Ameliorative effect of probiotics (Lactobacillus paracaseii and Protexin®) and prebiotics (propolis and bee pollen) on clindamycin and propionic acid-induced oxidative stress and altered gut microbiota in a rodent model of autism

Cellular and Molecular Biology

Volumn 65, Issue 1, 2019, Pages 1-7

  Aabed, Kawther ^a   Bhat, Ramesa Shaf ^b   Moubayed, Nadine ^b   Al Mutiri, Manar ^c   Al Marshoud, Majda ^c   Al Qahtani, Alaa ^a   El Ansary, Afaf ^c,d  

^a PRINCESS NOURAH BINT ABDULRAHMAN UNIVERSITY   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

^d NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Autism; Bee pollen; Clindamycin; Fecal transplant; Lactobacillus; Prebiotic; Probiotic; Propionic acid; Propolis

Indexed keywords

AMANTADINE; ASCORBIC ACID; BIOLOGICAL MARKER; CLINDAMYCIN; GLUTATHIONE; LIPID PEROXIDASE; PREBIOTIC AGENT; PROBIOTIC AGENT; PROPIONIC ACID; PROPOLIS; PROPIONIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTISM; BACTERIAL COUNT; BACTERIUM IDENTIFICATION; BACTEROIDETES; BRAIN HOMOGENATE; CLOSTRIDIUM; COLONY FORMING UNIT; CONTROLLED STUDY; FECAL MICROBIOTA TRANSPLANTATION; FIRMICUTES; HAMSTER MODEL; INTESTINE FLORA; LACTOBACILLUS; LACTOBACILLUS PARACASEII; MALE; NONHUMAN; OXIDATIVE STRESS; POLLEN; SYRIAN HAMSTER; ANIMAL; BACTERIUM; BEE; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; HAMSTER; MICROBIOLOGY; RECEIVER OPERATING CHARACTERISTIC;

ANIMALS; AUTISTIC DISORDER; BACTERIA; BEES; CLINDAMYCIN; COLONY COUNT, MICROBIAL; CRICETINAE; DISEASE MODELS, ANIMAL; GASTROINTESTINAL MICROBIOME; MALE; OXIDATIVE STRESS; PREBIOTICS; PROBIOTICS; PROPIONATES; PROPOLIS; ROC CURVE;

EID: 85061871049     PISSN: 01455680     EISSN: 1165158X     Source Type: Journal    
DOI: 10.14715/cmb/2019.65.1.1     Document Type: Article

References (43)

