diabetic patients undergoing hemodialysis: a randomized, double-blinded, placebo-controlled trial
    • COI: 1:CAS:528:DC%2BC1cXisFCitLfN
    • Soleimani, A. et al. The effects of synbiotic supplementation on metabolic status in diabetic patients undergoing hemodialysis: a randomized, double-blinded, placebo-controlled trial. Probiotics Antimicro. Prot. 11, 1248–1256 (2019).
    • (2019) Probiotics Antimicro. Prot. , vol.11 , pp. 1248-1256
    • Soleimani, A.1
  • 115
    • 84906854236 scopus 로고    scopus 로고
    • The efficacy of a synbiotic containing Bacillus coagulans in treatment of irritable bowel syndrome: a randomized placebo-controlled trial
    • PID: 25120896
    • Rogha, M., Esfahani, M. Z. & Zargarzadeh, A. H. The efficacy of a synbiotic containing Bacillus coagulans in treatment of irritable bowel syndrome: a randomized placebo-controlled trial. Gastroenterol. Hepatol. Bed Bench 7, 156–163 (2014).
    • (2014) Gastroenterol. Hepatol. Bed Bench , vol.7 , pp. 156-163
    • Rogha, M.1    Esfahani, M.Z.2    Zargarzadeh, A.H.3
  • 116
    • 85014413099 scopus 로고    scopus 로고
    • Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: a randomized controlled trial
    • PID: 27782892
    • Basturk, A., Artan, R. & Yilmaz, A. Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: a randomized controlled trial. Turk. J. Gastroenterol. 27, 439–443 (2016).
    • (2016) Turk. J. Gastroenterol. , vol.27 , pp. 439-443
    • Basturk, A.1    Artan, R.2    Yilmaz, A.3
  • 117
    • 85020898145 scopus 로고    scopus 로고
    • The effect of probiotic plus prebiotic supplementation on the tolerance and efficacy of Helicobacter pylori eradication quadruple therapy: a randomized prospective double blind controlled trial
    • PID: 27698967
    • Shafaghi, A. et al. The effect of probiotic plus prebiotic supplementation on the tolerance and efficacy of Helicobacter pylori eradication quadruple therapy: a randomized prospective double blind controlled trial. Middle East J. Dig. Dis. 8, 179–188 (2016).
    • (2016) Middle East J. Dig. Dis. , vol.8 , pp. 179-188
    • Shafaghi, A.1
  • 118
    • 85059784291 scopus 로고    scopus 로고
    • Are synbiotics added to the standard therapy to eradicate Helicobacter pylori in children beneficial? A randomized controlled study
    • Sirvan, B. N., Usta, M. K., Kizilkan, N. U. & Urganci, N. Are synbiotics added to the standard therapy to eradicate Helicobacter pylori in children beneficial? A randomized controlled study. Euroasian J. Hepatogastroenterol. 7, 17–22 (2017).
    • (2017) Euroasian J. Hepatogastroenterol. , vol.7 , pp. 17-22
    • Sirvan, B.N.1    Usta, M.K.2    Kizilkan, N.U.3    Urganci, N.4
  • 119
    • 85043485775 scopus 로고    scopus 로고
    • The effects of synbiotic supplementation on metabolic status in women with polycystic ovary syndrome: a randomized double-blind clinical trial
    • COI: 1:CAS:528:DC%2BC1cXksVegu70%3D
    • Samimi, M. et al. The effects of synbiotic supplementation on metabolic status in women with polycystic ovary syndrome: a randomized double-blind clinical trial. Probiotics Antimicrob. Prot. 11, 1355–1361 (2019).
    • (2019) Probiotics Antimicrob. Prot. , vol.11 , pp. 1355-1361
    • Samimi, M.1
  • 120
    • 85045411060 scopus 로고    scopus 로고
    • The effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial
    • PID: 29649996
    • Nasri, K. et al. The effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. BMC Endocr. Disord. 18, 21 (2018).
    • (2018) BMC Endocr. Disord. , vol.18
    • Nasri, K.1
  • 121
    • 84929045778 scopus 로고    scopus 로고
    • Effect of short-term synbiotic treatment on plasma p-cresol levels in patients with chronic renal failure: a randomized clinical trial
    • COI: 1:CAS:528:DC%2BC2cXhtVWrsLjI, PID: 24929795
    • Guida, B. et al. Effect of short-term synbiotic treatment on plasma p-cresol levels in patients with chronic renal failure: a randomized clinical trial. Nutr. Metab. Cardiovasc. Dis. 24, 1043–1049 (2014).
    • (2014) Nutr. Metab. Cardiovasc. Dis. , vol.24 , pp. 1043-1049
    • Guida, B.1
  • 122
    • 85003520704 scopus 로고    scopus 로고
    • Synbiotic supplementations for azotemia in patients with chronic kidney disease: a randomized controlled trial
    • PID: 27903994
    • Dehghani, H., Heidari, F., Mozaffari-Khosravi, H., Nouri-Majelan, N. & Dehghani, A. Synbiotic supplementations for azotemia in patients with chronic kidney disease: a randomized controlled trial. Iran. J. Kidney Dis. 10, 351–357 (2016).
