Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial

Turkish Journal of Gastroenterology

Volumn 27, Issue 5, 2016, Pages 439-443

  Başturk, Ahmet ^a   Artan, Reha ^a   Yilmaz, Aygen ^a  

^a AKDENIZ UNIVERSITY   (Turkey)

Author keywords

Bifidobacterium lactis B94; Child; Irritable bowel syndrome; Probiotic; Synbiotic

Indexed keywords

INULIN; MAFLOR; PROBIOTIC AGENT; SYNBIOTIC AGENT; UNCLASSIFIED DRUG; PREBIOTIC AGENT;

ABDOMINAL PAIN; ADOLESCENT; ARTICLE; BIFIDOBACTERIUM ANIMALIS; BLOATING; CHILD; CONSTIPATION; CONTROLLED STUDY; DEFECATION URGENCY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; ERUCTATION; FEMALE; HUMAN; IRRITABLE COLON; MAJOR CLINICAL STUDY; MALE; MUCUS; RANDOMIZED CONTROLLED TRIAL; COMPLICATION; FLATULENCE; MICROBIOLOGY; PRESCHOOL CHILD; PROSPECTIVE STUDY; TREATMENT OUTCOME;

ADOLESCENT; BIFIDOBACTERIUM ANIMALIS; CHILD; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; ERUCTATION; FEMALE; FLATULENCE; HUMANS; INULIN; IRRITABLE BOWEL SYNDROME; MALE; PREBIOTICS; PROBIOTICS; PROSPECTIVE STUDIES; SYNBIOTICS; TREATMENT OUTCOME;

EID: 85014413099     PISSN: 13004948     EISSN: 21485607     Source Type: Journal    
DOI: 10.5152/tjg.2016.16301     Document Type: Article

References (28)

1. Bercik P, Verdu EF, Collins SM. Is irritable bowel syndrome a lowgrade inflammatory bowel disease? Gastroenterol Clin North Am 2005; 34: 235-45. [CrossRef]
2. Tillisch K, Labus JS, Naliboff BD, et al. Characterization of the alternating bowel habit subtype in patients with irritable bowel syndrome. Am J Gastroenterol 2005; 100: 896-904. [CrossRef]
3. Saad R, Chey WD. Breath testing for small intestinal bacterial overgrowth: Maximizing test accuracy. Clin Gastroenterol Hepatol 2014; 12: 1964-72. [CrossRef]
4. Delvaux M. Role of visceral sensitivity in the pathophysiology of irritable bowel syndrome. Gut 2002; 51: 67-71. [CrossRef]
5. Spence MJ, Moss-Morris R. The cognitive behavioural model of irritable bowel syndrome: A prospective investigation of patients with gastroenteritis. Gut 2007; 56: 1066-71. [CrossRef]
6. Aragon G, Graham DB, Borum M, Doman DB. Probiotic therapy for irritable bowel syndrome. Gastroenterol Hepatol (NY) 2010; 6: 39-44.
7. Hill C, Guarner F, Reid G, et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 2014; 11: 506-14. [CrossRef]
8. Vandenplas Y. Oligosaccharides in infant formula. Br J Nutr 2002; 87: 293-6. [CrossRef]
9. Roberfroid M. Dietary fiber, inulin, and oligofructose: A review comparing their physiologica leffects. Crit Rev Food Sci Nutr 1993; 33: 103-48. [CrossRef]
10. Hosseini A, Nikfar S, Abdollahi M. Are probiotics effective in management of irritable bowel syndrome? Arch Med Sci 2012; 8: 403-5. [CrossRef]
11. O'Mahony L, McCarthy J, Kelly P, et al. Lactobacillus and Bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles. Gastroenterology 2005; 128: 541-51. [CrossRef]
12. Yoon JS, Sohn W, Lee OY, et al. Effect of multispecies probiotics on irritable bowel syndrome: A randomized, double-blind, placebocontrolled trial. J Gastroenterol Hepatol 2014; 29: 52-9. [CrossRef]
13. Ki Cha B, Mun Jung S, Hwan Choi C, et al. The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: A randomized, double-blind, placebo-controlled trial. J Clin Gastroenterol 2012; 46: 220-7. [CrossRef]
14. Williams EA, Stimpson J, Wang D, et al. Clinical trial: A multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study. Aliment Pharmacol Ther 2009; 29: 97-103. [CrossRef]
15. Kajander K, Myllyluoma E, Rajilić-Stojanović M, et al. Clinical trial: Multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota. Aliment Pharmacol Ther 2008; 27: 48-57. [CrossRef]
16. Sondergaard B, Olsson J, Ohlson K, et al. Effects of probiotic fermented milk on symptoms and intestinal flora in patients with irritable bowel syndrome: A randomized, placebo-controlled trial. Scand J Gastroenterol 2011; 46: 663-72. [CrossRef]
17. Min YW, Park SU, Jang YS, et al. Effect of composite yogurt enriched with acacia fiber and Bifidobacterium lactis. World J Gastroenterol 2012; 18: 4563-9. [CrossRef]
18. Agrawal A, Houghton LA, Morris J, et al. Clinical trial: The effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation. Aliment Pharmacol Ther 2009; 29: 104-14. [CrossRef]
19. Szajewska H, Setty M, Mrukowicz J, Guandalini S. Probiotics in gastrointestinal diseases in children: Hard and not-so-hard evidence of efficacy. J Pediatr Gastroenterol Nutr 2006; 42: 454-75. [CrossRef]
20. Quigley EM. Prebiotics for irritable bowel syndrome. Expert Rev Gastroenterol Hepatol 2009; 3: 487-92. [CrossRef]
21. Olesen M, Gudmand-Hoyer E. Efficacy, safety, and tolerability of fructooligosaccharides in the treatment of irritable bowel syndrome. Am J Clin Nutr 2000; 72: 1570-5.
22. Hunter JO, Tuffnell Q, Lee AJ. Controlled trial of oligofructose in the management of irritable bowel syndrome. J Nutr 1999; 129(Suppl 7): 1451-3.
23. Paineau D, Payen F, Panserieu S, et al. The effects of regular consumption of short-chain fructo-oligosaccharides on digestive comfort of subjects with minor functional bowel disorders. Br J Nutr 2008; 99: 311-8. [CrossRef]
24. Silk DB, Davis A, Vulevic J, et al. Clinical trial: The effects of a transgalactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome. Aliment Pharmacol Ther 2009; 29: 508-18. [CrossRef]
25. Cappello C, Tremolaterra F, Pascariello A, Ciacci C, Iovino P. A randomised clinical trial (RCT) of a synbiotic mixture in patients with irritable bowel syndrome (IBS): Effects on symptoms, colonic transit and quality of life. Int J Colorectal Dis 2013; 28: 349-58. [CrossRef]
26. Bittner AC, Croffut RM, Stranahan MC. Prescript-Assist probioticprebiotic treatment for irritable bowel syndrome: A methodologically oriented, 2-week, randomized, placebo-controlled, doubleblind clinical study. Clin Ther 2005; 27: 755-61. [CrossRef]
27. Işlek A, Sayar E, Yilmaz A, Baysan BO, Mutlu D, Artan R. The role of Bifidobacterium lactis B94 plus inulin in the treatment of acute infectious diarrhea in children. Turk J Gastroenterol 2014; 25: 628-33. [CrossRef]
28. Islek A, Sayar E, Yilmaz A, Artan R. Bifidobacterium lactis B94 plus inulin for Treatment of Helicobacter pylori infection in children: Does it increase eradication rate and patient compliance? Acta Gastroenterol Belg 2015; 78: 282-6.o