1. 1. Belzung C, Leman S, Vourc'h, P Andres C, Rodent models for autism: a critical review, Drug Discov. Today Dis. Model. 2005;2: 93-101
2. 2. Foley KA, MacFabe DF, Vaz A, Ossenkopp KP, Kavaliers M. Sexually dimorphic efects of prenatal exposure to propionic acid and lipopolysaccharide on social behavior in neonatal, adolescent,and adult rats: implications for autism spectrum disorders. Int J Dev Neurosci. 2014b;39:68-78.
3. 3. MacFabe, D.F. Cain, D.P. Rodriguez-Capote, K. Franklin, A.E. Hofman, J.E. Boon, F. Taylor, A.R. Kavaliers, M. Ossenkopp, K.P. Neurobiological efects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders, Behav. Brain Res. 2007;176 (1): 149-169.
4. 4. El-Ansary AK, Ben Bacha A, Kotb M Etiology of autistic features: the persisting neurotoxic efects of propionic acid. J Neuroin-fammation. 2012; 9:74.
5. 5. Xiong X, Liu D, Wang Y, Zeng T, Peng Y. Urinary 3-(3-hydroxyphenyl)-3-hydroxypropionic acid, 3-hydroxypheny-lacetic acid, and 3-Hydroxyhippuric acid are elevated in children with autism spectrum disorders BioMed Res. Int. 2016 9485412, 10.1155/2016/9485412
6. 6. Salminen MK, Rautelin H, Tynkkynen S, Lactobacillus bactere-mia, clinical signifcance, and patient outcome, with special focus on probiotic L. rhamnosus GG. Clin. Infect. Dis; 2004. 38, 62-69.
7. 7. Vibhute VM, Shelke RR, Chavan SD, Nage SP, Efect of pro-biotics supplementation on the performance of lactating crossbred cows. Vet. World 2011 4, 557-561.
8. 8. Chaucheyras F, Durand H, Probiotics in animal nutrition and health. Benef. Microbes 2010 25, 3-9.
9. 9. Preedy VR, Watson RR, Probiotics, prebiotics and synbiotics, second ed. Langford, London. 2016.
10. 10. McFarland LV. Meta-analysis of probiotics for the prevention of traveler's diarrhea. Travel Med Infect Dis. 2007;2:97-105.
11. 11. Hickson M. Probiotics in the prevention of antibiotic-associated diarrhoea and Clostridium difcile infection. Therap Adv Gastroen-terol. 2011; 4(3): 185-197.
12. 12. Alison Sinclair, Xuanqian Xie, Lama Saab, Nandini Denduku-ri, Lactobacillus probiotics in the prevention of diarrhea associated with Clostridium difcile: a systematic review and Bayesian hierarchical meta-analysis. CMAJ Open. 2016 4(4): 706-718.
13. 13. Komosinska-Vassev K, Olczyk P, Kazmierczak J, Mencner L, Olczyk K. Bee pollen: chemical composition and therapeutic application. Evid Based Complement Alternat Med. 2015; 2015: 297425.
14. 14. Baltrusayt V, Venskmonis PR, Ceksteryte V. Antibacterial activity of honey and beebread of diferent origin against Saureus and S-epidermidis. Food Technol Biotechnol. 2007; 45(2):201-8.
15. 15. Erkmen O, Ozcan MM. Antimicrobial efects of Turkishpropolis pollen, and laurel on spoilage and pathogenic foodrelated microorganisms. J Med Food. 2008;11(3):587-92
16. 16. Trevor D. Lawley, Simon Clare, Alan W. Walker1., Mark D. Stares, Thomas R. Connor, Claire Raisen, David Goulding, Roland Rad, Fernanda Schreiber1, Cordelia Brandt1, Laura J. Deakin, Derek J. Pickard, Sylvia H. Duncan, Harry J. Flint, Taane G. Clark, Julian Parkhill, Gordon Dougan. Targeted Restoration of the Intestinal Microbiota with a Simple, Defned Bacteriotherapy Resolves Relapsing Clostridium difcile Disease in Mice. PLOS pathogens, 2012 8: e1002995.
17. 17. Ruiz-Larrea MB, Leal AM, Liza M, Lacort M, de Groot H. Antioxidant efects of estradiol and 2-hydroxyestradiol on iron-induced lipid peroxidation of rat liver microsome. Steroids.1994; 159,383
18. 18. Jagota SK, Dani HMA. New colorimetric technique for the estimation of Vitamin C using Folin phenol reagent. Anal Bio-chem.1982; 15, 178.
19. 19. Beutle E, Duran O, Kelly BM Improved method for the determi-nation of blood glutathione. J Lab Clin Med. 1963; 61, 882.
20. 20. Habig WH, Pabst MJ, Jacoby WB, G. Glutathione-S-transferase, the frst enzymatic step. J Biol Chem 1974; 249, 7130-9.
21. 21. Ewing,W.HEdwards and Ewing's identifcation of Enterobacte-riaceae, 4th ed. Elsevier Science Publishing Co., Inc., New York, N.Y. 1986.