    • (2016) Iran. J. Kidney Dis. , vol.10 , pp. 351-357
    • Dehghani, H.1    Heidari, F.2    Mozaffari-Khosravi, H.3    Nouri-Majelan, N.4    Dehghani, A.5
  • 123
    • 84957107822 scopus 로고    scopus 로고
    • Synbiotics easing renal failure by improving gut microbiology (SYNERGY): a randomized trial
    • COI: 1:CAS:528:DC%2BC28XitV2qsbnJ, PID: 26772193
    • Rossi, M. et al. Synbiotics easing renal failure by improving gut microbiology (SYNERGY): a randomized trial. Clin. J. Am. Soc. Nephrol. 11, 223–231 (2016).
    • (2016) Clin. J. Am. Soc. Nephrol. , vol.11 , pp. 223-231
    • Rossi, M.1
  • 124
    • 33845951414 scopus 로고    scopus 로고
    • Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial
    • COI: 1:CAS:528:DC%2BD2sXit1Okug%3D%3D, PID: 17208601
    • Kukkonen, K. et al. Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. J. Allergy Clin. Immunol. 119, 192–198 (2007).
    • (2007) J. Allergy Clin. Immunol. , vol.119 , pp. 192-198
    • Kukkonen, K.1
  • 125
    • 77954803014 scopus 로고    scopus 로고
    • Probiotic supplement reduces atopic dermatitis in preschool children: a randomized, double-blind, placebo-controlled, clinical trial
    • PID: 20642296
    • Gerasimov, S. V., Vasjuta, V. V., Myhovych, O. O. & Bondarchuk, L. I. Probiotic supplement reduces atopic dermatitis in preschool children: a randomized, double-blind, placebo-controlled, clinical trial. Am. J. Clin. Dermatol. 11, 351–361 (2010).
    • (2010) Am. J. Clin. Dermatol. , vol.11 , pp. 351-361
    • Gerasimov, S.V.1    Vasjuta, V.V.2    Myhovych, O.O.3    Bondarchuk, L.I.4
  • 126
    • 79959206424 scopus 로고    scopus 로고
    • Effect of a new synbiotic mixture on atopic dermatitis in children: a randomized-controlled trial
    • PID: 23056792
    • Farid, R., Ahanchian, H., Jabbari, F. & Moghiman, T. Effect of a new synbiotic mixture on atopic dermatitis in children: a randomized-controlled trial. Iran. J. Pediatr. 21, 225–230 (2011).
    • (2011) Iran. J. Pediatr. , vol.21 , pp. 225-230
    • Farid, R.1    Ahanchian, H.2    Jabbari, F.3    Moghiman, T.4
  • 127
    • 84555167773 scopus 로고    scopus 로고
    • Lactobacillus salivarius plus fructo-oligosaccharide is superior to fructo-oligosaccharide alone for treating children with moderate to severe atopic dermatitis: a double-blind, randomized, clinical trial of efficacy and safety
    • COI: 1:CAS:528:DC%2BC38XivFOqt78%3D, PID: 21895621
    • Wu, K. G., Li, T. H. & Peng, H. J. Lactobacillus salivarius plus fructo-oligosaccharide is superior to fructo-oligosaccharide alone for treating children with moderate to severe atopic dermatitis: a double-blind, randomized, clinical trial of efficacy and safety. Br. J. Dermatol. 166, 129–136 (2012).
    • (2012) Br. J. Dermatol. , vol.166 , pp. 129-136
    • Wu, K.G.1    Li, T.H.2    Peng, H.J.3
  • 128
    • 84900505942 scopus 로고    scopus 로고
    • Xylo-oligosaccharides alone or in synbiotic combination with Bifidobacterium animalis subsp. lactis induce bifidogenesis and modulate markers of immune function in healthy adults: a double-blind, placebo-controlled, randomised, factorial cross-over study
    • COI: 1:CAS:528:DC%2BC2cXnslOisbw%3D, PID: 24661576
    • Childs, C. E. et al. Xylo-oligosaccharides alone or in synbiotic combination with Bifidobacterium animalis subsp. lactis induce bifidogenesis and modulate markers of immune function in healthy adults: a double-blind, placebo-controlled, randomised, factorial cross-over study. Br. J. Nutr. 111, 1945–1956 (2014).
    • (2014) Br. J. Nutr. , vol.111 , pp. 1945-1956
    • Childs, C.E.1
  • 129
    • 84885084856 scopus 로고    scopus 로고
    • Effect of the consumption of a cheese enriched with probiotic organisms (Bifidobacterium lactis Bi-07) in improving symptoms of constipation
    • PID: 24322191
    • Favretto, D. C., Pontin, B. & Moreira, T. R. Effect of the consumption of a cheese enriched with probiotic organisms (Bifidobacterium lactis Bi-07) in improving symptoms of constipation. Arq. Gastroenterol. 50, 196–201 (2013).
    • (2013) Arq. Gastroenterol. , vol.50 , pp. 196-201
    • Favretto, D.C.1    Pontin, B.2    Moreira, T.R.3


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