22. 22. Isenberg, H.D. Clinical microbiology procedures handbook. Am. Soc. Microbiol. Wash. P. 1;1994
23. 23. Al-Dbass A Efect of N-Acetylcysteine in ameliorating the neur-toxic efects of propionic acid in rat pups, King Saud university journal [science], 2014 26(4), 254-260.
24. 24. Allen J W, Shanker G. Aschner M. Methylmercury inhibits the in vitro uptake of the glutathione precursor, cystine, in astrocytes, but not in neurons. Brain Res. 2001a 894, 131-140.
25. 25. Ares AM, Valverde S, Bernal JL, Nozal MJ, Bernal J. Extraction and determination of bioactive compounds from bee pollen. J Pharm Biomed Anal. 2018 147:110-124. 8.
26. 26. Oryan A, Alemzadeh E, Moshiri A. Potential role of propolis in wound healing: Biological properties and therapeutic activities. Biomed Pharmacother. 2018;98:469-483. 27.
27. 27. Pasupuleti VR, Sammugam L, Ramesh N, Gan SH. Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their BiologicalActions and Health Benefts. Oxid Med Cell Longev. 2017:1259510.
28. 28. Andrade JKS, Denadai M, de Oliveira CS, Nunes ML, Narain N. Evaluation of bioactive compounds potential and antioxidant activity of brown, green and red propolis from Brazilian northeast region. Food Res Int. 2017; 101:129-138.
29. 29. Nanaware S, Shelar M, Sinnathambi A, Mahadik KR, Lohidasan S. Neuroprotective efect of Indian propolis in ß-amyloid induced memory defcit: Impact on behavioral and biochemical parameters in rats. Biomed Pharmacother. 2017; 93:543-553. 4.
30. 30. Ejtahed HS, Mohtadi-Nia J, Homayouni-Rad A, et al. Probiotic yogurt improvesantioxidant status in type 2 diabetic patients.Nutri-tion 2012; 28(5) 539-543.
31. 31. Asemi Z, Jazayeri S, Najaf M, Samimi M, Mofd V, Shidfar F, Shakeri H, Esmaillzadeh A. Efect of daily consumption of pro-biotic yogurt on oxidative stress in pregnantwomen: a randomized controlled clinical trial. Annals of Nutrition and Metabolism 2012; 60(1):62-68.
32. 32. Zhang Y, Du R, Wang L, Zhang H. The antioxidative efects of probiotic Lactobacilluscasei Zhang on the hyperlipidemic rats. European Food Research and Technology 2010; 231(1)151-158.
33. 33. Wang AN,Yi XW, Yu HF, Dong B, Qiao SY. Free radical scavenging activity ofLactobacillus fermentum in vitro and its antioxida-tive efect on growing-fnishing pigs.Journal of Applied Microbiology 2009; 107(4)1140-1148.
34. 34. Chang JY, Antonopoulos DA, Kalra A, Tonelli A, Khalife WT, et al. Decreased diversity of the fecal Microbiome in recurrent Clostri-dium difcile associated diarrhea. J Infect Dis. 2008. 197: 435-438.
35. 35. Robinson CJ, Bohannan BJ, Young VB From structure to function: the ecology of host-associated microbial communities. Micro-biol Mol Biol Rev 2010 74: 453-476.
36. 36. Borody TJ, Warren EF, Leis SM, Surace R, and Ashman O, et al. Bacteriotherapy using fecal fora: toying with human motions. J Clin Gastroenterol 2004. 38: 475-483.
37. 37. McFarland LV Evidence-based review of probiotics for antibio-ticassociated diarrhea and Clostridium difcile infections. Anaerobe 2009 15: 274-280.
38. 38. Dethlefsen L, Relman DA Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proc Natl Acad Sci 2011; 1: 4554-4561.
39. 39. Antonopoulos DA, Huse SM, Morrison HG, Schmidt TM, Sogin ML, et al. Reproducible community dynamics of the gastrointestinal microbiotafollowing antibiotic perturbation. Infect Immun 2009; 77: 2367-2375.
40. 40. Endt K, Stecher B, Chafron S, Slack E, Tchitchek N, et al. The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal Salmonella diarrhea. PLoS Pathog 2010; 6: e1001097.
41. 41. Croswell A, Amir E, Teggatz P, Barman M, Salzman NH Prolonged Impact of Antibiotics on Intestinal Microbial Ecology and Susceptibility to Enteric Salmonella Infection. Infect Immun 2009; 77: 2741-53.
42. 42. Finegold, S. Therapy and epidemiology of autism-clostridial spores as key elements. Medical Hypotheses 2008; 70, 508-511
43. 43. Borody TJ, Khoruts A Fecal microbiota transplantation and emer-gingapplications. Nat Rev Gastroenterol Hepatol 2012; 9: 88-96.